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Gene: Dlx5 (distal-less homeobox 5) Mus musculus
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Symbol: Dlx5
Name: distal-less homeobox 5
RGD ID: 10476
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; face morphogenesis; and interneuron axon guidance. Localizes to cytoplasm and nuclear chromatin. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; nervous system; and sensory organ. Used to study split hand-foot malformation 1. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 and split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5); INTERACTS WITH 1,2-dichloroethane; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI385752; homeobox protein DLX-5
Orthologs:
Homo sapiens (human) : DLX5 (distal-less homeobox 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dlx5 (distal-less homeobox 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlx5 (distal-less homeobox 5)
Pan paniscus (bonobo/pygmy chimpanzee) : DLX5 (distal-less homeobox 5)
Canis lupus familiaris (dog) : DLX5 (distal-less homeobox 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlx5 (distal-less homeobox 5)
Sus scrofa (pig) : DLX5 (distal-less homeobox 5)
Chlorocebus sabaeus (African green monkey) : DLX5 (distal-less homeobox 5)
Heterocephalus glaber (naked mole-rat) : Dlx5 (distal-less homeobox 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl66,877,805 - 6,882,085 (-)EnsemblGRCm38mm10GRCm38
GRCm3866,877,801 - 6,882,068 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3766,827,805 - 6,832,068 (-)NCBIGRCm37mm9NCBIm37
MGSCv3666,827,805 - 6,832,068 (-)NCBImm8
Celera67,023,868 - 7,028,132 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map62.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dlx5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10476
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-08-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.