Myocd (myocardin) - Rat Genome Database

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Gene: Myocd (myocardin) Rattus norvegicus
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Symbol: Myocd
Name: myocardin
RGD ID: 631347
Description: Predicted to enable several functions, including R-SMAD binding activity; enzyme binding activity; and transcription coactivator activity. Involved in several processes, including cardiocyte differentiation; hepatic stellate cell activation; and positive regulation of vascular associated smooth muscle cell migration. Located in cytoplasm and nucleus. Part of protein-DNA complex. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in congenital megabladder and dilated cardiomyopathy. Orthologous to human MYOCD (myocardin); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Mycd; transcription factor myocardin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81050,332,356 - 50,426,819 (-)NCBIGRCr8
mRatBN7.21049,833,219 - 49,928,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1049,836,641 - 49,927,627 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1054,505,304 - 54,596,319 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01053,995,291 - 54,086,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01049,509,995 - 49,600,991 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01051,682,053 - 51,781,458 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1051,683,540 - 51,778,986 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01051,439,727 - 51,534,567 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41051,496,223 - 51,588,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11051,509,851 - 51,601,849 (-)NCBI
Celera1049,052,568 - 49,143,747 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
MyocdRataortic atherosclerosis  ISORGD:1344327401793744protein:decreased expression:aortaRGD 
MyocdRataortic atherosclerosis exacerbatesISORGD:1614957401793744 RGD 
MyocdRatCardio-Renal Syndrome amelioratesIMP 401793740 RGD 
MyocdRatCardio-Renal Syndrome  ISORGD:1344327401793740mRNA,protein:increased expression:left ventricleRGD 
MyocdRatcongenital heart disease  IMP 401793743 RGD 
MyocdRatcongestive heart failure  ISORGD:161495711251948 RGD 
MyocdRatdilated cardiomyopathy  ISORGD:13867667401793745mRNA:increased expression:heartRGD 
MyocdRatdilated cardiomyopathy  ISORGD:1344327401793745mRNA:increased expression:left ventricleRGD 
MyocdRatintracranial aneurysm amelioratesISORGD:1614957401793751 RGD 
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MyocdRatcongenital megabladder  ISORGD:13443278554872ClinVar Annotator: match by term: MYOCD-related condition | ClinVar Annotator: match by term: Megabladder, congenitalClinVarPMID:25741868|PMID:31513549|PMID:35005812
MyocdRatepilepsy  ISORGD:13443278554872ClinVar Annotator: match by term: SeizureClinVarPMID:25558065
MyocdRatprostate cancer  ISORGD:13443278554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
MyocdRatprune belly syndrome  ISORGD:13443278554872ClinVar Annotator: match by term: Prune belly syndromeClinVarPMID:31513549
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MyocdRatatrial fibrillation  ISORGD:134432711554173CTD Direct Evidence: marker/mechanismCTDPMID:29892015|PMID:30061737
MyocdRatCardiomegaly  ISORGD:134432711554173CTD Direct Evidence: marker/mechanismCTDPMID:16556869
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Original Reference(s)
MyocdRatcongenital megabladder  ISSRGD:161495713592920OMIM:618719MouseDO 
MyocdRatdilated cardiomyopathy  ISSRGD:161495713592920 MouseDO 
MyocdRatpatent ductus arteriosus  ISSRGD:161495713592920OMIM:607411MouseDO 
