RGD Reference Report - Proteases and protease inhibitors in taurocholate-induced acute pancreatitis in rats. - Rat Genome Database

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Proteases and protease inhibitors in taurocholate-induced acute pancreatitis in rats.

Authors: Kruse, P  Hage, E  Lasson, A 
Citation: Kruse P, etal., Int J Pancreatol. 1999 Apr;25(2):113-21.
RGD ID: 8661651
Pubmed: PMID:10360224   (View Abstract at PubMed)
DOI: DOI:10.1385/IJGC:25:2:113   (Journal Full-text)

CONCLUSION: Taurocholate-induced acute pancreatitis (AP) in the rat mimics early necrotizing human pancreatitis. Protease activation and protease inhibitor consumption occur consistent with a two-stage development, and contact-phase activation is a possible primary event in this model. BACKGROUND: Proteases and protease inhibitors have been indicated to play an important role in both human and experimental acute pancreatitis, although little is known about them in rats. METHODS: Three percent sodium taurocholate was infused into the bilio-pancreatic duct to induce AP, and over 0-72 h we measured lipase, amylase, albumin, prekallikrein, factor X, alpha-1-macroglobulin, alpha-2-antiplasmin, antithrombin III, alpha-1-protease inhibitor, and C1-esterase inhibitor (all in plasma) and histologic and macroscopic findings. RESULTS: A severe necrotizing, nonlethal, AP was induced with an early increase in plasma lipase and alpha-amylase activity levels and peritoneal exudate followed by a return to near control levels after 72 h. Histologic score and pancreatic wet weight ratio increased initially and remained high during the observation period. The protease inhibitors C1-esterase inhibitor, alpha-2-antiplasmin, and antithrombin III decreased early, within 0-6 h, whereafter levels normalized. The protease inhibitors alpha-1-macroglobulin and alpha-1-protease inhibitor later gradually decreased over the 72 h.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acute necrotizing pancreatitis  ISOSerping1 (Rattus norvegicus)8661651; 8661651protein:decreased expression:plasmaRGD 
acute necrotizing pancreatitis  IEP 8661651protein:decreased expression:plasmaRGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
sodium taurocholate  ISOSerpinf1 (Rattus norvegicus)8661651; 8661651taurocholate decreased activity of Serpinf1 protein in plasmaRGD 
sodium taurocholate  EXP 8661651taurocholate decreased activity of Serpinf1 protein in plasmaRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to organic cyclic compound  IDA 8661651taurocholateRGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpinf1  (serpin family F member 1)
Serping1  (serpin family G member 1)

Genes (Mus musculus)
Serpinf1  (serine (or cysteine) peptidase inhibitor, clade F, member 1)
Serping1  (serine (or cysteine) peptidase inhibitor, clade G, member 1)

Genes (Homo sapiens)
SERPINF1  (serpin family F member 1)
SERPING1  (serpin family G member 1)


Additional Information