Rab38 (RAB38, member RAS oncogene family) - Rat Genome Database

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Gene: Rab38 (RAB38, member RAS oncogene family) Rattus norvegicus
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Symbol: Rab38
Name: RAB38, member RAS oncogene family
RGD ID: 628752
Description: Enables GTP binding activity. Involved in platelet dense granule organization; positive regulation of biosynthetic process; and positive regulation of protein localization to cell periphery. Located in cell body; melanosome; and perinuclear region of cytoplasm. Used to study Hermansky-Pudlak syndrome and proteinuria. Orthologous to human RAB38 (RAB38, member RAS oncogene family); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: R; R_mapped; Rab38, member of RAS oncogene family; ras-related protein Rab-38; red eyed dilution; Ruby; Ruby or red eyed dilution; ruby or red eyed dilution (mapped); small GTP binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Rab38ru   Rab38em1Mcwi  
Genetic Models: FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi-/- FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi-Rab38em1Mcwi+/+   FHH-TgTn(T2/Rab38)1Mcwi  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81151,595,153 - 151,675,492 (+)NCBIGRCr8
mRatBN7.21142,182,566 - 142,262,923 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1142,182,556 - 142,262,924 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1150,149,817 - 150,230,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,326,253 - 157,406,599 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01150,200,179 - 150,280,523 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01152,072,716 - 152,153,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1152,072,665 - 152,153,449 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01158,385,888 - 158,466,621 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,783,919 - 144,864,573 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,862,324 - 144,942,979 (+)NCBI
Celera1140,481,941 - 140,561,948 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
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Original Reference(s)
Rab38RatAlbuminuria  IAGP 1357409 RGD 
Rab38RatAlbuminuria  IAGP 13782139compared to FHH-Tg(CAG-Rab38)1Mcwi and FHH.BN-(D1Hmgc14-D1Hmgc15)/McwiRGD 
Rab38RatHermansky-Pudlak syndrome  IAGP 2324690 RGD 
Rab38Ratproteinuria  IAGP 1357409 RGD 
Object Symbol
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Original Reference(s)
Rab38Ratintellectual disability  ISORAB38 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 

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Original Reference(s)
Rab38Rat1,2-dimethylhydrazine increases expressionISORab38 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of RAB38 mRNACTDPMID:22206623
Rab38Rat1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine increases expressionEXP 6480464chlorcyclizine results in increased expression of RAB38 mRNACTDPMID:21058326
Rab38Rat17beta-estradiol multiple interactionsISORAB38 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of RAB38 mRNACTDPMID:30165855
Rab38Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORAB38 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of RAB38 mRNACTDPMID:22298810
Rab38Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORAB38 (Homo sapiens)6480464[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of RAB38 mRNACTDPMID:29704546
Rab38Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORAB38 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of RAB38 mRNACTDPMID:29704546
Rab38Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of RAB38 mRNACTDPMID:21215274
Rab38Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of RAB38 mRNACTDPMID:21346803
Rab38Rat3-chloropropane-1,2-diol decreases expressionEXP 6480464alpha-Chlorohydrin results in decreased expression of RAB38 mRNACTDPMID:28522335
Rab38Rat4,4'-sulfonyldiphenol increases expressionISORab38 (Mus musculus)6480464bisphenol S results in increased expression of RAB38 mRNACTDPMID:30951980
Rab38Rat4-hydroxyphenyl retinamide decreases expressionISORab38 (Mus musculus)6480464Fenretinide results in decreased expression of RAB38 mRNACTDPMID:28973697
Rab38Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of RAB38 mRNACTDPMID:24780913
Rab38Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of RAB38 mRNACTDPMID:28959563
Rab38Ratactinomycin D multiple interactionsISORAB38 (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased expression of RAB38 mRNACTDPMID:38460933
Rab38Rataflatoxin B1 decreases methylationISORAB38 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of RAB38 geneCTDPMID:27153756
Rab38Ratall-trans-retinoic acid increases expressionEXP 6480464Tretinoin results in increased expression of RAB38 mRNACTDPMID:20488242
Rab38Ratall-trans-retinoic acid decreases expressionISORAB38 (Homo sapiens)6480464Tretinoin results in decreased expression of RAB38 mRNACTDPMID:33167477
Rab38Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of RAB38 mRNACTDPMID:16483693
Rab38Ratamphetamine increases expressionEXP 6480464Amphetamine results in increased expression of RAB38 mRNACTDPMID:30779732
Rab38Ratbenzo[a]pyrene increases expressionISORAB38 (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of RAB38 mRNACTDPMID:20064835 and PMID:30453624

