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Gene: Spink5 (serine peptidase inhibitor, Kazal type 5) Rattus norvegicus

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Symbol:

Spink5

Name:

serine peptidase inhibitor, Kazal type 5

RGD ID:

1306540

Description:

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in epidermal cell differentiation. Predicted to act upstream of or within negative regulation of serine-type peptidase activity and regulation of cell adhesion. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; epidermal lamellar body; and perinuclear region of cytoplasm. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in Netherton syndrome. Orthologous to human SPINK5 (serine peptidase inhibitor Kazal type 5); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,7-dihydropurine-6-thione.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC100910851; LOC361319; serine protease inhibitor Kazal-type 5; serine protease inhibitor Kazal-type 5-like; serine protease inhibitor, Kazal type 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	36,515,347 - 36,584,038 (+)	NCBI		GRCr8
mRatBN7.2	18	36,264,452 - 36,333,143 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	36,264,452 - 36,332,185 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	36,368,467 - 36,437,168 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	37,086,815 - 37,155,518 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	36,463,716 - 36,532,415 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	35,118,300 - 35,190,458 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	35,121,967 - 35,191,069 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	1	229,267,916 - 229,343,584 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	34,787,562 - 34,856,081 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	37,563,911 - 37,631,579 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	37,599,079 - 37,648,851 (+)	NCBI
Cytogenetic Map	18	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Spink5	Rat	Exfoliative Dermatitis		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Erythroderma	ClinVar	PMID:15304086 more ...
Spink5	Rat	familial adenomatous polyposis 1		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Familial adenomatous polyposis 1	ClinVar	PMID:17963004 more ...
Spink5	Rat	genetic disease		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868 and PMID:28492532
Spink5	Rat	Hereditary Neoplastic Syndromes		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome	ClinVar	PMID:17963004 more ...
Spink5	Rat	Netherton syndrome		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10835624 more ...
Spink5	Rat	Neurodevelopmental Disorders		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
Spink5	Rat	otitis media		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Susceptibility to nonsyndromic otitis media	ClinVar	PMID:11511292 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Spink5	Rat	Netherton syndrome		ISO	SPINK5 (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:20657595
Spink5	Rat	Prostatic Neoplasms		ISO	SPINK5 (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17013881

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Spink5	Rat	Netherton syndrome		ISS	Spink5 (Mus musculus)	13592920	OMIM:256500	MouseDO

