CYP27B1 (cytochrome P450 family 27 subfamily B member 1) - Rat Genome Database

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Gene: CYP27B1 (cytochrome P450 family 27 subfamily B member 1) Sus scrofa
Analyze
Symbol: CYP27B1
Name: cytochrome P450 family 27 subfamily B member 1
RGD ID: 13959276
Description: ENCODES a protein that exhibits calcidiol 1-monooxygenase activity (ortholog); INVOLVED IN aging (ortholog); calcium ion transport (ortholog); lactation (ortholog); ASSOCIATED WITH vitamin D-dependent rickets type 1A; Acidoses (ortholog); acute kidney failure (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 25-hydroxyvitamin D3 1alpha-hydroxylase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl523,050,114 - 23,058,470 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,053,129 - 23,058,865 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
membrane  (IEA)
mitochondrion  (IBA,ISO)

References
Additional References at PubMed
PMID:10232681   PMID:19261615  


Genomics

Comparative Map Data
CYP27B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl523,050,114 - 23,058,470 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,053,129 - 23,058,865 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP27B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,762,334 - 57,767,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1257,762,334 - 57,768,986 (-)EnsemblGRCh38hg38GRCh38
GRCh371258,156,117 - 58,160,861 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,442,384 - 56,447,243 (-)NCBINCBI36hg18NCBI36
Build 341256,442,385 - 56,447,151NCBI
Celera1257,813,712 - 57,818,571 (-)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1255,192,956 - 55,197,815 (-)NCBIHuRef
CHM1_11258,123,921 - 58,128,780 (-)NCBICHM1_1
T2T-CHM13v2.01257,730,683 - 57,735,427 (-)NCBI
Cyp27b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910126,884,115 - 126,891,897 (+)NCBIGRCm39mm39
GRCm39 Ensembl10126,884,119 - 126,888,875 (+)Ensembl
GRCm3810127,048,246 - 127,054,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,048,250 - 127,053,006 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,485,302 - 126,490,062 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,451,200 - 126,455,955 (+)NCBImm8
Celera10129,440,145 - 129,444,905 (+)NCBICelera
Cytogenetic Map10D3NCBI
Cyp27b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2762,869,340 - 62,876,242 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl762,871,297 - 62,876,241 (+)Ensembl
Rnor_6.0770,333,150 - 70,340,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,335,061 - 70,340,005 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,512,763 - 70,517,707 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera760,014,507 - 60,019,451 (+)NCBICelera
Cytogenetic Map7q22NCBI
LOC102011841
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,472,404 - 5,477,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,472,404 - 5,477,001 (-)NCBIChiLan1.0ChiLan1.0
CYP27B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11231,419,773 - 31,424,822 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,419,773 - 31,424,822 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,158,814 - 31,164,462 (+)NCBIMhudiblu_PPA_v0panPan3
CYP27B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,825,224 - 1,830,845 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,826,046 - 1,829,911 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,888,246 - 1,893,920 (-)NCBI
ROS_Cfam_1.0101,834,457 - 1,840,136 (-)NCBI
ROS_Cfam_1.0 Ensembl101,834,464 - 1,839,154 (-)Ensembl
UMICH_Zoey_3.1101,812,161 - 1,817,832 (-)NCBI
UNSW_CanFamBas_1.0102,054,207 - 2,059,882 (-)NCBI
UU_Cfam_GSD_1.0102,179,134 - 2,184,808 (-)NCBI
LOC101978323
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494556,964,979 - 56,970,660 (+)NCBI
SpeTri2.0NW_0049366461,899,686 - 1,904,104 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP27B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,675,704 - 53,681,372 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,675,226 - 53,680,443 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037192,280,050 - 192,285,176 (+)NCBIVero_WHO_p1.0
LOC101700851
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,176,919 - 10,181,657 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462480210,176,865 - 10,181,725 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 6 2 3 5 2 23 2 2 2
Below cutoff 4 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000029435   ⟹   ENSSSCP00000022818
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl523,054,640 - 23,058,470 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000058007   ⟹   ENSSSCP00000044929
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl523,050,114 - 23,058,470 (-)Ensembl
RefSeq Acc Id: NM_213995   ⟹   NP_999160
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1523,053,891 - 23,058,470 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021091124   ⟹   XP_020946783
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1523,053,129 - 23,058,865 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999160 (Get FASTA)   NCBI Sequence Viewer  
  XP_020946783 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABC02209 (Get FASTA)   NCBI Sequence Viewer  
  BAA76605 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020946783   ⟸   XM_021091124
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999160   ⟸   NM_213995
- UniProtKB: Q9XS57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000022818   ⟸   ENSSSCT00000029435
RefSeq Acc Id: ENSSSCP00000044929   ⟸   ENSSSCT00000058007


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000028637 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00025021834 UniProtKB/TrEMBL
  ENSSSCG00035007718 UniProtKB/TrEMBL
  ENSSSCG00050000780 UniProtKB/TrEMBL
  ENSSSCG00055018265 UniProtKB/TrEMBL
  ENSSSCG00060006183 UniProtKB/TrEMBL
  ENSSSCG00065004071 UniProtKB/TrEMBL
  ENSSSCG00070028936 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000022818 UniProtKB/TrEMBL
  ENSSSCP00000044929 UniProtKB/TrEMBL
  ENSSSCP00025012656 UniProtKB/TrEMBL
  ENSSSCP00035003234 UniProtKB/TrEMBL
  ENSSSCP00050000181 UniProtKB/TrEMBL
  ENSSSCP00055028404 UniProtKB/TrEMBL
  ENSSSCP00060002830 UniProtKB/TrEMBL
  ENSSSCP00065002486 UniProtKB/TrEMBL
  ENSSSCP00070049335 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000029435 UniProtKB/TrEMBL
  ENSSSCT00000058007 UniProtKB/TrEMBL
  ENSSSCT00025029749 UniProtKB/TrEMBL
  ENSSSCT00035009602 UniProtKB/TrEMBL
  ENSSSCT00050000874 UniProtKB/TrEMBL
  ENSSSCT00055035762 UniProtKB/TrEMBL
  ENSSSCT00060007852 UniProtKB/TrEMBL
  ENSSSCT00065005595 UniProtKB/TrEMBL
  ENSSSCT00070058020 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report ssc:397055 UniProtKB/TrEMBL
NCBI Gene CYP27B1 ENTREZGENE
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A287ALY9_PIG UniProtKB/TrEMBL
  A0A4X1W5C0_PIG UniProtKB/TrEMBL
  A0A8D0R998_PIG UniProtKB/TrEMBL
  I3LFH6_PIG UniProtKB/TrEMBL
  Q9XS57 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:103376 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-21 CYP27B1  cytochrome P450 family 27 subfamily B member 1  CYP27B1  25-hydroxyvitamin D3 1alpha-hydroxylase  Symbol and/or name change 19259463 PROVISIONAL