Ercc1 (ERCC excision repair 1, endonuclease non-catalytic subunit) - Rat Genome Database

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Gene: Ercc1 (ERCC excision repair 1, endonuclease non-catalytic subunit) Rattus norvegicus
Analyze
Symbol: Ercc1
Name: ERCC excision repair 1, endonuclease non-catalytic subunit
RGD ID: 1306992
Description: Predicted to enable DNA binding activity; TFIID-class transcription factor complex binding activity; and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in several processes, including response to cadmium ion; response to immobilization stress; and response to sucrose. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Predicted to be active in nucleus. Used to study lung carcinoma. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit); PARTICIPATES IN nucleotide excision repair pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA excision repair protein ERCC-1; excision repair cross-complementation group 1; excision repair cross-complementing 1; excision repair cross-complementing rodent repair deficiency, complementation group 1; LOC292673
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,099,308 - 88,135,966 (+)NCBIGRCr8
mRatBN7.2178,971,310 - 79,007,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,996,390 - 79,007,963 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,385,658 - 84,396,816 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,943,314 - 92,954,535 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,140,755 - 86,151,914 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,256,973 - 80,268,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,256,973 - 80,268,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,523,234 - 81,534,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,711,249 - 78,722,474 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,787,675 - 78,800,533 (+)NCBI
Celera173,458,746 - 73,469,951 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Ercc1Ratacute lymphoblastic leukemia  ISOERCC1 (Homo sapiens)11252160DNA:SNPs: :8092C>A and 19007G>A (human)RGD 
Ercc1Ratacute lymphoblastic leukemia susceptibilityISOERCC1 (Homo sapiens)11340204DNA:SNPs more ...RGD 
Ercc1Ratacute myeloid leukemia no_associationISOERCC1 (Homo sapiens)11252173DNA:SNP: :p.Q504K (human)RGD 
Ercc1Ratacute myeloid leukemia  ISOERCC1 (Homo sapiens)11252193DNA:polymorphism: :p.R399Q (human)RGD 
Ercc1Ratacute myeloid leukemia treatmentISOERCC1 (Homo sapiens)11252179 RGD 
Ercc1Ratacute myeloid leukemia  ISOERCC1 (Homo sapiens)11252171 RGD 
Ercc1Ratacute myeloid leukemia  ISOERCC1 (Homo sapiens)11252170 RGD 
Ercc1Ratalcohol use disorder  IEP 10045658 RGD 
Ercc1Ratanemia treatmentISOERCC1 (Homo sapiens)11252176associated with Ovarian Neoplasms and DNA:SNP: :rs11615 (human)RGD 
Ercc1Ratazoospermia susceptibilityISOERCC1 (Homo sapiens)13207429DNA:snp:3' utr:c.8092C>A (human)RGD 
Ercc1Ratbreast cancer susceptibilityISOERCC1 (Homo sapiens)13207317DNA:snp:3' utr:c.8092C>A (human)RGD 
Ercc1Ratcolorectal cancer  ISOERCC1 (Homo sapiens)155260343mRNA:increased expression:colorectum (human)RGD 
Ercc1Ratcolorectal cancer  ISOERCC1 (Homo sapiens)155260348DNA:SNP:exon: (rs3212986) (human)RGD 
Ercc1Ratcolorectal cancer sexual_dimorphismISOERCC1 (Homo sapiens)153344543DNA:SNP:3'utr: (rs3212986) (human)RGD 
Ercc1RatColorectal Neoplasms severityISOERCC1 (Homo sapiens)13207315DNA:snp:cds:c.354C>T (human)RGD 
Ercc1RatColorectal Neoplasms susceptibilityISOERCC1 (Homo sapiens)13207423DNA:snp:3' utr:c.8092C>A (human)RGD 
Ercc1Ratdegenerative disc disease  ISOErcc1 (Mus musculus)13207419associated with ProgeriaRGD 
Ercc1RatDrug-induced Neutropenia treatmentISOERCC1 (Homo sapiens)11340199associated with Colorectal Neoplasms and DNA:SNPRGD 
Ercc1RatDrug-Related Side Effects and Adverse Reactions treatmentISOERCC1 (Homo sapiens)11252168associated with Breast Neoplasms and DNA:SNP: :p.Q504K (human)RGD 
Ercc1RatDrug-Related Side Effects and Adverse Reactions treatmentISOERCC1 (Homo sapiens)11252178associated with Leukemia more ...RGD 
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Ercc1Ratcerebrooculofacioskeletal syndrome 4  ISOERCC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17273966 more ...
Ercc1RatCockayne syndrome  ISOERCC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cockayne syndromeClinVarPMID:17273966 and PMID:23623389
Ercc1RatFailure to Thrive  ISOERCC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Failure to thriveClinVarPMID:25741868 more ...
Ercc1Ratxeroderma pigmentosum group D  ISOERCC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Xeroderma pigmentosum and group DClinVar 
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Ercc1RatArsenic Poisoning  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12569548
Ercc1Ratcerebrooculofacioskeletal syndrome 4  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Ercc1RatChromosome Aberrations  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24036326
Ercc1Ratdisease of cellular proliferation  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23203453
Ercc1RatGenetic Predisposition to Disease  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24036326
Ercc1RatGerm Cell and Embryonal Neoplasms  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19956886
Ercc1Ratlung adenocarcinoma  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21327329
Ercc1RatLung Neoplasms  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30453383
Ercc1Ratlung non-small cell carcinoma  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21553054 and PMID:23912706
Ercc1Ratmelanoma  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21722328
Ercc1RatNeoplasm Metastasis  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20801905
Ercc1Ratperipheral nervous system disease  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20979931
Ercc1RatStomach Neoplasms  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21133646
Ercc1RatTesticular Neoplasms  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19956886
Ercc1RatUterine Cervical Neoplasms  ISOERCC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20934765
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Ercc1RatXFE progeroid syndrome  ISSErcc1 (Mus musculus)13592920OMIM:610965MouseDO 
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Ercc1Ratcerebrooculofacioskeletal syndrome 4  ISOERCC1 (Homo sapiens)7240710 OMIM 