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Spink5	Rat	Netherton syndrome		ISO	SPINK5 (Homo sapiens)	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Spink5	Rat	17beta-estradiol	multiple interactions	ISO	SPINK5 (Homo sapiens)	6480464	[Estradiol co-treated with Progesterone] results in increased expression of SPINK5 mRNA	CTD	PMID:20660070
Spink5	Rat	17beta-estradiol	decreases expression	ISO	SPINK5 (Homo sapiens)	6480464	Estradiol results in decreased expression of SPINK5 mRNA	CTD	PMID:31614463
Spink5	Rat	17beta-estradiol	multiple interactions	EXP		6480464	[bisphenol A co-treated with Estradiol] results in decreased expression of SPINK5 mRNA and [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of SPINK5 mRNA	CTD	PMID:26496021 and PMID:32741896
Spink5	Rat	17beta-estradiol 3-benzoate	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of SPINK5 mRNA	CTD	PMID:32741896
Spink5	Rat	3,7-dihydropurine-6-thione	increases expression	EXP		6480464	Mercaptopurine results in increased expression of SPINK5 mRNA	CTD	PMID:23358152
Spink5	Rat	7,12-dimethyltetraphene	increases expression	EXP		6480464	9 more ...	CTD	PMID:19480007
Spink5	Rat	8-Br-cAMP	increases expression	ISO	SPINK5 (Homo sapiens)	6480464	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SPINK5 mRNA	CTD	PMID:22079614
Spink5	Rat	acrylamide	decreases expression	EXP		6480464	Acrylamide results in decreased expression of SPINK5 mRNA	CTD	PMID:28959563
Spink5	Rat	aflatoxin B1	increases expression	ISO	SPINK5 (Homo sapiens)	6480464	Aflatoxin B1 results in increased expression of SPINK5 mRNA	CTD	PMID:22100608
Spink5	Rat	all-trans-retinoic acid	increases expression	ISO	SPINK5 (Homo sapiens)	6480464	Tretinoin results in increased expression of SPINK5 mRNA	CTD	PMID:16249480
Spink5	Rat	Aroclor 1254	decreases expression	ISO	Spink5 (Mus musculus)	6480464	Chlorodiphenyl (54% Chlorine) results in decreased expression of SPINK5 mRNA	CTD	PMID:23650126
Spink5	Rat	benzo[a]pyrene	increases mutagenesis	ISO	SPINK5 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased mutagenesis of SPINK5 gene	CTD	PMID:25435355
Spink5	Rat	benzo[a]pyrene	increases expression	ISO	SPINK5 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased expression of SPINK5 mRNA	CTD	PMID:32234424
Spink5	Rat	benzo[a]pyrene	increases methylation	ISO	SPINK5 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased methylation of SPINK5 3' UTR and Benzo(a)pyrene results in increased methylation of SPINK5 promoter	CTD	PMID:27901495
Spink5	Rat	benzo[a]pyrene	increases expression	ISO	Spink5 (Mus musculus)	6480464	Benzo(a)pyrene results in increased expression of SPINK5 mRNA	CTD	PMID:19770486
Spink5	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	SPINK5 (Homo sapiens)	6480464	Diethylhexyl Phthalate results in decreased expression of SPINK5 mRNA	CTD	PMID:31163220
Spink5	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with Estradiol] results in decreased expression of SPINK5 mRNA	CTD	PMID:26496021
Spink5	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of SPINK5 mRNA	CTD	PMID:25181051
Spink5	Rat	choline	multiple interactions	ISO	Spink5 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPINK5 mRNA	CTD	PMID:20938992
Spink5	Rat	copper atom	multiple interactions	EXP		6480464	[Copper co-treated with Dietary Sucrose] results in increased expression of SPINK5 mRNA	CTD	PMID:26033743
Spink5	Rat	copper(0)	multiple interactions	EXP		6480464	[Copper co-treated with Dietary Sucrose] results in increased expression of SPINK5 mRNA	CTD	PMID:26033743
Spink5	Rat	epoxiconazole	decreases expression	ISO	Spink5 (Mus musculus)	6480464	epoxiconazole results in decreased expression of SPINK5 mRNA	CTD	PMID:35436446
Spink5	Rat	folic acid	multiple interactions	ISO	Spink5 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPINK5 mRNA	CTD	PMID:20938992
Spink5	Rat	furfural	multiple interactions	ISO	SPINK5 (Homo sapiens)	6480464	[Sodium Chloride co-treated with Furaldehyde] results in increased expression of SPINK5 protein	CTD	PMID:38598786
Spink5	Rat	indinavir	multiple interactions	ISO	Spink5 (Mus musculus)	6480464	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of SPINK5 mRNA	CTD	PMID:16931933
Spink5	Rat	L-methionine	multiple interactions	ISO	Spink5 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPINK5 mRNA	CTD	PMID:20938992
Spink5	Rat	lamivudine	multiple interactions	ISO	Spink5 (Mus musculus)	6480464	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of SPINK5 mRNA more ...	CTD	PMID:16931933
Spink5	Rat	mercaptopurine	increases expression	EXP		6480464	Mercaptopurine results in increased expression of SPINK5 mRNA	CTD	PMID:23358152
Spink5	Rat	naphthalene	decreases reduction	ISO	Spink5 (Mus musculus)	6480464	naphthalene results in decreased reduction of SPINK5 protein	CTD	PMID:19843705
Spink5	Rat	nicotinic acid	increases expression	EXP		6480464	Niacin results in increased expression of SPINK5 mRNA	CTD	PMID:20303128
Spink5	Rat	paracetamol	affects expression	ISO	Spink5 (Mus musculus)	6480464	Acetaminophen affects the expression of SPINK5 mRNA	CTD	PMID:17562736
Spink5	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of SPINK5 mRNA	CTD	PMID:33387578
Spink5	Rat	paracetamol	decreases expression	ISO	SPINK5 (Homo sapiens)	6480464	Acetaminophen results in decreased expression of SPINK5 mRNA	CTD	PMID:29067470
Spink5	Rat	progesterone	multiple interactions	ISO	SPINK5 (Homo sapiens)	6480464	[Estradiol co-treated with Progesterone] results in increased expression of SPINK5 mRNA	CTD	PMID:20660070
Spink5	Rat	purine-6-thiol	increases expression	EXP		6480464	Mercaptopurine results in increased expression of SPINK5 mRNA	CTD	PMID:23358152
Spink5	Rat	saquinavir	multiple interactions	ISO	Spink5 (Mus musculus)	6480464	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of SPINK5 mRNA	CTD	PMID:16931933
Spink5	Rat	silicon dioxide	increases expression	ISO	SPINK5 (Homo sapiens)	6480464	Silicon Dioxide analog results in increased expression of SPINK5 mRNA	CTD	PMID:23806026
Spink5	Rat	silicon dioxide	increases expression	ISO	Spink5 (Mus musculus)	6480464	Silicon Dioxide results in increased expression of SPINK5 mRNA	CTD	PMID:29341224
Spink5	Rat	sodium arsenite	decreases expression	ISO	Spink5 (Mus musculus)	6480464	sodium arsenite results in decreased expression of SPINK5 mRNA	CTD	PMID:36209798
Spink5	Rat	sodium chloride	multiple interactions	ISO	SPINK5 (Homo sapiens)	6480464	[Sodium Chloride co-treated with Furaldehyde] results in increased expression of SPINK5 protein	CTD	PMID:38598786
Spink5	Rat	sodium fluoride	increases expression	ISO	Spink5 (Mus musculus)	6480464	Sodium Fluoride results in increased expression of SPINK5 protein	CTD	PMID:28918527
Spink5	Rat	testosterone	multiple interactions	ISO	Spink5 (Mus musculus)	6480464	1 more ...	CTD	PMID:33848595
Spink5	Rat	testosterone	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of SPINK5 mRNA	CTD	PMID:32741896
Spink5	Rat	testosterone	decreases expression	ISO	Spink5 (Mus musculus)	6480464	Testosterone deficiency results in decreased expression of SPINK5 mRNA	CTD	PMID:33848595
Spink5	Rat	titanium dioxide	increases expression	ISO	Spink5 (Mus musculus)	6480464	titanium dioxide results in increased expression of SPINK5 mRNA	CTD	PMID:23557971
Spink5	Rat	titanium dioxide	decreases expression	ISO	Spink5 (Mus musculus)	6480464	titanium dioxide results in decreased expression of SPINK5 mRNA	CTD	PMID:27760801
Spink5	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of SPINK5 mRNA	CTD	PMID:33387578
Spink5	Rat	trichostatin A	increases expression	ISO	SPINK5 (Homo sapiens)	6480464	trichostatin A results in increased expression of SPINK5 mRNA	CTD	PMID:24935251
Spink5	Rat	Triptolide	increases expression	ISO	Spink5 (Mus musculus)	6480464	triptolide results in increased expression of SPINK5 mRNA	CTD	PMID:32835833
Spink5	Rat	valproic acid	decreases expression	ISO	SPINK5 (Homo sapiens)	6480464	Valproic Acid results in decreased expression of SPINK5 mRNA	CTD	PMID:23179753 and PMID:28001369
Spink5	Rat	valproic acid	affects expression	ISO	SPINK5 (Homo sapiens)	6480464	Valproic Acid affects the expression of SPINK5 mRNA	CTD	PMID:25979313
Spink5	Rat	zidovudine	multiple interactions	ISO	Spink5 (Mus musculus)	6480464	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of SPINK5 mRNA more ...	CTD	PMID:16931933

