Sri (sorcin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Sri (sorcin) Rattus norvegicus
Analyze
Symbol: Sri
Name: sorcin
RGD ID: 1584485
Description: Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in heart development. Located in several cellular components, including T-tubule; Z disc; and dendritic spine neck. Biomarker of congestive heart failure. Orthologous to human SRI (sorcin); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC683667; MGC188318; similar to sorcin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,928,338 - 26,952,980 (-)NCBIGRCr8
mRatBN7.2425,973,493 - 25,997,879 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,966,750 - 25,998,077 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,960,404 - 30,973,377 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,886,620 - 26,899,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0425,263,902 - 25,276,454 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0423,004,657 - 23,029,233 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl423,006,243 - 23,018,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,937,276 - 22,962,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera421,457,445 - 21,469,637 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycidyl methacrylate  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
menadione  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-nitrosodimethylamine  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pyrrolidine dithiocarbamate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sucrose  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
topotecan  (ISO)
triphenyl phosphate  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. N-methyl-D-aspartate receptor 1 in the caudate-putamen nucleus: ultrastructural localization and co-expression with sorcin, a 22,000 mol. wt calcium binding protein. Gracy KN, etal., Neuroscience. 1999 Apr;90(1):107-17.
3. Defective Ca(2+) handling proteins regulation during heart failure. Hu ST, etal., Physiol Res. 2011;60(1):27-37. Epub 2010 Oct 15.
4. Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels. Meyers MB, etal., J Biol Chem. 1998 Jul 24;273(30):18930-5.
5. Sorcin regulates excitation-contraction coupling in the heart. Meyers MB, etal., J Biol Chem. 2003 Aug 1;278(31):28865-71. Epub 2003 May 16.
6. Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction. Okamoto Y, etal., Am J Pathol. 2001 Aug;159(2):639-50.
7. Ultrastructural localization of sorcin, a 22 kDa calcium binding protein, in the rat caudate-putamen nucleus: association with ryanodine receptors and intracellular calcium release. Pickel VM, etal., J Comp Neurol. 1997 Oct 6;386(4):625-34.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Sorcin modulation of Ca2+ sparks in rat vascular smooth muscle cells. Rueda A, etal., J Physiol. 2006 Nov 1;576(Pt 3):887-901. Epub 2006 Aug 24.
Additional References at PubMed
PMID:3593728   PMID:9268363   PMID:10672515   PMID:10748169   PMID:12477932   PMID:12804766   PMID:12925238   PMID:14644162   PMID:15326289   PMID:16204356   PMID:17130302   PMID:17215369  
PMID:17699613   PMID:18330356   PMID:19056867   PMID:20458337   PMID:22326846   PMID:22338092   PMID:23151801   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Sri
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,928,338 - 26,952,980 (-)NCBIGRCr8
mRatBN7.2425,973,493 - 25,997,879 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,966,750 - 25,998,077 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,960,404 - 30,973,377 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,886,620 - 26,899,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0425,263,902 - 25,276,454 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0423,004,657 - 23,029,233 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl423,006,243 - 23,018,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,937,276 - 22,962,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera421,457,445 - 21,469,637 (-)NCBICelera
Cytogenetic Map4q12NCBI
SRI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38788,205,115 - 88,226,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl788,205,115 - 88,226,993 (-)EnsemblGRCh38hg38GRCh38
GRCh37787,834,430 - 87,856,291 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36787,672,368 - 87,694,244 (-)NCBINCBI36Build 36hg18NCBI36
Celera782,539,034 - 82,560,910 (-)NCBICelera
Cytogenetic Map7q21.12NCBI
HuRef782,444,285 - 82,466,161 (-)NCBIHuRef
CHM1_1787,764,960 - 87,786,830 (-)NCBICHM1_1
T2T-CHM13v2.0789,455,604 - 89,477,464 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2787,165,789 - 87,187,665 (-)NCBI
Sri
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,096,078 - 8,119,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl58,096,078 - 8,119,379 (+)EnsemblGRCm39 Ensembl
GRCm3858,046,078 - 8,069,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,046,078 - 8,069,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,046,080 - 8,069,245 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3658,052,084 - 8,073,860 (+)NCBIMGSCv36mm8
Celera57,979,518 - 8,002,729 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.38NCBI
Sri
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554325,541,311 - 5,560,294 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554325,541,311 - 5,559,781 (-)NCBIChiLan1.0ChiLan1.0
SRI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26106,086,942 - 106,101,957 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17154,351,580 - 154,366,595 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0780,199,719 - 80,214,733 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1793,849,129 - 93,864,088 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl793,850,496 - 93,864,029 (-)Ensemblpanpan1.1panPan2
SRI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11414,257,375 - 14,274,816 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1414,260,052 - 14,274,801 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,829,493 - 13,846,925 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01414,022,300 - 14,039,737 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1414,020,645 - 14,039,218 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11414,232,295 - 14,250,007 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01413,951,888 - 13,969,513 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01414,237,364 - 14,255,079 (-)NCBIUU_Cfam_GSD_1.0
