Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Regulation of protein kinase CK2 isoform expression during rat brain development.

Authors: Diaz-Nido, J  Mizuno, K  Nawa, H  Marshak, DR 
Citation: Diaz-Nido J, etal., Cell Mol Biol Res. 1994;40(5-6):581-5.
Pubmed: (View Article at PubMed) PMID:7735332

Protein kinase CK2 is very abundant in rat brain when compared with other rat tissues. The enzyme is an oligomeric protein with the structures alpha 2 beta 2, alpha alpha'beta 2 and alpha'2 beta 2. The alpha and alpha' subunits are catalytic and have a high degree of homology, whereas the beta subunit seems regulatory. Using specific antibodies to synthetic peptide antigens that discriminate among the alpha, alpha', and beta subunits of CK2, we have observed a significant increase in the amount of alpha' subunit during the late postnatal neocortical maturation period. The increased alpha' expression occurs at a parallel time to synaptogenesis. As for its distribution, the alpha' subunit of CK2 is much more abundant in neurons (particularly in large size neurons) than it is in glia. These results are consistent with a hypothetical role for CK2 isoforms containing alpha' subunits in the regulation of specific functions in fully differentiated neurons.

Annotation

Gene Ontology Annotations
Objects Annotated
Objects referenced in this article

Additional Information

 
RGD Object Information
RGD ID: 11565823
Created: 2016-11-28
Species: All species
Last Modified: 2016-11-28
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.