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Ercc1Rat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of ERCC1 mRNACTDPMID:17971868
Ercc1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ERCC1 mRNA]CTDPMID:31150632
Ercc1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOErcc1 (Mus musculus)6480464[epigallocatechin gallate co-treated with polylactic acid-polyglycolic acid copolymer analog] inhibits the reaction [9 more ...CTDPMID:23717041
Ercc1Rat(-)-quinic acid multiple interactionsISOERCC1 (Homo sapiens)6480464[Hydrogen Peroxide co-treated with Quinic Acid analog] results in increased expression of ERCC1 mRNACTDPMID:21751221
Ercc1Rat1,2-dimethylhydrazine increases expressionISOErcc1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of ERCC1 mRNACTDPMID:22206623
Ercc1Rat17alpha-ethynylestradiol multiple interactionsISOErcc1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ERCC1 mRNACTDPMID:17942748
Ercc1Rat17beta-estradiol multiple interactionsISOERCC1 (Homo sapiens)6480464decitabine inhibits the reaction [Estradiol results in decreased expression of ERCC1 mRNA]CTDPMID:22082530
Ercc1Rat17beta-estradiol decreases expressionISOERCC1 (Homo sapiens)6480464Estradiol results in decreased expression of ERCC1 mRNACTDPMID:22082530
Ercc1Rat1H-pyrazole increases expressionISOErcc1 (Mus musculus)6480464pyrazole results in increased expression of ERCC1 mRNACTDPMID:17945193
Ercc1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:28712647
Ercc1Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOErcc1 (Mus musculus)64804642 more ...CTDPMID:30294300
Ercc1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOERCC1 (Homo sapiens)64804642 more ...CTDPMID:26808241
Ercc1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOErcc1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ERCC1 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ERCC1 promoter]CTDPMID:17942748 and PMID:19654925
Ercc1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ERCC1 mRNACTDPMID:33387578
Ercc1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOErcc1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ERCC1 mRNACTDPMID:21570461
Ercc1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of ERCC1 mRNACTDPMID:21346803
Ercc1Rat2-hydroxypropanoic acid decreases expressionISOERCC1 (Homo sapiens)6480464Lactic Acid results in decreased expression of ERCC1 mRNACTDPMID:30851411
Ercc1Rat3,3',5,5'-tetrabromobisphenol A increases expressionISOErcc1 (Mus musculus)6480464tetrabromobisphenol A results in increased expression of ERCC1 mRNACTDPMID:25172293
Ercc1Rat3-aminobenzamide multiple interactionsISOERCC1 (Homo sapiens)64804643-aminobenzamide inhibits the reaction [Glucose results in increased expression of ERCC1 mRNA] and 3-aminobenzamide inhibits the reaction [Glucose results in increased expression of ERCC1 protein]CTDPMID:22228707
Ercc1Rat3-aminobenzamide multiple interactionsEXP 64804643-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA]CTDPMID:22228707

