Oprd1 (opioid receptor, delta 1) - Rat Genome Database

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Gene: Oprd1 (opioid receptor, delta 1) Rattus norvegicus
Analyze
Symbol: Oprd1
Name: opioid receptor, delta 1
RGD ID: 3233
Description: Enables G protein-coupled enkephalin receptor activity and receptor serine/threonine kinase binding activity. Involved in several processes, including eating behavior; response to ethanol; and response to nicotine. Located in several cellular components, including axon terminus; dendrite membrane; and postsynaptic membrane. Is active in secretory vesicle; spine apparatus; and synaptic membrane. Used to study alcohol use disorder and myocardial infarction. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; drug dependence (multiple); opioid abuse; and withdrawal disorder. Orthologous to human OPRD1 (opioid receptor delta 1); INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; (R)-noradrenaline; (R,R)-tramadol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: D-OR-1; delta-type opioid receptor; DOR-1; opioid receptor A; Opioid receptor delta 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,590,244 - 149,624,999 (-)NCBIGRCr8
mRatBN7.25144,306,188 - 144,340,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,306,188 - 144,340,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,005,532 - 147,040,056 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05148,775,378 - 148,809,896 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05148,764,406 - 148,799,337 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,288,126 - 150,323,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,288,126 - 150,323,063 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05153,962,767 - 153,997,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45150,979,252 - 151,014,066 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15150,989,290 - 151,024,105 (-)NCBI
Celera5142,741,006 - 142,775,820 (-)NCBICelera
RH 3.4 Map5965.9RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
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Original Reference(s)
Oprd1Ratalcohol dependence  ISOOPRD1 (Homo sapiens)401976552DNA:SNP more ...RGD 
Oprd1Ratalcohol use disorder  ISOOPRD1 (Homo sapiens)402525443DNA:SNPs and haplotype:intron 1:multiple (human)RGD 
Oprd1Ratalcohol use disorder  IEP 401976432associated with stress-related disorder and mRNA:decreased expression:dorsal striatum (rat)RGD 
Oprd1Ratalcohol use disorder  IMP 401976439 RGD 
Oprd1RatCardiac Arrhythmias  IDA 2316592 RGD 
Oprd1Ratcocaine dependence  ISOOPRD1 (Homo sapiens)402525443DNA:SNPs more ...RGD 
Oprd1Ratcocaine dependence  ISOOPRD1 (Homo sapiens)401976552DNA:SNP more ...RGD 
Oprd1Ratcocaine dependence  ISOOPRD1 (Homo sapiens)401976559DNA:SNP:intron more ...RGD 
Oprd1Ratcocaine dependence susceptibilityISOOPRD1 (Homo sapiens)402463960associated with alcohol use disorder and DNA:SNP:intron (rs678849) (human)RGD 
Oprd1Ratcocaine dependence treatmentISOOPRD1 (Homo sapiens)402463937associated with opiate dependence and DNA:SNP:intron (rs678849) (human)RGD 
Oprd1Ratheroin dependence treatmentISOOPRD1 (Homo sapiens)401976443DNA:SNP:CDS:intron more ...RGD 
Oprd1Ratheroin dependence  ISOOPRD1 (Homo sapiens)401977579associated with stress-related disorder more ...RGD 
Oprd1Ratheroin dependence  ISOOPRD1 (Homo sapiens)401976533DNA:SNP and haplotype:multiple (multiple) (human)RGD 
Oprd1Ratheroin dependence  ISOOPRD1 (Homo sapiens)401976535DNA:SNP and haplotype:intron 1 (multiple) (human)RGD 
Oprd1Ratheroin dependence treatmentISOOPRD1 (Homo sapiens)401976557associated with methadone treatment and DNA:SNP:intron (rs529520) (human)RGD 
Oprd1Ratheroin dependence onsetISOOPRD1 (Homo sapiens)401831045DNA:SNP: :rs508448 (human)RGD 
