PRKD2 (protein kinase D2) - Rat Genome Database

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Gene: PRKD2 (protein kinase D2) Homo sapiens
Analyze
Symbol: PRKD2
Name: protein kinase D2
RGD ID: 1342931
HGNC Page HGNC:17293
Description: Enables protein kinase C binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of signal transduction; protein phosphorylation; and regulation of DNA-templated transcription. Located in cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: HSPC187; nPKC-D2; PKD2; serine/threonine-protein kinase D2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: PKD2 (GeneID: 5311) and PRKD2 (GeneID: 25865) share the PKD2 symbol/alias in common. PKD2 is a widely used alternative name for protein kinase D2 (PRKD2), which can be confused with the official symbol for PKD2/polycystin-2/polycystic kidney disease 2. [19 Jun 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,674,316 - 46,717,114 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1946,674,275 - 46,717,127 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,177,573 - 47,220,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,869,413 - 51,912,224 (-)NCBINCBI36Build 36hg18NCBI36
Build 341951,869,412 - 51,911,506NCBI
Celera1943,981,103 - 44,023,914 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,602,696 - 43,645,312 (-)NCBIHuRef
CHM1_11947,179,449 - 47,222,284 (-)NCBICHM1_1
T2T-CHM13v2.01949,499,855 - 49,542,704 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IEA)
angiogenesis  (IEA)
cell adhesion  (IEA)
cell death  (IMP)
cellular response to vascular endothelial growth factor stimulus  (IGI,IMP)
endothelial tube morphogenesis  (TAS)
immune system process  (IEA)
intracellular signal transduction  (IEA,IMP)
peptidyl-serine phosphorylation  (IDA,IMP)
peptidyl-threonine phosphorylation  (IMP)
phosphorylation  (IEA)
positive regulation of angiogenesis  (IGI,IMP)
positive regulation of blood vessel endothelial cell migration  (IGI,IMP)
positive regulation of cell adhesion  (IMP)
positive regulation of CREB transcription factor activity  (IGI)
positive regulation of DNA biosynthetic process  (IEA,ISS)
positive regulation of DNA-binding transcription factor activity  (IMP)
positive regulation of endothelial cell chemotaxis  (IMP)
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  (IGI,IMP)
positive regulation of endothelial cell migration  (IMP)
positive regulation of endothelial cell proliferation  (IGI,IMP)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISS)
positive regulation of fibroblast growth factor receptor signaling pathway  (IMP)
positive regulation of histone deacetylase activity  (IGI)
positive regulation of interleukin-2 production  (IEA,ISS)
positive regulation of interleukin-8 production  (IMP)
positive regulation of intracellular signal transduction  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of peptidyl-serine phosphorylation  (IGI)
positive regulation of T cell receptor signaling pathway  (IEA,ISS)
positive regulation of transcription by RNA polymerase II  (IDA,IMP)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IMP)
protein autophosphorylation  (IDA,TAS)
protein kinase D signaling  (IBA,IGI)
protein modification process  (IEA)
protein phosphorylation  (IDA,IEA,NAS)
regulation of T cell apoptotic process  (IMP)
sphingolipid biosynthetic process  (TAS)
T cell receptor signaling pathway  (IDA)
vascular endothelial growth factor receptor signaling pathway  (IMP)

Cellular Component
cytoplasm  (IDA,IEA)
cytosol  (IDA,TAS)
Golgi apparatus  (IEA)
membrane  (IEA)
nucleoplasm  (IDA)
nucleus  (IDA,IEA)
plasma membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11042152   PMID:11062248   PMID:12058027   PMID:12477932   PMID:12646243   PMID:14702039   PMID:14743217   PMID:15231748   PMID:15604256   PMID:15623513   PMID:15975900   PMID:16083285  
PMID:16344560   PMID:16899224   PMID:16928771   PMID:17077180   PMID:17081983   PMID:17121608   PMID:17192257   PMID:17570131   PMID:17951978   PMID:17962809   PMID:18059339   PMID:18262756  