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Biological Process
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Original Reference(s)
Rab38Ratendosome to melanosome transport involved_inISORAB38 (Homo sapiens)1624291 PMID:22511774RGDPMID:22511774
Rab38Ratendosome to melanosome transport involved_inIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38Ratintracellular protein transport involved_inIBACGD:CAL0000181874 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rab38Ratmelanosome assembly involved_inISORAB38 (Homo sapiens)1624291 PMID:22511774 and PMID:23084991RGDPMID:22511774 and PMID:23084991
Rab38Ratmelanosome assembly involved_inIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38Ratmelanosome organization involved_inIBAPANTHER:PTN000636041 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rab38Ratmitochondrion organization involved_inISORAB38 (Homo sapiens)1624291 PMID:25767741RGDPMID:25767741
Rab38Ratmitochondrion organization involved_inIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38Ratphagosome acidification involved_inISORAB38 (Homo sapiens)1624291 PMID:21255211RGDPMID:21255211
Rab38Ratphagosome acidification involved_inIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38Ratplatelet dense granule organization  IMP 2324691 RGD 
Rab38Ratpositive regulation of melanin biosynthetic process  IMP 152025192 RGD 
Rab38Ratpositive regulation of phosphatidylcholine biosynthetic process  IDA 13524861 RGD 
Rab38Ratpositive regulation of protein localization to cell periphery  IMP 152025192 RGD 
Rab38Ratprotein localization to membrane involved_inISORAB38 (Homo sapiens)1624291 PMID:22511774 and PMID:25767741RGDPMID:22511774 and PMID:25767741
Rab38Ratprotein localization to membrane involved_inIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38Ratvesicle-mediated transport  NAS 633808 RGD 
Rab38Ratvesicle-mediated transport involved_inIEAInterPro:IPR0306971600115GO_REF:0000002InterProGO_REF:0000002
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Cellular Component
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Original Reference(s)
Rab38Ratcell body  IDA 152025192MMO:0000686RGD 
Rab38Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Rab38Ratearly endosome located_inISORAB38 (Homo sapiens)1624291 PMID:22511774RGDPMID:22511774
Rab38Ratearly endosome located_inIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38Ratearly endosome lumen NOT|located_inISORAB38 (Homo sapiens)1624291 PMID:22511774RGDPMID:22511774
Rab38Ratendomembrane system is_active_inIBACGD:CAL0000194609 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rab38Ratendomembrane system located_inIEAUniProtKB-SubCell:SL-01471600115GO_REF:0000044UniProtGO_REF:0000044
Rab38RatGolgi apparatus located_inIEAInterPro:IPR0306971600115GO_REF:0000002InterProGO_REF:0000002
Rab38Ratintracellular membrane-bounded organelle located_inIEAARBA:ARBA000290851600115GO_REF:0000117UniProtGO_REF:0000117
Rab38Ratlysosome located_inISORAB38 (Homo sapiens)1624291 PMID:25767741RGDPMID:25767741
Rab38Ratlysosome located_inIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38Ratmelanosome located_inIDA 152025192MMO:0000686RGD 
Rab38Ratmelanosome located_inIEAUniProtKB:Q8QZZ8 and ensembl:ENSMUSP000001028771600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38Ratmelanosome located_inIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38Ratmelanosome located_inISORab38 (Mus musculus)1624291 PMID:26620560RGDPMID:26620560
Rab38Ratmelanosome is_active_inIBAMGI:1915094 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rab38Ratmelanosome located_inISORAB38 (Homo sapiens)1624291 PMID:22511774RGDPMID:22511774
Rab38Ratmelanosome membrane located_inISORAB38 (Homo sapiens)1624291 PMID:23084991RGDPMID:23084991
Rab38Ratmelanosome membrane located_inIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38Ratmembrane located_inISORAB38 (Homo sapiens)1624291 PMID:22511774RGDPMID:22511774
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Molecular Function
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Original Reference(s)
Rab38RatAP-1 adaptor complex binding enablesISORAB38 (Homo sapiens)1624291UniProtKB:O43747 and PMID:22511774RGDPMID:22511774
Rab38RatAP-1 adaptor complex binding enablesIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38RatAP-2 adaptor complex binding NOT|enablesISORAB38 (Homo sapiens)1624291 PMID:22511774RGDPMID:22511774
Rab38RatAP-3 adaptor complex binding enablesISORAB38 (Homo sapiens)1624291UniProtKB:Q9Y2T2 and PMID:22511774RGDPMID:22511774
Rab38RatAP-3 adaptor complex binding enablesIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38RatBLOC-2 complex binding enablesISORAB38 (Homo sapiens)1624291UniProtKB:Q86YV9 and PMID:22511774RGDPMID:22511774
Rab38RatBLOC-2 complex binding enablesIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38RatGDP binding  ICGO:00055251599671 RGD 
Rab38RatGTP binding  TAS 633808 RGD 
Rab38RatGTP binding enablesIEAUniRule:UR0014537651600115GO_REF:0000104UniProtGO_REF:0000104
Rab38RatGTP binding enablesIEAInterPro:IPR001806 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Rab38RatGTP binding enablesIEAUniProtKB-KW:KW-03421600115GO_REF:0000043UniProtGO_REF:0000043
Rab38RatGTP binding  IDA 1599671 RGD 
Rab38RatGTP-dependent protein binding enablesISORAB38 (Homo sapiens)1624291UniProtKB:O00203 more ...RGDPMID:22511774
Rab38RatGTP-dependent protein binding enablesIEAUniProtKB:P57729 and ensembl:ENSP000002436621600115GO_REF:0000107EnsemblGO_REF:0000107
Rab38RatGTPase activity  TAS 633808 RGD 
Rab38RatGTPase activity enablesIEAInterPro:IPR001806 and InterPro:IPR0306971600115GO_REF:0000002InterProGO_REF:0000002
Rab38RatGTPase activity enablesIBAFB:FBgn0015797 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rab38RatGTPase activity enablesIEAUniRule:UR0014537651600115GO_REF:0000104UniProtGO_REF:0000104
Rab38RatGTPase activity  ICGO:00055251599671 RGD 
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Original Reference(s)
Rab38Ratabnormal coat/hair pigmentation  IAGP 1300411DNA:point mutation:exon:p.M1IRGD 
Rab38Ratabnormal platelet dense granule number  IAGP 2324691 RGD 
Rab38Ratabnormal surfactant secretion  IAGP 2324690 RGD 
Rab38Ratdilated respiratory conducting tube  IAGP 2324690 RGD 
Rab38Ratenlarged alveolar lamellar bodies  IMP 13524861 RGD 
Rab38Ratincreased bleeding time  IAGP 2324690 RGD 
Rab38Ratincreased urine protein level  IAGP 13782139compared to FHH-TgCAG-Rab381Mcwi and FHH.BN-D1Hmgc14-D1Hmgc15/McwiRGD 