Oprd1RatHyperphagia  IMP 9831410 RGD 
Oprd1RatHypothermia  IEP 401901086mRNA:increased expression:hypothalamusRGD 
Oprd1Ratmorphine withdrawal syndrome  IMP 405101374 RGD 
Oprd1Ratmyocardial infarction  IMP 9831425 RGD 
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Original Reference(s)
Oprd1Ratepilepsy  ISOOPRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2415332
Oprd1RatOrthostatic Hypotension  ISOOPRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2981652
Oprd1Ratsubstance-related disorder  ISOOPRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17622222 and PMID:20098672
Oprd1Ratwithdrawal disorder  ISOOPRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2415332

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Original Reference(s)
Oprd1Rat(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin multiple interactionsEXP 6480464Magnesium promotes the reaction [Enkephalin more ...CTDPMID:2162496
Oprd1Rat(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin affects bindingEXP 6480464Enkephalin and Ala(2)-MePhe(4)-Gly(5)- binds to OPRD1 proteinCTDPMID:7562497
Oprd1Rat(R)-noradrenaline multiple interactionsEXP 6480464[dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine more ...CTDPMID:7562497
Oprd1Rat(R,R)-tramadol affects bindingEXP 6480464Tramadol binds to OPRD1 proteinCTDPMID:7562497
Oprd1Rat(R,R)-tramadol multiple interactionsEXP 6480464[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine and [Tramadol binds to OPRD1 protein] which results in decreased uptake of SerotoninCTDPMID:7562497
Oprd1Rat(S)-amphetamine affects expressionEXP 6480464Dextroamphetamine affects the expression of OPRD1 mRNACTDPMID:12629526
Oprd1Rat(S)-nicotine multiple interactionsISOOprd1 (Mus musculus)6480464[naltrindole binds to and results in decreased activity of OPRD1 protein] which results in increased susceptibility to NicotineCTDPMID:15778877
Oprd1Rat1,2-dichloroethane increases expressionISOOprd1 (Mus musculus)6480464ethylene dichloride results in increased expression of OPRD1 mRNACTDPMID:28960355
Oprd1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of OPRD1 mRNACTDPMID:15212814
Oprd1Rat17beta-estradiol increases expressionISOOPRD1 (Homo sapiens)6480464Estradiol results in increased expression of OPRD1 mRNACTDPMID:31614463
Oprd1Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOOprd1 (Mus musculus)64804642 more ...CTDPMID:31388691
Oprd1Rat2,4,6-trinitrobenzenesulfonic acid multiple interactionsEXP 6480464Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 mRNA] more ...CTDPMID:24637189
Oprd1Rat2,4,6-trinitrobenzenesulfonic acid increases expressionEXP 6480464Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 mRNA and Trinitrobenzenesulfonic Acid results in increased expression of OPRD1 proteinCTDPMID:24637189
Oprd1Rat4,4'-sulfonyldiphenol increases methylationISOOprd1 (Mus musculus)6480464bisphenol S results in increased methylation of OPRD1 exonCTDPMID:33297965
Oprd1Rat4,4'-sulfonyldiphenol affects methylationISOOprd1 (Mus musculus)6480464bisphenol S affects the methylation of OPRD1 geneCTDPMID:31683443
Oprd1Rat7-Hydroxymitragynine multiple interactionsISOOprd1 (Mus musculus)64804647-hydroxymitragynine binds to and affects the activity of OPRD1 proteinCTDPMID:27192616
Oprd1Rat7-Hydroxymitragynine multiple interactionsISOOPRD1 (Homo sapiens)64804647-hydroxymitragynine affects the reaction [Enkephalin more ...CTDPMID:27192616
Oprd1Ratacetylmethadol multiple interactionsEXP 6480464[Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Norepinephrine and [Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of SerotoninCTDPMID:7562497
Oprd1Ratacetylmethadol affects bindingEXP 6480464Methadyl Acetate binds to OPRD1 proteinCTDPMID:7562497
