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Gene: DLX5 (distal-less homeobox 5) Pan paniscus

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Symbol:

DLX5

Name:

distal-less homeobox 5

RGD ID:

12013598

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); axon guidance (ortholog); axonogenesis (ortholog); ASSOCIATED WITH Birth Weight (ortholog); bone development disease (ortholog); Craniofacial Abnormalities (ortholog); FOUND IN chromatin (inferred); cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

homeobox protein DLX-5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DLX5 (distal-less homeobox 5)	NCBI	Ortholog
Mus musculus (house mouse):	Dlx5 (distal-less homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Dlx5 (distal-less homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dlx5 (distal-less homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DLX5 (distal-less homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dlx5 (distal-less homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DLX5 (distal-less homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103226510 (uncharacterized LOC103226510)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dlx5 (distal-less homeobox 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	114,856,668 - 114,863,007 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	163,121,305 - 163,127,639 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	88,972,066 - 88,977,588 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	102,556,636 - 102,561,186 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	102,555,267 - 102,561,186 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Birth Weight (ISO)

bone development disease (ISO)

Craniofacial Abnormalities (ISO)

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

split hand-foot malformation (ISO)

split hand-foot malformation 1 (ISO)

split hand-foot malformation 1 with sensorineural hearing loss (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anatomical structure formation involved in morphogenesis (IEA,ISO)

axon guidance (IEA,ISO)

axonogenesis (IEA,ISO)

BMP signaling pathway (IEA)

bone morphogenesis (IEA,ISO)

cell differentiation (IEA)

cell population proliferation (IEA)

cellular response to zinc ion starvation (ISO)

ear development (IEA,ISO)

embryonic limb morphogenesis (IEA,ISO)

endochondral ossification (IEA)

epithelial cell differentiation (IEA,ISO)

face morphogenesis (IEA,ISO)

head development (IEA,ISO)

inner ear morphogenesis (IEA,ISO)

interneuron axon guidance (IEA,ISO)

olfactory bulb interneuron differentiation (IEA,ISO)

olfactory pit development (IEA,ISO)

osteoblast differentiation (IEA)

positive regulation of canonical Wnt signaling pathway (IEA,ISO)

positive regulation of DNA-templated transcription (IEA)

positive regulation of epithelial cell proliferation (IEA,ISO)

positive regulation of gene expression (IEA,ISO)

positive regulation of osteoblast differentiation (ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA,ISO)

regulation of transcription by RNA polymerase II (IEA)

roof of mouth development (IEA,ISO)

Cellular Component

chromatin (IEA)

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

HMG box domain binding (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

transcription cis-regulatory region binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DLX5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	114,856,668 - 114,863,007 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	163,121,305 - 163,127,639 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	88,972,066 - 88,977,588 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	102,556,636 - 102,561,186 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	102,555,267 - 102,561,186 (-)	Ensembl	panpan1.1		panPan2

DLX5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	97,020,396 - 97,024,831 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	97,020,396 - 97,024,950 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	96,649,708 - 96,654,143 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	96,487,638 - 96,492,079 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	96,294,358 - 96,298,794	NCBI
Celera	7	91,343,634 - 91,348,072 (-)	NCBI		Celera
Cytogenetic Map	7	q21.3	NCBI
HuRef	7	91,251,295 - 91,255,732 (-)	NCBI		HuRef
CHM1_1	7	96,579,739 - 96,584,181 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	98,250,072 - 98,254,502 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	95,972,198 - 95,976,639 (-)	NCBI

Dlx5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	6,877,801 - 6,882,068 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	6,877,805 - 6,882,085 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	6,877,801 - 6,882,068 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	6,877,805 - 6,882,085 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	6,827,805 - 6,832,068 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	6,827,805 - 6,832,068 (-)	NCBI		MGSCv36	mm8
Celera	6	7,023,868 - 7,028,132 (-)	NCBI		Celera
Cytogenetic Map	6	A1	NCBI
cM Map	6	2.83	NCBI

Dlx5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	35,965,579 - 35,969,973 (-)	NCBI		GRCr8
mRatBN7.2	4	34,999,139 - 35,003,504 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	34,999,139 - 35,003,407 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	39,958,038 - 39,962,304 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	35,884,208 - 35,888,474 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	34,304,193 - 34,308,455 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	32,387,741 - 32,392,085 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	32,387,741 - 32,392,007 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	32,255,323 - 32,259,589 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	31,778,500 - 31,782,767 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	31,897,039 - 31,901,307 (-)	NCBI
Celera	4	30,515,648 - 30,519,914 (-)	NCBI		Celera
Cytogenetic Map	4	q21	NCBI

Dlx5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	13,429,415 - 13,434,258 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	13,429,832 - 13,434,160 (-)	NCBI	ChiLan1.0	ChiLan1.0

DLX5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	22,080,351 - 22,085,188 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	22,080,699 - 22,084,867 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	21,648,083 - 21,652,478 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	21,897,429 - 21,901,826 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	21,897,417 - 21,902,078 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	22,044,142 - 22,048,532 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	21,779,484 - 21,783,873 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	22,043,227 - 22,047,620 (-)	NCBI		UU_Cfam_GSD_1.0

Dlx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	35,346,260 - 35,401,337 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936585	3,461,944 - 3,466,641 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936585	3,462,063 - 3,466,641 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DLX5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	76,639,561 - 76,643,884 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	76,639,915 - 76,643,689 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LOC103226510
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	52,032,933 - 52,092,791 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	52,036,401 - 52,040,903 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	52,268,203 - 52,315,364 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dlx5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624813	3,760,661 - 3,765,517 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624813	3,760,890 - 3,765,309 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003809694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000038597 ⟹ ENSPPAP00000015904