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Biological Process
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Ercc1Ratcell development acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2158940 PMID:10834928RGDPMID:10834928
Ercc1Ratcell population proliferation acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2183944 PMID:15692571RGDPMID:15692571
Ercc1Ratchromosome organization acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2183944 PMID:15199134RGDPMID:15199134
Ercc1Ratdetermination of adult lifespan acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2183944 PMID:17183314RGDPMID:17183314
Ercc1RatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
Ercc1RatDNA damage response acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2183944 more ...RGDPMID:11707424 more ...
Ercc1RatDNA recombination acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2183944 PMID:11707424RGDPMID:11707424
Ercc1RatDNA recombination involved_inIEAARBA:ARBA000280261600115GO_REF:0000117UniProtGO_REF:0000117
Ercc1RatDNA repair acts_upstream_of_or_withinISOERCC1 (Homo sapiens)1624291 PMID:25538220RGDPMID:25538220
Ercc1RatDNA repair involved_inIEAInterPro:IPR0045791600115GO_REF:0000002InterProGO_REF:0000002
Ercc1RatDNA repair acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2158940 PMID:12466203RGDPMID:12466203
Ercc1RatDNA repair involved_inIEAUniProtKB-KW:KW-02341600115GO_REF:0000043UniProtGO_REF:0000043
Ercc1Ratdouble-strand break repair NOT|acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2183944 PMID:11707424RGDPMID:11707424
Ercc1Ratdouble-strand break repair acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2158940 more ...RGDPMID:15199134 and PMID:17912366
Ercc1Ratdouble-strand break repair via nonhomologous end joining involved_inISOERCC1 (Homo sapiens)1624291 PMID:14690602RGDPMID:14690602
Ercc1Ratembryonic organ development  IEP 2313673 RGD 
Ercc1Ratgerm cell development acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2158940 more ...RGDPMID:17912366
Ercc1Ratinsulin-like growth factor receptor signaling pathway acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2183944 PMID:17183314RGDPMID:17183314
Ercc1Ratinterstrand cross-link repair acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291 PMID:23637614RGDPMID:23637614
Ercc1Ratisotype switching acts_upstream_of_or_withinISOErcc1 (Mus musculus)1624291MGI:2183944 PMID:15280420RGDPMID:15280420
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Cellular Component
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Molecular Function
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Original Reference(s)
Ercc1Rat3' overhang single-stranded DNA endodeoxyribonuclease activity contributes_toISOERCC1 (Homo sapiens)1624291 PMID:14690602RGDPMID:14690602
Ercc1Ratdamaged DNA binding enablesISOERCC1 (Homo sapiens)1624291 PMID:17720715RGDPMID:17720715
Ercc1Ratdamaged DNA binding enablesIEAInterPro:IPR0045791600115GO_REF:0000002InterProGO_REF:0000002
Ercc1Ratdamaged DNA binding enablesIBAPANTHER:PTN000297520 and UniProtKB:P079921600115GO_REF:0000033GO_CentralGO_REF:0000033
Ercc1RatDNA binding contributes_toISOERCC1 (Homo sapiens)1624291 PMID:14734547RGDPMID:14734547
Ercc1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Ercc1Ratpromoter-specific chromatin binding enablesISOErcc1 (Mus musculus)1624291 PMID:22323595RGDPMID:22323595
Ercc1Ratprotein binding enablesISOERCC1 (Homo sapiens)1624291UniProtKB:P00533 more ...RGDPMID:11058119 more ...
Ercc1Ratprotein binding enablesISOErcc1 (Mus musculus)1624291PR:P29037 more ...RGDPMID:22323595 and PMID:25538220
Ercc1Ratprotein binding enablesISOERCC1 (Homo sapiens) and UniProtKB:P07992-31624291UniProtKB:O95995 more ...RGDPMID:25910212 and PMID:32296183
Ercc1Ratsingle-stranded DNA binding enablesISOERCC1 (Homo sapiens)1624291 PMID:16076955 and PMID:17720715RGDPMID:16076955 and PMID:17720715
Ercc1Ratsingle-stranded DNA binding enablesIBAPANTHER:PTN000297520 and UniProtKB:P079921600115GO_REF:0000033GO_CentralGO_REF:0000033
Ercc1Ratsingle-stranded DNA endodeoxyribonuclease activity contributes_toISOERCC1 (Homo sapiens)1624291 PMID:7559382RGDPMID:7559382
Ercc1RatTFIID-class transcription factor complex binding enablesISOErcc1 (Mus musculus)1624291 PMID:22323595RGDPMID:22323595
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RGD Manual Annotations