Oprd1Ratacrylamide decreases expressionISOOPRD1 (Homo sapiens)6480464Acrylamide results in decreased expression of OPRD1 mRNACTDPMID:37210002

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Biological Process
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Original Reference(s)
Oprd1Ratadenylate cyclase-activating dopamine receptor signaling pathway NOT|acts_upstream_of_or_withinISOOprd1 (Mus musculus)1624291 PMID:8738226RGDPMID:8738226
Oprd1Ratadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway acts_upstream_of_or_withinISOOprd1 (Mus musculus)1624291 PMID:8738226RGDPMID:8738226
Oprd1Ratadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway acts_upstream_of_or_withinIEAUniProtKB:P32300 and ensembl:ENSMUSP000000500771600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1Ratadult locomotory behavior acts_upstream_of_or_withinIEAUniProtKB:P32300 and ensembl:ENSMUSP000000500771600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1Ratadult locomotory behavior acts_upstream_of_or_withinISOOprd1 (Mus musculus)1624291MGI:2387013 PMID:10835636RGDPMID:10835636
Oprd1Ratcellular response to growth factor stimulus  IEP 2316598 RGD 
Oprd1Ratcellular response to hypoxia involved_inISOOPRD1 (Homo sapiens)1624291 PMID:24613828RGDPMID:24613828
Oprd1Ratcellular response to hypoxia involved_inIEAUniProtKB:P41143 and ensembl:ENSP000002349611600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1Ratcellular response to toxic substance involved_inISOOPRD1 (Homo sapiens)1624291 PMID:24613828RGDPMID:24613828
Oprd1Ratcellular response to toxic substance involved_inIEAUniProtKB:P41143 and ensembl:ENSP000002349611600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1Rateating behavior  IMP 9831409 RGD 
Oprd1RatG protein-coupled opioid receptor signaling pathway involved_inISOOPRD1 (Homo sapiens)1624291 PMID:9548483RGDPMID:9548483
Oprd1RatG protein-coupled opioid receptor signaling pathway involved_inIEAUniProtKB:P41143 and ensembl:ENSP000002349611600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1RatG protein-coupled opioid receptor signaling pathway involved_inIBAPANTHER:PTN002796213 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Oprd1RatG protein-coupled receptor signaling pathway involved_inISOOPRD1 (Homo sapiens)1624291 PMID:16325578RGDPMID:16325578
Oprd1RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Oprd1RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Oprd1RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB:P41143 and ensembl:ENSP000002349611600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1Ratnegative regulation of gene expression involved_inISOOPRD1 (Homo sapiens)1624291 PMID:24613828RGDPMID:24613828
Oprd1Ratnegative regulation of gene expression involved_inIEAUniProtKB:P41143 and ensembl:ENSP000002349611600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Oprd1Rataxon terminus  IDA 2316596 RGD 
Oprd1Ratdendrite membrane  IDA 2316596 RGD 
Oprd1Ratmembrane located_inIEAUniProtKB:P32300 and ensembl:ENSMUSP000000500771600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Oprd1Ratmembrane located_inISOOprd1 (Mus musculus)1624291 PMID:8393575 and PMID:8738226RGDPMID:8393575 and PMID:8738226
Oprd1Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Oprd1Ratneuron projection is_active_inIBAMGI:2180756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Oprd1Ratneuronal dense core vesicle is_active_inIDA 13702250PMID:7666182SynGO 
Oprd1Ratneuronal dense core vesicle is_active_inIEAUniProtKB:P32300 and ensembl:ENSMUSP000000500771600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1Ratneuronal dense core vesicle is_active_inISOOprd1 (Mus musculus)1624291 PMID:21321602RGDPMID:21321602
Oprd1Ratplasma membrane located_inISOOPRD1 (Homo sapiens)1624291 PMID:22184124RGDPMID:22184124