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Original Reference(s)
MyocdRatcongenital megabladder  ISORGD:13443277240710 OMIM 

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MyocdRat(-)-epigallocatechin 3-gallate multiple interactionsISORGD:1344327155230825(-)-epigallocatechin 3-gallate inhibits the reaction [angiotensin II decreases expression of MYOCD protein in vascular smooth more ...RGD 
MyocdRat1,2-dimethylhydrazine decreases expressionISORGD:161495764804641,2-Dimethylhydrazine results in decreased expression of MYOCD mRNACTDPMID:22206623
MyocdRat17alpha-ethynylestradiol multiple interactionsISORGD:16149576480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYOCD mRNACTDPMID:17942748
MyocdRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:16149576480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MYOCD mRNA; Tetrachlorodibenzodioxin promotes the more ...CTDPMID:17942748|PMID:19654925
MyocdRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of MYOCD mRNACTDPMID:33387578
MyocdRat4,4'-sulfonyldiphenol increases expressionISORGD:16149576480464bisphenol S results in increased expression of MYOCD mRNACTDPMID:30951980
MyocdRataflatoxin B1 increases methylationISORGD:13443276480464Aflatoxin B1 results in increased methylation of MYOCD geneCTDPMID:27153756
MyocdRatAflatoxin B2 alpha increases methylationISORGD:13443276480464aflatoxin B2 results in increased methylation of MYOCD intronCTDPMID:30157460
MyocdRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of MYOCD mRNACTDPMID:16483693
MyocdRatangiotensin II decreases expression ISORGD:1344327155230825angiotensin II decreases expression of MYOCD mRNA and protein in vascular smooth muscle cellRGD 
MyocdRatarsane affects methylationISORGD:13443276480464Arsenic affects the methylation of MYOCD geneCTDPMID:25304211
MyocdRatarsane multiple interactionsISORGD:13443276480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092
MyocdRatarsenic atom affects methylationISORGD:13443276480464Arsenic affects the methylation of MYOCD geneCTDPMID:25304211
MyocdRatarsenic atom multiple interactionsISORGD:13443276480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092
MyocdRatarsenous acid increases expressionISORGD:13443276480464Arsenic Trioxide results in increased expression of MYOCD mRNACTDPMID:26705709
MyocdRatbenzo[a]pyrene multiple interactionsISORGD:16149576480464AHR protein affects the reaction [Benzo(a)pyrene affects the expression of MYOCD mRNA]; Benzo(a)pyrene promotes the more ...CTDPMID:19654925|PMID:22228805
MyocdRatbenzo[a]pyrene affects methylationISORGD:13443276480464Benzo(a)pyrene affects the methylation of MYOCD intron; Benzo(a)pyrene affects the methylation of MYOCD promoterCTDPMID:27901495|PMID:30157460
MyocdRatbenzo[a]pyrene increases methylationISORGD:13443276480464Benzo(a)pyrene results in increased methylation of MYOCD 5' UTRCTDPMID:27901495
MyocdRatbenzo[a]pyrene decreases expressionISORGD:13443276480464Benzo(a)pyrene results in decreased expression of MYOCD mRNACTDPMID:22178795
MyocdRatbenzo[a]pyrene increases expressionISORGD:16149576480464Benzo(a)pyrene results in increased expression of MYOCD mRNACTDPMID:22228805

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Biological Process
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MyocdRatcardiac muscle cell apoptotic process acts_upstream_ofISORGD:16149571624291MGI:3773717 PMID:19850880RGDPMID:19850880
MyocdRatcardiac muscle cell differentiation involved_inISORGD:16149571624291 PMID:11439182RGDPMID:11439182
MyocdRatcardiac muscle cell differentiation acts_upstream_of_or_withinISORGD:16149571624291 PMID:14645532RGDPMID:14645532
