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Gene: Polr3b (RNA polymerase III subunit B) Rattus norvegicus

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Symbol:

Polr3b

Name:

RNA polymerase III subunit B

RGD ID:

1565311

Description:

Predicted to enable DNA/RNA hybrid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and snRNA transcription by RNA polymerase III. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Orthologous to human POLR3B (RNA polymerase III subunit B); PARTICIPATES IN RNA polymerase III transcription pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DNA-directed RNA polymerase III subunit RPC2; LOC362858; polymerase (RNA) III (DNA directed) polypeptide B; polymerase (RNA) III subunit B; RGD1565311; similar to RNA polymerase III subunit RPC2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	POLR3B (RNA polymerase III subunit B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Polr3b (polymerase (RNA) III (DNA directed) polypeptide B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Polr3b (RNA polymerase III subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	POLR3B (RNA polymerase III subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	POLR3B (RNA polymerase III subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Polr3b (RNA polymerase III subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	POLR3B (RNA polymerase III subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	POLR3B (RNA polymerase III subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Polr3b (RNA polymerase III subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TMEM91 (transmembrane protein 91)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	POLR3B (RNA polymerase III subunit B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Polr3b (polymerase (RNA) III (DNA directed) polypeptide B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	polr3b (polymerase (RNA) III (DNA directed) polypeptide B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RET1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RpIII128	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rpc-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	polr3b	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	20,926,866 - 21,030,133 (-)	NCBI		GRCr8
mRatBN7.2	7	19,039,179 - 19,142,450 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	19,038,552 - 19,142,598 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	21,000,048 - 21,103,388 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	23,162,717 - 23,266,061 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	22,939,694 - 23,043,036 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	24,745,051 - 24,851,227 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	24,745,051 - 24,851,227 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	24,893,473 - 24,997,174 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	21,167,374 - 21,271,601 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	16,249,574 - 16,351,645 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Polr3b	Rat	amenorrhea		ISO	RGD:1351468	8554872	ClinVar Annotator: match by term: Amenorrhea	ClinVar	PMID:22855961\|PMID:25133958\|PMID:25741868\|PMID:27029625\|PMID:27512013\|PMID:28492532\|PMID:32345981\|PMID:32870266\|PMID:33726816\|PMID:34440436\|PMID:35316923\|PMID:36268624\|PMID:37273706