PMID:18440775   PMID:18758461   PMID:19001381   PMID:19192391   PMID:19430480   PMID:19520973   PMID:19581308   PMID:19615732   PMID:19913121   PMID:20332261   PMID:20497126   PMID:20553269  
PMID:20628086   PMID:20731705   PMID:20732914   PMID:20855867   PMID:21081666   PMID:21173164   PMID:21488147   PMID:21736870   PMID:21865166   PMID:21873635   PMID:21900206   PMID:22020285  
PMID:22217708   PMID:22228765   PMID:22734003   PMID:22939624   PMID:23251465   PMID:23393329   PMID:23515950   PMID:23562655   PMID:24336522   PMID:24463355   PMID:24840177   PMID:25218347  
PMID:25802335   PMID:25874490   PMID:25921289   PMID:26186194   PMID:26241492   PMID:26253275   PMID:26426580   PMID:26496610   PMID:26673895   PMID:27662904   PMID:27684187   PMID:28428613  
PMID:28514442   PMID:28675297   PMID:29259300   PMID:29955894   PMID:30018032   PMID:30196744   PMID:30652415   PMID:30718593   PMID:30841931   PMID:30843621   PMID:30948266   PMID:31091453  
PMID:31332168   PMID:31753913   PMID:32509391   PMID:32707033   PMID:33519497   PMID:33567341   PMID:33949105   PMID:33961781   PMID:34315543   PMID:35256949   PMID:35271311   PMID:35563538  


Genomics

Comparative Map Data
PRKD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381946,674,316 - 46,717,114 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1946,674,275 - 46,717,127 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,177,573 - 47,220,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,869,413 - 51,912,224 (-)NCBINCBI36Build 36hg18NCBI36
Build 341951,869,412 - 51,911,506NCBI
Celera1943,981,103 - 44,023,914 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1943,602,696 - 43,645,312 (-)NCBIHuRef
CHM1_11947,179,449 - 47,222,284 (-)NCBICHM1_1
T2T-CHM13v2.01949,499,855 - 49,542,704 (-)NCBIT2T-CHM13v2.0
Prkd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,576,827 - 16,604,386 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,576,827 - 16,604,389 (+)EnsemblGRCm39 Ensembl
GRCm38716,842,902 - 16,870,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,842,902 - 16,870,464 (+)EnsemblGRCm38mm10GRCm38
MGSCv37717,428,414 - 17,455,810 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36716,001,587 - 16,028,983 (+)NCBIMGSCv36mm8
Celera714,041,053 - 14,076,870 (+)NCBICelera
Cytogenetic Map7A2NCBI
Prkd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,513,625 - 77,542,386 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,513,986 - 77,542,376 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx182,894,204 - 82,922,473 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0191,458,248 - 91,486,518 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0184,649,293 - 84,677,564 (+)NCBIRnor_WKY
Rnor_6.0178,767,911 - 78,796,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,767,911 - 78,796,231 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0180,015,106 - 80,043,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,168,290 - 77,197,277 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,246,400 - 77,275,388 (+)NCBI
Celera171,999,137 - 72,027,468 (+)NCBICelera
Cytogenetic Map1q21NCBI
Prkd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574723,933 - 750,793 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574723,933 - 750,794 (-)NCBIChiLan1.0ChiLan1.0
PRKD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11952,195,096 - 52,238,758 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,195,303 - 52,237,731 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01943,666,591 - 43,710,858 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRKD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,206,400 - 109,241,529 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,207,067 - 109,330,007 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,686,213 - 108,721,121 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,732,886 - 109,767,802 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,732,806 - 109,767,767 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11109,410,008 - 109,444,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,044,199 - 109,079,115 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,912,894 - 109,947,820 (+)NCBIUU_Cfam_GSD_1.0
