Crygb (crystallin, gamma B) - Rat Genome Database

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Gene: Crygb (crystallin, gamma B) Mus musculus
Analyze
Symbol: Crygb
Name: crystallin, gamma B
RGD ID: 10407
MGI Page MGI
Description: A structural constituent of eye lens. Acts upstream of or within lens fiber cell morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system and eye. Used to study cataract 39 multiple types. Human ortholog(s) of this gene implicated in cataract 39 multiple types. Orthologous to human CRYGB (crystallin gamma B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cryg-; Cryg-3; DGcry-; DGcry-3; gamma-B-crystallin; gamma-crystallin 3; gamma-crystallin B; gammaB-crystallin; Nop; nuclear opacity
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,119,381 - 65,121,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,119,378 - 65,121,447 (-)EnsemblGRCm39 Ensembl
GRCm38165,080,222 - 65,082,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,080,219 - 65,082,288 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,126,801 - 65,128,841 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,014,503 - 65,016,543 (-)NCBIMGSCv36mm8
Celera165,573,413 - 65,575,453 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA)
nucleus  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Genes for tensin, villin and desmin are linked on mouse chromosome 1. Jankowski SA and Gumucio DL, Mamm Genome 1995 Oct;6(10):744-5.
2. Three murine cataract mutants (Cat2) are defective in different gamma-crystallin genes. Klopp N, etal., Genomics 1998 Sep 1;52(2):152-8.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. Sagane K, etal., Gene 1999 Aug 5;236(1):79-86.
Additional References at PubMed
PMID:1511869   PMID:1623964   PMID:1889815   PMID:3428594   PMID:3792630   PMID:6096855   PMID:6479248   PMID:6953430   PMID:7797265   PMID:8043949   PMID:8075499   PMID:8293998  
PMID:8626090   PMID:8751373   PMID:9339368   PMID:9383296   PMID:9512512   PMID:9729047   PMID:10080188   PMID:10349636   PMID:10383433   PMID:10595510   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11146559   PMID:11217851   PMID:12426373   PMID:12446761   PMID:12466851   PMID:12477932   PMID:12835653   PMID:15037589   PMID:15483628   PMID:15593327   PMID:15878859  
PMID:16141072   PMID:16141073   PMID:16162653   PMID:16602821   PMID:18172107   PMID:20844585   PMID:20959464   PMID:21677750   PMID:21873635   PMID:21998302   PMID:26719333   PMID:27631609  
PMID:31814023   PMID:31847788   PMID:35726360   PMID:36293380   PMID:37331601   PMID:38933921  