Polr3b	Rat	Charcot-Marie-Tooth Disease Type 1I		ISO	RGD:1351468	8554872	ClinVar Annotator: match by term: CHARCOT-MARIE-TOOTH NEUROPATHY, TYPE 1I \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:16199547\|PMID:22036171\|PMID:22036172\|PMID:22855961\|PMID:23355746\|PMID:24190003\|PMID:25339210\|PMID:25741868\|PMID:26045207\|PMID:26204956\|PMID:26478204\|PMID:27029625\|PMID:27512013\|PMID:28492532\|PMID:28589944\|PMID:31969655\|PMID:32180488\|PMID:32319736\|PMID:32342562\|PMID:32371413\|PMID:33417887\|PMID:34440436\|PMID:34666706\|PMID:35253369\|PMID:35395209
Polr3b	Rat	genetic disease		ISO	RGD:1351468	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:17576681\|PMID:22855961\|PMID:25133958\|PMID:25339210\|PMID:25741868\|PMID:27029625\|PMID:27512013\|PMID:28492532\|PMID:32342562\|PMID:32345981\|PMID:32870266\|PMID:33726816\|PMID:34440436\|PMID:35316923\|PMID:36268624\|PMID:37273706\|PMID:9536098
Polr3b	Rat	hypogonadotropic hypogonadism		ISO	RGD:1351468	8554872	ClinVar Annotator: match by term: Hypogonadotropic hypogonadism \| ClinVar Annotator: match by term: Hypogonadotropic hypogonadism more ...	ClinVar	PMID:22036172\|PMID:22855961\|PMID:23355746\|PMID:24190003\|PMID:25339210\|PMID:25741868\|PMID:26045207\|PMID:26204956\|PMID:27512013\|PMID:28492532\|PMID:28589944\|PMID:32319736\|PMID:35253369
Polr3b	Rat	hypogonadotropic hypogonadism 7 with or without anosmia		ISO	RGD:1351468	8554872	ClinVar Annotator: match by term: Hypogonadotropic hypogonadism 7 with or without anosmia \| ClinVar Annotator: more ...	ClinVar	PMID:16199547\|PMID:22036172\|PMID:22855961\|PMID:23355746\|PMID:24190003\|PMID:25133958\|PMID:25339210\|PMID:25741868\|PMID:26045207\|PMID:26204956\|PMID:27029625\|PMID:27512013\|PMID:28492532\|PMID:28589944\|PMID:32319736\|PMID:32345981\|PMID:32870266\|PMID:33726816\|PMID:34440436\|PMID:35253369\|PMID:35316923\|PMID:36268624\|PMID:37273706
Polr3b	Rat	hypomyelinating leukodystrophy 7		ISO	RGD:1351468	8554872	ClinVar Annotator: match by term: Leukoencephalopathy, ataxia, hypodontia, hypomyelination syndrome \| ClinVar Annotator: match by more ...	ClinVar	PMID:16199547\|PMID:22036171\|PMID:22036172\|PMID:22855961\|PMID:23355746\|PMID:24190003\|PMID:25133958\|PMID:25339210\|PMID:25741868\|PMID:26045207\|PMID:26204956\|PMID:27029625\|PMID:27512013\|PMID:28492532\|PMID:28589944\|PMID:32180488\|PMID:32319736\|PMID:32345981\|PMID:32371413\|PMID:32870266\|PMID:33417887\|PMID:33726816\|PMID:34440436\|PMID:35253369\|PMID:35316923\|PMID:36268624\|PMID:37273706
Polr3b	Rat	hypomyelinating leukodystrophy 8		ISO	RGD:1351468	8554872	ClinVar Annotator: match by term: Endosteal sclerosis-cerebellar hypoplasia syndrome \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:16199547\|PMID:17576681\|PMID:18851904\|PMID:22036171\|PMID:22036172\|PMID:22855961\|PMID:23355746\|PMID:24190003\|PMID:25133958\|PMID:25339210\|PMID:25741868\|PMID:26011300\|PMID:26045207\|PMID:26204956\|PMID:26478204\|PMID:27029625\|PMID:27512013\|PMID:28492532\|PMID:28589944\|PMID:29141312\|PMID:30548255\|PMID:31221184\|PMID:31969655\|PMID:32180488\|PMID:32319736\|PMID:32342562\|PMID:32345981\|PMID:32371413\|PMID:32870266\|PMID:33417887\|PMID:33726816\|PMID:34440436\|PMID:35253369\|PMID:35316923\|PMID:36268624\|PMID:37273706\|PMID:9536098
Polr3b	Rat	Klinefelter syndrome		ISO	RGD:1351468	8554872	ClinVar Annotator: match by term: Hypogonadotropic hypogonadism	ClinVar	PMID:22036172\|PMID:22855961\|PMID:23355746\|PMID:24190003\|PMID:25339210\|PMID:25741868\|PMID:26045207\|PMID:26204956\|PMID:27512013\|PMID:28492532\|PMID:28589944\|PMID:32319736\|PMID:35253369
Polr3b	Rat	leukodystrophy		ISO	RGD:1351468	8554872	ClinVar Annotator: match by term: Leukodystrophy	ClinVar	PMID:22855961\|PMID:25741868\|PMID:27029625