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	102,555,267 - 102,561,186 (-)	Ensembl

RefSeq Acc Id:

XM_003809694 ⟹ XP_003809742

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	114,856,668 - 114,863,007 (-)	NCBI
NHGRI_mPanPan1	7	163,121,305 - 163,127,639 (-)	NCBI
Mhudiblu_PPA_v0	7	88,972,066 - 88,977,588 (-)	NCBI
PanPan1.1	7	102,556,636 - 102,561,186 (-)	NCBI

Sequence:

show sequence

GTTGGACGAGTTAGGGTGTTACTGCTGCTCCCGAGGCCCTGGCCAATAGAACCAGATCCACCCC
GCTGTGCGTAAGCGCGCAATTAAGGATTTAACCAAGGCTGTGCTGCGCCTCAGCCAGCAGTCAG
CCGGCCGGAGACAGAGACTTCACGACTCCCAGTCTCCTCCTCGCCGCGGCCGCCGCCTCCTCCT
TCTCTCCTCCTCCTCTTCCTCCTCCTCCCTCGCTCCCACAGCCATGTCTGCTTAGACCAGAGCA
GCCCCACAGCCAACTCGGGCAGCTGCCGCCGCCACAACAGCAAGGACAGCCGCTGCCGCCGCCC
GTGAGCGATGACAGGAGTGTTTGACAGAAGGGTCCCCAGCATCCGATCCGGCGACTTCCAAGCT
CCGTTCCAGACGTCCGCAGCTATGCACCATCCGTCTCAGGAATCGCCAACTTTGCCCGAGTCTT
CAGCTACCGATTCTGACTACTACAGCCCTACGGGGGGAGCCCCGCACGGCTACTGCTCTCCTAC
CTCGGCTTCCTATGGCAAAGCTCTCAACCCCTACCAGTATCAGTATCACGGCGTGAACGGCTCC
GCCGGGAGCTACCCAGCCAAAGCTTATGCCGACTACAGCTACGCTAGCTCCTACCACCAGTACG
GCGGTGCCTACAACCGCGTCCCAAGCGCCACCAACCAGCCAGAGAAAGAAGTGACCGAGCCCGA
GGTGAGAATGGTGAATGGCAAACCAAAGAAAGTTCGTAAACCCAGGACTATTTATTCCAGCTTT
CAGCTGGCCGCATTACAGAGAAGGTTTCAGAAGACTCAGTACCTCGCCTTGCCGGAACGCGCCG
AGCTGGCCGCCTCGCTGGGATTGACACAAACACAGGTGAAAATCTGGTTTCAGAACAAAAGATC
CAAGATCAAGAAGATCATGAAAAACGGGGAGATGCCCCCGGAGCACAGTCCCAGCTCCAGCGAC
CCAATGGCGTGTAACTCGCCGCAGTCTCCAGCGGTGTGGGAGCCCCAGGGCTCGTCCCGCTCGC
TCAGCCACCACCCTCATGCCCACCCTCCGACCTCCAACCAGTCCCCAGCGTCCAGCTACCTGGA
GAACTCTGCATCCTGGTACACAAGTGCAGCCAGCTCAATCAATTCCCACCTGCCGCCGCCGGGC
TCCTTACAGCACCCGCTGGCGCTGGCCTCCGGGACACTCTATTAGATGGGCTGCTCTCTCTTAC
TCTGTTTTTTGGGACTACTGTGTTTTGCTGTTCTAGAAAATCATAAAGGAATTCATATGGGGAA
GTTCGGAGAACTGAAAAAGATTCATGTGTAAAGCTTTTTTTTGCATGTAAGTTATTGCATTTCA
AAAGACCCCCCCTTTTTTTACAGAGGACTTTTTTTTGCGCAACTGTGGACACTTTCAATGGTGC
CTTGAAATCTATGACCTCAACTTTTCAAAAGACTTTTTTCAATGTTATTTTAGCCATGTAAATA
AGTGTAGATAGAGGAATTAAACTGTATATTCTGGATAAATAAAATTATTTCGACCATGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003809742	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000015904.1

RefSeq Acc Id:

XP_003809742 ⟸ XM_003809694

- UniProtKB:

A0A2R9ALQ5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTGVFDRRVPSIRSGDFQAPFQTSAAMHHPSQESPTLPESSATDSDYYSPTGGAPHGYCSPTSA
SYGKALNPYQYQYHGVNGSAGSYPAKAYADYSYASSYHQYGGAYNRVPSATNQPEKEVTEPEVR
MVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKI
KKIMKNGEMPPEHSPSSSDPMACNSPQSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENS
ASWYTSAASSINSHLPPPGSLQHPLALASGTLY

hide sequence

Ensembl Acc Id:

ENSPPAP00000015904 ⟸ ENSPPAT00000038597

Protein Domains

Homeobox

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000031068	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000038597.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Distal-less_Homeobox_TF	UniProtKB/TrEMBL
	Distal-less_N	UniProtKB/TrEMBL
	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/TrEMBL
	HTH_motif	UniProtKB/TrEMBL
KEGG Report	pps:100995470	UniProtKB/TrEMBL
NCBI Gene	DLX5	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN	UniProtKB/TrEMBL
	HOMEOBOX PROTEIN DLX-5	UniProtKB/TrEMBL
Pfam	DLL_N	UniProtKB/TrEMBL
	Homeodomain	UniProtKB/TrEMBL
PRINTS	HOMEOBOX	UniProtKB/TrEMBL
	HTHREPRESSR	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A2R9ALQ5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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