Pilrb1 (paired immunoglobin-like type 2 receptor beta 1) - Rat Genome Database

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Gene: Pilrb1 (paired immunoglobin-like type 2 receptor beta 1) Rattus norvegicus
Analyze
Symbol: Pilrb1
Name: paired immunoglobin-like type 2 receptor beta 1
RGD ID: 1584675
Description: Predicted to enable MHC class I protein binding activity. Predicted to be involved in negative regulation of osteoclast differentiation. Predicted to act upstream of or within myeloid dendritic cell activation. Predicted to be located in plasma membrane. Orthologous to human PILRA (paired immunoglobin like type 2 receptor alpha) and PILRB (paired immunoglobin like type 2 receptor beta); INTERACTS WITH bis(2-ethylhexyl) phthalate; (+)-catechin (ortholog); 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC681069; LOC681341; paired immunoglobin-like type 2 receptor beta; paired immunoglobulin-like type 2 receptor beta; Pilrb; similar to paired immunoglobin-like type 2 receptor beta; uncharacterized protein LOC681341
RGD Orthologs
Human
Mouse
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,220,304 - 24,239,811 (+)NCBIGRCr8
mRatBN7.21218,516,161 - 18,525,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,516,156 - 18,525,346 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01220,882,062 - 20,900,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,140,765 - 20,142,069 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,882,344 - 20,890,965 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,194,940 - 22,196,462 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41218,630,556 - 18,637,912 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 36 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pilrb1Rat(+)-catechin multiple interactionsISORGD:16033966480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PILRB mRNACTDPMID:24763279
Pilrb1Rat1,2-dimethylhydrazine increases expressionISORGD:132325664804641,2-Dimethylhydrazine results in increased expression of PILRB1 mRNACTDPMID:22206623
Pilrb1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:16033966480464Tetrachlorodibenzodioxin results in increased expression of PILRB mRNACTDPMID:19684285
Pilrb1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:13232566480464Tetrachlorodibenzodioxin results in decreased expression of PILRB1 mRNACTDPMID:31961203
Pilrb1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13232566480464Tetrachlorodibenzodioxin affects the expression of PILRB1 mRNACTDPMID:26377647
Pilrb1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:16033966480464[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PILRB mRNACTDPMID:19684285
Pilrb1Rat2-hydroxypropanoic acid increases expressionISORGD:16033966480464Lactic Acid results in increased expression of PILRB mRNACTDPMID:30851411
Pilrb1Rat2-methylcholine affects expressionISORGD:16033966480464beta-methylcholine affects the expression of PILRB mRNACTDPMID:21179406
Pilrb1Rat4,4'-sulfonyldiphenol decreases expressionISORGD:16033966480464bisphenol S results in decreased expression of PILRB mRNACTDPMID:27685785
Pilrb1Ratacrolein multiple interactionsISORGD:16033966480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ...CTDPMID:32699268|PMID:32845096
Pilrb1Rataflatoxin B1 increases methylationISORGD:16033966480464Aflatoxin B1 results in increased methylation of PILRB geneCTDPMID:27153756
Pilrb1Ratalpha-pinene multiple interactionsISORGD:16033966480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ...CTDPMID:32699268
Pilrb1Ratatrazine decreases expressionISORGD:16033966480464Atrazine results in decreased expression of PILRB mRNACTDPMID:22378314
Pilrb1Ratbenzo[a]pyrene increases methylationISORGD:16033966480464Benzo(a)pyrene results in increased methylation of PILRB 5' UTRCTDPMID:27901495
Pilrb1Ratbis(2-ethylhexyl) phthalate decreases expressionEXP 6480464Diethylhexyl Phthalate results in decreased expression of PILRB mRNACTDPMID:29945229
Pilrb1Ratbisphenol A decreases expressionISORGD:16033966480464bisphenol A results in decreased expression of PILRB mRNACTDPMID:25047013|PMID:27685785
Pilrb1Ratbisphenol A increases methylationISORGD:13232566480464bisphenol A results in increased methylation of PILRB1 promoterCTDPMID:27312807
Pilrb1Ratcarbon nanotube increases expressionISORGD:13232566480464Nanotubes, Carbon analog results in increased expression of PILRB1 mRNA; Nanotubes, Carbon results in increased more ...CTDPMID:25554681
Pilrb1Ratcycloheximide multiple interactionsISORGD:16033966480464[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PILRB mRNACTDPMID:19684285
Pilrb1Ratcyclosporin A affects expressionISORGD:16033966480464Cyclosporine affects the expression of PILRB mRNACTDPMID:25562108

1 to 20 of 36 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pilrb1Ratmyeloid dendritic cell activation acts_upstream_of_or_withinISORGD:13232561624291 PMID:14970179RGDPMID:14970179
Pilrb1Ratnegative regulation of osteoclast differentiation involved_inISORGD:13232561624291 PMID:18802077RGDPMID:18802077

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pilrb1Ratcell periphery located_inIEAARBA:ARBA000274431600115GO_REF:0000117UniProtGO_REF:0000117
Pilrb1Ratmembrane located_inIEAARBA:ARBA000287631600115GO_REF:0000117UniProtGO_REF:0000117
Pilrb1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Pilrb1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Pilrb1Ratplasma membrane located_inISORGD:13232561624291 PMID:14970179RGDPMID:14970179

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pilrb1RatMHC class I protein binding enablesIBAMGI:2450532|PANTHER:PTN0003994881600115GO_REF:0000033GO_CentralGO_REF:0000033
Pilrb1RatMHC class I protein binding enablesISORGD:13232561624291 PMID:18802077RGDPMID:18802077
Pilrb1Ratprotein binding enablesISORGD:16033961624291UniProtKB:P29350 PMID:10660620RGDPMID:10660620
Pilrb1Ratprotein binding enablesISORGD:13232561624291PR:O54885|PR:Q8VCN6 PMID:14970179, PMID:18209065RGDPMID:14970179|PMID:18209065