Prkd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934918,906,807 - 18,933,390 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936664522,910 - 551,469 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936664524,532 - 551,451 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,559,393 - 52,599,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,559,066 - 52,599,174 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,880,007 - 47,919,799 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,028,214 - 40,071,523 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl640,027,552 - 40,071,455 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607319,740,729 - 19,783,637 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,886,327 - 6,915,179 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,885,627 - 6,915,316 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRKD2
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.32(chr19:46434490-46831000)x3 copy number gain See cases [RCV000050320] Chr19:46434490..46831000 [GRCh38]
Chr19:46937747..47334257 [GRCh37]
Chr19:51629587..52026097 [NCBI36]
Chr19:19q13.32
uncertain significance
GRCh38/hg38 19q13.32-13.33(chr19:46658791-49050450)x3 copy number gain See cases [RCV000052913] Chr19:46658791..49050450 [GRCh38]
Chr19:47162048..49553707 [GRCh37]
Chr19:51853888..54245519 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh38/hg38 19q13.32-13.33(chr19:46458122-47683579)x1 copy number loss See cases [RCV000053976] Chr19:46458122..47683579 [GRCh38]
Chr19:46961379..48186836 [GRCh37]
Chr19:51653219..52878648 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh38/hg38 19q13.32-13.33(chr19:44971420-48257402)x3 copy number gain See cases [RCV000136578] Chr19:44971420..48257402 [GRCh38]
Chr19:45474677..48760659 [GRCh37]
Chr19:50166517..53452471 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh38/hg38 19q13.32(chr19:45387389-46831000)x1 copy number loss See cases [RCV000137832] Chr19:45387389..46831000 [GRCh38]
Chr19:45890647..47334257 [GRCh37]
Chr19:50582487..52026097 [NCBI36]
Chr19:19q13.32
likely pathogenic
GRCh38/hg38 19q13.32(chr19:46434490-46831000)x3 copy number gain See cases [RCV000148268] Chr19:46434490..46831000 [GRCh38]
Chr19:46937747..47334257 [GRCh37]
Chr19:51629587..52026097 [NCBI36]
Chr19:19q13.32
uncertain significance
GRCh37/hg19 19q13.2-13.32(chr19:43013365-47241534)x1 copy number loss See cases [RCV000240182] Chr19:43013365..47241534 [GRCh37]
Chr19:19q13.2-13.32
pathogenic
GRCh37/hg19 19q13.32(chr19:46918881-47782258)x3 copy number gain See cases [RCV000446734] Chr19:46918881..47782258 [GRCh37]
Chr19:19q13.32
uncertain significance
GRCh37/hg19 19q13.32-13.33(chr19:46404248-48488721)x1 copy number loss See cases [RCV000511362] Chr19:46404248..48488721 [GRCh37]
Chr19:19q13.32-13.33
likely pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
NM_016457.5(PRKD2):c.1478G>C (p.Gly493Ala) single nucleotide variant not provided [RCV000962733] Chr19:46693973 [GRCh38]
Chr19:47197230 [GRCh37]
Chr19:19q13.32
benign
NM_016457.5(PRKD2):c.918C>T (p.Cys306=) single nucleotide variant not provided [RCV000882940] Chr19:46701084 [GRCh38]
Chr19:47204341 [GRCh37]
Chr19:19q13.32
benign
NC_000019.10:g.(?_46605817)_(46756948_?)dup duplication Walker-Warburg congenital muscular dystrophy [RCV001031501] Chr19:47109074..47260205 [GRCh37]
Chr19:19q13.32
uncertain significance
NM_016457.5(PRKD2):c.1824C>G (p.Pro608=) single nucleotide variant not provided [RCV000970363] Chr19:46689684 [GRCh38]
Chr19:47192941 [GRCh37]
Chr19:19q13.32
benign
GRCh37/hg19 19q13.32-13.33(chr19:47036361-48525536) copy number gain not provided [RCV000767770] Chr19:47036361..48525536 [GRCh37]
Chr19:19q13.32-13.33
pathogenic
NM_016457.5(PRKD2):c.1318-9G>A single nucleotide variant not provided [RCV000962748] Chr19:46694142 [GRCh38]
Chr19:47197399 [GRCh37]
Chr19:19q13.32
benign
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33