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Spink5	Rat	biological_process		ND		1598407	1/2007: no relevant rat data	RGD
Spink5	Rat	cell differentiation	involved_in	IBA	FB:FBgn0030439 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Spink5	Rat	epidermal cell differentiation	involved_in	ISO	SPINK5 (Homo sapiens)	1624291	PMID:12915442	RGD	PMID:12915442
Spink5	Rat	epidermal cell differentiation	involved_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	negative regulation of antibacterial peptide production	involved_in	IEA	UniProtKB:Q148R4 and ensembl:ENSMUSP00000066214	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	negative regulation of proteolysis	acts_upstream_of_or_within	ISO	Spink5 (Mus musculus)	1624291	PMID:15466487	RGD	PMID:15466487
Spink5	Rat	negative regulation of proteolysis	acts_upstream_of_or_within	IEA	UniProtKB:Q148R4 and ensembl:ENSMUSP00000066214	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	negative regulation of serine-type peptidase activity	acts_upstream_of_or_within	ISO	Spink5 (Mus musculus)	1624291	MGI:3573756 PMID:20179351	RGD	PMID:20179351
Spink5	Rat	regulation of cell adhesion	acts_upstream_of_or_within	ISO	Spink5 (Mus musculus)	1624291	PMID:15466487	RGD	PMID:15466487
Spink5	Rat	regulation of cell adhesion	acts_upstream_of_or_within	IEA	UniProtKB:Q148R4 and ensembl:ENSMUSP00000066214	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Spink5	Rat	cell cortex	located_in	ISO	SPINK5 (Homo sapiens)	1624291	PMID:12915442	RGD	PMID:12915442
Spink5	Rat	cell cortex	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	cytoplasm	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	cytoplasm	located_in	ISO	SPINK5 (Homo sapiens)	1624291	PMID:12915442	RGD	PMID:12915442
Spink5	Rat	cytosol	located_in	ISO	SPINK5 (Homo sapiens)	1624291	PMID:15680911	RGD	PMID:15680911
Spink5	Rat	cytosol	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	endoplasmic reticulum	located_in	ISO	SPINK5 (Homo sapiens)	1624291	PMID:15680911	RGD	PMID:15680911
Spink5	Rat	endoplasmic reticulum	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	endoplasmic reticulum membrane	located_in	ISO	SPINK5 (Homo sapiens)	1624291	PMID:15680911	RGD	PMID:15680911
Spink5	Rat	endoplasmic reticulum membrane	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	epidermal lamellar body	located_in	ISO	SPINK5 (Homo sapiens)	1624291	PMID:15675955	RGD	PMID:15675955
Spink5	Rat	epidermal lamellar body	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	extracellular region	located_in	ISO	SPINK5 (Homo sapiens)	1624291	PMID:15680911	RGD	PMID:15680911
Spink5	Rat	extracellular region	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	extracellular region	is_active_in	IBA	FB:FBgn0259878 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Spink5	Rat	extracellular region	located_in	IEA	UniProtKB-KW:KW-0964	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Spink5	Rat	extracellular region	located_in	IEA	UniProtKB-SubCell:SL-0243	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Spink5	Rat	intracellular membrane-bounded organelle	located_in	ISO	SPINK5 (Homo sapiens) more ...	1624291		RGD	GO_REF:0000052
Spink5	Rat	intracellular membrane-bounded organelle	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	perinuclear region of cytoplasm	located_in	ISO	SPINK5 (Homo sapiens)	1624291	PMID:15680911	RGD	PMID:15680911
Spink5	Rat	perinuclear region of cytoplasm	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Spink5	Rat	peptidase inhibitor activity	enables	ISO	Spink5 (Mus musculus)	1624291	PMID:15466487	RGD	PMID:15466487
Spink5	Rat	peptidase inhibitor activity	enables	IEA	UniProtKB:Q148R4 and ensembl:ENSMUSP00000066214	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	serine-type endopeptidase inhibitor activity	enables	ISO	SPINK5 (Homo sapiens)	1624291	PMID:10419450 and PMID:15680911	RGD	PMID:10419450 and PMID:15680911
Spink5	Rat	serine-type endopeptidase inhibitor activity	enables	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Spink5	Rat	serine-type endopeptidase inhibitor activity	enables	IBA	PANTHER:PTN000099251 and UniProtKB:Q9NQ38	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