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Polr3b	Rat	hypomyelinating leukodystrophy 7		ISO	RGD:1351468	11554173	CTD Direct Evidence: marker/mechanism	CTD
Polr3b	Rat	intellectual disability		ISO	RGD:1351468	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:21937992

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Polr3b	Rat	Charcot-Marie-Tooth Disease Type 1I		ISO	RGD:1351468	7240710		OMIM
Polr3b	Rat	hypomyelinating leukodystrophy 8		ISO	RGD:1351468	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Polr3b	Rat	(-)-epigallocatechin 3-gallate	multiple interactions	ISO	RGD:1351468	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of POLR3B mRNA	CTD	PMID:22079256
Polr3b	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1557860	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of POLR3B mRNA	CTD	PMID:22206623
Polr3b	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of POLR3B mRNA	CTD	PMID:22298810
Polr3b	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of POLR3B mRNA	CTD	PMID:33387578
Polr3b	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1557860	6480464	Tetrachlorodibenzodioxin affects the expression of POLR3B mRNA	CTD	PMID:21570461
Polr3b	Rat	2-hydroxypropanoic acid	decreases expression	ISO	RGD:1351468	6480464	Lactic Acid results in decreased expression of POLR3B mRNA	CTD	PMID:30851411
Polr3b	Rat	4,4'-sulfonyldiphenol	decreases expression	ISO	RGD:1557860	6480464	bisphenol S results in decreased expression of POLR3B mRNA	CTD	PMID:39298647
Polr3b	Rat	5-aza-2'-deoxycytidine	affects expression	ISO	RGD:1351468	6480464	Decitabine affects the expression of POLR3B mRNA	CTD	PMID:23300844
Polr3b	Rat	acrylamide	increases expression	EXP		6480464	Acrylamide results in increased expression of POLR3B mRNA	CTD	PMID:28959563
Polr3b	Rat	aflatoxin B1	increases expression	ISO	RGD:1557860	6480464	Aflatoxin B1 results in increased expression of POLR3B mRNA	CTD	PMID:19770486
Polr3b	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1351468	6480464	Tretinoin results in decreased expression of POLR3B mRNA	CTD	PMID:33167477
Polr3b	Rat	aristolochic acid A	decreases expression	ISO	RGD:1351468	6480464	aristolochic acid I results in decreased expression of POLR3B mRNA	CTD	PMID:33212167
Polr3b	Rat	arsane	affects methylation	ISO	RGD:1351468	6480464	Arsenic affects the methylation of POLR3B gene	CTD	PMID:25304211
Polr3b	Rat	arsenic atom	affects methylation	ISO	RGD:1351468	6480464	Arsenic affects the methylation of POLR3B gene	CTD	PMID:25304211
Polr3b	Rat	atrazine	decreases expression	ISO	RGD:1351468	6480464	Atrazine results in decreased expression of POLR3B mRNA	CTD	PMID:22378314
Polr3b	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1351468	6480464	Benzo(a)pyrene results in decreased expression of POLR3B mRNA	CTD	PMID:20064835
Polr3b	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1351468	6480464	Benzo(a)pyrene affects the methylation of POLR3B promoter	CTD	PMID:27901495
Polr3b	Rat	benzo[a]pyrene diol epoxide I	affects expression	ISO	RGD:1351468	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of POLR3B mRNA	CTD	PMID:20382639
Polr3b	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1351468	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of POLR3B mRNA	CTD	PMID:19150397
Polr3b	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of POLR3B mRNA	CTD	PMID:25181051
Polr3b	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of POLR3B mRNA	CTD	PMID:30816183\|PMID:32528016\|PMID:34947998
Polr3b	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of POLR3B gene	CTD	PMID:28505145
Polr3b	Rat	captan	decreases expression	ISO	RGD:1557860	6480464	Captan results in decreased expression of POLR3B mRNA	CTD	PMID:31558096
Polr3b	Rat	CGP 52608	multiple interactions	ISO	RGD:1351468	6480464	CGP 52608 promotes the reaction [RORA protein binds to POLR3B gene]	CTD	PMID:28238834
Polr3b	Rat	choline	multiple interactions	ISO	RGD:1557860	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Polr3b	Rat	cisplatin	affects expression	ISO	RGD:1351468	6480464	Cisplatin affects the expression of POLR3B mRNA	CTD	PMID:23300844
Polr3b	Rat	copper(II) sulfate	decreases expression	ISO	RGD:1351468	6480464	Copper Sulfate results in decreased expression of POLR3B mRNA	CTD	PMID:19549813
Polr3b	Rat	cyclosporin A	decreases expression	ISO	RGD:1351468	6480464	Cyclosporine results in decreased expression of POLR3B mRNA	CTD	PMID:25562108
Polr3b	Rat	dioxygen	decreases expression	ISO	RGD:1351468	6480464	Oxygen deficiency results in decreased expression of POLR3B mRNA	CTD	PMID:24236059
Polr3b	Rat	epoxiconazole	decreases expression	ISO	RGD:1557860	6480464	epoxiconazole results in decreased expression of POLR3B mRNA	CTD	PMID:35436446
