Serpinf1 (serpin family F member 1) - Rat Genome Database

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Gene: Serpinf1 (serpin family F member 1) Chinchilla lanigera
Analyze
Symbol: Serpinf1
Name: serpin family F member 1
RGD ID: 8729020
Description: INVOLVED IN cellular response to cobalt ion (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to glucose stimulus (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Albuminuria (ortholog); alcoholic liver cirrhosis (ortholog); FOUND IN axon (ortholog); axon hillock (ortholog); basement membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pigment epithelium-derived factor; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,414,930 - 1,426,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,414,930 - 1,426,436 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenoid cystic carcinoma  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anogenital venereal wart  (ISO)
Arterial Thrombosis  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
Carotid Artery Injuries  (ISO)
central retinal vein occlusion  (ISO)
Choroidal Neovascularization  (ISO)
chronic fatigue syndrome  (ISO)
colorectal cancer  (ISO)
corneal neovascularization  (ISO)
corneal ulcer  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Endotoxin-Induced Uveitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
hepatosplenic schistosomiasis  (ISO)
Hirschsprung's disease  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Keloid  (ISO)
kidney failure  (ISO)
leukostasis  (ISO)
lung non-small cell carcinoma  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
melioidosis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
middle cerebral artery infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephroblastoma  (ISO)
obesity  (ISO)
Olfaction Disorders  (ISO)
Osteoarthritis, Experimental  (ISO)
osteogenesis imperfecta  (ISO)
osteogenesis imperfecta type 3  (ISO)
osteogenesis imperfecta type 6  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Parkinson's disease  (ISO)
Peripheral Nerve Injuries  (ISO)
portal hypertension  (ISO)
proliferative diabetic retinopathy  (ISO)
Prostatic Neoplasms  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (ISO)
retinal vein occlusion  (ISO)
retinitis pigmentosa  (ISO)
retinoblastoma  (ISO)
retinopathy of prematurity  (ISO)
Salivary Gland Neoplasms  (ISO)
sciatic neuropathy  (ISO)
Septic Peritonitis  (ISO)
Sickle Cell Retinopathy  (ISO)
Staphylococcal Skin Infections  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveal melanoma  (ISO)
uveitis  (ISO)
venous tributary occlusion of retina  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Serpinf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,414,930 - 1,426,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,414,930 - 1,426,436 (-)NCBIChiLan1.0ChiLan1.0
SERPINF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,762,060 - 1,777,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,762,029 - 1,777,565 (+)EnsemblGRCh38hg38GRCh38
GRCh37171,665,354 - 1,680,859 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,612,009 - 1,627,618 (+)NCBINCBI36Build 36hg18NCBI36
Build 34171,612,008 - 1,627,618NCBI
Celera171,681,796 - 1,697,412 (+)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,562,622 - 1,578,251 (+)NCBIHuRef
CHM1_1171,673,331 - 1,688,930 (+)NCBICHM1_1
T2T-CHM13v2.0171,650,754 - 1,666,265 (+)NCBIT2T-CHM13v2.0
Serpinf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,300,855 - 75,313,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,300,595 - 75,313,527 (-)EnsemblGRCm39 Ensembl
GRCm381175,410,029 - 75,422,623 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,409,769 - 75,422,701 (-)EnsemblGRCm38mm10GRCm38
MGSCv371175,223,531 - 75,236,125 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,225,964 - 75,238,707 (-)NCBIMGSCv36mm8
Celera1182,918,458 - 82,931,037 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.87NCBI
Serpinf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,748,504 - 60,760,898 (-)NCBIGRCr8
mRatBN7.21060,250,198 - 60,262,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,249,708 - 60,262,646 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1064,896,641 - 64,909,534 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,402,235 - 64,415,134 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01059,864,629 - 59,877,513 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,241,750 - 62,254,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,241,756 - 62,254,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01061,954,919 - 61,969,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,713,441 - 62,739,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,727,065 - 62,753,067 (-)NCBI
Celera1059,279,849 - 59,291,539 (-)NCBICelera
Cytogenetic Map10q24NCBI
SERPINF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,333,350 - 9,349,052 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,299,810 - 11,315,648 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,745,597 - 1,761,399 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,638,479 - 1,653,568 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,638,556 - 1,653,568 (+)Ensemblpanpan1.1panPan2
SERPINF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,891,368 - 45,902,768 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,891,410 - 45,902,765 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha945,042,116 - 45,052,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,718,522 - 46,730,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,718,590 - 46,730,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,488,488 - 45,499,827 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,782,914 - 45,794,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,837,469 - 45,848,807 (+)NCBIUU_Cfam_GSD_1.0
Serpinf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560245,008,093 - 45,020,363 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,885,475 - 7,899,113 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365387,885,816 - 7,898,308 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,948,510 - 47,959,470 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,949,004 - 47,959,471 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SERPINF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,408,453 - 1,424,197 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605920,549,218 - 20,565,247 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpinf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,486,978 - 4,497,585 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,487,005 - 4,497,706 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000006268   ⟹   ENSCLAP00000006165
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554811,414,930 - 1,426,241 (-)Ensembl
RefSeq Acc Id: XM_005402604   ⟹   XP_005402661
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554811,414,930 - 1,426,436 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005402605   ⟹   XP_005402662
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554811,414,930 - 1,426,241 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005402661 (Get FASTA)   NCBI Sequence Viewer  
  XP_005402662 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000006165
  ENSCLAP00000006165.1
RefSeq Acc Id: XP_005402661   ⟸   XM_005402604
- UniProtKB: A0A8C2UVY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005402662   ⟸   XM_005402605
- UniProtKB: A0A8C2UVY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000006165   ⟸   ENSCLAT00000006268
Protein Domains
SERPIN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004364 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000006268 ENTREZGENE
  ENSCLAT00000006268.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro PEDF_serpin_dom UniProtKB/TrEMBL
  Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene Serpinf1 ENTREZGENE
PANTHER PIGMENT EPITHELIUM-DERIVED FACTOR UniProtKB/TrEMBL
  PTHR11461 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A8C2UVY0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Serpinf1  serpin family F member 1    serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1  Symbol and/or name change 5135510 APPROVED