Nupr2 (nuclear protein 2, transcriptional regulator) - Rat Genome Database

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Gene: Nupr2 (nuclear protein 2, transcriptional regulator) Rattus norvegicus
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Symbol: Nupr2
Name: nuclear protein 2, transcriptional regulator
RGD ID: 1560258
Description: Predicted to be involved in several processes, including cellular response to starvation; negative regulation of cell population proliferation; and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human NUPR2 (nuclear protein 2, transcriptional regulator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC360799; LOC360799; nuclear protein 2; nuclear protein, transcriptional regulator, 1-like; nuclear transcriptional regulator 1-like protein; Nupr1l; RGD1560258; similar to RIKEN cDNA 4930579G22; uncharacterized protein LOC360799
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,436,233 - 32,439,391 (-)NCBIGRCr8
mRatBN7.21226,800,123 - 26,803,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,799,800 - 26,803,304 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1227,946,416 - 27,949,534 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,556,950 - 28,560,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,618,445 - 27,621,565 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,300,936 - 30,304,041 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,303,725 - 30,304,036 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,245,778 - 32,248,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,847,750 - 27,850,855 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1228,513,877 - 28,516,982 (-)NCBICelera
Cytogenetic Map12q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nupr2Ratautistic disorder  ISONUPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Nupr2Ratpleomorphic xanthoastrocytoma  ISONUPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358

1 to 20 of 38 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nupr2Rat1,2-dichloroethane increases expressionISONupr2 (Mus musculus)6480464ethylene dichloride results in increased expression of NUPR2 mRNACTDPMID:28960355
Nupr2Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISONupr2 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Nupr2Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISONupr2 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Nupr2Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISONupr2 (Mus musculus)64804642 more ...CTDPMID:31388691
Nupr2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of NUPR2 mRNACTDPMID:33387578
Nupr2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of NUPR2 mRNACTDPMID:21215274
Nupr2Rat2,5-hexanedione increases expressionEXP 64804642 and 5-hexanedione results in increased expression of NUPR2 mRNACTDPMID:22952946
Nupr2Rat3-chloropropane-1,2-diol decreases expressionEXP 6480464alpha-Chlorohydrin results in decreased expression of NUPR2 mRNACTDPMID:28522335
Nupr2Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of NUPR2 mRNACTDPMID:36843608
Nupr2Rataflatoxin B1 increases methylationISONUPR2 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of NUPR2 intronCTDPMID:30157460
Nupr2Ratbenzo[a]pyrene decreases methylationISONUPR2 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of NUPR2 promoterCTDPMID:27901495
Nupr2Ratbenzo[a]pyrene increases methylationISONUPR2 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of NUPR2 3' UTRCTDPMID:27901495
Nupr2Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of NUPR2 mRNACTDPMID:25181051
Nupr2Ratcarbon nanotube decreases expressionISONupr2 (Mus musculus)6480464Nanotubes more ...CTDPMID:25554681
Nupr2Ratcarbon nanotube increases expressionISONupr2 (Mus musculus)6480464Nanotubes and Carbon analog results in increased expression of NUPR2 mRNACTDPMID:25620056
Nupr2Ratcisplatin multiple interactionsISONUPR2 (Homo sapiens)6480464[Cisplatin co-treated with jinfukang] results in increased expression of NUPR2 mRNACTDPMID:27392435
Nupr2Ratcisplatin increases expressionISONUPR2 (Homo sapiens)6480464Cisplatin results in increased expression of NUPR2 mRNACTDPMID:27392435
Nupr2Ratcobalt dichloride decreases expressionEXP 6480464cobaltous chloride results in decreased expression of NUPR2 mRNACTDPMID:24386269
Nupr2Ratdextran sulfate increases expressionISONupr2 (Mus musculus)6480464Dextran Sulfate results in increased expression of NUPR2 mRNACTDPMID:35093514
Nupr2Ratfinasteride increases expressionEXP 6480464Finasteride results in increased expression of NUPR2 mRNACTDPMID:24136188

1 to 20 of 38 rows

Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nupr2Ratnucleus located_inISONUPR2 (Homo sapiens)1624291 PMID:25899918RGDPMID:25899918
Nupr2Ratnucleus is_active_inIBAPANTHER:PTN000425213 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:25899918  



