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Gene: Csnk2a1 (casein kinase 2 alpha 1) Heterocephalus glaber

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Symbol:

Csnk2a1

Name:

casein kinase 2 alpha 1

RGD ID:

18936953

Description:

ENCODES a protein that exhibits beta-catenin binding (ortholog); identical protein binding (ortholog); kinase activity (ortholog); INVOLVED IN cerebral cortex development (ortholog); DNA damage response (ortholog); double-strand break repair (ortholog); PARTICIPATES IN E-cadherin signaling pathway; mitochondrial autophagy pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); autism spectrum disorder (ortholog); breast cancer (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog); PcG protein complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

casein kinase II subunit alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624741	1,566,380 - 1,635,365 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult T-cell leukemia/lymphoma (ISO)

autism spectrum disorder (ISO)

breast cancer (ISO)

Brown-Vialetto-Van Laere syndrome 1 (ISO)

Developmental Disease (ISO)

Experimental Mammary Neoplasms (ISO)

genetic disease (ISO)

intellectual disability (ISO)

myocardial infarction (ISO)

Neurodevelopmental Disorders (ISO)

Okur-Chung Neurodevelopmental Syndrome (ISO)

Oxygen-Induced Retinopathy (ISO)

Polyglucosan Body Myopathy 1 with or without Immunodeficiency (ISO)

Skin Neoplasms (ISO)

squamous cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cerebral cortex development (ISO)

DNA damage response (ISO)

double-strand break repair (ISO)

liver regeneration (ISO)

negative regulation of apoptotic signaling pathway (ISO)

negative regulation of double-strand break repair via homologous recombination (ISO)

negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

negative regulation of translation (ISO)

positive regulation of aggrephagy (ISO)

positive regulation of cell growth (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of protein catabolic process (ISO)

positive regulation of Wnt signaling pathway (ISO)

protein autophosphorylation (ISO)

protein phosphorylation (ISO)

protein stabilization (ISO)

regulation of cell cycle (IEA)

regulation of chromosome separation (ISO)

regulation of protein localization to plasma membrane (ISO)

response to testosterone (ISO)

symbiont-mediated disruption of host cell PML body (ISO)

Cellular Component

chromatin (ISO)

cytosol (IEA)

nucleoplasm (ISO)

nucleus (IEA)

PcG protein complex (ISO)

PML body (ISO)

protein kinase CK2 complex (IEA)

Sin3-type complex (ISO)

Molecular Function

ATP binding (IEA)

beta-catenin binding (ISO)

identical protein binding (ISO)

kinase activity (ISO)

protein binding (ISO)

protein phosphatase regulator activity (ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IEA)

ribonucleoprotein complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

E-cadherin signaling pathway (ISO)

mitochondrial autophagy pathway (ISO)

nuclear factor kappa B signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Csnk2a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624741	1,566,380 - 1,635,365 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

CSNK2A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	472,498 - 543,790 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	472,498 - 543,835 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	453,142 - 524,434 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	411,338 - 472,482 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	411,337 - 472,482	NCBI
Celera	20	558,168 - 619,315 (-)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	414,534 - 475,783 (-)	NCBI		HuRef
CHM1_1	20	463,361 - 524,481 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	516,232 - 587,494 (-)	NCBI		T2T-CHM13v2.0

Csnk2a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	152,068,468 - 152,123,772 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	152,068,759 - 152,123,772 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	152,226,535 - 152,281,856 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	152,226,839 - 152,281,852 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	152,052,576 - 152,107,588 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	151,918,392 - 151,973,288 (+)	NCBI		MGSCv36	mm8
Celera	2	158,043,147 - 158,095,936 (+)	NCBI		Celera
Cytogenetic Map	2	G3	NCBI
cM Map	2	74.83	NCBI

Csnk2a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	161,170,295 - 161,217,073 (+)	NCBI		GRCr8
mRatBN7.2	3	140,709,984 - 140,756,757 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	140,709,991 - 140,756,696 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	144,614,755 - 144,658,895 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	153,198,587 - 153,242,728 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	150,938,676 - 150,982,746 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	147,713,808 - 147,760,375 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	147,713,821 - 147,757,862 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	154,061,948 - 154,108,516 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	142,564,754 - 142,609,311 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	142,470,349 - 142,514,931 (+)	NCBI
Celera	3	139,476,391 - 139,506,459 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

Csnk2a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955597	326,601 - 397,112 (-)	NCBI	ChiLan1.0	ChiLan1.0

CSNK2A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	1,569,710 - 1,632,281 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	1,568,135 - 1,629,104 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	689,494 - 752,092 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	459,070 - 521,126 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	456,629 - 521,126 (-)	Ensembl	panpan1.1		panPan2

CSNK2A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	20,333,593 - 20,390,341 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	19,985,091 - 20,044,278 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	21,024,162 - 21,083,612 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	21,024,195 - 21,083,217 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	20,299,232 - 20,358,675 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	20,405,477 - 20,464,884 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	20,835,744 - 20,895,178 (+)	NCBI		UU_Cfam_GSD_1.0

Csnk2a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	169,535,585 - 169,588,246 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936485	17,966,993 - 18,021,191 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CSNK2A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	17	34,692,960 - 34,748,067 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	39,413,860 - 39,467,386 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CSNK2A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	55,982,259 - 56,047,023 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666078	7,905,841 - 7,970,771 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004840633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01018771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01018772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_004840633 ⟹ XP_004840690

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624741	1,566,380 - 1,635,365 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_004840690	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000026507

RefSeq Acc Id:	XP_004840690 ⟸ XM_004840633
- UniProtKB:	A0AAX6NZR7 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000018853	ENTREZGENE
Ensembl Transcript	ENSHGLT00000026743	ENTREZGENE
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	CK2_alpha	UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
NCBI Gene	Csnk2a1	ENTREZGENE
PANTHER	CASEIN KINASE II SUBUNIT ALPHA	UniProtKB/TrEMBL
	CASEIN KINASE II SUBUNIT ALPHA-RELATED	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Protein kinase-like (PK-like)	UniProtKB/TrEMBL
UniProt	A0AAX6NZR7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)