#	Reference Title	Reference Citation
1.	Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome.	Chavanas S, etal., Nat Genet. 2000 Jun;25(2):141-2.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

PMID:10419450	PMID:12915442	PMID:15466487	PMID:15675955	PMID:15680911	PMID:17012259	PMID:20179351	PMID:23376485

Spink5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	36,515,347 - 36,584,038 (+)	NCBI		GRCr8
mRatBN7.2	18	36,264,452 - 36,333,143 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	36,264,452 - 36,332,185 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	36,368,467 - 36,437,168 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	37,086,815 - 37,155,518 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	36,463,716 - 36,532,415 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	35,118,300 - 35,190,458 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	35,121,967 - 35,191,069 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	1	229,267,916 - 229,343,584 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	34,787,562 - 34,856,081 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	37,563,911 - 37,631,579 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	37,599,079 - 37,648,851 (+)	NCBI
Cytogenetic Map	18	q11	NCBI

SPINK5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	148,063,980 - 148,137,382 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	148,025,683 - 148,137,382 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	147,443,543 - 147,516,945 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	147,423,759 - 147,497,120 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	147,423,758 - 147,497,037	NCBI
Celera	5	143,524,323 - 143,597,562 (+)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI
HuRef	5	142,590,808 - 142,664,035 (+)	NCBI		HuRef
CHM1_1	5	146,875,990 - 146,949,062 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	148,599,687 - 148,673,088 (+)	NCBI		T2T-CHM13v2.0

Spink5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	44,092,612 - 44,155,554 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	44,096,302 - 44,155,568 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	43,959,545 - 44,022,487 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	43,963,235 - 44,022,501 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	44,122,895 - 44,182,141 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	44,088,572 - 44,147,818 (+)	NCBI		MGSCv36	mm8
Celera	18	45,339,414 - 45,398,624 (+)	NCBI		Celera
Cytogenetic Map	18	B3	NCBI
cM Map	18	23.74	NCBI

Spink5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955415	6,118,616 - 6,186,632 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPINK5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	143,191,450 - 143,382,914 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	141,330,972 - 141,522,438 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	143,387,981 - 143,578,839 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	149,507,003 - 149,587,249 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	149,506,367 - 149,590,930 (+)	Ensembl	panpan1.1		panPan2