Oprd1Ratplasma membrane located_inIEAUniProtKB:P41143 and ensembl:ENSP000002349611600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Oprd1Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Oprd1Ratplasma membrane is_active_inIBAFB:FBgn0036789 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Oprd1Ratpostsynaptic density membrane is_active_inIDA 13702315PMID:11312309SynGO 
Oprd1Ratpostsynaptic membrane  IDA 2316596 RGD 
Oprd1Ratpresynaptic membrane is_active_inIDA 13702250PMID:7666182SynGO 
Oprd1Ratspine apparatus is_active_inIDA 13702315PMID:11312309SynGO 
Oprd1Ratsynaptic vesicle membrane is_active_inIDA 13702250PMID:7666182SynGO 
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Molecular Function
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Original Reference(s)
Oprd1RatG protein-coupled enkephalin receptor activity  IDA 2316599 RGD 
Oprd1RatG protein-coupled enkephalin receptor activity enablesIEAInterPro:IPR0003211600115GO_REF:0000002InterProGO_REF:0000002
Oprd1RatG protein-coupled enkephalin receptor activity enablesIEAUniProtKB:P41143 and ensembl:ENSP000002349611600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1RatG protein-coupled enkephalin receptor activity enablesIBAPANTHER:PTN002796213 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Oprd1RatG protein-coupled enkephalin receptor activity enablesISOOPRD1 (Homo sapiens)1624291 PMID:9548483RGDPMID:9548483
Oprd1RatG protein-coupled opioid receptor activity enablesISOOPRD1 (Homo sapiens)1624291 PMID:22184124RGDPMID:22184124
Oprd1RatG protein-coupled opioid receptor activity enablesIEAUniProtKB:P41143 and ensembl:ENSP000002349611600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1RatG protein-coupled opioid receptor activity enablesISOOprd1 (Mus musculus)1624291MGI:2387013 PMID:12113946 more ...RGDPMID:12113946 more ...
Oprd1RatG protein-coupled opioid receptor activity enablesIEAUniProtKB:P32300 and ensembl:ENSMUSP000000500771600115GO_REF:0000107EnsemblGO_REF:0000107
Oprd1RatG protein-coupled opioid receptor activity enablesIEAInterPro:IPR0014181600115GO_REF:0000002InterProGO_REF:0000002
Oprd1RatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Oprd1RatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Oprd1Ratneuropeptide binding enablesIBAPANTHER:PTN000659780 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Oprd1Ratprotein binding enablesISOOprd1 (Mus musculus)1624291UniProtKB:Q9ER80 and PMID:18836069RGDPMID:18836069
Oprd1Ratprotein binding enablesISOOPRD1 (Homo sapiens)1624291UniProtKB:P11607 more ...RGDPMID:15086532 more ...
Oprd1Ratreceptor serine/threonine kinase binding  IPIGrk2 (Rattus norvegicus)13513978 RGD 
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#
Reference Title
Reference Citation
1. Characterization of a delta opioid receptor in rat pheochromocytoma cells. Abood ME and Tao Q, J Pharmacol Exp Ther. 1995 Sep;274(3):1566-73.
2. Molecular cloning and expression of a delta-opioid receptor from rat brain. Abood ME, etal., J Neurosci Res. 1994 Apr 15;37(6):714-9.
3. delta opioid receptor modulation of several voltage-dependent Ca(2+) currents in rat sensory neurons. Acosta CG and Lopez HS, J Neurosci. 1999 Oct 1;19(19):8337-48.
4. Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study. Beer B, etal., PLoS One. 2013 Sep 25;8(9):e75359. doi: 10.1371/journal.pone.0075359. eCollection 2013.
5. Identification of a signaling cascade that maintains constitutive d-opioid receptor incompetence in peripheral sensory neurons. Brackley AD, etal., J Biol Chem. 2017 May 26;292(21):8762-8772. doi: 10.1074/jbc.M117.776799. Epub 2017 Apr 5.
6. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory. Charles AC, etal., Mol Pharmacol 2003 Jan;63(1):89-95.
