Crygb (crystallin, gamma B) - Rat Genome Database

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Gene: Crygb (crystallin, gamma B) Rattus norvegicus
Analyze
Symbol: Crygb
Name: crystallin, gamma B
RGD ID: 1584991
Description: Predicted to be a structural constituent of eye lens. Involved in lens development in camera-type eye. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in cataract 39 multiple types. Orthologous to human CRYGB (crystallin gamma B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CRY-gamma-B; Cryg2; Crygb_mapped; crystallin, gamma B (mapped); crystallin, gamma polypeptide 2; gamma-B-crystallin; gamma-crystallin 1-2; gamma-crystallin B; Len
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,955,204 - 73,957,264 (-)NCBIGRCr8
mRatBN7.2966,461,460 - 66,463,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,461,460 - 66,463,520 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,974,717 - 74,976,777 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,109,999 - 80,112,059 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,518,408 - 78,520,468 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,796,204 - 71,798,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,796,204 - 71,798,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,771,494 - 70,773,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,730,906 - 63,732,966 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera963,857,232 - 63,859,292 (-)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
8. Differential synthesis of crystallins in the developing rat eye lens. Voorter CE, etal., Exp Eye Res. 1990 Apr;50(4):429-37.
Additional References at PubMed
PMID:2777080   PMID:3783678   PMID:8626090   PMID:12426373   PMID:15037589   PMID:18172107  


Genomics

Comparative Map Data
Crygb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,955,204 - 73,957,264 (-)NCBIGRCr8
mRatBN7.2966,461,460 - 66,463,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,461,460 - 66,463,520 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,974,717 - 74,976,777 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,109,999 - 80,112,059 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,518,408 - 78,520,468 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,796,204 - 71,798,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,796,204 - 71,798,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,771,494 - 70,773,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,730,906 - 63,732,966 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera963,857,232 - 63,859,292 (-)NCBICelera
Cytogenetic Map9q32NCBI
CRYGB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382208,142,573 - 208,146,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2208,142,573 - 208,146,158 (-)EnsemblGRCh38hg38GRCh38
GRCh372209,007,297 - 209,010,882 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,715,542 - 208,719,122 (-)NCBINCBI36Build 36hg18NCBI36
Build 342208,832,802 - 208,836,386NCBI
Celera2202,775,571 - 202,779,097 (-)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2200,855,757 - 200,859,294 (-)NCBIHuRef
CHM1_12209,013,085 - 209,016,704 (-)NCBICHM1_1
T2T-CHM13v2.02208,622,590 - 208,626,302 (-)NCBIT2T-CHM13v2.0
Crygb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,119,381 - 65,121,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,119,378 - 65,121,447 (-)EnsemblGRCm39 Ensembl
GRCm38165,080,222 - 65,082,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,080,219 - 65,082,288 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,126,801 - 65,128,841 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,014,503 - 65,016,543 (-)NCBIMGSCv36mm8
Celera165,573,413 - 65,575,453 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.82NCBI
LOC100978706
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,748,024 - 110,753,105 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,763,000 - 110,768,081 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,373,199 - 95,378,131 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,497,286 - 213,500,951 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,497,286 - 213,500,951 (-)Ensemblpanpan1.1panPan2
CRYGB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,440,804 - 16,442,823 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3716,440,805 - 16,442,912 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3717,323,904 - 17,325,920 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03716,376,454 - 16,378,472 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3716,367,491 - 16,379,514 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13716,321,158 - 16,323,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03716,294,463 - 16,296,479 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03716,303,543 - 16,305,558 (-)NCBIUU_Cfam_GSD_1.0
LOC100156107
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115111,267,071 - 111,268,898 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,786,581 - 122,788,663 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103217733
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11093,945,141 - 93,950,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040105,420,483 - 105,423,997 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Crygb
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:45
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000043766
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat

Markers in Region
Crygb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,461,523 - 66,461,657 (+)MAPPERmRatBN7.2
Rnor_6.0971,796,268 - 71,796,401NCBIRnor6.0
Rnor_5.0970,773,358 - 70,773,491UniSTSRnor5.0
RGSC_v3.4963,730,970 - 63,731,103UniSTSRGSC3.4
Celera963,857,296 - 63,857,429UniSTS
Cytogenetic Map9q32UniSTS
UniSTS:259203  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2966,461,570 - 66,463,204 (+)MAPPERmRatBN7.2
Rnor_6.0971,796,315 - 71,797,949NCBIRnor6.0
Rnor_5.0970,771,810 - 70,773,444UniSTSRnor5.0
RGSC_v3.4963,731,017 - 63,732,650UniSTSRGSC3.4
Celera963,857,343 - 63,858,976UniSTS
Cytogenetic Map9q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

integumental system musculoskeletal system nervous system reproductive system appendage
High
Medium
Low 25 5
Below cutoff 7 9 24 5 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000043766   ⟹   ENSRNOP00000043562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl966,461,460 - 66,463,520 (-)Ensembl
Rnor_6.0 Ensembl971,796,204 - 71,798,265 (-)Ensembl
RefSeq Acc Id: NM_001109875   ⟹   NP_001103345
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,955,204 - 73,957,264 (-)NCBI
mRatBN7.2966,461,460 - 66,463,520 (-)NCBI
Rnor_6.0971,796,204 - 71,798,265 (-)NCBI
Rnor_5.0970,771,494 - 70,773,555 (+)NCBI
RGSC_v3.4963,730,906 - 63,732,966 (-)RGD
Celera963,857,232 - 63,859,292 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103345 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40982 (Get FASTA)   NCBI Sequence Viewer  
  EDL98867 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043562
  ENSRNOP00000043562.5
  ENSRNOP00055031495
  ENSRNOP00060028695
  ENSRNOP00065039945
GenBank Protein P10066 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001103345   ⟸   NM_001109875
- UniProtKB: P10066 (UniProtKB/Swiss-Prot),   F1LP53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043562   ⟸   ENSRNOT00000043766
Protein Domains
Beta/gamma crystallin 'Greek key'

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10066-F1-model_v2 AlphaFold P10066 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696720
Promoter ID:EPDNEW_R7244
Type:single initiation site
Name:Crygb_1
Description:crystallin, gamma B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0971,798,265 - 71,798,325EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584991 AgrOrtholog
BioCyc Gene G2FUF-27303 BioCyc
Ensembl Genes ENSRNOG00000032926 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055022614 UniProtKB/Swiss-Prot
  ENSRNOG00060020187 UniProtKB/Swiss-Prot
  ENSRNOG00065028275 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000043766 ENTREZGENE
  ENSRNOT00000043766.4 UniProtKB/TrEMBL
  ENSRNOT00055038799 UniProtKB/Swiss-Prot
  ENSRNOT00060034941 UniProtKB/Swiss-Prot
  ENSRNOT00065048709 UniProtKB/Swiss-Prot
Gene3D-CATH Crystallins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Beta/gamma_crystallin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_crystallin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301468 UniProtKB/Swiss-Prot
NCBI Gene 301468 ENTREZGENE
PANTHER BETA/GAMMA CRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GAMMA-CRYSTALLIN B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Crystall UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Crygb PhenoGen
PRINTS BGCRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CRYSTALLIN_BETA_GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032926 RatGTEx
  ENSRNOG00055022614 RatGTEx
  ENSRNOG00060020187 RatGTEx
  ENSRNOG00065028275 RatGTEx
SMART XTALbg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IPJ3_RAT UniProtKB/TrEMBL
  CRGB_RAT UniProtKB/Swiss-Prot
  F1LP53 ENTREZGENE, UniProtKB/TrEMBL
  P10066 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   crystallin, gamma B  Crygb  crystallin, gamma B (mapped)  Name updated 737654 APPROVED
2007-04-11 Crygb  crystallin, gamma B (mapped)  Crygb_mapped  crystallin, gamma B (mapped)  Data merged from RGD:2420 737654 APPROVED
2006-11-19 Crygb  crystallin, gamma B (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Crygb_mapped  crystallin, gamma B (mapped)  Crygb  crystallin, gamma B   Symbol and Name updated 1556543 APPROVED
2003-04-09 Crygb  crystallin, gamma B     crystallin, gamma polypeptide 2  Name updated 629478 APPROVED
2002-06-10 Crygb  crystallin, gamma polypeptide 2      Symbol and Name status set to approved 70586 APPROVED