MyocdRatcardiac muscle cell differentiation involved_inIBAMGI:2137495|PANTHER:PTN002736064|RGD:6313471600115GO_REF:0000033GO_CentralGO_REF:0000033
MyocdRatcardiac muscle cell myoblast differentiation involved_inISORGD:13443271624291 PMID:15907818RGDPMID:15907818
MyocdRatcardiac vascular smooth muscle cell differentiation involved_inIDA 8554320PMID:16151017BHF-UCL 
MyocdRatcardiac ventricle development acts_upstream_of_or_withinISORGD:16149571624291MGI:3052940 PMID:21357509RGDPMID:21357509
MyocdRatcell growth involved in cardiac muscle cell development  IMP 5132877 RGD 
MyocdRatcellular response to angiotensin  IEP 529389387 RGD 
MyocdRatcellular response to angiotensin  IEP 401793757 RGD 
MyocdRatcellular response to growth factor stimulus  IEP 5132874 RGD 
MyocdRatcellular response to hypoxia  IEP 5132874 RGD 
MyocdRatcellular response to transforming growth factor beta stimulus  IEP 529389387 RGD 
MyocdRatchromatin organization acts_upstream_of_or_withinISORGD:16149571624291 PMID:15601857RGDPMID:15601857
MyocdRatdigestive tract development acts_upstream_of_or_withinISORGD:16149571624291MGI:3052940 PMID:21357509RGDPMID:21357509
MyocdRatductus arteriosus closure acts_upstream_of_or_withinISORGD:16149571624291MGI:3773718 PMID:18188448RGDPMID:18188448
MyocdRatheart development acts_upstream_of_or_withinISORGD:16149571624291 PMID:11439182RGDPMID:11439182
MyocdRatheart development involved_inISORGD:16149571624291 PMID:24068960RGDPMID:24068960
MyocdRathepatic stellate cell activation  IMP 5132876 RGD 
MyocdRathepatic stellate cell activation  IEP 529195969 RGD 
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Cellular Component
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Original Reference(s)
MyocdRatchromatin located_inISORGD:16149571624291 PMID:24068960RGDPMID:24068960
MyocdRatcytoplasm located_inIDA 401901238PMID:19237536UniProt 
MyocdRatnucleus  IDA 529195969MMO:0000679RGD 
MyocdRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
MyocdRatnucleus located_inISSUniProtKB:Q8VIM51600115GO_REF:0000024UniProtGO_REF:0000024
MyocdRatnucleus located_inISORGD:16149571624291 PMID:11439182, PMID:15601857, PMID:15798203, PMID:19850880RGDPMID:11439182|PMID:15601857|PMID:15798203|PMID:19850880
MyocdRatnucleus located_inIDA 401901238PMID:19237536UniProt 
MyocdRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
MyocdRatnucleus located_inISORGD:13443271624291 PMID:14970199RGDPMID:14970199
MyocdRatnucleus is_active_inIBAFB:FBgn0052296|MGI:2137495|MGI:2384495|PANTHER:PTN008582099|RGD:631347|UniProtKB:Q8IZQ8|UniProtKB:Q969V61600115GO_REF:0000033GO_CentralGO_REF:0000033
MyocdRatprotein-DNA complex  IDA 401793757MMO:0000100RGD 
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Molecular Function
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MyocdRatDNA-binding transcription factor binding enablesISORGD:13443271624291UniProtKB:P52952|UniProtKB:P98177|UniProtKB:Q99801 PMID:16054032, PMID:19797053RGDPMID:16054032|PMID:19797053
MyocdRathistone acetyltransferase binding enablesISORGD:16149571624291PR:Q9JHD1 PMID:15601857RGDPMID:15601857
MyocdRathistone deacetylase binding enablesISORGD:16149571624291PR:Q9Z2V6 PMID:15601857RGDPMID:15601857
MyocdRatprotein binding  IPIRGD:156120110402362 RGD 
MyocdRatprotein binding enablesISORGD:1614957,PR:Q8VIM5-11624291UniProtKB:P10085|UniProtKB:Q04206|UniProtKB:Q04206-1|UniProtKB:Q9Y6Q9 PMID:17360478, PMID:17940050, PMID:18296632RGDPMID:17360478|PMID:17940050|PMID:18296632
MyocdRatprotein binding enablesIPIUniProtKB:A6HD62401901238PMID:19237536UniProt 
MyocdRatprotein binding  IPIRGD:1306035401793755 RGD 
MyocdRatprotein binding enablesISORGD:13443271624291UniProtKB:P11831|UniProtKB:Q969V6|UniProtKB:Q9HD26 PMID:12397177, PMID:14970199, PMID:25416956, PMID:31515488RGDPMID:12397177|PMID:14970199|PMID:25416956|PMID:31515488