7. Ultrastructural immunolabeling shows prominent presynaptic vesicular localization of delta-opioid receptor within both enkephalin- and nonenkephalin-containing axon terminals in the superficial layers of the rat cervical spinal cord. Cheng PY, etal., J Neurosci. 1995 Sep;15(9):5976-88.
8. Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females. Clarke TK, etal., Pharmacogenomics J. 2014 Jun;14(3):303-8. doi: 10.1038/tpj.2013.30. Epub 2013 Oct 15.
9. Case-control association analysis of polymorphisms in the δ-opioid receptor, OPRD1, with cocaine and opioid addicted populations. Crist RC, etal., Drug Alcohol Depend. 2013 Jan 1;127(1-3):122-8. doi: 10.1016/j.drugalcdep.2012.06.023. Epub 2012 Jul 12.
10. A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment. Crist RC, etal., Drug Alcohol Depend. 2016 Sep 1;166:268-71. doi: 10.1016/j.drugalcdep.2016.07.008. Epub 2016 Jul 14.
11. An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans. Crist RC, etal., Neuropsychopharmacology. 2013 Sep;38(10):2003-10. doi: 10.1038/npp.2013.99. Epub 2013 Apr 23.
12. Genetic polymorphisms in the opioid receptor delta 1 (OPRD1) gene are associated with methadone dose in methadone maintenance treatment for heroin dependence. Fang CP, etal., J Hum Genet. 2020 Apr;65(4):381-386. doi: 10.1038/s10038-019-0718-x. Epub 2020 Jan 7.
13. Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. Fryer RM, etal., J Pharmacol Exp Ther. 2000 Aug;294(2):451-7.
14. Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes. Fukuda K, etal., FEBS Lett 1993 Aug 2;327(3):311-4.
15. Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese. Gao X, etal., OMICS. 2017 Jul;21(7):404-412. doi: 10.1089/omi.2017.0057.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake. Granholm L, etal., Brain Res. 2017 Aug 1;1668:36-45. doi: 10.1016/j.brainres.2017.05.006. Epub 2017 May 13.
19. Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Hu Z, etal., Exp Ther Med. 2016 Jan;11(1):89-97. doi: 10.3892/etm.2015.2868. Epub 2015 Nov 13.
20. OPRD1 gene affects disease vulnerability and environmental stress in patients with heroin dependence in Han Chinese. Huang CC, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:109-116. doi: 10.1016/j.pnpbp.2018.08.028. Epub 2018 Aug 30.
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PMID:8393575   PMID:8738226   PMID:9548483   PMID:9915326   PMID:10835636   PMID:12113946   PMID:12855366   PMID:14608598   PMID:14689476   PMID:15467355   PMID:15862537   PMID:16159882  
PMID:16316997   PMID:16325578   PMID:16405927   PMID:16514101   PMID:17175187   PMID:17352824   PMID:17513490   PMID:18417105   PMID:18541716   PMID:18559244   PMID:18572383   PMID:18579738  
PMID:18602454   PMID:19036960   PMID:19056363   PMID:19180644   PMID:19279569   PMID:19295160   PMID:19545549   PMID:19581316   PMID:19619588   PMID:19686472   PMID:19709398   PMID:20399742  
PMID:20574683   PMID:20615975   PMID:20730419   PMID:20977770   PMID:21280046   PMID:21444630   PMID:21600884   PMID:22072818   PMID:22184124   PMID:22200548   PMID:22575599   PMID:22592774  
PMID:22796630   PMID:23272051   PMID:23272113   PMID:23286559   PMID:23843537   PMID:23844255   PMID:24033469   PMID:24416361   PMID:24613828   PMID:24758591   PMID:24847082   PMID:24976397  
PMID:25480575   PMID:25639363   PMID:27246300   PMID:27376372   PMID:27568556   PMID:28645621   PMID:29262398   PMID:29563057   PMID:29687347   PMID:30132200   PMID:30560518   PMID:31030416  
PMID:32228617   PMID:33197884   PMID:35674691   PMID:36592113   PMID:39155080  



Oprd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,590,244 - 149,624,999 (-)NCBIGRCr8
mRatBN7.25144,306,188 - 144,340,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,306,188 - 144,340,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,005,532 - 147,040,056 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05148,775,378 - 148,809,896 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05148,764,406 - 148,799,337 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,288,126 - 150,323,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,288,126 - 150,323,063 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05153,962,767 - 153,997,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45150,979,252 - 151,014,066 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15150,989,290 - 151,024,105 (-)NCBI
