Dlx5 (distal-less homeobox 5) - Rat Genome Database

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Gene: Dlx5 (distal-less homeobox 5) Rattus norvegicus
Analyze
Symbol: Dlx5
Name: distal-less homeobox 5
RGD ID: 2506
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to zinc ion starvation and positive regulation of osteoblast differentiation. Predicted to be located in chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 and split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Distal-less homeobox; DLX-3; homeobox protein DLX-3; homeobox protein DLX-5; RDLX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8435,965,579 - 35,969,973 (-)NCBIGRCr8
mRatBN7.2434,999,139 - 35,003,504 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl434,999,139 - 35,003,407 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx439,958,038 - 39,962,304 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0435,884,208 - 35,888,474 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0434,304,193 - 34,308,455 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0432,387,741 - 32,392,085 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl432,387,741 - 32,392,007 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0432,255,323 - 32,259,589 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4431,778,500 - 31,782,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1431,897,039 - 31,901,307 (-)NCBI
Celera430,515,648 - 30,519,914 (-)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
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Qualifier
Evidence
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Original Reference(s)
Dlx5Ratgenetic disease  ISODLX5 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
Dlx5Ratpleomorphic xanthoastrocytoma  ISODLX5 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
Dlx5Ratsplit hand-foot malformation 1  ISODLX5 (Homo sapiens)8554872ClinVar Annotator: match by term: Split hand-foot malformation 1ClinVarPMID:24496061 more ...
Dlx5Ratsplit hand-foot malformation 1 with sensorineural hearing loss  ISODLX5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22121204 more ...
Object Symbol
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Original Reference(s)
Dlx5RatBirth Weight  ISODLX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31082282
Dlx5Ratbone development disease  ISODLX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10433909
Dlx5RatCraniofacial Abnormalities  ISODLX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10433909 more ...
Dlx5Ratsplit hand-foot malformation  ISODLX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Dlx5Ratsplit hand-foot malformation 1 with sensorineural hearing loss  ISODLX5 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
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Original Reference(s)
Dlx5Ratsplit hand-foot malformation 1  ISSDlx5 (Mus musculus)13592920OMIM:183600MouseDO 
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Original Reference(s)
Dlx5Ratsplit hand-foot malformation 1  ISODLX5 (Homo sapiens)7240710 OMIM 
Dlx5Ratsplit hand-foot malformation 1 with sensorineural hearing loss  ISODLX5 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Dlx5Rat1,2,4-trimethylbenzene increases expressionEXP 6480464pseudocumene results in increased expression of DLX5 proteinCTDPMID:17337753
Dlx5Rat1,2-dichloroethane increases expressionISODlx5 (Mus musculus)6480464ethylene dichloride results in increased expression of DLX5 mRNACTDPMID:28189721 and PMID:28960355
Dlx5Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISODlx5 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:29627306
Dlx5Rat17alpha-ethynylestradiol affects expressionISODlx5 (Mus musculus)6480464Ethinyl Estradiol affects the expression of DLX5 mRNACTDPMID:17555576
Dlx5Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of DLX5 mRNACTDPMID:12075121
Dlx5Rat17alpha-ethynylestradiol multiple interactionsISODlx5 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLX5 mRNACTDPMID:17942748
Dlx5Rat17alpha-ethynylestradiol increases expressionISODlx5 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of DLX5 mRNACTDPMID:17942748
Dlx5Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISODLX5 (Homo sapiens)64804642 more ...CTDPMID:31326446
Dlx5Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISODlx5 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of DLX5 mRNACTDPMID:24058054
Dlx5Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISODLX5 (Homo sapiens)6480464N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of DLX5 mRNA]CTDPMID:30203000
Dlx5Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISODLX5 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of DLX5 mRNACTDPMID:30203000
Dlx5Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISODlx5 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of DLX5 mRNACTDPMID:15034205
Dlx5Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISODlx5 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLX5 mRNACTDPMID:17942748
Dlx5Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISODlx5 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of DLX5 mRNACTDPMID:16962184 more ...
