RGD Reference Report - Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor. - Rat Genome Database

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Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor.

Authors: Zhang, SX  Wang, JJ  Gao, G  Shao, C  Mott, R  Ma, JX 
Citation: Zhang SX, etal., FASEB J. 2006 Feb;20(2):323-5. Epub 2005 Dec 20.
RGD ID: 1580133
Pubmed: PMID:16368716   (View Abstract at PubMed)
DOI: DOI:10.1096/fj.05-4313fje   (Journal Full-text)

Pigment epithelium-derived factor (PEDF) is a potent angiogenic inhibitor. Reduced PEDF levels are associated with diabetic retinopathy. However, the mechanism for the protective effects of PEDF against diabetic retinopathy (DR) is presently unclear. As inflammation plays a role in DR, the present study determined the effect of PEDF on inflammation. Western blot analysis and ELISA demonstrated that retinal and plasma PEDF levels were drastically decreased in rats with endotoxin-induced uveitis (EIU), which suggests that PEDF is a negative acute-phase protein. Intravitreal injection of PEDF significantly reduced vascular hyper-permeability in rat models of diabetes and oxygen-induced retinopathy, correlating with the decreased levels of retinal inflammatory factors, including VEGF, VEGF receptor-2, MCP-1, TNF-alpha, and ICAM-1. In cultured retinal capillary endothelial cells, PEDF significantly decreased TNF-alpha and ICAM-1 expression under hypoxia. Moreover, down-regulation of PEDF expression by siRNA resulted in significantly increases of VEGF and TNF-alpha secretion in retinal Muller cells. These findings suggest that PEDF is a novel endogenous anti-inflammatory factor in the eye. The decrease of ocular PEDF levels may contribute to inflammation and vascular leakage in DR.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Endotoxin-Induced Uveitis  ISOSerpinf1 (Rattus norvegicus)1580133; 1580133protein:decreased expression:retina and plasma (rat)RGD 
Endotoxin-Induced Uveitis  IEP 1580133protein:decreased expression:retina and plasma (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpinf1  (serpin family F member 1)

Genes (Mus musculus)
Serpinf1  (serine (or cysteine) peptidase inhibitor, clade F, member 1)

Genes (Homo sapiens)
SERPINF1  (serpin family F member 1)


Additional Information