Celera5142,741,006 - 142,775,820 (-)NCBICelera
RH 3.4 Map5965.9RGD
Cytogenetic Map5q36NCBI
OPRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,812,170 - 28,871,267 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,812,170 - 28,871,267 (+)EnsemblGRCh38hg38GRCh38
GRCh37129,138,682 - 29,197,779 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,011,241 - 29,062,795 (+)NCBINCBI36Build 36hg18NCBI36
Build 34128,959,269 - 29,010,821NCBI
Celera127,534,800 - 27,586,335 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,391,067 - 27,442,611 (+)NCBIHuRef
CHM1_1129,254,016 - 29,305,583 (+)NCBICHM1_1
T2T-CHM13v2.0128,654,162 - 28,713,229 (+)NCBIT2T-CHM13v2.0
Oprd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394131,834,980 - 131,872,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4131,838,037 - 131,871,797 (-)EnsemblGRCm39 Ensembl
GRCm384132,110,188 - 132,144,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,110,726 - 132,144,486 (-)EnsemblGRCm38mm10GRCm38
MGSCv374131,666,641 - 131,700,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,382,802 - 131,416,562 (-)NCBIMGSCv36mm8
Celera4130,271,660 - 130,305,734 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map464.78NCBI
Oprd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,866,758 - 7,913,399 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,866,790 - 7,913,399 (+)NCBIChiLan1.0ChiLan1.0
OPRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21197,970,746 - 198,030,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,090,112 - 197,149,063 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,068,053 - 28,143,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,112,328 - 29,163,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,112,152 - 29,163,464 (+)Ensemblpanpan1.1panPan2
OPRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,685,129 - 71,721,692 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,689,084 - 71,721,875 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,264,922 - 68,297,415 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,248,368 - 72,280,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,247,773 - 72,281,077 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,077,265 - 69,109,751 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,084,707 - 70,117,198 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,082,831 - 71,115,319 (-)NCBIUU_Cfam_GSD_1.0
Oprd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505847,035,433 - 47,078,632 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,860,293 - 12,903,466 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,860,293 - 12,902,389 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,785,276 - 85,830,877 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,775,576 - 85,827,170 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,611,950 - 79,662,042 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120103,950,505 - 104,002,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603312,520,984 - 12,574,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oprd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476412,604,164 - 12,676,279 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476412,604,051 - 12,676,368 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Oprd1
338 total Variants

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:100
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000014084
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 40 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat

1 to 10 of 40 rows
D5Mgh21  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85149,661,912 - 149,662,130 (+)Marker Load Pipeline