Nupr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,436,233 - 32,439,391 (-)NCBIGRCr8
mRatBN7.21226,800,123 - 26,803,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,799,800 - 26,803,304 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1227,946,416 - 27,949,534 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,556,950 - 28,560,070 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,618,445 - 27,621,565 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,300,936 - 30,304,041 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,303,725 - 30,304,036 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,245,778 - 32,248,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,847,750 - 27,850,855 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1228,513,877 - 28,516,982 (-)NCBICelera
Cytogenetic Map12q13NCBI
NUPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38756,114,681 - 56,116,417 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl756,114,681 - 56,116,417 (-)EnsemblGRCh38hg38GRCh38
GRCh37756,182,374 - 56,184,110 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36756,149,869 - 56,157,505 (-)NCBINCBI36Build 36hg18NCBI36
Celera767,235,281 - 67,237,043 (-)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef755,996,671 - 55,998,401 (-)NCBIHuRef
CHM1_1756,185,401 - 56,187,163 (-)NCBICHM1_1
T2T-CHM13v2.0756,274,492 - 56,276,280 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2756,186,621 - 56,188,337 (-)NCBI
Nupr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395129,937,381 - 129,942,629 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5129,937,381 - 129,942,630 (+)EnsemblGRCm39 Ensembl
GRCm385129,908,540 - 129,913,788 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5129,908,540 - 129,913,789 (+)EnsemblGRCm38mm10GRCm38
MGSCv375130,384,410 - 130,387,151 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365130,193,268 - 130,195,983 (+)NCBIMGSCv36mm8
Celera5126,911,103 - 126,913,757 (+)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.26NCBI
Nupr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554568,268,429 - 8,269,517 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554568,268,429 - 8,269,517 (-)NCBIChiLan1.0ChiLan1.0
NUPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2660,966,842 - 60,968,575 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17109,291,568 - 109,293,307 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0756,727,702 - 56,729,433 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1757,149,240 - 57,150,946 (-)NCBIpanpan1.1PanPan1.1panPan2
NUPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.16589,882 - 590,763 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl6590,410 - 590,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha62,289,351 - 2,290,218 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.06393,719 - 394,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl6394,247 - 394,543 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.16337,473 - 338,340 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.06331,557 - 332,424 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.06502,798 - 503,665 (-)NCBIUU_Cfam_GSD_1.0
NUPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl316,806,900 - 16,807,196 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1316,803,928 - 16,807,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,059,566 - 17,060,439 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NUPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1212,655,437 - 2,667,287 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041179,833,677 - 179,869,749 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Nupr2
64 total Variants

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:105
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000001218
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 53 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat

1 to 10 of 53 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000001218   ⟹   ENSRNOP00000001218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1226,799,800 - 26,803,304 (-)Ensembl
Rnor_6.0 Ensembl1230,303,725 - 30,304,036 (-)Ensembl
RefSeq Acc Id: NM_001134570   ⟹   NP_001128042
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,436,234 - 32,439,339 (-)NCBI
mRatBN7.21226,800,123 - 26,803,228 (-)NCBI
Rnor_6.01230,300,936 - 30,304,041 (-)NCBI
Rnor_5.01232,245,778 - 32,248,883 (-)NCBI
RGSC_v3.41227,847,750 - 27,850,855 (-)RGD
Celera1228,513,877 - 28,516,982 (-)RGD
Sequence:
RefSeq Acc Id: XM_063271496   ⟹   XP_063127566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,436,233 - 32,439,391 (-)NCBI
Protein RefSeqs NP_001128042 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127566 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13481 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001218.4
  ENSRNOP00000107105
RefSeq Acc Id: NP_001128042   ⟸   NM_001134570
- UniProtKB: D3ZTS1 (UniProtKB/TrEMBL),   A6J0P2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001218   ⟸   ENSRNOT00000001218
RefSeq Acc Id: XP_063127566   ⟸   XM_063271496
- Peptide Label: isoform X1
- UniProtKB: A6J0P2 (UniProtKB/TrEMBL),   D3ZTS1 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTS1-F1-model_v2 AlphaFold D3ZTS1 1-103 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698581
Promoter ID:EPDNEW_R9106
Type:initiation region
Name:Nupr2_1
Description:nuclear protein 2, transcriptional regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01230,304,078 - 30,304,138EPDNEW


1 to 16 of 16 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19510 BioCyc
Ensembl Genes ENSRNOG00000000917 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000074054 ENTREZGENE
Ensembl Transcript ENSRNOT00000001218.5 UniProtKB/TrEMBL
  ENSRNOT00000124199 ENTREZGENE
InterPro Nuclear_phosphoprot_p8_DNA-bd UniProtKB/TrEMBL
KEGG Report rno:360799 UniProtKB/TrEMBL
NCBI Gene 360799 ENTREZGENE
PANTHER NUCLEAR PROTEIN 2 UniProtKB/TrEMBL
  PTHR17149 UniProtKB/TrEMBL
Pfam Phospho_p8 UniProtKB/TrEMBL
PhenoGen Nupr2 PhenoGen
RatGTEx ENSRNOG00000000917 RatGTEx
  ENSRNOG00000074054 RatGTEx
UniProt A6J0P2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTS1 ENTREZGENE, UniProtKB/TrEMBL
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Nupr2  nuclear protein 2, transcriptional regulator  Nupr1l  nuclear protein, transcriptional regulator, 1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-11 Nupr1l  nuclear protein, transcriptional regulator, 1-like  RGD1560258  similar to RIKEN cDNA 4930579G22  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560258  similar to RIKEN cDNA 4930579G22   RGD1560258_predicted  similar to RIKEN cDNA 4930579G22 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560258_predicted  similar to RIKEN cDNA 4930579G22 (predicted)  LOC360799  similar to RIKEN cDNA 4930579G22  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360799  similar to RIKEN cDNA 4930579G22      Symbol and Name status set to provisional 70820 PROVISIONAL