  
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Ercc1Ratnucleotide excision repair pathway   ISOERCC1 (Homo sapiens)7246926 RGD 

Imported Annotations - KEGG (archival)

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Ercc1Ratnucleotide excision repair pathway   IEA 6907045 KEGGrno:03420

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Reference Title
Reference Citation
1. DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia. Batar B, etal., Leuk Res. 2009 Jun;33(6):759-63. doi: 10.1016/j.leukres.2008.11.005. Epub 2008 Dec 19.
2. SNPs and taxane toxicity in breast cancer patients. Boso V, etal., Pharmacogenomics. 2014;15(15):1845-58. doi: 10.2217/pgs.14.127.
3. Polymorphisms of cancer-related genes and risk of multipleprimary malignancies involving colorectal cancer Cao P, etal., Turk J Med Sci. 2017 Nov 13;47(5):1549-1554. doi: 10.3906/sag-1612-119.
4. DNA damage drives accelerated bone aging via an NF-kappaB-dependent mechanism. Chen Q, etal., J Bone Miner Res. 2013 May;28(5):1214-28. doi: 10.1002/jbmr.1851.
5. Impact on response and survival of DNA repair single nucleotide polymorphisms in relapsed or refractory multiple myeloma patients treated with thalidomide. Cibeira MT, etal., Leuk Res. 2011 Sep;35(9):1178-83. doi: 10.1016/j.leukres.2011.02.009. Epub 2011 Mar 23.
6. Differential toxicity biomarkers for irinotecan- and oxaliplatin-containing chemotherapy in colorectal cancer. Cortejoso L, etal., Cancer Chemother Pharmacol. 2013 Jun;71(6):1463-72. doi: 10.1007/s00280-013-2145-6. Epub 2013 Mar 31.
7. Phase 1a/1b and pharmacogenetic study of docetaxel, oxaliplatin and capecitabine in patients with advanced cancer of the stomach or the gastroesophageal junction. Deenen MJ, etal., Cancer Chemother Pharmacol. 2015 Dec;76(6):1285-95. doi: 10.1007/s00280-015-2872-y. Epub 2015 Oct 23.
8. DNA adduct formation and oxidative stress in colon and liver of Big Blue rats after dietary exposure to diesel particles. Dybdahl M, etal., Carcinogenesis. 2003 Nov;24(11):1759-66. Epub 2003 Aug 14.
9. Tumour regression and ERCC1 nuclear protein expression predict clinical outcome in patients with gastro-oesophageal cancer treated with neoadjuvant chemotherapy. Fareed KR, etal., Br J Cancer. 2010 May 25;102(11):1600-7. doi: 10.1038/sj.bjc.6605686. Epub 2010 May 11.
10. Overexpression of the two nucleotide excision repair genes ERCC1 and XPC in human hepatocellular carcinoma. Fautrel A, etal., J Hepatol. 2005 Aug;43(2):288-93. doi: 10.1016/j.jhep.2005.02.020. Epub 2005 Apr 25.
11. Dynamic regulation of cerebral DNA repair genes by psychological stress. Forsberg K, etal., Mutat Res Genet Toxicol Environ Mutagen. 2015 Jan 15;778:37-43. doi: 10.1016/j.mrgentox.2014.12.003. Epub 2014 Dec 27.
12. Expression of DNA repair genes in ovarian cancer samples: biological and clinical considerations. Ganzinelli M, etal., Eur J Cancer. 2011 May;47(7):1086-94. doi: 10.1016/j.ejca.2010.11.029. Epub 2011 Jan 7.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Association of four ERCC1 and ERCC2 SNPs with survival of bone tumour patients. Hao T, etal., Asian Pac J Cancer Prev. 2012;13(8):3821-4.
16. Myelofibrosis in Philadelphia chromosome-negative myeloproliferative neoplasms is associated with aberrant karyotypes. Hauck G, etal., Cancer Genet. 2013 Apr;206(4):116-23. doi: 10.1016/j.cancergen.2013.02.002. Epub 2013 Apr 6.
17. Excision repair cross-complementing 1 expression protects against ischemic injury following middle cerebral artery occlusion in the rat brain. He KY, etal., Gene Ther. 2009 Jul;16(7):840-8. Epub 2009 May 14.
18. Evaluation of cell proliferation, apoptosis, and DNA-repair genes as potential biomarkers for ethanol-induced CNS alterations. Hicks SD, etal., BMC Neurosci. 2012 Oct 25;13:128. doi: 10.1186/1471-2202-13-128.
19. A phase II study of neoadjuvant combination chemotherapy with docetaxel, cisplatin, and S-1 for locally advanced resectable gastric cancer: nucleotide excision repair (NER) as potential chemoresistance marker. Hirakawa M, etal., Cancer Chemother Pharmacol. 2013 Mar;71(3):789-97. doi: 10.1007/s00280-013-2073-5. Epub 2013 Jan 22.
20. A phase II study of biweekly paclitaxel and cisplatin chemotherapy for recurrent or metastatic esophageal squamous cell carcinoma: ERCC1 expression predicts response to chemotherapy. Huang J, etal., Med Oncol. 2013 Mar;30(1):343. doi: 10.1007/s12032-012-0343-4. Epub 2012 Dec 21.
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PMID:3290851   PMID:7559382   PMID:7657672   PMID:8197175   PMID:8275084   PMID:8811092   PMID:9197240   PMID:9256505   PMID:9722633   PMID:10413517   PMID:10454634   PMID:10834928  
PMID:11707424   PMID:12466203   PMID:14690602   PMID:14734547   PMID:15199134   PMID:15280420   PMID:15692571   PMID:15979950   PMID:16076955   PMID:16682947   PMID:17055345   PMID:17173483  
PMID:17183314   PMID:17614221   PMID:17720715   PMID:17912366   PMID:22579284   PMID:23637614   PMID:25538220  