SPINK5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	42,285,537 - 42,365,637 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	42,285,537 - 42,365,690 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	39,331,980 - 39,411,492 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	42,745,184 - 42,825,339 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	42,723,407 - 42,825,338 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	39,815,140 - 39,895,271 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	40,625,209 - 40,705,273 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	41,448,356 - 41,528,467 (+)	NCBI		UU_Cfam_GSD_1.0

Spink5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	145,079,694 - 145,182,465 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936504	6,653,703 - 6,750,110 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPINK5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	149,309,540 - 149,382,282 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	149,309,482 - 149,382,286 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	155,870,595 - 155,896,727 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPINK5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	50,587,698 - 50,667,219 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	50,592,412 - 50,663,302 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	27,098,281 - 27,174,482 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spink5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	7,489,687 - 7,576,088 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624774	7,469,195 - 7,579,603 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Spink5
285 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	208
Count of miRNA genes:	87
Interacting mature miRNAs:	99
Transcripts:	ENSRNOT00000017522, ENSRNOT00000073717
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	59796643	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26548082	46969551	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31271681	60377755	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	59796643	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31359408	59796643	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	35870723	80870723	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26548082	46969551	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26548082	46969551	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	22066242	52293055	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26548082	46969551	Rat
6903347	Bp350	Blood pressure QTL 350	4.4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359530	59796478	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
1331727	Bp237	Blood pressure QTL 237	3.053		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	61698465	Rat
2300157	Bmd66	Bone mineral density QTL 66	13.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
738005	Anxrr11	Anxiety related response QTL 11	3.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	18	30039813	75039813	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26548082	46969551	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31393320	77209694	Rat
1358193	Emca2	Estrogen-induced mammary cancer QTL 2	1.6		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	18	18007599	63571040	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26548082	46969551	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26548082	46969551	Rat
2293704	Bss35	Bone structure and strength QTL 35	4.59	0.0002	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	18	28964853	73964853	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	29792965	74792965	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31359408	59796643	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	29792965	74792965	Rat
2300177	Bmd65	Bone mineral density QTL 65	19.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31359408	83218561	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31359408	70263868	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	29792965	74792965	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	29792965	74792965	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat

RH133717

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	18	34,855,720 - 34,855,938	NCBI	Rnor5.0
Rnor_5.0	2	55,120,392 - 55,120,610	NCBI	Rnor5.0
Rnor_5.0	1	236,500,194 - 236,500,412	NCBI	Rnor5.0
RGSC_v3.4	18	37,632,179 - 37,632,396	UniSTS	RGSC3.4
Cytogenetic Map	18	q11	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
12	7	37	40	31	10	7	10	12	61	36	13	3	33	21


RefSeq Transcripts	NM_001170606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017522 ⟹ ENSRNOP00000017522

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	36,264,452 - 36,332,185 (+)	Ensembl
Rnor_6.0 Ensembl	18	35,121,967 - 35,189,644 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000073717 ⟹ ENSRNOP00000066620

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	229,267,916 - 229,343,054 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076941 ⟹ ENSRNOP00000068512

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	229,267,944 - 229,342,240 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000078731 ⟹ ENSRNOP00000069499

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	18	35,136,132 - 35,191,069 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082670 ⟹ ENSRNOP00000070505

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	229,267,926 - 229,343,584 (+)	Ensembl

RefSeq Acc Id:

NM_001170606 ⟹ NP_001164077

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	36,515,347 - 36,584,038 (+)	NCBI
mRatBN7.2	18	36,264,452 - 36,333,143 (+)	NCBI
Rnor_6.0	18	35,121,939 - 35,190,458 (+)	NCBI
Rnor_5.0	18	34,787,562 - 34,856,081 (+)	NCBI

Sequence:

show sequence

AGTCTTAGAGCACCAGCTGAGCAATGCACAGAGCAGTCCTGTAACCAACTTACATCATCTTCAGCATGAAGACAGCCACGGTGCCAATGCTTCTCACCCTGGCATTTTATCTCACACAAGATGCCTCC
AGTTGGAAAGGAAATCAGGACCCATGCATGAAATTTCGAGCACTGATGAAAAATGGGACACTGTCATGTCCACAAGGCAACAATTCTTCTCAAAGTCTCAATGACATTATTTTCCAAAGTGAATGCAT
CTTGTGCAAAAAAACACTAGAACAAGAAACAAATACCAAGGACATGGTGATGGTGAGGTTTTTGTCAAGAGCCACCAGGGCCACTGCCCCAGCAAAGTTGAATTGTGAGAACTTCAAGCAAAGAAGAA
AAGATGGGGATTTCATCTGTCCATCTGATGCTTCTGCAGTTTGTGGCACAGATGGGAAAACGTACCCCAGCAGATGTCACCTGTGTGCTGAGAATGCGAAAAGCCAGAGCCATGTTGAAGTAAAAAGT
GAAGGTGAATGTGGCAGCAGCCACCTAGAGACGGATATGTGCAGTGATTTTCGGGCCTACGTGCAAGATGGAAGACTCGGATGTACAAGGGAAAATGATCCAATCCGTGGTCCTGATGGGAGGACACA
TGGCAATAGGTGTGCCATGTGTGCTGAGCTCTTTTTAAAAGAAGCTCAAGTAAATGCCACACGTGACAGAGAAAGCAGAATTCGGAGAGATGCCGAGGAGGAACTTTGCAAGGAATTTGAAAACCAAG
TGAGGAGTGGAAGACTCTTTTGTACCCGAGAAAGTGACCCAATCCGTGGCCCTGATGGCAAGATGCATGGGAACAAGTGTGCCCTCTGTGCTGAGATATTCATGAAGCGTTTTACAGAAGGAAAAGAT
AAAGCAGAGACAAAACAGAGAGATGCTGAAGAAAGGGCTAAAGCTAAAATGGAAATTAGGAAACGATGCAGTGAATTCCAGGATCGTGCAAAGAATGGAACACTGTTCTGTACCAGAGAAAATGATCC
TATTCGTGGTCTAGATGGAAAAACACATGGCAACTTGTGTTCCATGTGCCAAGCTTTCTTCAAAACAGAAGCTGAAGAAAAGAAGGCTGAAGCTGGAACCAGAAACAGAAGAGGGTCTGAAAAATCAG
AAACATATGCAAAGCTATGTGATGAATTTCGGAAGGTCAGAAAGAATGGACAACTATATTGCACCAGAGAGAATGACCCAGTCAGGGGTCCTGATGGGAAAATCCATGGGAACATATGCTCCATGTGT
CAGTCTTTCTTTATTCAAGAAGACAAAGCAAGAGCAAAGGTTAAAAGAGAAGCTGCAAAGGAAATGTGCAGTGAGTTCCAGGACCAAGCAAAGAATGGAATGCTCATTTGCACCAGAGAAAATGACCC
TGTTGTTGGCCCAGATGGAAAAACACATGCAAACAAGTGTGCAATGTGTGCAAGTGTGTTTCTACTAGAAGAAGAAGAGAAGAAAAATGATGACAAAGGGGAAAGGGAGAAGGCTGAGGCTGGAAAGA
CGAAGAGAGAAGCAGTGCAGAATCTATGTAGTAAATATCGTACCTTGCTAAAAAATGGGCGGCTCCCCTGCACCAAAAAGAATGACCCCATTGAGGGCCTGGATGGGAAGATCTATGCAAGTACCTGC
TCCATGTGTGAGGCCTTCTTCCACCAAGAAGCGAAGAAAAATGAAGCTGGCTTCGGAGCAAAGGCTAAAAGAGAAGTTAAGGTTGATTGCAGTGAATTTCTGACTCTTTTAAGAGGTGGAGAACTCTT
TTGCACACGAGAAAATGACCCTGTGCGTGGCCCAGATGGCAAGACCCATGGCAACAAGTGTGCCATGTGCAAGGCTGTCTTTGAGAAAGAAAATGAAGAAAGGAAGAGGAAAGAAGGGGAAAACCAGA
GAATTGCTGCAGGGCAGAGTTCCGGTGGTGGGAACCAGAAAGCTAAGGATGAATGTGCTCAATATTGGGAAAGCATGAAAAATGGAGAACTTAGCTGTACTCGGGAGAGTGACCCTGTACGTGGTGCT
GATGGGAAACCATACAACAATAAATGTGTCATGTGTAAAGAACTACTGCGGAGAGAAATGGAGGAAAAAAATAAAAATTCTGCCTCAAGGTCAAATGGGACTGAAACAAGAAAGGATGTATGCGACCA
