Nop58 (NOP58 ribonucleoprotein) - Rat Genome Database

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Gene: Nop58 (NOP58 ribonucleoprotein) Rattus norvegicus
Analyze
Symbol: Nop58
Name: NOP58 ribonucleoprotein
RGD ID: 620484
Description: Predicted to enable ATPase binding activity; TFIID-class transcription factor complex binding activity; and snoRNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis and snoRNA localization. Predicted to be located in Cajal body; cytosol; and fibrillar center. Predicted to be part of box C/D methylation guide snoRNP complex; pre-snoRNP complex; and small-subunit processome. Orthologous to human NOP58 (NOP58 ribonucleoprotein); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC105440; Nap65; Nol5; NOP58 ribonucleoprotein homolog; NOP58 ribonucleoprotein homolog (yeast); Nopp140 associated protein; nopp140-associated protein of 65 kDa; nucleolar protein 5; nucleolar protein 58; nucleolar protein NOP58
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8968,614,992 - 68,638,911 (+)NCBIGRCr8
mRatBN7.2961,120,939 - 61,144,810 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl961,120,929 - 61,144,810 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx969,615,623 - 69,639,722 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0974,731,599 - 74,755,698 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0973,049,892 - 73,073,989 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0966,495,881 - 66,520,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,495,832 - 66,519,788 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0966,300,036 - 66,323,766 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4958,255,685 - 58,279,522 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1958,402,666 - 58,426,502 (+)NCBI
Celera958,555,582 - 58,579,638 (+)NCBICelera
Cytogenetic Map9q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nop58Ratautoimmune lymphoproliferative syndrome type 2B  ISONOP58 (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome type 2BClinVarPMID:11343122 more ...
Nop58RatAutoimmune Lymphoproliferative Syndrome, Type V  ISONOP58 (Homo sapiens)8554872ClinVar Annotator: match by term: Autoimmune lymphoproliferative syndrome type VClinVarPMID:11343122 more ...
Nop58Ratcommon variable immunodeficiency 1  ISONOP58 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency more ...ClinVarPMID:11343122 more ...
Nop58RatNeurodevelopmental Disorders  ISONOP58 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Nop58Ratprimary pulmonary hypertension  ISONOP58 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary pulmonary hypertensionClinVarPMID:16429395 more ...
Nop58Ratprimary pulmonary hypertension 1  ISONOP58 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary hypertension more ...ClinVarPMID:23579436
Nop58RatPulmonary Arterial Hypertension  ISONOP58 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary arterial hypertensionClinVarPMID:32581362
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nop58RatAnimal Disease Models  ISONOP58 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27602772
Nop58Ratlung adenocarcinoma  ISONOP58 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27602772

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nop58Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of NOP58 mRNA]CTDPMID:31150632
Nop58Rat(1->4)-beta-D-glucan multiple interactionsISONop58 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of NOP58 mRNACTDPMID:36331819
Nop58Rat1,2-dichloroethane decreases expressionISONop58 (Mus musculus)6480464ethylene dichloride results in decreased expression of NOP58 mRNACTDPMID:28189721 and PMID:28960355
Nop58Rat1,2-dimethylhydrazine multiple interactionsISONop58 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NOP58 mRNACTDPMID:22206623
Nop58Rat17alpha-ethynylestradiol increases expressionISONop58 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of NOL5 mRNA and Ethinyl Estradiol results in increased expression of NOP58 mRNACTDPMID:17555576 and PMID:17942748
Nop58Rat17alpha-ethynylestradiol multiple interactionsISONop58 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOP58 mRNACTDPMID:17942748
Nop58Rat17beta-estradiol increases expressionISONop58 (Mus musculus)6480464Estradiol results in increased expression of NOP58 mRNACTDPMID:39298647
Nop58Rat17beta-estradiol increases expressionISONOP58 (Homo sapiens)6480464Estradiol results in increased expression of NOP58 mRNACTDPMID:31614463
Nop58Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISONop58 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Nop58Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISONOP58 (Homo sapiens)64804642 more ...CTDPMID:31675489
Nop58Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISONop58 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Nop58Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONop58 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NOP58 mRNACTDPMID:17942748
Nop58Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISONop58 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of NOL5 mRNACTDPMID:20159946
Nop58Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISONop58 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of NOL5 mRNACTDPMID:21570461
Nop58Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of NOL5 mRNACTDPMID:21346803
Nop58Rat2,6-dimethoxyphenol multiple interactionsISONOP58 (Homo sapiens)6480464[Furaldehyde co-treated with pyrogallol 1 more ...CTDPMID:38598786
Nop58Rat3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643 more ...CTDPMID:23196670
Nop58Rat3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of NOP58 mRNACTDPMID:30071829
Nop58Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of NOP58 proteinCTDPMID:34915118
Nop58Rat3-methylcholanthrene increases expressionISONop58 (Mus musculus)6480464Methylcholanthrene results in increased expression of NOL5 mRNACTDPMID:20713471