MyocdRatprotein binding enablesISORGD:16149571624291PR:P13297|PR:P56581|PR:Q3TKT4|PR:Q6PCM1|PR:Q8CFN5|PR:Q9JM73|UniProtKB:B2RWS6|UniProtKB:O35295|UniProtKB:Q6NZM9|UniProtKB:Q8CFN5|UniProtKB:Q9Z2V6 PMID:11439182, PMID:15601857, PMID:16818234, PMID:17030628, PMID:17991879, PMID:18945672, PMID:19342595, PMID:33743134RGDPMID:11439182|PMID:15601857|PMID:16818234|PMID:17030628|PMID:17991879|PMID:18945672|PMID:19342595|PMID:33743134
MyocdRatprotein binding  IPIRGD:23242809587795 RGD 
MyocdRatR-SMAD binding enablesISORGD:16149571624291UniProtKB:Q8BUN5 PMID:16224064RGDPMID:16224064
MyocdRatRNA polymerase II-specific DNA-binding transcription factor binding enablesISORGD:16149571624291UniProtKB:Q9JM73 PMID:11439182RGDPMID:11439182
MyocdRattranscription coactivator activity enablesIBAFB:FBgn0052296|MGI:2137495|MGI:2384495|MGI:3050795|PANTHER:PTN008582099|UniProtKB:Q8IZQ8|UniProtKB:Q969V6|UniProtKB:Q9ULH71600115GO_REF:0000033GO_CentralGO_REF:0000033
MyocdRattranscription coactivator activity enablesISORGD:13443271624291 PMID:19098903, PMID:19578358, PMID:19797053, PMID:22157009RGDPMID:19098903|PMID:19578358|PMID:19797053|PMID:22157009
MyocdRattranscription coactivator activity enablesISORGD:16149571624291 PMID:11439182, PMID:19578358RGDPMID:11439182|PMID:19578358
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Imported Annotations - PID (archival)

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Original Reference(s)
MyocdRatplatelet-derived growth factor signaling pathway  ISORGD:13443276484113 PIDPID:200149

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#
Reference Title
Reference Citation
1. Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells. Brønnum H, etal., Exp Cell Res. 2013 Feb 15;319(4):424-35. doi: 10.1016/j.yexcr.2012.12.019. Epub 2012 Dec 24.
2. Myocardin: a component of a molecular switch for smooth muscle differentiation. Chen J, etal., J Mol Cell Cardiol 2002 Oct;34(10):1345-56.
3. Effects of cyclic stretch on the molecular regulation of myocardin in rat aortic vascular smooth muscle cells. Chiu CZ, etal., J Biomed Sci. 2013 Jul 15;20(1):50. doi: 10.1186/1423-0127-20-50.
4. HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box. Doi H, etal., Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2328-34. Epub 2005 Sep 8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Drug-eluting stent specifically designed to target vascular smooth muscle cell phenotypic modulation attenuated restenosis through the YAP pathway. Huang C, etal., Am J Physiol Heart Circ Physiol. 2019 Sep 1;317(3):H541-H551. doi: 10.1152/ajpheart.00089.2019. Epub 2019 Jul 12.
8. Myocardin regulates BMP10 expression and is required for heart development. Huang J, etal., J Clin Invest. 2012 Oct;122(10):3678-91. doi: 10.1172/JCI63635. Epub 2012 Sep 17.
9. Myocardin is required for cardiomyocyte survival and maintenance of heart function. Huang J, etal., Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18734-9. doi: 10.1073/pnas.0910749106. Epub 2009 Oct 22.
10. Contribution of myocardin in the hypoxia-induced phenotypic switching of rat pulmonary arterial smooth muscle cells. Jie W, etal., Exp Mol Pathol. 2010 Dec;89(3):301-6. Epub 2010 Jul 14.
11. Enhancer of polycomb1 lessens neointima formation by potentiation of myocardin-induced smooth muscle differentiation. Joung H, etal., Atherosclerosis. 2012 May;222(1):84-91. doi: 10.1016/j.atherosclerosis.2012.02.015. Epub 2012 Feb 18.
12. Myocardin-related transcription factor-A induces cardiomyocyte hypertrophy. Liao XH, etal., IUBMB Life. 2011 Jan;63(1):54-61. doi: 10.1002/iub.415.