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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. TM rats: a model for platelet storage pool deficiency. Hamada S, etal., Exp Anim 1997 Jul;46(3):235-9.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. The role of Rab38 in platelet dense granule defects. Ninkovic I, etal., J Thromb Haemost. 2008 Dec;6(12):2143-51. Epub 2008 Oct 1.
6. The rat Ruby ( R) locus is Rab38: identical mutations in Fawn-hooded and Tester-Moriyama rats derived from an ancestral Long Evans rat sub-strain. Oiso N, etal., Mamm Genome 2004 Apr;15(4):307-14.
7. Expression and localization of a novel Rab small G protein (Rab38) in the rat lung. Osanai K, etal., Am J Pathol 2001 May;158(5):1665-75.
8. Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-Pudlak syndrome. Osanai K, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L243-51. Epub 2009 Nov 6.
9. Expression and characterization of Rab38, a new member of the Rab small G protein family. Osanai K, etal., Biol Chem. 2005 Feb;386(2):143-53.
10. Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats. Osanai K, etal., Respir Res. 2017 Apr 24;18(1):70. doi: 10.1186/s12931-017-0549-2.
11. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. Rangel-Filho A, etal., J Am Soc Nephrol 2005 Apr;16(4):852-6. Epub 2005 Mar 9.
12. Rab38 modulates proteinuria in model of hypertension-associated renal disease. Rangel-Filho A, etal., J Am Soc Nephrol. 2013 Feb;24(2):283-92. doi: 10.1681/ASN.2012090927. Epub 2013 Jan 4.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. Wasmeier C, etal., J Cell Biol. 2006 Oct 23;175(2):271-81. doi: 10.1083/jcb.200606050. Epub 2006 Oct 16.
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PMID:21255211   PMID:21764986   PMID:22511774   PMID:23084991   PMID:25767741   PMID:26620560   PMID:26631737  