Polr3b	Rat	ethyl methanesulfonate	decreases expression	ISO	RGD:1351468	6480464	Ethyl Methanesulfonate results in decreased expression of POLR3B mRNA	CTD	PMID:23649840
Polr3b	Rat	fenthion	decreases expression	ISO	RGD:1557860	6480464	Fenthion results in decreased expression of POLR3B mRNA	CTD	PMID:34813904
Polr3b	Rat	folic acid	multiple interactions	ISO	RGD:1557860	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of POLR3B mRNA; [Methionine deficiency co-treated more ...	CTD	PMID:20938992\|PMID:22206623
Polr3b	Rat	folic acid	decreases expression	ISO	RGD:1557860	6480464	Folic Acid results in decreased expression of POLR3B mRNA	CTD	PMID:25629700
Polr3b	Rat	folpet	decreases expression	ISO	RGD:1557860	6480464	folpet results in decreased expression of POLR3B mRNA	CTD	PMID:31558096
Polr3b	Rat	formaldehyde	decreases expression	ISO	RGD:1351468	6480464	Formaldehyde results in decreased expression of POLR3B mRNA	CTD	PMID:20655997\|PMID:23649840
Polr3b	Rat	inulin	multiple interactions	ISO	RGD:1557860	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of POLR3B mRNA	CTD	PMID:36331819
Polr3b	Rat	L-methionine	multiple interactions	ISO	RGD:1557860	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation more ...	CTD	PMID:20938992
Polr3b	Rat	lead(0)	increases expression	ISO	RGD:1351468	6480464	Lead results in increased expression of POLR3B mRNA	CTD	PMID:19921347
Polr3b	Rat	lithium chloride	decreases expression	ISO	RGD:1351468	6480464	Lithium Chloride results in decreased expression of POLR3B mRNA	CTD	PMID:23527032
Polr3b	Rat	methidathion	decreases expression	ISO	RGD:1557860	6480464	methidathion results in decreased expression of POLR3B mRNA	CTD	PMID:34813904
Polr3b	Rat	methyl methanesulfonate	decreases expression	ISO	RGD:1351468	6480464	Methyl Methanesulfonate results in decreased expression of POLR3B mRNA	CTD	PMID:23649840
Polr3b	Rat	methylmercury chloride	decreases expression	ISO	RGD:1351468	6480464	methylmercuric chloride results in decreased expression of POLR3B mRNA	CTD	PMID:28001369
Polr3b	Rat	paracetamol	decreases expression	ISO	RGD:1351468	6480464	Acetaminophen results in decreased expression of POLR3B mRNA	CTD	PMID:21420995
Polr3b	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of POLR3B mRNA	CTD	PMID:33387578
Polr3b	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1557860	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of POLR3B mRNA	CTD	PMID:36331819
Polr3b	Rat	potassium chromate	multiple interactions	ISO	RGD:1351468	6480464	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of POLR3B mRNA	CTD	PMID:22079256
Polr3b	Rat	potassium chromate	decreases expression	ISO	RGD:1351468	6480464	potassium chromate(VI) results in decreased expression of POLR3B mRNA	CTD	PMID:22079256
Polr3b	Rat	quercetin	decreases expression	ISO	RGD:1351468	6480464	Quercetin results in decreased expression of POLR3B mRNA	CTD	PMID:21632981
Polr3b	Rat	rac-lactic acid	decreases expression	ISO	RGD:1351468	6480464	Lactic Acid results in decreased expression of POLR3B mRNA	CTD	PMID:30851411
Polr3b	Rat	resveratrol	multiple interactions	ISO	RGD:1351468	6480464	[Plant Extracts co-treated with Resveratrol] results in increased expression of POLR3B mRNA	CTD	PMID:23557933
Polr3b	Rat	sodium arsenite	decreases expression	ISO	RGD:1351468	6480464	sodium arsenite results in decreased expression of POLR3B mRNA	CTD	PMID:38568856
Polr3b	Rat	sodium dichromate	decreases expression	ISO	RGD:1557860	6480464	sodium bichromate results in decreased expression of POLR3B mRNA	CTD	PMID:31558096
Polr3b	Rat	sunitinib	increases expression	ISO	RGD:1351468	6480464	Sunitinib results in increased expression of POLR3B mRNA	CTD	PMID:31533062
Polr3b	Rat	temozolomide	increases expression	ISO	RGD:1351468	6480464	Temozolomide results in increased expression of POLR3B mRNA	CTD	PMID:31758290
Polr3b	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of POLR3B mRNA	CTD	PMID:23411599\|PMID:34492290
Polr3b	Rat	troglitazone	decreases expression	ISO	RGD:1557860	6480464	troglitazone results in decreased expression of POLR3B mRNA	CTD	PMID:28973697
Polr3b	Rat	trovafloxacin	decreases expression	ISO	RGD:1557860	6480464	trovafloxacin results in decreased expression of POLR3B mRNA	CTD	PMID:35537566
Polr3b	Rat	valproic acid	increases expression	ISO	RGD:1351468	6480464	Valproic Acid results in increased expression of POLR3B mRNA	CTD	PMID:23179753
Polr3b	Rat	valproic acid	affects expression	ISO	RGD:1351468	6480464	Valproic Acid affects the expression of POLR3B mRNA	CTD	PMID:25979313
Polr3b	Rat	vinclozolin	increases expression	EXP		6480464	vinclozolin results in increased expression of POLR3B mRNA	CTD	PMID:23034163