GTTTAGAAACCAAATGAAAAATGGGAAACTCCTGTGCACTCGGGAAAGCGACCCTACCCGGGGTCCAGATGGCAAGACCCATGGCAATAAGTGTGCCATGTGCAAGGAGAGATTGGAAAGAGAAGCTG
CTGAAAAGAAAAAGAAAGAGGATGAAGACAAGAGAAACACAGGAGCAAACAAGAGCAATAAGAAGGATCAGTGTCATGAATTCCGGAGCATGCAGCTAAATGGAAGGCTGATCTGCACCCGAGAAAAT
GATCCCATTCGAGGTCCAGATGGCAAGACACATGTAAACAAGTGTGCCATGTGTCAGATGATGTTTGAGCATGAAGCCAGTGAAAGAAAAATGAGACATGAAGAAAACTCACGCTCCCAGTCCACAAA
TGAGGCAGAGGACAACTGTGGAGAAGTTCATAACACAGCACAGGATGTCAAACCCAGGCAGGCCAGGAGTTCTTTGCCCTCCATACGTGGGATCAGTGAAGATGAGTGCAGCAATTTTCAAAATCTCA
TAAGTAATGGAAAGCTTATCTGTCCAGAAATGGATGATCCATTGCATGGTGCTGATGGAAGCTTTTATCAGAACAAGTGCAACATGTGCAGAGATGTCCTTGAAAAAAAAGCTTTAGAAAGGTCAGGA
TTTCAAGAAAAGTCATCACAAATTAGATCTACTAAAGAAGATGGTCCAGAATTTTCCAGCTCCTCTCTGGACTCTCACATGTGCAAAAACTACCGAATATTACCCAGGGTGGGATATCTTTGCCCAAA
GAATCTAAACCCTGTCTGTGGTGATGATGGCCAAACATATGCCAACCCTTGTATGCTCTGTCATGAAAACTTGATGCGTCAGACTAATACACACATACATAAACAAGGAACATGTGAGGAGAACAGTA
ACCTGGAAGCAGTGTCTGCTGGCACACTTGCCTCTGAAAAAATGATGCAATGATTGGTGAAATCACAGAGAAAAAGCTAAGCTTCGATTCTGAACTGCCTGTCTTTACCAACTGTGTATATAAAGAAT
TCTTCAAACTCATCTTTTTACTATAGACAATAATACAGAGCTGTTGGTACTGGACTCAACTGGTTTTCAGTCTTTCCATCTCTTTCCTTCTAGACTCAGTGATCTGAGGATGTGCAGAAATCTCCACT
CAGTCTATGCTCTGGAAATCTGATCACAATATTGTCTATCCAGCTGCCTGTTTAATAAAAGTAGACACTCAGCAGAACATCCTTCTGGGGATTTGTTTATCACTGCTAGAAAATGGGAATATTTTTTA
ATAGTAGCTGAATATATGGTGCCCTTTGTCTTACGAAACACAGTAGTAGGCAAGTTGTTGCCATCATTGAAGAGGTGGGGCAATATGGGCTCTCAGGCAGCCAATATATGTGTGAAGCTACCTGTTAG
CATATCCCTTAACTAGTGTCTGTATTTCCATAAACATCATACCTCAATTATATAATTGACATAATCTCATATCTAATTATTTACCTATTCATAATTGTTTTTTTTAATTTTTGAGATTATCCCATTGC
TTTCTACATACAATGTGGGAAAAACAAAGGAAATGAATCTACAAATATATGTAAATCTCTAGATTGTCAATCTCTAACATAAATGTTGTATGATATATATATAATTTAAATTTTTAGTTGTTAACAAA
ACAACTAGATAAAAATAATTATAATTATATTATCTAGCCCTATATATCACTCACTAAGTCAACTAATACAACTATTTTATTTAATAAACCTTTGATACTGATGTGTATTTTCCACTATTAGTACCTCT
AGTGTGGACCAGTCATATTTCAAGTGTTCACTGGCCACATGGAGATGGAGGTGGCTATAGTGGATAATGTAGCTATACCATGATACCATGGAATAACAGAGATGGGAAATCTGAGAAGGAATACATGT
ATTGGATAGGGATGACATTAAACCAAACTTGTGGCTTCAGGATCTCTGATGAAACTCTGCTACTCTCAGAGTTTAGTTGCTGGTTTTCTGTGGCGGTTTAGGTACCAGATGCACACCAGAAAGTTCAG
AGAATCTTACATACCTCCAGCCACTCTCAGCTACAGAAAAAACATGTTCAGAGTGAGACTGACCTATCTGGATCTAGGAAGTTATTTTTGTATTTTTTCTCTGCTCTTTTGTTTTTATAAATAAATCT
CCACTAAACTAAA