Rab38
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81151,595,153 - 151,675,492 (+)NCBIGRCr8
mRatBN7.21142,182,566 - 142,262,923 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1142,182,556 - 142,262,924 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1150,149,817 - 150,230,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,326,253 - 157,406,599 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01150,200,179 - 150,280,523 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01152,072,716 - 152,153,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1152,072,665 - 152,153,449 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01158,385,888 - 158,466,621 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,783,919 - 144,864,573 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,862,324 - 144,942,979 (+)NCBI
Celera1140,481,941 - 140,561,948 (+)NCBICelera
Cytogenetic Map1q32NCBI
RAB38
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381187,803,715 - 88,175,443 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1188,113,251 - 88,175,443 (-)EnsemblGRCh38hg38GRCh38
GRCh371187,846,419 - 87,908,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361187,486,079 - 87,548,247 (-)NCBINCBI36Build 36hg18NCBI36
Build 341187,486,078 - 87,548,247NCBI
Celera1186,723,503 - 86,785,679 (+)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1184,086,688 - 84,148,798 (-)NCBIHuRef
CHM1_11187,729,200 - 87,791,404 (-)NCBICHM1_1
T2T-CHM13v2.01187,746,041 - 88,094,423 (-)NCBIT2T-CHM13v2.0
Rab38
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39788,079,481 - 88,140,780 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl788,079,481 - 88,140,780 (+)EnsemblGRCm39 Ensembl
GRCm38788,430,273 - 88,491,572 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl788,430,273 - 88,491,572 (+)EnsemblGRCm38mm10GRCm38
MGSCv37795,578,783 - 95,640,082 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36788,305,465 - 88,366,764 (+)NCBIMGSCv36mm8
Celera785,784,928 - 85,846,216 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.19NCBI
Rab38
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554145,158,261 - 5,215,698 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554145,158,860 - 5,214,108 (+)NCBIChiLan1.0ChiLan1.0
RAB38
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2988,982,414 - 89,051,335 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,026,601 - 90,092,945 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01183,121,858 - 83,183,698 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,710,358 - 86,772,796 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,710,358 - 86,773,142 (-)Ensemblpanpan1.1panPan2
RAB38
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12111,769,924 - 11,823,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2111,769,351 - 11,822,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2111,629,645 - 11,685,137 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02111,951,012 - 12,006,559 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2111,950,427 - 12,014,114 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12111,739,658 - 11,795,116 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02111,810,618 - 11,866,135 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02111,864,785 - 11,920,329 (+)NCBIUU_Cfam_GSD_1.0
Rab38
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494773,981,078 - 74,037,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367361,304,185 - 1,361,221 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367361,304,290 - 1,360,412 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB38
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl921,577,033 - 21,640,115 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1921,577,083 - 21,640,637 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2923,798,471 - 23,863,103 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB38
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1179,256,996 - 79,316,967 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl179,256,835 - 79,316,789 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604346,404,298 - 46,464,013 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab38
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248451,906,671 - 1,984,029 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248451,908,410 - 1,983,897 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Rab38
613 total Variants

Predicted Target Of
Summary Value
Count of predictions:403
Count of miRNA genes:240
Interacting mature miRNAs:287
Transcripts:ENSRNOT00000022538
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 64 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat

1 to 10 of 64 rows
AU043391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,262,559 - 142,262,829 (+)MAPPERmRatBN7.2
Rnor_6.01152,153,086 - 152,153,355NCBIRnor6.0
Rnor_5.01158,466,258 - 158,466,527UniSTSRnor5.0
RGSC_v3.41144,864,210 - 144,864,479UniSTSRGSC3.4
Celera1140,561,585 - 140,561,854UniSTS
Cytogenetic Map1q32UniSTS
RH143545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,262,293 - 142,262,398 (+)MAPPERmRatBN7.2
Rnor_6.01152,152,820 - 152,152,924NCBIRnor6.0
Rnor_5.01158,465,992 - 158,466,096UniSTSRnor5.0
RGSC_v3.41144,863,944 - 144,864,048UniSTSRGSC3.4
Celera1140,561,319 - 140,561,423UniSTS
RH 3.4 Map11115.4UniSTS
Cytogenetic Map1q32UniSTS
RH135407  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,262,616 - 142,262,820 (+)MAPPERmRatBN7.2
Rnor_6.01152,153,143 - 152,153,346NCBIRnor6.0
Rnor_5.01158,466,315 - 158,466,518UniSTSRnor5.0
RGSC_v3.41144,864,267 - 144,864,470UniSTSRGSC3.4
Celera1140,561,642 - 140,561,845UniSTS
RH 3.4 Map11115.8UniSTS
Cytogenetic Map1q32UniSTS


The following Strains have been annotated to Rab38


This gene Rab38 is modified in the following models/strains:




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000022538   ⟹   ENSRNOP00000022538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1142,182,556 - 142,262,924 (+)Ensembl
Rnor_6.0 Ensembl1152,072,665 - 152,153,449 (+)Ensembl
RefSeq Acc Id: NM_145774   ⟹   NP_665717
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81151,595,153 - 151,675,492 (+)NCBI
mRatBN7.21142,182,566 - 142,262,923 (+)NCBI
Rnor_6.01152,072,716 - 152,153,449 (+)NCBI
Rnor_5.01158,385,888 - 158,466,621 (+)NCBI
RGSC_v3.41144,783,919 - 144,864,573 (+)RGD
Celera1140,481,941 - 140,561,948 (+)RGD
Sequence:
Protein RefSeqs NP_665717 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42000 (Get FASTA)   NCBI Sequence Viewer  
  AAH70513 (Get FASTA)   NCBI Sequence Viewer  
  AAR84221 (Get FASTA)   NCBI Sequence Viewer  
  EDM18585 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022538
  ENSRNOP00000022538.3
RefSeq Acc Id: NP_665717   ⟸   NM_145774
- UniProtKB: Q63483 (UniProtKB/TrEMBL),   A6I5Z5 (UniProtKB/TrEMBL),   F7F483 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022538   ⟸   ENSRNOT00000022538

Name Modeler Protein Id AA Range Protein Structure
AF-Q63483-F1-model_v2 AlphaFold Q63483 1-211 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690179
Promoter ID:EPDNEW_R704
Type:multiple initiation site
Name:Rab38_1
Description:RAB38, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01152,072,684 - 152,072,744EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58574 BioCyc
Ensembl Genes ENSRNOG00000016769 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022538 ENTREZGENE
  ENSRNOT00000022538.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Rab29/Rab38/Rab32 UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
KEGG Report rno:252916 UniProtKB/TrEMBL
NCBI Gene 252916 ENTREZGENE
PANTHER RAB FAMILY UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAB UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rab38 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016769 RatGTEx
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A6I5Z5 ENTREZGENE
  F7F483 ENTREZGENE, UniProtKB/TrEMBL
  Q63483 ENTREZGENE, UniProtKB/TrEMBL
  Q6TAS0_RAT UniProtKB/TrEMBL
UniProt Secondary A6I5Z5 UniProtKB/TrEMBL
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-02-12 Rab38  Rab38, member of RAS oncogene family  R_mapped  ruby or red eyed dilution (mapped)  Data merged from RGD:3462 737654 APPROVED
2005-11-17 R_mapped  ruby or red eyed dilution (mapped)  Ruby or red eyed dilution  Symbol and Name updated 1556543 APPROVED
2004-02-26 Rab38  Rab38, member of RAS oncogene family      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Rab38  Rab38, member of RAS oncogene family      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ruby or red eyed dilution      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease Met1Ile mutation is responsible for the Ruby (red eyed dilution) phenotype in both the Fawn-hooded (FHH) and Tester Moriyama (TM) strains, two models for platelet storage pool deficiency 1300411
gene_expression expressed in alveolar type II cells and in bronchial epithelial cells 633808