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Gene: CYP27B1 (cytochrome P450 family 27 subfamily B member 1) Homo sapiens
Symbol: CYP27B1
Name: cytochrome P450 family 27 subfamily B member 1
RGD ID: 69201
Description: Exhibits calcidiol 1-monooxygenase activity and secalciferol 1-monooxygenase activity. Involved in several processes, including decidualization; positive regulation of vitamin D receptor signaling pathway; and regulation of monooxygenase activity. Localizes to cytoplasm. Implicated in hepatitis B; obesity; rickets; and type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1alpha(OH)ase; 25 hydroxyvitamin D3-1-alpha hydroxylase; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 25-OHD-1 alpha-hydroxylase; calcidiol 1-monooxygenase; CP2B; CYP1; CYP1alpha; CYP27B; cytochrome p450 27B1; cytochrome P450 subfamily XXVIIB polypeptide 1; cytochrome P450, family 27, subfamily B, polypeptide 1; cytochrome P450C1 alpha; cytochrome P450VD1-alpha; P450c1; PDDR; VD3 1A hydroxylase; VDD1; VDDR; VDDRI; VDR
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1257,762,334 - 57,768,986 (-)EnsemblGRCh38hg38GRCh38
GRCh381257,762,334 - 57,767,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371258,156,117 - 58,160,976 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,442,384 - 56,447,243 (-)NCBINCBI36hg18NCBI36
Build 341256,442,385 - 56,447,151NCBI
Celera1257,813,712 - 57,818,571 (-)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1255,192,956 - 55,197,815 (-)NCBIHuRef
CHM1_11258,123,921 - 58,128,780 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYP27B1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69201
Created: 2001-11-13
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.