13. Effects of flavonoids on MicroRNA 145 regulation through Klf4 and myocardin in neointimal formation in vitro and in vivo. Lin CM, etal., J Nutr Biochem. 2018 Feb;52:27-35. doi: 10.1016/j.jnutbio.2017.08.016. Epub 2017 Sep 14.
14. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Liu ZP, etal., Dev Cell. 2005 Aug;9(2):261-70.
15. Myocardin ablation in a cardiac-renal rat model. Mittal A, etal., Sci Rep. 2019 Apr 10;9(1):5872. doi: 10.1038/s41598-019-42009-z.
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
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PMID:11439182   PMID:12392987   PMID:12640126   PMID:12663482   PMID:12867591   PMID:14645532   PMID:14970199   PMID:15014501   PMID:15256479   PMID:15601857   PMID:15623517   PMID:15798203  
PMID:15907818   PMID:16224064   PMID:16818234   PMID:17030628   PMID:17215356   PMID:17940050   PMID:18188448   PMID:18296632   PMID:18451334   PMID:18511849   PMID:18945672   PMID:19098903  
PMID:19342595   PMID:19578358   PMID:19797053   PMID:20177053   PMID:20385216   PMID:20566642   PMID:20847050   PMID:21357509   PMID:21385583   PMID:22157009   PMID:22362485   PMID:22411986  
PMID:23283978   PMID:23526547   PMID:23825366   PMID:24068960   PMID:24252873   PMID:24344135   PMID:25157858   PMID:25485719   PMID:25614278   PMID:26147104   PMID:26206583   PMID:27155398  
PMID:27861881   PMID:27939576   PMID:28003268   PMID:29035375   PMID:29199045   PMID:29303357   PMID:31513549   PMID:34694145  



Myocd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81050,332,356 - 50,426,819 (-)NCBIGRCr8
mRatBN7.21049,833,219 - 49,928,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1049,836,641 - 49,927,627 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1054,505,304 - 54,596,319 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01053,995,291 - 54,086,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01049,509,995 - 49,600,991 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01051,682,053 - 51,781,458 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1051,683,540 - 51,778,986 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01051,439,727 - 51,534,567 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41051,496,223 - 51,588,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11051,509,851 - 51,601,849 (-)NCBI
Celera1049,052,568 - 49,143,747 (-)NCBICelera
Cytogenetic Map10q24NCBI
MYOCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381712,665,890 - 12,768,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1712,665,890 - 12,768,949 (+)EnsemblGRCh38hg38GRCh38
GRCh371712,569,207 - 12,672,266 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361712,510,231 - 12,607,686 (+)NCBINCBI36Build 36hg18NCBI36
Build 341712,510,230 - 12,607,686NCBI
Celera1712,594,549 - 12,695,987 (+)NCBICelera
Cytogenetic Map17p12NCBI
HuRef1712,464,600 - 12,566,080 (+)NCBIHuRef
CHM1_11712,577,982 - 12,679,406 (+)NCBICHM1_1
T2T-CHM13v2.01712,573,362 - 12,676,444 (+)NCBIT2T-CHM13v2.0
Myocd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,064,434 - 65,160,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,067,387 - 65,160,815 (-)EnsemblGRCm39 Ensembl
GRCm381165,173,608 - 65,269,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,176,561 - 65,269,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,990,063 - 65,083,491 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,992,756 - 65,086,175 (-)NCBIMGSCv36mm8
Celera1172,112,506 - 72,207,425 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.42NCBI
Myocd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554674,656,380 - 4,743,110 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554674,653,065 - 4,743,438 (-)NCBIChiLan1.0ChiLan1.0
MYOCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21960,982,668 - 61,082,874 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11765,789,278 - 65,889,518 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01738,880,120 - 38,983,246 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11743,578,967 - 43,681,659 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1743,584,259 - 43,681,659 (-)Ensemblpanpan1.1panPan2