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Polr3b	Rat	biological_process		ND		1598407	02/2015: no relevant rat data	RGD
Polr3b	Rat	DNA-templated transcription	involved_in	IEA	InterPro:IPR007120\|InterPro:IPR007121\|InterPro:IPR007641\|InterPro:IPR007642\|InterPro:IPR007644\|InterPro:IPR007645\|InterPro:IPR007646\|InterPro:IPR007647\|InterPro:IPR015712\|InterPro:IPR037033	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Polr3b	Rat	positive regulation of innate immune response	involved_in	ISO	RGD:1351468	1624291	PMID:19609254	RGD	PMID:19609254
Polr3b	Rat	positive regulation of interferon-beta production	involved_in	ISO	RGD:1351468	1624291	PMID:19609254	RGD	PMID:19609254
Polr3b	Rat	snRNA transcription by RNA polymerase III	involved_in	ISO	RGD:1351468	1624291	PMID:35637192	RGD	PMID:35637192

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Polr3b	Rat	cytoplasm	located_in	ISO	RGD:1351468	1624291	PMID:33335104	RGD	PMID:33335104
Polr3b	Rat	DNA-directed RNA polymerase complex	part_of	IEA	UniProtKB-KW:KW-0240	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Polr3b	Rat	mitochondrion	located_in	IEA	GO:0006390	1600115	GO_REF:0000108	GOC	GO_REF:0000108
Polr3b	Rat	RNA polymerase III complex	part_of	ISO	RGD:1351468	1624291	PMID:24107381, PMID:33335104, PMID:34675218	RGD	PMID:24107381\|PMID:33335104\|PMID:34675218
Polr3b	Rat	RNA polymerase III complex	part_of	IBA	PANTHER:PTN000465879\|SGD:S000005733\|UniProtKB:Q9NW08	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Polr3b	Rat	5'-3' RNA polymerase activity	enables	IEA	RHEA:21248	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Polr3b	Rat	DNA binding	enables	IEA	InterPro:IPR007120\|InterPro:IPR007121\|InterPro:IPR007641\|InterPro:IPR007642\|InterPro:IPR007644\|InterPro:IPR007645\|InterPro:IPR007646\|InterPro:IPR037033	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Polr3b	Rat	DNA-directed RNA polymerase activity	enables	ISO	RGD:1351468	1624291	PMID:34675218	RGD	PMID:34675218
Polr3b	Rat	DNA-directed RNA polymerase activity	enables	IEA	InterPro:IPR007120\|InterPro:IPR007121\|InterPro:IPR007641\|InterPro:IPR007642\|InterPro:IPR007644\|InterPro:IPR007645\|InterPro:IPR007646\|InterPro:IPR014724\|InterPro:IPR015712\|InterPro:IPR037033	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Polr3b	Rat	DNA-directed RNA polymerase activity	enables	IEA	EC:2.7.7.6	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Polr3b	Rat	DNA/RNA hybrid binding	enables	ISO	RGD:1351468	1624291	PMID:34675218	RGD	PMID:34675218
Polr3b	Rat	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Polr3b	Rat	nucleotidyltransferase activity	enables	IEA	UniProtKB-KW:KW-0548	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Polr3b	Rat	ribonucleoside binding	enables	IEA	InterPro:IPR015712	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Polr3b	Rat	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Polr3b	Rat	zinc ion binding	enables	ISO	RGD:1351468	1624291	PMID:34675218	RGD	PMID:34675218
Polr3b	Rat	zinc ion binding	enables	IEA	UniProtKB-KW:KW-0863	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Polr3b	Rat	RNA polymerase III transcription pathway		ISO	RGD:1351468	9685217		RGD
Polr3b	Rat	RNA polymerase III transcription pathway		ISO	RGD:1351468	9685218		RGD

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Polr3b	Rat	purine metabolic pathway		IEA		6907045		KEGG	rno:00230
Polr3b	Rat	pyrimidine metabolic pathway		IEA		6907045		KEGG	rno:00240

#	Reference Title	Reference Citation
1.	Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.	Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.	Hu P, etal., Mol Cell Biol. 2002 Nov;22(22):8044-55.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation

PMID:19609254	PMID:24107381

Polr3b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	20,926,866 - 21,030,133 (-)	NCBI		GRCr8
mRatBN7.2	7	19,039,179 - 19,142,450 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	19,038,552 - 19,142,598 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	21,000,048 - 21,103,388 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	23,162,717 - 23,266,061 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	22,939,694 - 23,043,036 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	24,745,051 - 24,851,227 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	24,745,051 - 24,851,227 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	24,893,473 - 24,997,174 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	21,167,374 - 21,271,601 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	16,249,574 - 16,351,645 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

POLR3B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	106,357,748 - 106,510,198 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	106,357,748 - 106,510,198 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	106,751,526 - 106,903,976 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	105,275,619 - 105,428,105 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	105,253,955 - 105,406,442	NCBI
Celera	12	106,417,035 - 106,569,571 (+)	NCBI		Celera
Cytogenetic Map	12	q23.3	NCBI
HuRef	12	103,811,761 - 103,964,299 (+)	NCBI		HuRef
CHM1_1	12	106,717,271 - 106,869,784 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	106,321,061 - 106,473,832 (+)	NCBI		T2T-CHM13v2.0

Polr3b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	84,458,156 - 84,563,042 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	84,458,156 - 84,563,042 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	84,622,292 - 84,727,178 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	84,622,292 - 84,727,178 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	84,085,182 - 84,189,923 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	84,052,236 - 84,156,977 (+)	NCBI		MGSCv36	mm8
Celera	10	86,601,354 - 86,706,135 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	41.58	NCBI

Polr3b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	40,353,281 - 40,451,479 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	40,353,289 - 40,451,445 (+)	NCBI	ChiLan1.0	ChiLan1.0

POLR3B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	114,424,006 - 114,574,339 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	114,420,433 - 114,570,732 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	103,936,650 - 104,083,470 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	107,330,315 - 107,477,279 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	107,330,306 - 107,477,279 (+)	Ensembl	panpan1.1		panPan2

POLR3B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	32,202,188 - 32,309,775 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	32,202,190 - 32,309,614 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	32,122,143 - 32,229,740 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	33,043,060 - 33,150,697 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	33,043,081 - 33,150,688 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	32,779,093 - 32,886,667 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	33,067,892 - 33,175,469 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	33,255,591 - 33,362,991 (-)	NCBI		UU_Cfam_GSD_1.0

Polr3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	15,405,578 - 15,531,312 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	8,415,997 - 8,541,762 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	8,415,997 - 8,544,149 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POLR3B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	13,804,930 - 13,926,604 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	13,805,157 - 13,926,733 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	13,910,702 - 14,030,557 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POLR3B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	101,577,134 - 101,719,214 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	101,585,900 - 101,713,126 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	143,325,202 - 143,462,920 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Polr3b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	2,905,747 - 3,004,237 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624750	2,906,041 - 3,004,241 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Polr3b
470 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	84
Count of miRNA genes:	72
Interacting mature miRNAs:	80
Transcripts:	ENSRNOT00000009746
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	17004598	62004598	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
61369	Mcs2	Mammary carcinoma susceptibility QTL 2	3.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	19032807	35526300	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	15573889	60573889	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
70207	Niddm31	Non-insulin dependent diabetes mellitus QTL 31	3.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	18169505	26029351	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	17944357	62944357	Rat

D7Rat154

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	7	20,982,958 - 20,983,189 (+)	Marker Load Pipeline
mRatBN7.2	7	19,095,272 - 19,095,503 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	24,803,959 - 24,804,189	NCBI	Rnor6.0
Rnor_5.0	7	24,949,906 - 24,950,136	UniSTS	Rnor5.0
RGSC_v3.4	7	21,224,425 - 21,224,656	RGD	RGSC3.4
RGSC_v3.4	7	21,224,426 - 21,224,656	UniSTS	RGSC3.4
RGSC_v3.1	7	21,244,641 - 21,245,021	RGD
Celera	7	16,304,545 - 16,304,775	UniSTS
RH 2.0 Map	7	92.2	RGD
SHRSP x BN Map	7	10.35	RGD
Cytogenetic Map	7	q13	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001191878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009746 ⟹ ENSRNOP00000009746

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	19,038,552 - 19,142,598 (-)	Ensembl
Rnor_6.0 Ensembl	7	24,745,051 - 24,851,227 (-)	Ensembl

RefSeq Acc Id:

NM_001191878 ⟹ NP_001178807

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	20,926,866 - 21,030,133 (-)	NCBI
mRatBN7.2	7	19,039,179 - 19,142,450 (-)	NCBI
Rnor_6.0	7	24,745,051 - 24,851,227 (-)	NCBI
Rnor_5.0	7	24,893,473 - 24,997,174 (-)	NCBI
Celera	7	16,249,574 - 16,351,645 (-)	NCBI

Sequence:

show sequence

ATGGACGTGCTAGCTGAGGAGTTCGGGAGCCTGACTCCGGAGGAGCTGGCTGCGCCGATCCCGACTGTGGAGGAAAAATGGAGGCTGCTTCCAGCATTTTTAAAGGTAAAAGGCCTGGTGAAACAGCA
CATCGACTCCTTTAACTATTTCATTAATGTAGAGATAAAGAAGATAATGAAAGCCAACGAAAAGGTTACAAGCGATGCTGATCCCATGTGGTACTTAAAGTATCTTAATATCTATGTTGGACTTCCTG
ACGTCGAAGAAAGCTTCAATGTAACTAGACCAGTGTCCCCTCATGAGTGCCGTCTGCGGGACATGACGTACTCCGCCCCCATCACCGTGGACATCGAGTATACCCGAGGCAGCCAGAGGATAATCCGC
AATGCCTTACCCATTGGCAGAATGCCCATCATGCTCCGAAGTTCAAACTGTGTTCTGACAGGGAAAACTCCAGCAGAGTTTGCCAAACTCAACGAGTGTCCATTAGACCCAGGTGGCTACTTCATCGT
TAAAGGAGTGGAGAAAGTCATTCTTATCCAGGAGCAGCTGTCCAAGAACAGGATCATTGTGGAGGCAGACAGGAAGGGGGCTGTTGGGGCTTCAGTTACCAGCTCCACCCACGAGAAAAAAAGTAGAA
CCAACATGGCGGTGAAACAAGGGCGCTTTTATCTGAGGCATAACACCCTGTCTGAAGATATACCCATTGTCATCATATTCAAGGCCATGGGTGTTGAGAGTGACCAGGAAATTGTGCAGATGATTGGA
ACGGAGGAGCACGTGATGGCTGCGTTTGGGCCCAGCCTGGAGGAGTGCCAGAAAGCTCAGATCTTCACCCAGATGCAGGCGTTGAAGTATATAGGGAATAAAGTAAGAAGACAAAGAATGTGGGGAGG
TGGACCAAAGAAGACCAAAATAGAAGAAGCAAGAGAACTTCTGGCCTCTACCATTCTGACCCATGTACCAGTTAAGGAATTCAATTTCCGAGCTAAGTGTATCTACACGGCAGTGATGGTGCGAAGGG
TGATCTTGGCCCAAGGAGATAACAAGGTCGATGACAGAGACTATTACGGCAACAAGCGACTGGAGCTGGCAGGCCAGCTCTTGTCTCTTCTTTTTGAAGATTTGTTTAAAAAGTTTAATTCAGAAATG
AAGAAGATTGCAGACCAAGTGATTCCTAAACAAAGAGCAGCCCAGTTTGACGTCGTGAAACACATGCGCCAAGACCAGATTACCAATGGCATGGTCAATGCCATCTCCACGGGAAATTGGTCTCTGAA
GAGATTTAAGATGGACCGGCAGGGTGTGACCCAAGTGCTGTCTCGCTTGTCCTATATATCTGCACTTGGCATGATGACAAGAATCTCTTCCCAGTTCGAAAAAACAAGAAAAGTGAGTGGCCCTCGTT
CTCTGCAGCCATCTCAGTGGGGAATGCTCTGTCCCTCCGACACACCTGAAGGAGAGGCCTGCGGTTTGGTTAAGAACTTGGCCCTCATGACACATATAACAACCGACATGGAAGATGGACCCATTATT
AAGTTAGCTGGGAACTTGGGAGTAGAAGATGTGAATTTATTATGTGGAGAAGAGCTCTCTTACCCAAATGTATTCCTTGTCTTCCTGAATGGTAACATCCTGGGTGTCATTCGAGACCATAAAAAGCT
TGTGAGCACGTTCCGGCTGATGCGAAGAGCAGGCTACATCAATGAATTTGTCTCCATCTCCACAAACCTTACGGACCGATGTGTTTACATTTCCTCTGATGGCGGGCGCTTGTGCAGGCCTTACATCA