Ercc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,099,308 - 88,135,966 (+)NCBIGRCr8
mRatBN7.2178,971,310 - 79,007,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,996,390 - 79,007,963 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,385,658 - 84,396,816 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,943,314 - 92,954,535 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,140,755 - 86,151,914 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,256,973 - 80,268,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,256,973 - 80,268,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,523,234 - 81,534,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,711,249 - 78,722,474 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,787,675 - 78,800,533 (+)NCBI
Celera173,458,746 - 73,469,951 (+)NCBICelera
Cytogenetic Map1q21NCBI
ERCC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,407,334 - 45,451,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,407,334 - 45,478,828 (-)EnsemblGRCh38hg38GRCh38
GRCh371945,910,592 - 45,954,805 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,604,712 - 50,619,017 (-)NCBINCBI36Build 36hg18NCBI36
Build 341950,608,532 - 50,618,642NCBI
Celera1942,716,697 - 42,733,283 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,340,919 - 42,357,653 (-)NCBIHuRef
CHM1_11945,913,883 - 45,930,469 (-)NCBICHM1_1
T2T-CHM13v2.01948,234,581 - 48,278,793 (-)NCBIT2T-CHM13v2.0
Ercc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,079,016 - 19,090,449 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,078,703 - 19,090,449 (+)EnsemblGRCm39 Ensembl
GRCm38719,344,067 - 19,356,524 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,344,778 - 19,356,524 (+)EnsemblGRCm38mm10GRCm38
MGSCv37719,930,420 - 19,941,873 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,503,628 - 18,515,044 (+)NCBIMGSCv36mm8
Celera716,751,825 - 16,763,278 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.6NCBI
Ercc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555552,393,278 - 2,406,582 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555552,393,510 - 2,430,180 (-)NCBIChiLan1.0ChiLan1.0
ERCC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,568,054 - 51,639,947 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,439,598 - 53,511,447 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,356,039 - 42,427,754 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,951,674 - 50,994,600 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,951,674 - 50,968,430 (-)Ensemblpanpan1.1panPan2
ERCC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,130,353 - 110,146,660 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,130,481 - 110,146,602 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,614,480 - 109,631,191 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,662,831 - 110,679,536 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,662,958 - 110,679,533 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,338,665 - 110,355,163 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,972,731 - 109,989,322 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,842,133 - 110,858,633 (+)NCBIUU_Cfam_GSD_1.0
Ercc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,507,594 - 17,520,240 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,852,359 - 1,867,745 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,854,938 - 1,867,521 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERCC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,783,478 - 51,798,984 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,783,537 - 51,808,898 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ERCC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,857,067 - 38,900,177 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl638,854,803 - 38,872,967 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607318,458,810 - 18,478,494 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ercc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249072,288,423 - 2,298,373 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249072,288,380 - 2,298,909 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ercc1
80 total Variants