pathogenic
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42
pathogenic
GRCh37/hg19 19q13.32-13.33(chr19:45531056-48174177)x3 copy number gain not provided [RCV001007051] Chr19:45531056..48174177 [GRCh37]
Chr19:19q13.32-13.33
uncertain significance
NM_016457.5(PRKD2):c.667-6C>T single nucleotide variant not provided [RCV001641355] Chr19:46704397 [GRCh38]
Chr19:47207654 [GRCh37]
Chr19:19q13.32
benign
GRCh37/hg19 19q13.32(chr19:46918881-47782258) copy number gain not specified [RCV002052687] Chr19:46918881..47782258 [GRCh37]
Chr19:19q13.32
uncertain significance
NC_000019.9:g.(?_47104692)_(47260195_?)dup duplication Long QT syndrome 1 [RCV001918807]|Walker-Warburg congenital muscular dystrophy [RCV001942938] Chr19:47104692..47260195 [GRCh37]
Chr19:19q13.32
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR17hsa-miR-17-5pMirecordsexternal_infoNANA18700987

Predicted Target Of
Summary Value
Count of predictions:5006
Count of miRNA genes:999
Interacting mature miRNAs:1264
Transcripts:ENST00000291281, ENST00000433867, ENST00000593363, ENST00000593492, ENST00000595132, ENST00000595515, ENST00000597088, ENST00000597390, ENST00000597589, ENST00000597641, ENST00000598633, ENST00000599019, ENST00000599464, ENST00000600194, ENST00000601605, ENST00000601806, ENST00000602155
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
A006X30  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,177,597 - 47,177,723UniSTSGRCh37
Build 361951,869,437 - 51,869,563RGDNCBI36
Celera1943,981,127 - 43,981,253RGD
Cytogenetic Map19q13.3UniSTS
HuRef1943,602,720 - 43,602,846UniSTS
GeneMap99-GB4 RH Map19255.98UniSTS
NCBI RH Map19516.7UniSTS
D19S1076  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371947,177,608 - 47,177,721UniSTSGRCh37
GRCh371947,177,639 - 47,177,788UniSTSGRCh37
Build 361951,869,448 - 51,869,561RGDNCBI36
Celera1943,981,138 - 43,981,251RGD
Celera1943,981,169 - 43,981,318UniSTS
Cytogenetic Map19q13.3UniSTS
HuRef1943,602,731 - 43,602,844UniSTS
HuRef1943,602,762 - 43,602,911UniSTS
TNG Radiation Hybrid Map1917573.0UniSTS
Stanford-G3 RH Map192361.0UniSTS
NCBI RH Map19509.8UniSTS
GeneMap99-G3 RH Map192372.0UniSTS
D19S1076  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19q13.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2410 2268 1407 352 1915 194 3575 1038 1100 338 1414 1596 171 1204 2017 3
Low 28 722 318 272 35 271 781 1159 2616 81 45 17 3 1 771 2 2
Below cutoff 1 1 14 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001079880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001079881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001079882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005258716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047438567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047438568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC093503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF151021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF309082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL050147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ783562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA475821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000291281   ⟹   ENSP00000291281
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,674,316 - 46,717,114 (-)Ensembl
RefSeq Acc Id: ENST00000433867   ⟹   ENSP00000393978
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,674,317 - 46,717,127 (-)Ensembl
RefSeq Acc Id: ENST00000593363   ⟹   ENSP00000472987
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,716,165 - 46,717,112 (-)Ensembl
RefSeq Acc Id: ENST00000593492
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,678,529 - 46,686,180 (-)Ensembl
RefSeq Acc Id: ENST00000595132   ⟹   ENSP00000470363
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,704,487 - 46,714,599 (-)Ensembl
RefSeq Acc Id: ENST00000595515   ⟹   ENSP00000470804
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,674,508 - 46,717,115 (-)Ensembl
RefSeq Acc Id: ENST00000597088