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nop58Ratbiological_process  ND 159840702/2016: no relevant rat dataRGD 
Nop58Ratribosomal small subunit biogenesis involved_inISONOP58 (Homo sapiens)1624291 PMID:34516797RGDPMID:34516797
Nop58Ratribosomal small subunit biogenesis involved_inIEAUniProtKB:Q9Y2X3 and ensembl:ENSP000002642791600115GO_REF:0000107EnsemblGO_REF:0000107
Nop58Ratribosomal small subunit biogenesis involved_inISSUniProtKB:Q9Y2X31600115GO_REF:0000024UniProtGO_REF:0000024
Nop58Ratribosome biogenesis involved_inIEAUniProtKB-KW:KW-06901600115GO_REF:0000043UniProtGO_REF:0000043
Nop58RatsnoRNA localization involved_inISONOP58 (Homo sapiens)1624291 PMID:17636026RGDPMID:17636026
Nop58RatsnoRNA localization involved_inIEAUniProtKB:Q9Y2X3 and ensembl:ENSP000002642791600115GO_REF:0000107EnsemblGO_REF:0000107

Cellular Component
1 to 20 of 27 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nop58Ratbox C/D methylation guide snoRNP complex part_ofIEAInterPro:IPR0450561600115GO_REF:0000002InterProGO_REF:0000002
Nop58Ratbox C/D methylation guide snoRNP complex part_ofISONOP58 (Homo sapiens)1624291 PMID:33367824 and PMID:39570315RGDPMID:33367824 and PMID:39570315
Nop58Ratbox C/D methylation guide snoRNP complex part_ofIEAUniProtKB:Q9Y2X3 and ensembl:ENSP000002642791600115GO_REF:0000107EnsemblGO_REF:0000107
Nop58Ratbox C/D methylation guide snoRNP complex part_ofIBAPANTHER:PTN000096022 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nop58RatCajal body located_inISONOP58 (Homo sapiens)1624291 PMID:16687569RGDPMID:16687569
Nop58RatCajal body located_inIEAUniProtKB:Q9Y2X3 and ensembl:ENSP000002642791600115GO_REF:0000107EnsemblGO_REF:0000107
Nop58Ratcytosol located_inIEAUniProtKB:Q9Y2X3 and ensembl:ENSP000002642791600115GO_REF:0000107EnsemblGO_REF:0000107
Nop58Ratcytosol located_inISONOP58 (Homo sapiens)1624291 RGDGO_REF:0000052
Nop58Ratfibrillar center located_inIEAUniProtKB:Q9Y2X3 and ensembl:ENSP000002642791600115GO_REF:0000107EnsemblGO_REF:0000107
Nop58Ratfibrillar center located_inISONOP58 (Homo sapiens)1624291 RGDGO_REF:0000052
Nop58Ratnucleolus located_inISONOP58 (Homo sapiens)1624291 PMID:16687569 and PMID:33367824RGDPMID:16687569 and PMID:33367824
Nop58Ratnucleolus located_inIEAUniProtKB:Q9Y2X3 and ensembl:ENSP000002642791600115GO_REF:0000107EnsemblGO_REF:0000107
Nop58Ratnucleolus located_inIEAUniProtKB-SubCell:SL-01881600115GO_REF:0000044UniProtGO_REF:0000044
Nop58Ratnucleoplasm located_inISONOP58 (Homo sapiens)1624291 RGDGO_REF:0000052
Nop58Ratnucleoplasm located_inIEAUniProtKB:Q9Y2X3 and ensembl:ENSP000002642791600115GO_REF:0000107EnsemblGO_REF:0000107
Nop58Ratnucleoplasm located_inIEAUniProtKB-SubCell:SL-01901600115GO_REF:0000044UniProtGO_REF:0000044
Nop58Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Nop58Ratpre-snoRNP complex part_ofISONOP58 (Homo sapiens)1624291 PMID:17636026RGDPMID:17636026
Nop58Ratpre-snoRNP complex part_ofIEAUniProtKB:Q9Y2X3 and ensembl:ENSP000002642791600115GO_REF:0000107EnsemblGO_REF:0000107
Nop58Ratribonucleoprotein complex part_ofIEAUniProtKB-KW:KW-06871600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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1 to 10 of 10 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nop58Ratribosome biogenesis pathway   ISONOP58 (Homo sapiens)9999451 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nop58Ratribosome biogenesis pathway   IEA 6907045 KEGGrno:03008