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 79007011 79007012 G A snv European Variation Archive Release 3, European Variation Archive Release 4, European Variation Archive Release 6, SS/JrHsd (2021), SS/HsdMcwiCrl (2021), SS/JrHsdMcwi (2019NG), SS/JrHsdMcwi (2019) View more Information


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 78721522 78721523 G A snv SS/JrHsdMcwi (MCW), SS/JrHsdMcwi (ICL), SS/Jr (ICL), SS/JrHsdMcwi (MDC) View more Information


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 81533507 81533508 G A snv SS/JrHsdMcwi (MCW), SS/JrHsdMcwi (KNAW), SS/Jr (KNAW) View more Information


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 80267246 80267247 G A snv SS/JrHsdMcwi (MCW), SS/JrHsdMcwi (2019), SS/JrHsdMcwi (RGD), SS/Jr (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:57
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000024113
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 47 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat

1 to 10 of 47 rows
BE120839  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,008,387 - 79,008,538 (+)MAPPERmRatBN7.2
Rnor_6.0180,268,623 - 80,268,773NCBIRnor6.0
Rnor_5.0181,534,884 - 81,535,034UniSTSRnor5.0
RGSC_v3.4178,722,899 - 78,723,049UniSTSRGSC3.4
Celera173,470,376 - 73,470,526UniSTS
RH 3.4 Map1794.6UniSTS
Cytogenetic Map1q21UniSTS
ERCC1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,001,770 - 79,001,871 (+)MAPPERmRatBN7.2
Rnor_6.0180,262,008 - 80,262,108NCBIRnor6.0
Rnor_5.0181,528,269 - 81,528,369UniSTSRnor5.0
RGSC_v3.4178,716,284 - 78,716,384UniSTSRGSC3.4
Celera173,463,775 - 73,463,875UniSTS
Cytogenetic Map1q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000024113   ⟹   ENSRNOP00000024113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,996,531 - 79,007,960 (+)Ensembl
Rnor_6.0 Ensembl180,256,973 - 80,268,198 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104471   ⟹   ENSRNOP00000087227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,996,390 - 79,006,013 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117664   ⟹   ENSRNOP00000090301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,998,625 - 79,007,963 (+)Ensembl
RefSeq Acc Id: NM_001106228   ⟹   NP_001099698
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,124,741 - 88,135,966 (+)NCBI
mRatBN7.2178,996,736 - 79,007,963 (+)NCBI
Rnor_6.0180,256,973 - 80,268,198 (+)NCBI
Rnor_5.0181,523,234 - 81,534,459 (+)NCBI
RGSC_v3.4178,711,249 - 78,722,474 (+)RGD
Celera173,458,746 - 73,469,951 (+)RGD
Sequence:
RefSeq Acc Id: XM_006228395   ⟹   XP_006228457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,124,921 - 88,135,964 (+)NCBI
mRatBN7.2178,996,912 - 79,007,962 (+)NCBI
Rnor_6.0180,257,156 - 80,268,197 (+)NCBI
Rnor_5.0181,523,234 - 81,534,459 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228396   ⟹   XP_006228458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,125,009 - 88,135,964 (+)NCBI
mRatBN7.2178,997,007 - 79,007,962 (+)NCBI
Rnor_6.0180,257,287 - 80,268,197 (+)NCBI
Rnor_5.0181,523,234 - 81,534,459 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103935   ⟹   XP_038959863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,124,143 - 88,135,964 (+)NCBI
mRatBN7.2178,996,095 - 79,007,962 (+)NCBI
RefSeq Acc Id: XM_039103939   ⟹   XP_038959867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,099,308 - 88,135,964 (+)NCBI
mRatBN7.2178,971,310 - 79,007,962 (+)NCBI
RefSeq Acc Id: NP_001099698   ⟸   NM_001106228
- UniProtKB: D3ZAQ9 (UniProtKB/TrEMBL),   A6J8M3 (UniProtKB/TrEMBL),   A0A8I6GI31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228457   ⟸   XM_006228395
- Peptide Label: isoform X1
- UniProtKB: D3ZAQ9 (UniProtKB/TrEMBL),   A6J8M3 (UniProtKB/TrEMBL),   A0A8I6GI31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228458   ⟸   XM_006228396
- Peptide Label: isoform X1
- UniProtKB: D3ZAQ9 (UniProtKB/TrEMBL),   A6J8M3 (UniProtKB/TrEMBL),   A0A8I6GI31 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024113   ⟸   ENSRNOT00000024113
RefSeq Acc Id: XP_038959867   ⟸   XM_039103939
- Peptide Label: isoform X1
- UniProtKB: D3ZAQ9 (UniProtKB/TrEMBL),   A6J8M3 (UniProtKB/TrEMBL),   A0A8I6GI31 (UniProtKB/TrEMBL)
ERCC1-like central