Dlx5Rat3,3',5,5'-tetrabromobisphenol A increases expressionISODLX5 (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of DLX5 mRNACTDPMID:31326446
Dlx5Rat4,4'-sulfonyldiphenol decreases methylationISODLX5 (Homo sapiens)6480464bisphenol S results in decreased methylation of DLX5 geneCTDPMID:31601247
Dlx5Rat5-aza-2'-deoxycytidine decreases expressionISODlx5 (Mus musculus)6480464Decitabine results in decreased expression of DLX5 mRNACTDPMID:27915011
Dlx5Rat5-azacytidine increases expressionISODlx5 (Mus musculus)6480464Azacitidine results in increased expression of DLX5 mRNACTDPMID:17085970
Dlx5Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of DLX5 mRNACTDPMID:24780913 and PMID:30047161
Dlx5Ratacetohydrazide decreases expressionISODlx5 (Mus musculus)6480464acetylhydrazine results in decreased expression of DLX5 mRNACTDPMID:15282401

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Biological Process
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Original Reference(s)
Dlx5Ratanatomical structure formation involved in morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Ratanatomical structure formation involved in morphogenesis acts_upstream_of_or_withinISODlx5 (Mus musculus)1624291MGI:101927 PMID:17878916RGDPMID:17878916
Dlx5Rataxon guidance acts_upstream_of_or_withinISODlx5 (Mus musculus)1624291MGI:2180475 PMID:17804636RGDPMID:17804636
Dlx5Rataxon guidance acts_upstream_of_or_withinIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Rataxonogenesis acts_upstream_of_or_withinIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Rataxonogenesis acts_upstream_of_or_withinISODlx5 (Mus musculus)1624291MGI:1857789 PMID:12533617RGDPMID:12533617
Dlx5RatBMP signaling pathway involved_inIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5RatBMP signaling pathway involved_inISODlx5 (Mus musculus)1624291 PMID:20843790RGDPMID:20843790
Dlx5Ratbone morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Ratbone morphogenesis acts_upstream_of_or_withinISODlx5 (Mus musculus)1624291MGI:2180474 PMID:16330189RGDPMID:16330189
Dlx5Ratcell differentiation involved_inIBAFB:FBgn0000529 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dlx5Ratcell population proliferation involved_inISODLX5 (Homo sapiens)1624291 PMID:19497851RGDPMID:19497851
Dlx5Ratcell population proliferation involved_inISSUniProtKB:P561781600115GO_REF:0000024UniProtGO_REF:0000024
Dlx5Ratcell population proliferation involved_inIEAUniProtKB:P56178 and ensembl:ENSP000004981161600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Ratcellular response to zinc ion starvation  IEP 151667428 RGD 
Dlx5Ratear development acts_upstream_of_or_withinIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Ratear development acts_upstream_of_or_withinISODlx5 (Mus musculus)1624291MGI:2180474 PMID:16330189RGDPMID:16330189
Dlx5Ratembryonic limb morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Ratembryonic limb morphogenesis acts_upstream_of_or_withinISODlx5 (Mus musculus)1624291MGI:101927 more ...RGDPMID:12112878 and PMID:18326838
Dlx5Ratembryonic skeletal system development involved_inIBAMGI:94901 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component
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Original Reference(s)
Dlx5Ratchromatin located_inIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Ratchromatin located_inISODlx5 (Mus musculus)1624291 PMID:20843790RGDPMID:20843790
Dlx5Ratcytoplasm located_inIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Ratcytoplasm located_inISODlx5 (Mus musculus)1624291 PMID:10516593RGDPMID:10516593
Dlx5Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Dlx5Ratnucleus located_inIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Ratnucleus located_inIEAUniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
Dlx5Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Dlx5Ratnucleus located_inISODlx5 (Mus musculus)1624291 PMID:10516593RGDPMID:10516593
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Molecular Function
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Original Reference(s)
Dlx5RatDNA binding enablesIEAInterPro:IPR000047 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Dlx5RatDNA binding enablesIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5RatDNA binding enablesIEAUniProtKB-KW:KW-0238 and UniProtKB-KW:KW-03711600115GO_REF:0000043UniProtGO_REF:0000043
Dlx5RatDNA binding enablesIEAUniRule:UR0004010371600115GO_REF:0000104UniProtGO_REF:0000104
