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Gene: Dlx5 (distal-less homeobox 5) Mus musculus
Symbol: Dlx5
Name: distal-less homeobox 5
RGD ID: 10476
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; face morphogenesis; and interneuron axon guidance. Localizes to cytoplasm and nuclear chromatin. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; nervous system; and sensory organ. Used to study split hand-foot malformation 1. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 and split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5); INTERACTS WITH 1,2-dichloroethane; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI385752; homeobox protein DLX-5
Homo sapiens (human) : DLX5 (distal-less homeobox 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dlx5 (distal-less homeobox 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlx5 (distal-less homeobox 5)
Pan paniscus (bonobo/pygmy chimpanzee) : DLX5 (distal-less homeobox 5)
Canis lupus familiaris (dog) : DLX5 (distal-less homeobox 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlx5 (distal-less homeobox 5)
Sus scrofa (pig) : DLX5 (distal-less homeobox 5)
Chlorocebus sabaeus (African green monkey) : DLX5 (distal-less homeobox 5)
Heterocephalus glaber (naked mole-rat) : Dlx5 (distal-less homeobox 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl66,877,805 - 6,882,085 (-)EnsemblGRCm38mm10GRCm38
GRCm3866,877,801 - 6,882,068 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3766,827,805 - 6,832,068 (-)NCBIGRCm37mm9NCBIm37
MGSCv3666,827,805 - 6,832,068 (-)NCBImm8
Celera67,023,868 - 7,028,132 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map62.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dlx5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10476
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-08-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.