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Pilrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,220,304 - 24,239,811 (+)NCBIGRCr8
mRatBN7.21218,516,161 - 18,525,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,516,156 - 18,525,346 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01220,882,062 - 20,900,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,140,765 - 20,142,069 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,882,344 - 20,890,965 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01222,194,940 - 22,196,462 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41218,630,556 - 18,637,912 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map12q12NCBI
PILRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,358,117 - 100,367,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,352,176 - 100,367,831 (+)EnsemblGRCh38hg38GRCh38
GRCh37799,955,740 - 99,965,454 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,771,673 - 99,803,388 (+)NCBINCBI36Build 36hg18NCBI36
Celera794,685,426 - 94,695,252 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,588,903 - 94,598,990 (+)NCBIHuRef
CHM1_1799,886,201 - 99,896,029 (+)NCBICHM1_1
T2T-CHM13v2.07101,598,196 - 101,607,910 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,315,712 - 99,325,540 (+)NCBI
Pilrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,850,403 - 137,856,687 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,850,409 - 137,856,368 (-)EnsemblGRCm39 Ensembl
GRCm385137,852,141 - 137,858,425 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,852,147 - 137,858,106 (-)EnsemblGRCm38mm10GRCm38
MGSCv375138,293,375 - 138,299,277 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,081,935 - 138,087,786 (-)NCBIMGSCv36mm8
Celera5134,838,831 - 134,844,805 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.82NCBI
PILRB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236673566,933 - 16,745 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Pilrb1
251 total Variants

1 to 10 of 48 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat

1 to 10 of 48 rows



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 6 25 43 45 19 20 19 6 66 40 8 1 18 26



Ensembl Acc Id: ENSRNOT00000036416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1218,516,156 - 18,523,250 (+)Ensembl
Rnor_6.0 Ensembl1220,140,765 - 20,142,069 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000068118   ⟹   ENSRNOP00000063274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1218,517,225 - 18,525,346 (+)Ensembl
Rnor_6.0 Ensembl1220,882,344 - 20,890,965 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107849   ⟹   ENSRNOP00000095550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1218,516,156 - 18,521,081 (+)Ensembl
RefSeq Acc Id: XM_039090020   ⟹   XP_038945948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,220,327 - 24,229,486 (+)NCBI
mRatBN7.21218,516,161 - 18,525,350 (+)NCBI
RefSeq Acc Id: XM_039090021   ⟹   XP_038945949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,220,330 - 24,229,486 (+)NCBI
mRatBN7.21218,516,200 - 18,525,350 (+)NCBI
RefSeq Acc Id: XM_039090022   ⟹   XP_038945950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,220,326 - 24,229,486 (+)NCBI
mRatBN7.21218,516,199 - 18,525,375 (+)NCBI
RefSeq Acc Id: XM_063271757   ⟹   XP_063127827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,220,320 - 24,239,811 (+)NCBI
RefSeq Acc Id: XM_063271758   ⟹   XP_063127828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81224,220,304 - 24,229,486 (+)NCBI
Ensembl Acc Id: ENSRNOP00000063274   ⟸   ENSRNOT00000068118
RefSeq Acc Id: XP_038945948   ⟸   XM_039090020
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038945950   ⟸   XM_039090022
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038945949   ⟸   XM_039090021
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000095550   ⟸   ENSRNOT00000107849

Name Modeler Protein Id AA Range Protein Structure
AF-F1M3E2-F1-model_v2 AlphaFold F1M3E2 1-212 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 24 of 24 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSRNOG00000047077 Ensembl
  ENSRNOG00000052542 Ensembl
  ENSRNOG00000070677 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000087413 ENTREZGENE
Ensembl Transcript ENSRNOT00000036416.7 UniProtKB/TrEMBL
  ENSRNOT00000068118.5 UniProtKB/TrEMBL
  ENSRNOT00000107849.1 UniProtKB/TrEMBL
  ENSRNOT00000156426 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Immunoregulatory_rcpt-like UniProtKB/TrEMBL
NCBI Gene Pilrb1 ENTREZGENE
PANTHER PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR UniProtKB/TrEMBL
  PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR BETA-RELATED UniProtKB/TrEMBL
PhenoGen Pilrb1 PhenoGen
RatGTEx ENSRNOG00000047077 RatGTEx
  ENSRNOG00000052542 RatGTEx
  ENSRNOG00000070677 RatGTEx
  ENSRNOG00000087413 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8I6A5E5_RAT UniProtKB/TrEMBL
  A0A8I6AN38 ENTREZGENE, UniProtKB/TrEMBL
  F1M3E2_RAT UniProtKB/TrEMBL
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-03-30 Pilrb1  paired immunoglobin-like type 2 receptor beta 1  Pilrb  paired immunoglobin-like type 2 receptor beta  Name and Symbol changed 629549 APPROVED
2021-03-09 Pilrb  paired immunoglobin-like type 2 receptor beta  LOC681341  similar to paired immunoglobin-like type 2 receptor beta  Data merged from RGD:1596749 737654 PROVISIONAL
2016-06-22 Pilrb  paired immunoglobin-like type 2 receptor beta  LOC681069  similar to paired immunoglobin-like type 2 receptor beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681341  similar to paired immunoglobin-like type 2 receptor beta      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC681069  similar to paired immunoglobin-like type 2 receptor beta      Symbol and Name status set to provisional 70820 PROVISIONAL