Dlx5RatDNA binding enablesISODlx5 (Mus musculus)1624291 PMID:9415433RGDPMID:9415433
Dlx5RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISODlx5 (Mus musculus)1624291 PMID:20843790RGDPMID:20843790
Dlx5RatDNA-binding transcription factor activity  TAS 1298882 RGD 
Dlx5RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAInterPro:IPR0179701600115GO_REF:0000002InterProGO_REF:0000002
Dlx5RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAMGI:101926 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dlx5RatHMG box domain binding enablesIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5RatHMG box domain binding enablesISODlx5 (Mus musculus)1624291UniProtKB:O55170 more ...RGDPMID:16582099
Dlx5Ratprotein binding enablesISODlx5 (Mus musculus)1624291PR:Q9QYH6 more ...RGDPMID:11084035
Dlx5RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:P70396 and ensembl:ENSMUSP000000525591600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISODlx5 (Mus musculus)1624291 PMID:20843790RGDPMID:20843790
Dlx5RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAMGI:101926 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dlx5Ratsequence-specific double-stranded DNA binding enablesISODLX5 (Homo sapiens)1624291 PMID:28473536RGDPMID:28473536
Dlx5Ratsequence-specific double-stranded DNA binding enablesIEAUniProtKB:P56178 and ensembl:ENSP000004981161600115GO_REF:0000107EnsemblGO_REF:0000107
Dlx5Rattranscription cis-regulatory region binding enablesISODlx5 (Mus musculus)1624291 PMID:15383550RGDPMID:15383550
Dlx5Rattranscription cis-regulatory region binding enablesIEAUniProtKB:P56178 and ensembl:ENSP000004981161600115GO_REF:0000107EnsemblGO_REF:0000107
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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
4. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. Lee MH, etal., J Biol Chem 2003 Sep 5;278(36):34387-94. Epub 2003 Jun 18.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular cloning and evolutional analysis of a mammalian homologue of the Distal-less 3 (Dlx-3) homeobox gene. Shirasawa T, etal., FEBS Lett 1994 Sep 12;351(3):380-4.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. rDlx, a novel distal-less-like homeoprotein is expressed in developing cartilages and discrete neuronal tissues. Zhao GQ, etal., Dev Biol 1994 Jul;164(1):37-51.
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PMID:9415433   PMID:10516593   PMID:12112878   PMID:12142028   PMID:12533617   PMID:15306564   PMID:15383550   PMID:15456894   PMID:16115867   PMID:16330189   PMID:16582099   PMID:16900517  
PMID:17420000   PMID:17804636   PMID:17878916   PMID:18326838   PMID:19497851   PMID:19956613   PMID:20843790   PMID:21503878   PMID:24042587   PMID:25937343   PMID:29901112  



Dlx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8435,965,579 - 35,969,973 (-)NCBIGRCr8
mRatBN7.2434,999,139 - 35,003,504 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl434,999,139 - 35,003,407 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx439,958,038 - 39,962,304 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0435,884,208 - 35,888,474 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0434,304,193 - 34,308,455 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0432,387,741 - 32,392,085 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl432,387,741 - 32,392,007 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0432,255,323 - 32,259,589 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4431,778,500 - 31,782,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1431,897,039 - 31,901,307 (-)NCBI
Celera430,515,648 - 30,519,914 (-)NCBICelera
Cytogenetic Map4q21NCBI
DLX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38797,020,396 - 97,024,831 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl797,020,396 - 97,024,950 (-)EnsemblGRCh38hg38GRCh38
GRCh37796,649,708 - 96,654,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36796,487,638 - 96,492,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 34796,294,358 - 96,298,794NCBI
Celera791,343,634 - 91,348,072 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef791,251,295 - 91,255,732 (-)NCBIHuRef
CHM1_1796,579,739 - 96,584,181 (-)NCBICHM1_1
T2T-CHM13v2.0798,250,072 - 98,254,502 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2795,972,198 - 95,976,639 (-)NCBI
Dlx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3966,877,801 - 6,882,068 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl66,877,805 - 6,882,085 (-)EnsemblGRCm39 Ensembl
GRCm3866,877,801 - 6,882,068 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl66,877,805 - 6,882,085 (-)EnsemblGRCm38mm10GRCm38
MGSCv3766,827,805 - 6,832,068 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3666,827,805 - 6,832,068 (-)NCBIMGSCv36mm8
Celera67,023,868 - 7,028,132 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map62.83NCBI
Dlx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543213,429,415 - 13,434,258 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543213,429,832 - 13,434,160 (-)NCBIChiLan1.0ChiLan1.0
DLX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26114,856,668 - 114,863,007 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17163,121,305 - 163,127,639 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0788,972,066 - 88,977,588 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17102,556,636 - 102,561,186 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7102,555,267 - 102,561,186 (-)Ensemblpanpan1.1panPan2
DLX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11422,080,351 - 22,085,188 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1422,080,699 - 22,084,867 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1421,648,083 - 21,652,478 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01421,897,429 - 21,901,826 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1421,897,417 - 21,902,078 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11422,044,142 - 22,048,532 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01421,779,484 - 21,783,873 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01422,043,227 - 22,047,620 (-)NCBIUU_Cfam_GSD_1.0
Dlx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511835,346,260 - 35,401,337 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365853,461,944 - 3,466,641 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365853,462,063 - 3,466,641 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl976,639,561 - 76,643,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1976,639,915 - 76,643,689 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103226510
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12152,032,933 - 52,092,791 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2152,036,401 - 52,040,903 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604252,268,203 - 52,315,364 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248133,760,661 - 3,765,517 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248133,760,890 - 3,765,309 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Dlx5
21 total Variants

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:48
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000014946
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 33 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
8655949Rf62Renal function QTL 6222blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)43443011944463908Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat

1 to 10 of 33 rows
AA998469  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8435,965,762 - 35,966,628 (+)Marker Load Pipeline
Rnor_6.0432,387,925 - 32,388,790NCBIRnor6.0
Rnor_5.0432,255,507 - 32,256,372UniSTSRnor5.0
RGSC_v3.4431,778,684 - 31,779,550UniSTSRGSC3.4
Celera430,515,832 - 30,516,697UniSTS
RH 3.4 Map4811.83UniSTS
Cytogenetic Map4q13UniSTS
AI385752  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2434,999,397 - 34,999,499 (+)MAPPERmRatBN7.2
Rnor_6.0432,388,000 - 32,388,101NCBIRnor6.0
Rnor_5.0432,255,582 - 32,255,683UniSTSRnor5.0
RGSC_v3.4431,778,759 - 31,778,860UniSTSRGSC3.4
Celera430,515,907 - 30,516,008UniSTS
Cytogenetic Map4q13UniSTS
MARC_9717-9718:996688547:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2435,002,916 - 35,003,225 (+)MAPPERmRatBN7.2
Rnor_6.0432,391,517 - 32,391,825NCBIRnor6.0
Rnor_5.0432,259,099 - 32,259,407UniSTSRnor5.0
RGSC_v3.4431,782,277 - 31,782,585UniSTSRGSC3.4
Celera430,519,424 - 30,519,732UniSTS
Cytogenetic Map4q13UniSTS
Dlx5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2434,999,262 - 34,999,813 (+)MAPPERmRatBN7.2
Rnor_6.0432,387,865 - 32,388,415NCBIRnor6.0
Rnor_5.0432,255,447 - 32,255,997UniSTSRnor5.0
RGSC_v3.4431,778,624 - 31,779,174UniSTSRGSC3.4
Celera430,515,772 - 30,516,322UniSTS
Cytogenetic Map4q13UniSTS
DLX5_2316  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2434,999,093 - 34,999,786 (+)MAPPERmRatBN7.2
