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Gene: SPINK5 (serine peptidase inhibitor Kazal type 5) Pan paniscus

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Symbol:

SPINK5

Name:

serine peptidase inhibitor Kazal type 5

RGD ID:

11939731

Description:

ENCODES a protein that exhibits peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN negative regulation of serine-type peptidase activity (ortholog); ASSOCIATED WITH Exfoliative Dermatitis (ortholog); familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); FOUND IN cell cortex (inferred); cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC112439838; serine peptidase inhibitor, Kazal type 5; serine protease inhibitor Kazal-type 5; uncharacterized LOC112439838

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	143,191,450 - 143,382,914 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	141,330,972 - 141,522,438 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	143,387,981 - 143,578,839 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	149,507,003 - 149,587,249 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	149,506,367 - 149,590,930 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SPINK5	Bonobo	Exfoliative Dermatitis		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Erythroderma	ClinVar	PMID:15304086 more ...
SPINK5	Bonobo	familial adenomatous polyposis 1		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Familial adenomatous polyposis 1	ClinVar	PMID:17963004 more ...
SPINK5	Bonobo	genetic disease		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868 and PMID:28492532
SPINK5	Bonobo	Hereditary Neoplastic Syndromes		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome	ClinVar	PMID:17963004 more ...
SPINK5	Bonobo	Netherton syndrome		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10835624 more ...
SPINK5	Bonobo	Neurodevelopmental Disorders		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
SPINK5	Bonobo	otitis media		ISO	SPINK5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Susceptibility to nonsyndromic otitis media	ClinVar	PMID:11511292 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SPINK5	Bonobo	Prostatic Neoplasms		ISO	SPINK5 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:17013881

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SPINK5	Bonobo	Netherton syndrome		ISO	SPINK5 (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SPINK5	Bonobo	epidermal cell differentiation	involved_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	negative regulation of antibacterial peptide production	involved_in	IEA	UniProtKB:Q148R4 and ensembl:ENSMUSP00000066214	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	negative regulation of proteolysis	acts_upstream_of_or_within	IEA	UniProtKB:Q148R4 and ensembl:ENSMUSP00000066214	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	negative regulation of serine-type peptidase activity	acts_upstream_of_or_within	ISO	MGI:3573756	9068941	PMID:20179351	MGI	PMID:20179351
SPINK5	Bonobo	regulation of cell adhesion	acts_upstream_of_or_within	IEA	UniProtKB:Q148R4 and ensembl:ENSMUSP00000066214	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SPINK5	Bonobo	cell cortex	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	cytoplasm	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	cytosol	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	endoplasmic reticulum	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	endoplasmic reticulum membrane	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	epidermal lamellar body	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	extracellular region	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	extracellular region	located_in	IEA	UniProtKB-SubCell:SL-0243	150520179		UniProt	GO_REF:0000044
SPINK5	Bonobo	extracellular region	located_in	IEA	UniProtKB-KW:KW-0964	150520179		UniProt	GO_REF:0000043
SPINK5	Bonobo	intracellular membrane-bounded organelle	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	perinuclear region of cytoplasm	located_in	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
SPINK5	Bonobo	peptidase inhibitor activity	enables	IEA	UniProtKB:Q148R4 and ensembl:ENSMUSP00000066214	150520179		Ensembl	GO_REF:0000107
SPINK5	Bonobo	serine-type endopeptidase inhibitor activity	enables	IEA	UniProtKB:Q9NQ38 and ensembl:ENSP00000256084	150520179		Ensembl	GO_REF:0000107

PMID:22301074

SPINK5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	143,191,450 - 143,382,914 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	141,330,972 - 141,522,438 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	143,387,981 - 143,578,839 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	149,507,003 - 149,587,249 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	149,506,367 - 149,590,930 (+)	Ensembl	panpan1.1		panPan2

SPINK5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	148,063,980 - 148,137,382 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	148,025,683 - 148,137,382 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	147,443,543 - 147,516,945 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	147,423,759 - 147,497,120 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	147,423,758 - 147,497,037	NCBI
Celera	5	143,524,323 - 143,597,562 (+)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI
HuRef	5	142,590,808 - 142,664,035 (+)	NCBI		HuRef
CHM1_1	5	146,875,990 - 146,949,062 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	148,599,687 - 148,673,088 (+)	NCBI		T2T-CHM13v2.0

Spink5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	44,092,612 - 44,155,554 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	44,096,302 - 44,155,568 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	43,959,545 - 44,022,487 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	43,963,235 - 44,022,501 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	44,122,895 - 44,182,141 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	44,088,572 - 44,147,818 (+)	NCBI		MGSCv36	mm8
Celera	18	45,339,414 - 45,398,624 (+)	NCBI		Celera
Cytogenetic Map	18	B3	NCBI
cM Map	18	23.74	NCBI