mRatBN7.25144,377,876 - 144,378,094 (+)MAPPERmRatBN7.2
Rnor_6.05150,360,936 - 150,361,153NCBIRnor6.0
Rnor_5.05154,034,053 - 154,034,270UniSTSRnor5.0
RGSC_v3.45151,060,403 - 151,060,621RGDRGSC3.4
RGSC_v3.45151,060,404 - 151,060,621UniSTSRGSC3.4
RGSC_v3.15151,070,442 - 151,070,660RGD
Celera5142,812,193 - 142,812,410UniSTS
RH 3.4 Map5988.6UniSTS
RH 3.4 Map5988.6RGD
RH 2.0 Map5157.0RGD
Cytogenetic Map5q36UniSTS
D5Rat103  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85149,642,129 - 149,642,320 (+)Marker Load Pipeline
mRatBN7.25144,358,090 - 144,358,281 (+)MAPPERmRatBN7.2
Rnor_6.05150,340,838 - 150,341,028NCBIRnor6.0
Rnor_5.05154,014,163 - 154,014,353UniSTSRnor5.0
RGSC_v3.45151,039,766 - 151,039,956UniSTSRGSC3.4
RGSC_v3.45151,039,725 - 151,039,965RGDRGSC3.4
RGSC_v3.15151,049,805 - 151,049,995RGD
Celera5142,792,480 - 142,792,670UniSTS
RH 3.4 Map5964.21UniSTS
RH 3.4 Map5964.21RGD
SHRSP x BN Map580.7699RGD
SHRSP x BN Map580.7699UniSTS
Cytogenetic Map5q36UniSTS
RH94603  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85149,590,274 - 149,590,427 (+)Marker Load Pipeline
mRatBN7.25144,306,218 - 144,306,372 (+)MAPPERmRatBN7.2
Rnor_6.05150,288,157 - 150,288,309NCBIRnor6.0
Rnor_5.05153,962,798 - 153,962,950UniSTSRnor5.0
RGSC_v3.45150,979,283 - 150,979,435UniSTSRGSC3.4
Celera5142,741,037 - 142,741,188UniSTS
RH 3.4 Map5965.9UniSTS
Cytogenetic Map5q36UniSTS
BE119486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25144,316,650 - 144,316,823 (+)MAPPERmRatBN7.2
Rnor_6.05150,298,478 - 150,298,650NCBIRnor6.0
Rnor_5.05153,973,040 - 153,973,212UniSTSRnor5.0
RGSC_v3.45150,990,090 - 150,990,262UniSTSRGSC3.4
Celera5142,751,643 - 142,751,815UniSTS
RH 3.4 Map5965.41UniSTS
Cytogenetic Map5q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 30 102 30 23 10 4 10 6 107 50 87 34 48 13



Ensembl Acc Id: ENSRNOT00000014084   ⟹   ENSRNOP00000014084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5144,306,188 - 144,340,960 (-)Ensembl
Rnor_6.0 Ensembl5150,288,126 - 150,323,063 (-)Ensembl
RefSeq Acc Id: NM_012617   ⟹   NP_036749
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85149,590,244 - 149,624,999 (-)NCBI
mRatBN7.25144,306,188 - 144,340,960 (-)NCBI
Rnor_6.05150,288,126 - 150,323,063 (-)NCBI
Rnor_5.05153,962,767 - 153,997,858 (-)NCBI
RGSC_v3.45150,979,252 - 151,014,066 (-)RGD
Celera5142,741,006 - 142,775,820 (-)RGD
Sequence:
Protein RefSeqs NP_036749 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19939 (Get FASTA)   NCBI Sequence Viewer  
  BAA03851 (Get FASTA)   NCBI Sequence Viewer  
  EDL80617 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014084
  ENSRNOP00000014084.2
GenBank Protein P33533 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036749   ⟸   NM_012617
- UniProtKB: P33533 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014084   ⟸   ENSRNOT00000014084
Name Modeler Protein Id AA Range Protein Structure
AF-P33533-F1-model_v2 AlphaFold P33533 1-372 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-39716 BioCyc
Ensembl Genes ENSRNOG00000010531 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014084 ENTREZGENE
  ENSRNOT00000014084.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Delta_opi_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Opioid_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:24613 UniProtKB/Swiss-Prot
NCBI Gene 24613 ENTREZGENE
PANTHER DELTA-TYPE OPIOID RECEPTOR UniProtKB/Swiss-Prot
  NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB OPRD1 RGD
PhenoGen Oprd1 PhenoGen
PRINTS DELTAOPIOIDR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
  OPIOIDR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010531 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC224017
UniProt A6ISR6_RAT UniProtKB/TrEMBL
  OPRD_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Oprd1  Opioid receptor delta 1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_physical_interaction may interact with micro-opioid receptors to effect action potentials in GH3 cells 729249