MYOCD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1536,674,476 - 36,774,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl536,674,300 - 36,769,327 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha536,774,863 - 36,918,323 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0536,738,753 - 36,883,183 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl536,782,154 - 36,879,172 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1536,711,643 - 36,856,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0536,659,301 - 36,802,936 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0536,843,479 - 36,993,391 (+)NCBIUU_Cfam_GSD_1.0
Myocd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560251,782,304 - 51,881,336 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365955,256,785 - 5,351,723 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365955,256,615 - 5,356,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOCD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1256,931,317 - 57,029,258 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11256,931,628 - 57,029,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21259,928,695 - 59,945,526 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYOCD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11611,923,464 - 12,100,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1612,000,197 - 12,095,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660599,137,934 - 9,239,568 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myocd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624877618,789 - 647,471 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Myocd
484 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir145rno-miR-145-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19542014

Predicted Target Of
Summary Value
Count of predictions:236
Count of miRNA genes:155
Interacting mature miRNAs:189
Transcripts:ENSRNOT00000057562
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 73 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat

1 to 10 of 73 rows
D10Rat62  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,900,287 - 49,900,435 (+)MAPPERmRatBN7.2
Rnor_6.01051,747,009 - 51,747,156NCBIRnor6.0
Rnor_5.01051,503,287 - 51,503,434UniSTSRnor5.0
RGSC_v3.41051,560,410 - 51,560,558RGDRGSC3.4
RGSC_v3.41051,560,411 - 51,560,558UniSTSRGSC3.4
RGSC_v3.11051,574,034 - 51,574,181RGD
Celera1049,116,392 - 49,116,539UniSTS
RH 3.4 Map10581.0UniSTS
RH 3.4 Map10581.0RGD
RH 2.0 Map10568.7RGD
FHH x ACI Map1040.36RGD
Cytogenetic Map10q24UniSTS
RH133589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,907,920 - 49,908,113 (+)MAPPERmRatBN7.2
Rnor_6.01051,758,961 - 51,759,153NCBIRnor6.0
Rnor_5.01051,514,423 - 51,514,615UniSTSRnor5.0
RGSC_v3.41051,568,519 - 51,568,711UniSTSRGSC3.4
Celera1049,124,042 - 49,124,234UniSTS
RH 3.4 Map10580.3UniSTS
Cytogenetic Map10q24UniSTS
PMC150745P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81050,348,690 - 50,348,798 (+)Marker Load Pipeline
mRatBN7.21049,849,554 - 49,849,663 (+)MAPPERmRatBN7.2
Rnor_6.01051,696,454 - 51,696,562NCBIRnor6.0
Rnor_5.01051,452,647 - 51,452,755UniSTSRnor5.0
RGSC_v3.41051,509,143 - 51,509,251UniSTSRGSC3.4
Celera1049,065,353 - 49,065,461UniSTS
Cytogenetic Map10q24UniSTS
PMC309615P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,849,919 - 49,850,213 (+)MAPPERmRatBN7.2
Rnor_6.01051,696,819 - 51,697,112NCBIRnor6.0
Rnor_5.01051,453,012 - 51,453,305UniSTSRnor5.0
RGSC_v3.41051,509,508 - 51,509,801UniSTSRGSC3.4
Celera1049,065,718 - 49,066,011UniSTS
Cytogenetic Map10q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 112 74 73 42 25 42 6 200 97 92 44 60 31



Ensembl Acc Id: ENSRNOT00000057562   ⟹   ENSRNOP00000054372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1049,836,641 - 49,927,627 (-)Ensembl
Rnor_6.0 Ensembl1051,683,540 - 51,778,986 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078675   ⟹   ENSRNOP00000072988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1049,836,641 - 49,927,627 (-)Ensembl
Rnor_6.0 Ensembl1051,685,228 - 51,778,939 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109338   ⟹   ENSRNOP00000084177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1049,836,641 - 49,892,157 (-)Ensembl
RefSeq Acc Id: NM_001414232   ⟹   NP_001401161
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,332,356 - 50,426,819 (-)NCBI
mRatBN7.21049,833,219 - 49,927,682 (-)NCBI
RefSeq Acc Id: NM_182667   ⟹   NP_872608
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,332,356 - 50,426,819 (-)NCBI
mRatBN7.21049,833,219 - 49,927,682 (-)NCBI
Rnor_6.01051,683,534 - 51,778,986 (-)NCBI
Rnor_5.01051,439,727 - 51,534,567 (-)NCBI
RGSC_v3.41051,496,223 - 51,588,226 (-)RGD
Celera1049,052,568 - 49,143,747 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246583   ⟹   XP_006246645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,332,502 - 50,426,534 (-)NCBI
mRatBN7.21049,833,219 - 49,928,806 (-)NCBI
Rnor_6.01051,682,053 - 51,781,458 (-)NCBI
Rnor_5.01051,439,727 - 51,534,567 (-)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_001401161 (Get FASTA)   NCBI Sequence Viewer  
  NP_872608 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246645 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL75447 (Get FASTA)   NCBI Sequence Viewer  
  BAC65150 (Get FASTA)   NCBI Sequence Viewer  
  DAA01467 (Get FASTA)   NCBI Sequence Viewer  
  EDM04761 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054372
  ENSRNOP00000054372.2
  ENSRNOP00000072988
GenBank Protein Q8R5I7 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_872608   ⟸   NM_182667
- Peptide Label: isoform 2
- UniProtKB: Q7M6Y4 (UniProtKB/Swiss-Prot),   Q8R5I8 (UniProtKB/Swiss-Prot),   Q8R5I7 (UniProtKB/Swiss-Prot),   A0A8I5ZYX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246645   ⟸   XM_006246583
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYX5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054372   ⟸   ENSRNOT00000057562
Ensembl Acc Id: ENSRNOP00000072988   ⟸   ENSRNOT00000078675
Ensembl Acc Id: ENSRNOP00000084177   ⟸   ENSRNOT00000109338
SAP

Name Modeler Protein Id AA Range Protein Structure
AF-Q8R5I7-F1-model_v2 AlphaFold Q8R5I7 1-938 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697286
Promoter ID:EPDNEW_R7811
Type:single initiation site
Name:Myocd_1
Description:myocardin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01051,779,041 - 51,779,101EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24715 BioCyc
Ensembl Genes ENSRNOG00000003669 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057562 ENTREZGENE
  ENSRNOT00000057562.4 UniProtKB/Swiss-Prot
  ENSRNOT00000078675 ENTREZGENE
Gene3D-CATH 1.10.720.30 UniProtKB/Swiss-Prot
  6.10.140.2040 UniProtKB/Swiss-Prot
  6.10.150.10 UniProtKB/Swiss-Prot
InterPro Myocardin-like UniProtKB/Swiss-Prot
  RPEL_repeat UniProtKB/Swiss-Prot
  SAP_dom UniProtKB/Swiss-Prot
  SAP_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:246297 UniProtKB/Swiss-Prot
NCBI Gene 246297 ENTREZGENE
PANTHER PTHR22793 UniProtKB/Swiss-Prot
  PTHR22793:SF11 UniProtKB/Swiss-Prot
Pfam RPEL UniProtKB/Swiss-Prot
  SAP UniProtKB/Swiss-Prot
PhenoGen Myocd PhenoGen
PROSITE RPEL UniProtKB/Swiss-Prot
  SAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003669 RatGTEx
SMART RPEL UniProtKB/Swiss-Prot
  SAP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF68906 UniProtKB/Swiss-Prot
UniProt A0A0G2K4C5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYX5 ENTREZGENE, UniProtKB/TrEMBL
  A6HFF6_RAT UniProtKB/TrEMBL
  MYCD_RAT UniProtKB/Swiss-Prot
  Q7M6Y4 ENTREZGENE
  Q8R5I7 ENTREZGENE
  Q8R5I8 ENTREZGENE
UniProt Secondary Q7M6Y4 UniProtKB/Swiss-Prot
  Q8R5I8 UniProtKB/Swiss-Prot
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Myocd  myocardin  Myocd  transcription factor myocardin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Myocd  transcription factor myocardin  Mycd    Symbol and Name updated 1299863 APPROVED