Spink5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	36,515,347 - 36,584,038 (+)	NCBI		GRCr8
mRatBN7.2	18	36,264,452 - 36,333,143 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	36,264,452 - 36,332,185 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	36,368,467 - 36,437,168 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	37,086,815 - 37,155,518 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	36,463,716 - 36,532,415 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	35,118,300 - 35,190,458 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	35,121,967 - 35,191,069 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	1	229,267,916 - 229,343,584 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	34,787,562 - 34,856,081 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	37,563,911 - 37,631,579 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	37,599,079 - 37,648,851 (+)	NCBI
Cytogenetic Map	18	q11	NCBI

Spink5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955415	6,118,616 - 6,186,632 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPINK5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	42,285,537 - 42,365,637 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	42,285,537 - 42,365,690 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	39,331,980 - 39,411,492 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	42,745,184 - 42,825,339 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	42,723,407 - 42,825,338 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	39,815,140 - 39,895,271 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	40,625,209 - 40,705,273 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	41,448,356 - 41,528,467 (+)	NCBI		UU_Cfam_GSD_1.0

Spink5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	145,079,694 - 145,182,465 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936504	6,653,703 - 6,750,110 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPINK5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	149,309,540 - 149,382,282 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	149,309,482 - 149,382,286 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	155,870,595 - 155,896,727 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPINK5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	50,587,698 - 50,667,219 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	50,592,412 - 50,663,302 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	27,098,281 - 27,174,482 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spink5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	7,489,687 - 7,576,088 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624774	7,469,195 - 7,579,603 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_024928882	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034960742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055112771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000059380 ⟹ ENSPPAP00000036488

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	149,506,367 - 149,590,930 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000059386 ⟹ ENSPPAP00000036494

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	149,506,367 - 149,575,955 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000059394 ⟹ ENSPPAP00000036502

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	149,507,085 - 149,586,878 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000059398 ⟹ ENSPPAP00000036506

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	149,508,317 - 149,583,755 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000059401 ⟹ ENSPPAP00000036509

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	149,509,791 - 149,590,930 (+)	Ensembl

RefSeq Acc Id:

XM_055112771 ⟹ XP_054968746

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	4	143,191,450 - 143,382,914 (+)	NCBI
NHGRI_mPanPan1	5	141,330,972 - 141,522,438 (+)	NCBI


Protein RefSeqs	XP_054968746	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000036488.1
	ENSPPAP00000036494.1
	ENSPPAP00000036502.1
	ENSPPAP00000036506.1
	ENSPPAP00000036509.1

Ensembl Acc Id:

ENSPPAP00000036494 ⟸ ENSPPAT00000059386

Ensembl Acc Id:

ENSPPAP00000036488 ⟸ ENSPPAT00000059380

Ensembl Acc Id:

ENSPPAP00000036506 ⟸ ENSPPAT00000059398

Ensembl Acc Id:

ENSPPAP00000036502 ⟸ ENSPPAT00000059394

Ensembl Acc Id:

ENSPPAP00000036509 ⟸ ENSPPAT00000059401

Protein Domains

Kazal-like

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000040944	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000059380.1	UniProtKB/TrEMBL
	ENSPPAT00000059386.1	UniProtKB/TrEMBL
	ENSPPAT00000059394.1	UniProtKB/TrEMBL
	ENSPPAT00000059398.1	UniProtKB/TrEMBL
	ENSPPAT00000059401.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.60.30	UniProtKB/TrEMBL
InterPro	Kazal-type_SerProtInhib	UniProtKB/TrEMBL
	Kazal_dom	UniProtKB/TrEMBL
	Kazal_dom_sf	UniProtKB/TrEMBL
NCBI Gene	SPINK5	ENTREZGENE
PANTHER	SERINE PROTEASE INHIBITOR KAZAL-TYPE 7	UniProtKB/TrEMBL
	SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7	UniProtKB/TrEMBL
Pfam	Kazal_1	UniProtKB/TrEMBL
PROSITE	KAZAL_1	UniProtKB/TrEMBL
	KAZAL_2	UniProtKB/TrEMBL
SMART	KAZAL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF100895	UniProtKB/TrEMBL
UniProt	A0A2R9C3F8_PANPA	UniProtKB/TrEMBL
	A0A2R9C3Z1_PANPA	UniProtKB/TrEMBL
	A0A2R9C402_PANPA	UniProtKB/TrEMBL
	A0A2R9C6G8_PANPA	UniProtKB/TrEMBL
	A0A2R9CDW6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-06-11	SPINK5	serine peptidase inhibitor Kazal type 5	LOC112439838	uncharacterized LOC112439838	Data merged from RGD:13581950	737654	PROVISIONAL
2019-10-08	SPINK5	serine peptidase inhibitor Kazal type 5	SPINK5	serine peptidase inhibitor, Kazal type 5	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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