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,710,354 - 46,714,032 (-)Ensembl
RefSeq Acc Id: ENST00000597390   ⟹   ENSP00000472913
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,674,314 - 46,691,985 (-)Ensembl
RefSeq Acc Id: ENST00000597589
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,674,346 - 46,697,341 (-)Ensembl
RefSeq Acc Id: ENST00000597641   ⟹   ENSP00000469064
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,704,337 - 46,716,244 (-)Ensembl
RefSeq Acc Id: ENST00000598633   ⟹   ENSP00000470919
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,704,634 - 46,717,114 (-)Ensembl
RefSeq Acc Id: ENST00000599019
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,674,339 - 46,697,325 (-)Ensembl
RefSeq Acc Id: ENST00000599464
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,681,683 - 46,691,851 (-)Ensembl
RefSeq Acc Id: ENST00000600194   ⟹   ENSP00000472744
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,674,320 - 46,714,324 (-)Ensembl
RefSeq Acc Id: ENST00000601605   ⟹   ENSP00000470442
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,697,840 - 46,714,023 (-)Ensembl
RefSeq Acc Id: ENST00000601806   ⟹   ENSP00000469106
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,674,275 - 46,717,082 (-)Ensembl
RefSeq Acc Id: ENST00000602155
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1946,674,319 - 46,689,709 (-)Ensembl
RefSeq Acc Id: NM_001079880   ⟹   NP_001073349
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,674,316 - 46,717,114 (-)NCBI
GRCh371947,177,573 - 47,220,384 (-)NCBI
Build 361951,869,413 - 51,912,224 (-)NCBI Archive
HuRef1943,602,696 - 43,645,312 (-)ENTREZGENE
CHM1_11947,179,449 - 47,222,284 (-)NCBI
T2T-CHM13v2.01949,499,855 - 49,542,704 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001079881   ⟹   NP_001073350
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,674,316 - 46,717,114 (-)NCBI
GRCh371947,177,573 - 47,220,384 (-)NCBI
Build 361951,869,413 - 51,912,224 (-)NCBI Archive
HuRef1943,602,696 - 43,645,312 (-)ENTREZGENE
CHM1_11947,179,449 - 47,222,284 (-)NCBI
T2T-CHM13v2.01949,499,855 - 49,542,704 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001079882   ⟹   NP_001073351
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,674,316 - 46,714,320 (-)NCBI
GRCh371947,177,573 - 47,220,384 (-)ENTREZGENE
Build 361951,869,413 - 51,909,417 (-)NCBI Archive
HuRef1943,602,696 - 43,645,312 (-)ENTREZGENE
CHM1_11947,179,449 - 47,219,483 (-)NCBI
T2T-CHM13v2.01949,499,855 - 49,539,902 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016457   ⟹   NP_057541
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,674,316 - 46,717,114 (-)NCBI
GRCh371947,177,573 - 47,220,384 (-)ENTREZGENE
Build 361951,869,413 - 51,912,224 (-)NCBI Archive
HuRef1943,602,696 - 43,645,312 (-)ENTREZGENE
CHM1_11947,179,449 - 47,222,284 (-)NCBI
T2T-CHM13v2.01949,499,855 - 49,542,704 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005258716   ⟹   XP_005258773
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,674,316 - 46,717,114 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047438567   ⟹   XP_047294523
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,674,316 - 46,716,050 (-)NCBI
RefSeq Acc Id: XM_047438568   ⟹   XP_047294524
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,674,316 - 46,717,114 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001073350   ⟸   NM_001079881
- Peptide Label: isoform A
- UniProtKB: Q9Y3X8 (UniProtKB/Swiss-Prot),   Q9BZL6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001073349   ⟸   NM_001079880
- Peptide Label: isoform A
- UniProtKB: Q9Y3X8 (UniProtKB/Swiss-Prot),   Q9BZL6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_057541   ⟸   NM_016457
- Peptide Label: isoform A
- UniProtKB: Q9Y3X8 (UniProtKB/Swiss-Prot),   Q9BZL6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001073351   ⟸   NM_001079882
- Peptide Label: isoform B
- UniProtKB: Q9BZL6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005258773   ⟸   XM_005258716
- Peptide Label: isoform X1
