SPINK5 (serine peptidase inhibitor Kazal type 5) - Rat Genome Database

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Gene: SPINK5 (serine peptidase inhibitor Kazal type 5) Pan paniscus
Analyze
Symbol: SPINK5
Name: serine peptidase inhibitor Kazal type 5
RGD ID: 11939731
Description: ENCODES a protein that exhibits peptidase inhibitor activity (inferred); serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN negative regulation of proteolysis (ortholog); negative regulation of serine-type peptidase activity (ortholog); regulation of cell adhesion (ortholog); ASSOCIATED WITH Exfoliative Dermatitis (ortholog); familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); FOUND IN cell cortex (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC112439838; serine peptidase inhibitor, Kazal type 5; serine protease inhibitor Kazal-type 5; uncharacterized LOC112439838
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24143,191,450 - 143,382,914 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15141,330,972 - 141,522,438 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05143,387,981 - 143,578,839 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15149,507,003 - 149,587,249 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5149,506,367 - 149,590,930 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
SPINK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24143,191,450 - 143,382,914 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15141,330,972 - 141,522,438 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05143,387,981 - 143,578,839 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15149,507,003 - 149,587,249 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5149,506,367 - 149,590,930 (+)Ensemblpanpan1.1panPan2
SPINK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385148,063,980 - 148,137,382 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5148,025,683 - 148,137,382 (+)EnsemblGRCh38hg38GRCh38
GRCh375147,443,543 - 147,516,945 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365147,423,759 - 147,497,120 (+)NCBINCBI36Build 36hg18NCBI36
Build 345147,423,758 - 147,497,037NCBI
Celera5143,524,323 - 143,597,562 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5142,590,808 - 142,664,035 (+)NCBIHuRef
CHM1_15146,875,990 - 146,949,062 (+)NCBICHM1_1
T2T-CHM13v2.05148,599,687 - 148,673,088 (+)NCBIT2T-CHM13v2.0
Spink5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391844,092,612 - 44,155,554 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1844,096,302 - 44,155,568 (+)EnsemblGRCm39 Ensembl
GRCm381843,959,545 - 44,022,487 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1843,963,235 - 44,022,501 (+)EnsemblGRCm38mm10GRCm38
MGSCv371844,122,895 - 44,182,141 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361844,088,572 - 44,147,818 (+)NCBIMGSCv36mm8
Celera1845,339,414 - 45,398,624 (+)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.74NCBI
Spink5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,515,347 - 36,584,038 (+)NCBIGRCr8
mRatBN7.21836,264,452 - 36,333,143 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1836,264,452 - 36,332,185 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1836,368,467 - 36,437,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01837,086,815 - 37,155,518 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,463,716 - 36,532,415 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01835,118,300 - 35,190,458 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1835,121,967 - 35,191,069 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1229,267,916 - 229,343,584 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01834,787,562 - 34,856,081 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,563,911 - 37,631,579 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11837,599,079 - 37,648,851 (+)NCBI
Cytogenetic Map18q11NCBI
Spink5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554156,118,616 - 6,186,632 (-)NCBIChiLan1.0ChiLan1.0
SPINK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,285,537 - 42,365,637 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,285,537 - 42,365,690 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,331,980 - 39,411,492 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,745,184 - 42,825,339 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,723,407 - 42,825,338 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,815,140 - 39,895,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,625,209 - 40,705,273 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0241,448,356 - 41,528,467 (+)NCBIUU_Cfam_GSD_1.0
Spink5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213145,079,694 - 145,182,465 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365046,653,703 - 6,750,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2149,309,540 - 149,382,282 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12149,309,482 - 149,382,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22155,870,595 - 155,896,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12350,587,698 - 50,667,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2350,592,412 - 50,663,302 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603427,098,281 - 27,174,482 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spink5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247747,489,687 - 7,576,088 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247747,469,195 - 7,579,603 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000059380   ⟹   ENSPPAP00000036488
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5149,506,367 - 149,590,930 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000059386   ⟹   ENSPPAP00000036494
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5149,506,367 - 149,575,955 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000059394   ⟹   ENSPPAP00000036502
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5149,507,085 - 149,586,878 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000059398   ⟹   ENSPPAP00000036506
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5149,508,317 - 149,583,755 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000059401   ⟹   ENSPPAP00000036509
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5149,509,791 - 149,590,930 (+)Ensembl
RefSeq Acc Id: XM_055112771   ⟹   XP_054968746
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24143,191,450 - 143,382,914 (+)NCBI
NHGRI_mPanPan15141,330,972 - 141,522,438 (+)NCBI
Protein Sequences
Protein RefSeqs XP_054968746 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000036488.1
  ENSPPAP00000036494.1
  ENSPPAP00000036502.1
  ENSPPAP00000036506.1
  ENSPPAP00000036509.1
Ensembl Acc Id: ENSPPAP00000036494   ⟸   ENSPPAT00000059386
Ensembl Acc Id: ENSPPAP00000036488   ⟸   ENSPPAT00000059380
Ensembl Acc Id: ENSPPAP00000036506   ⟸   ENSPPAT00000059398
Ensembl Acc Id: ENSPPAP00000036502   ⟸   ENSPPAT00000059394
Ensembl Acc Id: ENSPPAP00000036509   ⟸   ENSPPAT00000059401
RefSeq Acc Id: XP_054968746   ⟸   XM_055112771
- UniProtKB: A0A2R9CDW6 (UniProtKB/TrEMBL)
Protein Domains
Kazal-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040944 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059380.1 UniProtKB/TrEMBL
  ENSPPAT00000059386.1 UniProtKB/TrEMBL
  ENSPPAT00000059394.1 UniProtKB/TrEMBL
  ENSPPAT00000059398.1 UniProtKB/TrEMBL
  ENSPPAT00000059401.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/TrEMBL
InterPro Kazal-type_SerProtInhib UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
NCBI Gene SPINK5 ENTREZGENE
PANTHER SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7 UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 9 UniProtKB/TrEMBL
Pfam Kazal_1 UniProtKB/TrEMBL
PROSITE KAZAL_1 UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
SMART KAZAL UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
UniProt A0A2R9C3F8_PANPA UniProtKB/TrEMBL
  A0A2R9C3Z1_PANPA UniProtKB/TrEMBL
  A0A2R9C402_PANPA UniProtKB/TrEMBL
  A0A2R9C6G8_PANPA UniProtKB/TrEMBL
  A0A2R9CDW6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 SPINK5  serine peptidase inhibitor Kazal type 5  LOC112439838  uncharacterized LOC112439838  Data merged from RGD:13581950 737654 PROVISIONAL
2019-10-08 SPINK5  serine peptidase inhibitor Kazal type 5  SPINK5  serine peptidase inhibitor, Kazal type 5  Symbol and/or name change 5135510 APPROVED