Genomics

Comparative Map Data
Crygb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,119,381 - 65,121,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,119,378 - 65,121,447 (-)EnsemblGRCm39 Ensembl
GRCm38165,080,222 - 65,082,290 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,080,219 - 65,082,288 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,126,801 - 65,128,841 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,014,503 - 65,016,543 (-)NCBIMGSCv36mm8
Celera165,573,413 - 65,575,453 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.82NCBI
CRYGB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382208,142,573 - 208,146,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2208,142,573 - 208,146,158 (-)EnsemblGRCh38hg38GRCh38
GRCh372209,007,297 - 209,010,882 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,715,542 - 208,719,122 (-)NCBINCBI36Build 36hg18NCBI36
Build 342208,832,802 - 208,836,386NCBI
Celera2202,775,571 - 202,779,097 (-)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2200,855,757 - 200,859,294 (-)NCBIHuRef
CHM1_12209,013,085 - 209,016,704 (-)NCBICHM1_1
T2T-CHM13v2.02208,622,590 - 208,626,302 (-)NCBIT2T-CHM13v2.0
Crygb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,955,204 - 73,957,264 (-)NCBIGRCr8
mRatBN7.2966,461,460 - 66,463,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl966,461,460 - 66,463,520 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,974,717 - 74,976,777 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0980,109,999 - 80,112,059 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0978,518,408 - 78,520,468 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,796,204 - 71,798,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,796,204 - 71,798,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0970,771,494 - 70,773,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,730,906 - 63,732,966 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera963,857,232 - 63,859,292 (-)NCBICelera
Cytogenetic Map9q32NCBI
LOC100978706
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,748,024 - 110,753,105 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,763,000 - 110,768,081 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B95,373,199 - 95,378,131 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B213,497,286 - 213,500,951 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B213,497,286 - 213,500,951 (-)Ensemblpanpan1.1panPan2
CRYGB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13716,440,804 - 16,442,823 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3716,440,805 - 16,442,912 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3717,323,904 - 17,325,920 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03716,376,454 - 16,378,472 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3716,367,491 - 16,379,514 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13716,321,158 - 16,323,174 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03716,294,463 - 16,296,479 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03716,303,543 - 16,305,558 (-)NCBIUU_Cfam_GSD_1.0
LOC100156107
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115111,267,071 - 111,268,898 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,786,581 - 122,788,663 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103217733
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11093,945,141 - 93,950,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040105,420,483 - 105,423,997 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:103
Interacting mature miRNAs:106
Transcripts:ENSMUST00000027090
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
12910788Pwgrq9_mpost-weaning growth rate QTL 9 (mouse)14086800867270256Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
12910786Pwgrq10_mpost-weaning growth rate QTL 10 (mouse)14086800867270256Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
4142307Shali1_msurvival time to hyperoxic acute lung injury 1 (mouse)Not determined5196402570406589Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
12910780Pwgrq11_mpost-weaning growth rate QTL 11 (mouse)14086800867270256Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
Crygb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38165,080,291 - 65,080,424UniSTSGRCm38
MGSCv37165,126,865 - 65,126,998UniSTSGRCm37
Celera165,573,477 - 65,573,610UniSTS
Cytogenetic Map1C2UniSTS
cM Map132.0UniSTS
Crygb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C2UniSTS
Crygb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38165,080,338 - 65,081,971UniSTSGRCm38
MGSCv37165,126,912 - 65,128,545UniSTSGRCm37
Celera165,573,524 - 65,575,157UniSTS
Cytogenetic Map1C2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000027090   ⟹   ENSMUSP00000027090
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,119,378 - 65,121,447 (-)Ensembl
GRCm38.p6 Ensembl165,080,219 - 65,082,288 (-)Ensembl
RefSeq Acc Id: NM_144761   ⟹   NP_658906
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,119,381 - 65,121,449 (-)NCBI
GRCm38165,080,222 - 65,082,290 (-)NCBI
MGSCv37165,126,801 - 65,128,841 (-)RGD
Celera165,573,408 - 65,575,476 (-)NCBI
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_658906   ⟸   NM_144761
- UniProtKB: Q61593 (UniProtKB/Swiss-Prot),   Q6PHP7 (UniProtKB/Swiss-Prot),   P04344 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027090   ⟸   ENSMUST00000027090
Protein Domains
Beta/gamma crystallin 'Greek key'

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04344-F1-model_v2 AlphaFold P04344 1-175 view protein structure

Promoters
RGD ID:6873968
Promoter ID:EPDNEW_M428
Type:multiple initiation site
Name:Crygb_1
Description:Mus musculus crystallin, gamma B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38165,082,288 - 65,082,348EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88522 AgrOrtholog
Ensembl Genes ENSMUSG00000073658 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027090 ENTREZGENE
  ENSMUST00000027090.9 UniProtKB/Swiss-Prot
Gene3D-CATH Crystallins UniProtKB/Swiss-Prot
InterPro Beta/Gamma-Crystallin UniProtKB/Swiss-Prot
  Beta/gamma_crystallin UniProtKB/Swiss-Prot
  G_crystallin-like UniProtKB/Swiss-Prot
KEGG Report mmu:12965 UniProtKB/Swiss-Prot
MGD MGI:88522 ENTREZGENE
NCBI Gene 12965 ENTREZGENE
PANTHER BETA/GAMMA CRYSTALLIN UniProtKB/Swiss-Prot
  GAMMA-CRYSTALLIN B UniProtKB/Swiss-Prot
Pfam Crystall UniProtKB/Swiss-Prot
PhenoGen Crygb PhenoGen
PRINTS BGCRYSTALLIN UniProtKB/Swiss-Prot
PROSITE CRYSTALLIN_BETA_GAMMA UniProtKB/Swiss-Prot
SMART XTALbg UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49695 UniProtKB/Swiss-Prot
UniProt CRGB_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q61593 ENTREZGENE
  Q6PHP7 ENTREZGENE
UniProt Secondary Q61593 UniProtKB/Swiss-Prot
  Q6PHP7 UniProtKB/Swiss-Prot