- UniProtKB: Q9BZL6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000291281   ⟸   ENST00000291281
RefSeq Acc Id: ENSP00000470363   ⟸   ENST00000595132
RefSeq Acc Id: ENSP00000470804   ⟸   ENST00000595515
RefSeq Acc Id: ENSP00000469064   ⟸   ENST00000597641
RefSeq Acc Id: ENSP00000472913   ⟸   ENST00000597390
RefSeq Acc Id: ENSP00000470919   ⟸   ENST00000598633
RefSeq Acc Id: ENSP00000472744   ⟸   ENST00000600194
RefSeq Acc Id: ENSP00000469106   ⟸   ENST00000601806
RefSeq Acc Id: ENSP00000470442   ⟸   ENST00000601605
RefSeq Acc Id: ENSP00000393978   ⟸   ENST00000433867
RefSeq Acc Id: ENSP00000472987   ⟸   ENST00000593363
RefSeq Acc Id: XP_047294524   ⟸   XM_047438568
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047294523   ⟸   XM_047438567
- Peptide Label: isoform X1
Protein Domains
PH   Phorbol-ester/DAG-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9BZL6-F1-model_v2 AlphaFold Q9BZL6 1-878 view protein structure

Promoters
RGD ID:12914181
Promoter ID:EPDNEW_H26002
Type:initiation region
Name:PRKD2_1
Description:protein kinase D2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381946,716,676 - 46,716,736EPDNEW
RGD ID:6795939
Promoter ID:HG_KWN:30353
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:UC002PFE.1,   UC002PFF.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361951,892,481 - 51,892,981 (-)MPROMDB
RGD ID:6795941
Promoter ID:HG_KWN:30356
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_001079882
Position:
Human AssemblyChrPosition (strand)Source
Build 361951,909,106 - 51,909,772 (-)MPROMDB
RGD ID:6795940
Promoter ID:HG_KWN:30357
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001079880,   NM_001079881,   NM_016457,   UC002PFK.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361951,911,271 - 51,912,882 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17293 AgrOrtholog
COSMIC PRKD2 COSMIC
Ensembl Genes ENSG00000105287 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000291281 ENTREZGENE
  ENSP00000291281.3 UniProtKB/Swiss-Prot
  ENSP00000393978 ENTREZGENE
  ENSP00000393978.1 UniProtKB/Swiss-Prot
  ENSP00000469064.1 UniProtKB/TrEMBL
  ENSP00000469106.1 UniProtKB/Swiss-Prot
  ENSP00000470363.1 UniProtKB/TrEMBL
  ENSP00000470442.1 UniProtKB/TrEMBL
  ENSP00000470804 ENTREZGENE
  ENSP00000470804.1 UniProtKB/Swiss-Prot
  ENSP00000470919.1 UniProtKB/TrEMBL
  ENSP00000472744 ENTREZGENE
  ENSP00000472744.1 UniProtKB/Swiss-Prot
  ENSP00000472913.1 UniProtKB/TrEMBL
  ENSP00000472987.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000291281 ENTREZGENE
  ENST00000291281.9 UniProtKB/Swiss-Prot
  ENST00000433867 ENTREZGENE
  ENST00000433867.5 UniProtKB/Swiss-Prot
  ENST00000593363.1 UniProtKB/TrEMBL
  ENST00000595132.5 UniProtKB/TrEMBL
  ENST00000595515 ENTREZGENE
  ENST00000595515.5 UniProtKB/Swiss-Prot
  ENST00000597390.5 UniProtKB/TrEMBL
  ENST00000597641.1 UniProtKB/TrEMBL
  ENST00000598633.1 UniProtKB/TrEMBL
  ENST00000600194 ENTREZGENE
  ENST00000600194.5 UniProtKB/Swiss-Prot
  ENST00000601605.5 UniProtKB/TrEMBL
  ENST00000601806.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
GTEx ENSG00000105287 GTEx
HGNC ID HGNC:17293 ENTREZGENE
Human Proteome Map PRKD2 Human Proteome Map
InterPro C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_Kinase_C_mu-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:25865 UniProtKB/Swiss-Prot
NCBI Gene 25865 ENTREZGENE
OMIM 607074 OMIM
PANTHER PTHR22968 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134903505 PharmGKB
PIRSF PKC_mu_nu_D2 UniProtKB/Swiss-Prot
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0JLT6_HUMAN UniProtKB/TrEMBL
  KPCD2_HUMAN UniProtKB/Swiss-Prot
  M0QXC6_HUMAN UniProtKB/TrEMBL
  M0QZ82_HUMAN UniProtKB/TrEMBL
  M0QZC2_HUMAN UniProtKB/TrEMBL
  M0R012_HUMAN UniProtKB/TrEMBL
  M0R2Z8_HUMAN UniProtKB/TrEMBL
  M0R346_HUMAN UniProtKB/TrEMBL
  Q9BZL6 ENTREZGENE
  Q9Y3X8 ENTREZGENE
UniProt Secondary B4DTS2 UniProtKB/Swiss-Prot
  M0QZW1 UniProtKB/Swiss-Prot
  M0R2R2 UniProtKB/Swiss-Prot
  Q8NCK8 UniProtKB/Swiss-Prot
  Q8TB08 UniProtKB/Swiss-Prot
  Q9P0T6 UniProtKB/Swiss-Prot
  Q9Y3X8 UniProtKB/Swiss-Prot