Rnor_6.0432,387,696 - 32,388,388NCBIRnor6.0
Rnor_5.0432,255,278 - 32,255,970UniSTSRnor5.0
RGSC_v3.4431,778,455 - 31,779,147UniSTSRGSC3.4
Celera430,515,603 - 30,516,295UniSTS
Cytogenetic Map4q13UniSTS
Dlx5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2434,999,182 - 34,999,598 (+)MAPPERmRatBN7.2
Rnor_6.0432,387,785 - 32,388,200NCBIRnor6.0
Rnor_5.0432,255,367 - 32,255,782UniSTSRnor5.0
RGSC_v3.4431,778,544 - 31,778,959UniSTSRGSC3.4
Celera430,515,692 - 30,516,107UniSTS
Cytogenetic Map4q13UniSTS
Dlx5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2435,003,163 - 35,003,228 (+)MAPPERmRatBN7.2
Rnor_6.0432,391,764 - 32,391,828NCBIRnor6.0
Rnor_5.0432,259,346 - 32,259,410UniSTSRnor5.0
RGSC_v3.4431,782,524 - 31,782,588UniSTSRGSC3.4
Celera430,519,671 - 30,519,735UniSTS
Cytogenetic Map4q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 3 46 106 36 33 11 10 11 6 120 73 89 26 48 22



Ensembl Acc Id: ENSRNOT00000014946   ⟹   ENSRNOP00000014946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl434,999,139 - 35,003,407 (-)Ensembl
Rnor_6.0 Ensembl432,387,741 - 32,392,007 (-)Ensembl
RefSeq Acc Id: NM_012943   ⟹   NP_037075
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8435,965,579 - 35,969,845 (-)NCBI
mRatBN7.2434,999,139 - 35,003,407 (-)NCBI
Rnor_6.0432,387,741 - 32,392,007 (-)NCBI
Rnor_5.0432,255,323 - 32,259,589 (-)NCBI
RGSC_v3.4431,778,500 - 31,782,767 (-)RGD
Celera430,515,648 - 30,519,914 (-)RGD
Sequence:
RefSeq Acc Id: XM_017592486   ⟹   XP_017447975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8435,966,225 - 35,969,973 (-)NCBI
mRatBN7.2434,999,675 - 35,003,504 (-)NCBI
Rnor_6.0432,389,485 - 32,392,085 (-)NCBI
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_037075 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447975 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42026 (Get FASTA)   NCBI Sequence Viewer  
  BAA06534 (Get FASTA)   NCBI Sequence Viewer  
  BAB71722 (Get FASTA)   NCBI Sequence Viewer  
  EDM15037 (Get FASTA)   NCBI Sequence Viewer  
  EDM15038 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014946
GenBank Protein P50575 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_037075   ⟸   NM_012943
- UniProtKB: A0A0G2JSK6 (UniProtKB/TrEMBL),   A6IDV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447975   ⟸   XM_017592486
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000014946   ⟸   ENSRNOT00000014946
Homeobox

Name Modeler Protein Id AA Range Protein Structure
AF-P50575-F1-model_v2 AlphaFold P50575 1-289 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692867
Promoter ID:EPDNEW_R3391
Type:single initiation site
Name:Dlx5_1
Description:distal-less homeobox 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0432,392,025 - 32,392,085EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-45680 BioCyc
Ensembl Genes ENSRNOG00000010905 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014946 ENTREZGENE
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
InterPro Distal-less_Homeobox_TF UniProtKB/Swiss-Prot
  Distal-less_N UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
  HTH_motif UniProtKB/Swiss-Prot
KEGG Report rno:25431 UniProtKB/Swiss-Prot
NCBI Gene 25431 ENTREZGENE
PANTHER HOMEOBOX PROTEIN UniProtKB/Swiss-Prot
  HOMEOBOX PROTEIN DLX-5 UniProtKB/Swiss-Prot
Pfam DLL_N UniProtKB/Swiss-Prot
  Homeodomain UniProtKB/Swiss-Prot
PhenoGen Dlx5 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot
  HTHREPRESSR UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010905 RatGTEx
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
TIGR TC219849
UniProt A0A0G2JSK6 ENTREZGENE, UniProtKB/TrEMBL
  A6IDV0_RAT UniProtKB/TrEMBL
  A6IDV1 ENTREZGENE, UniProtKB/TrEMBL
  DLX5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q91WY7_RAT UniProtKB/TrEMBL
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Dlx5  Distal-less homeobox      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed specifically in osteogenic cells 1298882
gene_expression expressed in developing skeletal and neuronal tissues 1298881
gene_expression expressed in fibroblasts 1298881
gene_process important mediator of BMP-2-induced Runx2 expression 1298882
gene_process induces BMP-2 mediated osetoeblast differentiation and blocks TGFB1-mediated inhibition of osteoblast differentiation 1298882
gene_transcript induced by bone morphogenic protein (BMP) 2 and 4 signaling 1298882
gene_transcript suppressed by TGFB1 1298882