Sri
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511827,273,150 - 27,285,562 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936763710,777 - 730,276 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936763715,884 - 728,548 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl968,490,890 - 68,515,322 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1968,492,235 - 68,515,247 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2974,928,185 - 74,950,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12160,730,164 - 60,751,054 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2160,730,051 - 60,749,678 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604243,353,983 - 43,369,330 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sri
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248095,160,737 - 5,191,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248095,160,731 - 5,187,914 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sri
206 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:46
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000073790
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat

Markers in Region
RH129956  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map16560.81UniSTS
BF404841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,984,410 - 25,984,565 (+)MAPPERmRatBN7.2
Rnor_6.0423,015,601 - 23,015,755NCBIRnor6.0
Rnor_5.0422,948,713 - 22,948,867UniSTSRnor5.0
Celera421,466,302 - 21,466,456UniSTS
RH 3.4 Map4156.9UniSTS
RH139017  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,974,831 - 25,974,974 (+)MAPPERmRatBN7.2
Rnor_6.0423,006,062 - 23,006,204NCBIRnor6.0
Rnor_5.0422,938,681 - 22,938,823UniSTSRnor5.0
Celera421,457,266 - 21,457,408UniSTS
RH 3.4 MapX33.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 5 6 74 35 41 11 5
Low 3 5 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073790   ⟹   ENSRNOP00000066499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,975,000 - 25,987,791 (-)Ensembl
Rnor_6.0 Ensembl423,006,243 - 23,018,983 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094260   ⟹   ENSRNOP00000081785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,973,426 - 25,995,400 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096644   ⟹   ENSRNOP00000095706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,973,426 - 25,987,543 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109314   ⟹   ENSRNOP00000077627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,966,750 - 25,988,036 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112226   ⟹   ENSRNOP00000083569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,973,426 - 25,998,077 (-)Ensembl
RefSeq Acc Id: NM_001128190   ⟹   NP_001121662
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,929,922 - 26,942,657 (-)NCBI
mRatBN7.2425,975,011 - 25,987,746 (-)NCBI
Rnor_6.0423,006,241 - 23,018,936 (-)NCBI
Rnor_5.0422,937,276 - 22,962,347 (-)NCBI
Celera421,457,445 - 21,469,637 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236007   ⟹   XP_006236069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,928,338 - 26,952,980 (-)NCBI
mRatBN7.2425,973,493 - 25,997,879 (-)NCBI
Rnor_6.0423,004,657 - 23,029,233 (-)NCBI
Rnor_5.0422,937,276 - 22,962,347 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039108350   ⟹   XP_038964278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,928,338 - 26,952,103 (-)NCBI
mRatBN7.2425,973,493 - 25,997,119 (-)NCBI
RefSeq Acc Id: XM_039108351   ⟹   XP_038964279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,939,111 - 26,942,781 (-)NCBI
mRatBN7.2425,984,200 - 25,987,857 (-)NCBI
RefSeq Acc Id: XM_063286687   ⟹   XP_063142757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,939,111 - 26,942,775 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001121662   ⟸   NM_001128190
- UniProtKB: B0BNJ1 (UniProtKB/TrEMBL),   A0A8I5ZTT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236069   ⟸   XM_006236007
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWU9 (UniProtKB/TrEMBL),   A0A8I5ZTT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066499   ⟸   ENSRNOT00000073790
RefSeq Acc Id: XP_038964278   ⟸   XM_039108350
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964279   ⟸   XM_039108351
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000081785   ⟸   ENSRNOT00000094260
RefSeq Acc Id: ENSRNOP00000083569   ⟸   ENSRNOT00000112226
RefSeq Acc Id: ENSRNOP00000095706   ⟸   ENSRNOT00000096644
RefSeq Acc Id: ENSRNOP00000077627   ⟸   ENSRNOT00000109314
RefSeq Acc Id: XP_063142757   ⟸   XM_063286687
- Peptide Label: isoform X4
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNJ1-F1-model_v2 AlphaFold B0BNJ1 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692832
Promoter ID:EPDNEW_R3356
Type:initiation region
Name:Sri_1
Description:sorcin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0423,018,948 - 23,019,008EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584485 AgrOrtholog
BioCyc Gene G2FUF-45816 BioCyc
Ensembl Genes ENSRNOG00000049780 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073790 ENTREZGENE
  ENSRNOT00000073790.3 UniProtKB/TrEMBL
  ENSRNOT00000094260.1 UniProtKB/TrEMBL
  ENSRNOT00000096644.1 UniProtKB/TrEMBL
  ENSRNOT00000109314.1 UniProtKB/TrEMBL
  ENSRNOT00000112226.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.900 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7442862 IMAGE-MGC_LOAD
InterPro EF-hand-like_dom UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_Ca_bd UniProtKB/TrEMBL
KEGG Report rno:683667 UniProtKB/TrEMBL
MGC_CLONE MGC:188318 IMAGE-MGC_LOAD
NCBI Gene 683667 ENTREZGENE
PANTHER CALPAIN, SMALL SUBUNIT 1 A-RELATED UniProtKB/TrEMBL
  SORCIN UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/TrEMBL
PhenoGen Sri PhenoGen
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049780 RatGTEx
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8I5Y9M9_RAT UniProtKB/TrEMBL
  A0A8I5ZTT7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AU02_RAT UniProtKB/TrEMBL
  B0BNJ1 ENTREZGENE, UniProtKB/TrEMBL
  M0RAF3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-12-03 Sri  sorcin  LOC683667  similar to sorcin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC683667  similar to sorcin      Symbol and Name status set to provisional 70820 PROVISIONAL