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAQ9-F1-model_v2 AlphaFold D3ZAQ9 1-298 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689768
Promoter ID:EPDNEW_R292
Type:initiation region
Name:Ercc1_1
Description:ERCC excision repair 1, endonuclease non-catalytic subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,256,990 - 80,257,050EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-60511 BioCyc
Ensembl Genes ENSRNOG00000017839 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024113 ENTREZGENE
  ENSRNOT00000024113.6 UniProtKB/TrEMBL
  ENSRNOT00000104471 ENTREZGENE
  ENSRNOT00000104471.1 UniProtKB/TrEMBL
  ENSRNOT00000117664.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10130 UniProtKB/TrEMBL
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
InterPro DNA_repair_Rad10 UniProtKB/TrEMBL
  ERCC1-like_central_dom UniProtKB/TrEMBL
  Restrct_endonuc_II-like UniProtKB/TrEMBL
  RuvA_2-like UniProtKB/TrEMBL
KEGG Report rno:292673 UniProtKB/TrEMBL
NCBI Gene 292673 ENTREZGENE
PANTHER DNA EXCISION REPAIR PROTEIN ERCC-1 UniProtKB/TrEMBL
  PTHR12749 UniProtKB/TrEMBL
Pfam HHH_5 UniProtKB/TrEMBL
  Rad10 UniProtKB/TrEMBL
PharmGKB ERCC1 RGD
PhenoGen Ercc1 PhenoGen
RatGTEx ENSRNOG00000017839 RatGTEx
Superfamily-SCOP Restrict_endonuc_II-like_core UniProtKB/TrEMBL
  RuvA_2_like UniProtKB/TrEMBL
UniProt A0A8I6A2U2_RAT UniProtKB/TrEMBL
  A0A8I6GI31 ENTREZGENE, UniProtKB/TrEMBL
  A6J8M3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAQ9 ENTREZGENE, UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Ercc1  ERCC excision repair 1, endonuclease non-catalytic subunit  Ercc1  excision repair cross-complementation group 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-02-02 Ercc1  excision repair cross-complementation group 1  Ercc1  excision repair cross-complementing rodent repair deficiency, complementation group 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ercc1  excision repair cross-complementing rodent repair deficiency, complementation group 1   Ercc1_predicted  excision repair cross-complementing rodent repair deficiency, complementation group 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ercc1_predicted  excision repair cross-complementing rodent repair deficiency, complementation group 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED