CYP27B1 (cytochrome P450 family 27 subfamily B member 1) - Rat Genome Database

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Gene: CYP27B1 (cytochrome P450 family 27 subfamily B member 1) Pan paniscus
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Symbol: CYP27B1
Name: cytochrome P450 family 27 subfamily B member 1
RGD ID: 11890035
Description: ENCODES a protein that exhibits calcidiol 1-monooxygenase activity (ortholog); INVOLVED IN calcium ion transport (ortholog); lactation (ortholog); negative regulation of bone trabecula formation (ortholog); ASSOCIATED WITH Acidoses (ortholog); acute kidney failure (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (inferred); mitochondrial inner membrane (inferred); mitochondrial membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; LOC100974264
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,572,617 - 36,578,661 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,569,388 - 36,575,667 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,158,814 - 31,164,462 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,419,773 - 31,424,822 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,419,773 - 31,424,822 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CYP27B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,572,617 - 36,578,661 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,569,388 - 36,575,667 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,158,814 - 31,164,462 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,419,773 - 31,424,822 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,419,773 - 31,424,822 (+)Ensemblpanpan1.1panPan2
CYP27B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,762,334 - 57,767,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,762,334 - 57,768,986 (-)EnsemblGRCh38hg38GRCh38
GRCh371258,156,117 - 58,160,861 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,442,384 - 56,447,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 341256,442,385 - 56,447,151NCBI
Celera1257,813,712 - 57,818,571 (-)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1255,192,956 - 55,197,815 (-)NCBIHuRef
CHM1_11258,123,921 - 58,128,780 (-)NCBICHM1_1
T2T-CHM13v2.01257,730,683 - 57,735,427 (-)NCBIT2T-CHM13v2.0
Cyp27b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910126,884,115 - 126,891,897 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10126,884,119 - 126,888,875 (+)EnsemblGRCm39 Ensembl
GRCm3810127,048,246 - 127,054,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,048,250 - 127,053,006 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,485,302 - 126,490,062 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,451,200 - 126,455,955 (+)NCBIMGSCv36mm8
Celera10129,440,145 - 129,444,905 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Cyp27b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8764,756,626 - 64,761,570 (+)NCBIGRCr8
mRatBN7.2762,869,340 - 62,876,242 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl762,871,297 - 62,876,241 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,760,608 - 64,765,551 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0766,963,010 - 66,967,953 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,764,060 - 66,769,003 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,333,150 - 70,340,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,335,061 - 70,340,005 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,512,763 - 70,517,707 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera760,014,507 - 60,019,451 (+)NCBICelera
Cytogenetic Map7q22NCBI
LOC102011841
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,472,404 - 5,477,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,472,404 - 5,477,001 (-)NCBIChiLan1.0ChiLan1.0
CYP27B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,825,224 - 1,830,845 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,826,046 - 1,829,911 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,888,246 - 1,893,920 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,834,457 - 1,840,136 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,834,464 - 1,839,154 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,812,161 - 1,817,832 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0102,054,207 - 2,059,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0102,179,134 - 2,184,808 (-)NCBIUU_Cfam_GSD_1.0
LOC101978323
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494556,964,979 - 56,970,660 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,900,259 - 1,904,104 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,899,686 - 1,904,104 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP27B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl523,053,892 - 23,058,470 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,053,129 - 23,058,865 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP27B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,675,704 - 53,681,372 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,675,226 - 53,680,443 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,280,050 - 192,285,176 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101700851
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,176,919 - 10,181,657 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,176,865 - 10,181,725 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003824832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000038485   ⟹   ENSPPAP00000015794
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1231,419,773 - 31,424,822 (+)Ensembl
RefSeq Acc Id: XM_003824832   ⟹   XP_003824880
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21036,572,617 - 36,578,661 (+)NCBI
NHGRI_mPanPan11236,569,388 - 36,575,667 (+)NCBI
Mhudiblu_PPA_v01231,158,814 - 31,164,462 (+)NCBI
PanPan1.11231,419,773 - 31,424,822 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003824880 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000015794.1
RefSeq Acc Id: XP_003824880   ⟸   XM_003824832
- Sequence:
Ensembl Acc Id: ENSPPAP00000015794   ⟸   ENSPPAT00000038485


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031025 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000038485.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro CYP11_CYP27_families UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report pps:100974264 UniProtKB/TrEMBL
NCBI Gene LOC100974264 ENTREZGENE
PANTHER CYTOCHROME P450 FAMILY 27 SUBFAMILY A MEMBER 1 UniProtKB/TrEMBL
  PTHR24279 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A2R9ALD4_PANPA UniProtKB/TrEMBL
VGNC ID VGNC:83030 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-25 CYP27B1  cytochrome P450 family 27 subfamily B member 1  LOC100974264  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial  Symbol and/or name change 5135510 APPROVED