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA. Watkins NJ and Bohnsack MT, Wiley Interdiscip Rev RNA. 2012 May-Jun;3(3):397-414. doi: 10.1002/wrna.117. Epub 2011 Nov 7.
9. Conserved composition of mammalian box H/ACA and box C/D small nucleolar ribonucleoprotein particles and their interaction with the common factor Nopp140. Yang Y, etal., Mol Biol Cell 2000 Feb;11(2):567-77.
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PMID:10925205   PMID:12477932   PMID:16687569   PMID:17636026   PMID:19946888   PMID:22082260   PMID:22658674   PMID:22681889  



Nop58
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8968,614,992 - 68,638,911 (+)NCBIGRCr8
mRatBN7.2961,120,939 - 61,144,810 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl961,120,929 - 61,144,810 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx969,615,623 - 69,639,722 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0974,731,599 - 74,755,698 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0973,049,892 - 73,073,989 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0966,495,881 - 66,520,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,495,832 - 66,519,788 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0966,300,036 - 66,323,766 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4958,255,685 - 58,279,522 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1958,402,666 - 58,426,502 (+)NCBI
Celera958,555,582 - 58,579,638 (+)NCBICelera
Cytogenetic Map9q31NCBI
NOP58
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382202,265,763 - 202,303,661 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2202,265,736 - 202,303,661 (+)EnsemblGRCh38hg38GRCh38
GRCh372203,130,486 - 203,168,384 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,838,760 - 202,876,629 (+)NCBINCBI36Build 36hg18NCBI36
Build 342202,956,020 - 202,993,888NCBI
Celera2196,882,417 - 196,920,291 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2194,979,023 - 195,015,805 (+)NCBIHuRef
CHM1_12203,136,987 - 203,174,808 (+)NCBICHM1_1
T2T-CHM13v2.02202,746,796 - 202,784,682 (+)NCBIT2T-CHM13v2.0
Nop58
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,724,165 - 59,751,352 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,724,130 - 59,758,203 (+)EnsemblGRCm39 Ensembl
GRCm38159,684,961 - 59,711,510 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,684,971 - 59,719,044 (+)EnsemblGRCm38mm10GRCm38
MGSCv37159,741,850 - 59,768,354 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36159,629,645 - 59,656,054 (+)NCBIMGSCv36mm8
Celera160,199,706 - 60,226,206 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.38NCBI
Nop58
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545712,479,965 - 12,511,678 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545712,481,467 - 12,511,678 (-)NCBIChiLan1.0ChiLan1.0
NOP58
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213104,890,221 - 104,928,093 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B104,905,239 - 104,943,091 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B89,520,961 - 89,558,794 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B207,674,433 - 207,707,763 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B207,674,654 - 207,707,763 (+)Ensemblpanpan1.1panPan2
NOP58
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13711,255,562 - 11,287,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3711,255,589 - 11,287,279 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3712,138,970 - 12,170,731 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03711,191,615 - 11,223,536 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3711,191,646 - 11,223,757 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13711,142,546 - 11,173,876 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03711,121,045 - 11,152,921 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03711,114,468 - 11,146,228 (+)NCBIUU_Cfam_GSD_1.0
Nop58
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303159,486,721 - 159,517,681 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367261,457,002 - 1,486,530 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367261,457,038 - 1,487,374 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOP58
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15105,893,637 - 105,930,459 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115105,893,589 - 105,930,458 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215117,351,116 - 117,380,896 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOP58
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11087,989,687 - 88,026,774 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1087,989,699 - 88,026,904 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040111,362,208 - 111,399,710 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nop58
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476514,139,815 - 14,172,413 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nop58
146 total Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
9 66510772 66510773 C G snv LEW/Crl (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:19
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000022676
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 29 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000022676   ⟹   ENSRNOP00000022676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl961,120,942 - 61,144,810 (+)Ensembl
Rnor_6.0 Ensembl966,495,832 - 66,519,769 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091283   ⟹   ENSRNOP00000073311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl961,120,929 - 61,144,806 (+)Ensembl
Rnor_6.0 Ensembl966,495,840 - 66,519,788 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099256   ⟹   ENSRNOP00000082410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl961,121,671 - 61,144,810 (+)Ensembl
RefSeq Acc Id: NM_021754   ⟹   NP_068522
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,615,074 - 68,638,911 (+)NCBI
mRatBN7.2961,120,970 - 61,144,810 (+)NCBI
Rnor_6.0966,495,881 - 66,519,790 (+)NCBI
Rnor_5.0966,300,036 - 66,323,766 (+)NCBI
RGSC_v3.4958,255,685 - 58,279,522 (+)RGD
Celera958,555,582 - 58,579,638 (+)RGD
Sequence:
RefSeq Acc Id: XM_063267663   ⟹   XP_063123733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,614,992 - 68,638,911 (+)NCBI
RefSeq Acc Id: XM_063267664   ⟹   XP_063123734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8968,618,608 - 68,638,911 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_068522 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123733 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123734 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF05769 (Get FASTA)   NCBI Sequence Viewer  
  AAH87637 (Get FASTA)   NCBI Sequence Viewer  
  EDL98947 (Get FASTA)   NCBI Sequence Viewer  
  EDL98948 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022676
  ENSRNOP00000022676.3
GenBank Protein Q9QZ86 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_068522   ⟸   NM_021754
- UniProtKB: O88525 (UniProtKB/Swiss-Prot),   Q9QZ86 (UniProtKB/Swiss-Prot),   A6IPB2 (UniProtKB/TrEMBL),   A0A8I5ZV87 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073311   ⟸   ENSRNOT00000091283
Ensembl Acc Id: ENSRNOP00000022676   ⟸   ENSRNOT00000022676
Ensembl Acc Id: ENSRNOP00000082410   ⟸   ENSRNOT00000099256
RefSeq Acc Id: XP_063123733   ⟸   XM_063267663
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZV87 (UniProtKB/TrEMBL)
Nop

Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZ86-F1-model_v2 AlphaFold Q9QZ86 1-534 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696709
Promoter ID:EPDNEW_R7228
Type:initiation region
Name:Nop58_1
Description:NOP58 ribonucleoprotein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0966,495,853 - 66,495,913EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-27403 BioCyc
Ensembl Genes ENSRNOG00000016486 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022676 ENTREZGENE
  ENSRNOT00000022676.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.246.90 UniProtKB/Swiss-Prot
  1.10.287.4070 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7309062 IMAGE-MGC_LOAD
InterPro Nop56/Nop58 UniProtKB/Swiss-Prot
  NOP5_N UniProtKB/Swiss-Prot
  Nop_C UniProtKB/Swiss-Prot
  Nop_dom UniProtKB/Swiss-Prot
  Nop_dom_sf UniProtKB/Swiss-Prot
  NOSIC UniProtKB/Swiss-Prot
KEGG Report rno:60373 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105440 IMAGE-MGC_LOAD
NCBI Gene 60373 ENTREZGENE
PANTHER NUCLEOLAR PROTEIN 58 UniProtKB/Swiss-Prot
  PTHR10894 UniProtKB/Swiss-Prot
Pfam Nop UniProtKB/Swiss-Prot
  NOP5NT UniProtKB/Swiss-Prot
PhenoGen Nop58 PhenoGen
PROSITE NOP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016486 RatGTEx
SMART NOSIC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF89124 UniProtKB/Swiss-Prot
UniProt A0A8I5ZV87 ENTREZGENE, UniProtKB/TrEMBL
  A6IPB2 ENTREZGENE, UniProtKB/TrEMBL
  A6IPB3_RAT UniProtKB/TrEMBL
  NOP58_RAT UniProtKB/Swiss-Prot
  O88525 ENTREZGENE
  Q5PPK6_RAT UniProtKB/TrEMBL
  Q9QZ86 ENTREZGENE
UniProt Secondary O88525 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Nop58  NOP58 ribonucleoprotein  Nop58  NOP58 ribonucleoprotein homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-05-03 Nop58  NOP58 ribonucleoprotein homolog (yeast)  Nop58  nucleolar protein NOP58  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Nop58  nucleolar protein NOP58  Nol5  nucleolar protein 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nol5  nucleolar protein 5  Nap65  Nopp140 associated protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Nap65  Nopp140 associated protein      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_homology has homology with yeast Nop5/58p 633515
gene_physical_interaction interacts with Nopp140 633515