hide sequence


Protein RefSeqs	NP_001164077	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017522
	ENSRNOP00000017522.6

RefSeq Acc Id:	NP_001164077 ⟸ NM_001170606
- Peptide Label:	precursor
- UniProtKB:	D3ZET2 (UniProtKB/TrEMBL), A6KUC9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKTATVPMLLTLAFYLTQDASSWKGNQDPCMKFRALMKNGTLSCPQGNNSSQSLNDIIFQSECILCKKTLEQETNTKDMVMVRFLSRATRATAPAKLNCENFKQRRKDGDFICPSDASAVCGTDGKTY PSRCHLCAENAKSQSHVEVKSEGECGSSHLETDMCSDFRAYVQDGRLGCTRENDPIRGPDGRTHGNRCAMCAELFLKEAQVNATRDRESRIRRDAEEELCKEFENQVRSGRLFCTRESDPIRGPDGKM HGNKCALCAEIFMKRFTEGKDKAETKQRDAEERAKAKMEIRKRCSEFQDRAKNGTLFCTRENDPIRGLDGKTHGNLCSMCQAFFKTEAEEKKAEAGTRNRRGSEKSETYAKLCDEFRKVRKNGQLYCT RENDPVRGPDGKIHGNICSMCQSFFIQEDKARAKVKREAAKEMCSEFQDQAKNGMLICTRENDPVVGPDGKTHANKCAMCASVFLLEEEEKKNDDKGEREKAEAGKTKREAVQNLCSKYRTLLKNGRL PCTKKNDPIEGLDGKIYASTCSMCEAFFHQEAKKNEAGFGAKAKREVKVDCSEFLTLLRGGELFCTRENDPVRGPDGKTHGNKCAMCKAVFEKENEERKRKEGENQRIAAGQSSGGGNQKAKDECAQY WESMKNGELSCTRESDPVRGADGKPYNNKCVMCKELLRREMEEKNKNSASRSNGTETRKDVCDQFRNQMKNGKLLCTRESDPTRGPDGKTHGNKCAMCKERLEREAAEKKKKEDEDKRNTGANKSNKK DQCHEFRSMQLNGRLICTRENDPIRGPDGKTHVNKCAMCQMMFEHEASERKMRHEENSRSQSTNEAEDNCGEVHNTAQDVKPRQARSSLPSIRGISEDECSNFQNLISNGKLICPEMDDPLHGADGSF YQNKCNMCRDVLEKKALERSGFQEKSSQIRSTKEDGPEFSSSSLDSHMCKNYRILPRVGYLCPKNLNPVCGDDGQTYANPCMLCHENLMRQTNTHIHKQGTCEENSNLEAVSAGTLASEKMMQ hide sequence

Ensembl Acc Id:

ENSRNOP00000070505 ⟸ ENSRNOT00000082670

Ensembl Acc Id:

ENSRNOP00000017522 ⟸ ENSRNOT00000017522

Ensembl Acc Id:

ENSRNOP00000066620 ⟸ ENSRNOT00000073717

Ensembl Acc Id:

ENSRNOP00000068512 ⟸ ENSRNOT00000076941

Protein Domains

Kazal-like

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZET2-F1-model_v2	AlphaFold	D3ZET2	1-1019	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-7671	BioCyc
Ensembl Genes	ENSRNOG00000013116	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000048953	Ensembl
Ensembl Transcript	ENSRNOT00000017522	ENTREZGENE
	ENSRNOT00000017522.9	UniProtKB/TrEMBL
Gene3D-CATH	3.30.60.30	UniProtKB/TrEMBL
InterPro	Kazal-type_SerProtInhib	UniProtKB/TrEMBL
	Kazal_dom_sf	UniProtKB/TrEMBL
	Prot_inh_Kazal	UniProtKB/TrEMBL
KEGG Report	rno:361319	UniProtKB/TrEMBL
NCBI Gene	361319	ENTREZGENE
PANTHER	SERINE PROTEASE INHIBITOR KAZAL-TYPE 7	UniProtKB/TrEMBL
	SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7	UniProtKB/TrEMBL
Pfam	Kazal_1	UniProtKB/TrEMBL
PhenoGen	Spink5	PhenoGen
PROSITE	KAZAL	UniProtKB/TrEMBL
	KAZAL_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013116	RatGTEx
	ENSRNOG00000048953	RatGTEx
SMART	KAZAL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF100895	UniProtKB/TrEMBL
UniProt	A6KUC9	ENTREZGENE, UniProtKB/TrEMBL
	D3ZET2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Spink5	serine peptidase inhibitor, Kazal type 5	LOC100910851	serine protease inhibitor Kazal-type 5-like	Data merged from RGD:6496266	737654	PROVISIONAL
2012-07-05	LOC100910851	serine protease inhibitor Kazal-type 5-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-07	Spink5	serine peptidase inhibitor, Kazal type 5	Spink5_predicted	serine protease inhibitor, Kazal type 5 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Spink5_predicted	serine protease inhibitor, Kazal type 5 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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