Myocd (myocardin) - Rat Genome Database

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Gene: Myocd (myocardin) Ictidomys tridecemlineatus
Analyze
Symbol: Myocd
Name: myocardin
RGD ID: 12511380
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (inferred); histone acetyltransferase binding (inferred); histone deacetylase binding (inferred); INVOLVED IN cardiac muscle cell apoptotic process (ortholog); cardiac muscle cell differentiation (ortholog); cardiac vascular smooth muscle cell differentiation (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH aortic atherosclerosis (ortholog); atrial fibrillation (ortholog); Cardio-Renal Syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-DNA complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560251,782,304 - 51,881,336 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365955,256,785 - 5,351,723 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365955,256,615 - 5,356,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle cell apoptotic process  (IEA,ISO)
cardiac muscle cell differentiation  (IEA,ISO)
cardiac muscle cell myoblast differentiation  (IEA)
cardiac vascular smooth muscle cell differentiation  (ISO)
cardiac ventricle development  (IEA,ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cellular component maintenance  (IEA,ISO)
cellular response to angiotensin  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromatin organization  (IEA,ISO)
digestive tract development  (IEA,ISO)
ductus arteriosus closure  (IEA,ISO)
heart development  (IEA,ISO)
hepatic stellate cell activation  (ISO)
lung alveolus development  (IEA,ISO)
negative regulation of amyloid-beta clearance  (IEA)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of cell adhesion molecule production  (IEA,ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of myotube differentiation  (IEA,ISO)
negative regulation of platelet-derived growth factor receptor-beta signaling pathway  (IEA)
negative regulation of skeletal muscle cell differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell migration  (IEA)
negative regulation of vascular associated smooth muscle cell proliferation  (IEA)
positive regulation of cardiac muscle cell differentiation  (IEA)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of miRNA transcription  (IEA)
positive regulation of smooth muscle cell differentiation  (IEA)
positive regulation of smooth muscle contraction  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
regulation of cell growth by extracellular stimulus  (IEA,ISO)
regulation of myoblast differentiation  (IEA,ISO)
regulation of phenotypic switching  (IEA)
regulation of smooth muscle cell differentiation  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to hypoxia  (IEA)
response to mechanical stimulus  (ISO)
response to muscle stretch  (ISO)
smooth muscle cell differentiation  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
transcription initiation-coupled chromatin remodeling  (IEA)
urinary bladder development  (IEA,ISO)
uterus development  (IEA,ISO)
vascular associated smooth muscle cell differentiation  (IEA)
vasculogenesis  (IEA,ISO)
ventricular cardiac muscle cell differentiation  (IEA,ISO)

Cellular Component
chromatin  (IEA)
cytoplasm  (ISO)
nucleus  (IEA,ISO)
protein-DNA complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Myocd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560251,782,304 - 51,881,336 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365955,256,785 - 5,351,723 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365955,256,615 - 5,356,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381712,665,890 - 12,768,949 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1712,665,890 - 12,768,949 (+)EnsemblGRCh38hg38GRCh38
GRCh371712,569,207 - 12,672,266 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361712,510,231 - 12,607,686 (+)NCBINCBI36Build 36hg18NCBI36
Build 341712,510,230 - 12,607,686NCBI
Celera1712,594,549 - 12,695,987 (+)NCBICelera
Cytogenetic Map17p12NCBI
HuRef1712,464,600 - 12,566,080 (+)NCBIHuRef
CHM1_11712,577,982 - 12,679,406 (+)NCBICHM1_1
T2T-CHM13v2.01712,573,362 - 12,676,444 (+)NCBIT2T-CHM13v2.0
Myocd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,064,434 - 65,160,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,067,387 - 65,160,815 (-)EnsemblGRCm39 Ensembl
GRCm381165,173,608 - 65,269,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,176,561 - 65,269,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,990,063 - 65,083,491 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,992,756 - 65,086,175 (-)NCBIMGSCv36mm8
Celera1172,112,506 - 72,207,425 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.42NCBI
Myocd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81050,332,356 - 50,426,819 (-)NCBIGRCr8
mRatBN7.21049,833,219 - 49,928,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1049,836,641 - 49,927,627 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1054,505,304 - 54,596,319 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01053,995,291 - 54,086,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01049,509,995 - 49,600,991 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01051,682,053 - 51,781,458 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1051,683,540 - 51,778,986 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01051,439,727 - 51,534,567 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41051,496,223 - 51,588,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11051,509,851 - 51,601,849 (-)NCBI
Celera1049,052,568 - 49,143,747 (-)NCBICelera
Cytogenetic Map10q24NCBI
Myocd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554674,656,380 - 4,743,110 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554674,653,065 - 4,743,438 (-)NCBIChiLan1.0ChiLan1.0
MYOCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21960,982,668 - 61,082,874 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11765,789,278 - 65,889,518 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01738,880,120 - 38,983,246 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11743,578,967 - 43,681,659 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1743,584,259 - 43,681,659 (-)Ensemblpanpan1.1panPan2
MYOCD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1536,674,476 - 36,774,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl536,674,300 - 36,769,327 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha536,774,863 - 36,918,323 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0536,738,753 - 36,883,183 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl536,782,154 - 36,879,172 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1536,711,643 - 36,856,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0536,659,301 - 36,802,936 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0536,843,479 - 36,993,391 (+)NCBIUU_Cfam_GSD_1.0
MYOCD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1256,931,317 - 57,029,258 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11256,931,628 - 57,029,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21259,928,695 - 59,945,526 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYOCD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11611,923,464 - 12,100,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1612,000,197 - 12,095,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660599,137,934 - 9,239,568 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myocd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624877618,789 - 647,471 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005332888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000011748   ⟹   ENSSTOP00000010541
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365955,256,785 - 5,351,723 (+)Ensembl
RefSeq Acc Id: XM_005332888   ⟹   XP_005332945
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560251,782,304 - 51,881,336 (+)NCBI
SpeTri2.0NW_0049365955,256,615 - 5,356,563 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005332945 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000010541.3
GenBank Protein KAG3270009 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005332945   ⟸   XM_005332888
- UniProtKB: I3MHX4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000010541   ⟸   ENSSTOT00000011748
Protein Domains
SAP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000011741 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000011748.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/TrEMBL
  6.10.140.2040 UniProtKB/TrEMBL
  6.10.150.10 UniProtKB/TrEMBL
InterPro Myocardin-like UniProtKB/TrEMBL
  RPEL_repeat UniProtKB/TrEMBL
  SAP_dom UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
NCBI Gene Myocd ENTREZGENE
PANTHER PTHR22793 UniProtKB/TrEMBL
  PTHR22793:SF11 UniProtKB/TrEMBL
Pfam RPEL UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
PROSITE RPEL UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
SMART RPEL UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/TrEMBL
UniProt I3MHX4 ENTREZGENE, UniProtKB/TrEMBL