RGD Reference Report - Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients. - Rat Genome Database

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Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients.

Authors: Jenkins, A  Zhang, SX  Gosmanova, A  Aston, C  Dashti, A  Baker, MZ  Lyons, T  Ma, JX 
Citation: Jenkins A, etal., Diabetes Res Clin Pract. 2008 Oct;82(1):e5-7. Epub 2008 Aug 19.
RGD ID: 2312340
Pubmed: PMID:18715664   (View Abstract at PubMed)
PMCID: PMC2597065   (View Article at PubMed Central)
DOI: DOI:10.1016/j.diabres.2008.06.019   (Journal Full-text)

Serum PEDF levels (mean (S.D.)) were increased in 96 Type 2 diabetic vs. 54 non-diabetic subjects; 5.3 (2.8) vs. 3.2 (2.0)mug/ml, p<0.001. In diabetes, PEDF correlated with BMI, serum creatinine and LDL-cholesterol, but not with other lipids, HbA1c or CRP. PEDF did not differ by drugs, complications, or gender.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  IEP 2312340protein:increased expression:serumRGD 
type 2 diabetes mellitus  ISOSERPINF1 (Homo sapiens)2312340; 2312340protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpinf1  (serpin family F member 1)

Genes (Mus musculus)
Serpinf1  (serine (or cysteine) peptidase inhibitor, clade F, member 1)

Genes (Homo sapiens)
SERPINF1  (serpin family F member 1)


Additional Information