TTGTCAAGAAACAGAAGCCCGCAGTTACCAATAAGCACATGGAAGAGCTGGCTCAAGGTTACAGGAATTTTGAAGATTTCTTACATGAGAGTCTGGTTGAGTACTTAGATGTGAATGAAGAAAATGAT
TGTAACATTGCGCTCTACGAACATACAATTAATAAAGACACCACCCACTTGGAGATTGAACCCTTCACTCTTCTCGGTGTTTGCGCCGGCCTGATCCCGTACCCTCATCACAACCAGTCTCCAAGAAA
CACCTACCAGTGTGCCATGGGCAAGCAAGCCATGGGTACCATTGGATACAATCAGCGAAACAGAATTGATACACTAATGTATCTACTAGCATATCCACAAAAACCCATGGTTAAAACAAAAACCATTG
AGTTGATAGACTTTGAGAAATTGCCAGCTGGGCAGAATGCAACTGTTGCCGTGATGAGCTACAGCGGCTATGACATTGAAGACGCCCTTGTTTTGAACAAGGCCTCTCTGGACAGAGGTTTTGGGCGT
TGTCTCGTCTATAAAAACGCTAAGTGCACATTGAAGCGATATACCAATCAGACTTTTGATAAGGTGATGGGTCCCATGTTGGATGCTGCTACCAGAAAACCCATCTGGCGACATGAAATTTTAGATGC
AGATGGCATTTGTTCTCCAGGTGAGAAAGTAGAAAACAAGCAGGTGCTTGTAAACAAGTCCATGCCCACAGTGACTCAGATTCCTCTGGAAGGGAGCAACGTGCCACAGCAGCCACAGTATAAGGATG
TGCCCATCACGTACAAAGGTGCAACAGACTCTTACATCGAGAAAGTGATGATCTCTTCCAACGCTGAGGACGCTTTCCTCATCAAGATGCTCCTGAGACAGACGCGGCGTCCAGAGATCGGAGACAAA
TTCAGCAGTCGCCATGGACAAAAGGGTGTCTGCGGCCTGATCGTCCCCCAAGAAGACATGCCGTTCTGTGACTCTGGCATCTGTCCCGACATCATAATGAACCCTCACGGCTTCCCATCGAGAATGAC
GGTTGGAAAGTTGATTGAGTTGCTGGCCGGCAAGGCAGGCGTGTTAGACGGCAGGTTCCACTACGGCACCGCCTTTGGAGGGAGTAAAGTGAAGGACGTGTGTGAAGACCTCGTTCGCCATGGTTACA
ACTACCTGGGGAAGGACTATGTCACCTCGGGCATCACCGGTGAGCCCTTAGAAGCCTACATCTATTTTGGGCCTGTGTACTATCAGAAACTGAAACACATGGTGCTGGATAAAATGCATGCCCGGGCC
AGAGGACCACGAGCTGTCCTTACCAGGCAGCCCACTGAAGGGCGATCTCGCGATGGCGGCCTGCGTCTTGGAGAAATGGAGCGTGACTGTTTAATTGGCTATGGAGCGAGTATGCTTTTGCTGGAGAG
ACTAATGATCTCAAGTGATGCCTTCGAAGTTGACGTCTGTGGGCAGTGTGGACTACTTGGATATTCTGGCTGGTGTCACTACTGCAAGTCCTCGTGCCACGTGTCCTCCCTCCGCATCCCATATGCCT
GCAAGCTGCTCTTCCAGGAGTTGCAGTCCATGAACATCATCCCCAGGTTGAAACTGGCCAAGTACAACGAGTAAAGACGTGCAGTGCTCACGAGGAGGATGTAGTCTCGGCGACCTGTGCAGCCAGAG
GCAGAGGGCGCACGGTGACTTCTCTGCTCATTCTGCTTCCTGGAGAACGGCGAGGGCCAGCAGCAGCTGAGGTCCAGAGGCTGGCTTGACACCTTGGACCTGCATCCTCGAACCGCAGGAGGTGCTGG
GCCCCACACAGCACAGCACCGTGTGGAGTCACACACAGATGGGCACAGGCTAGAGAAAGTGCCAACGCCTATTAATTTTGTCGTTTGTTTGTTTGTTTGTTTGTTTGTGTTGAGTTGAGTTGGAGCCT
CACTCTGTATCCCAGGCTGGATTGGAACTCACCCCAATCCTGCCTTCGTCTTGCACAAGTGCTGGAGTCATGGATGTGAGCCAGCATATCTGGTTTGTTTATGTTATTATGTTTTAAAATTTACGTAT
TAGAAAAATCTTCCTCCTTAAAATCCCCCCGACGTCCTCTGGTTAGCAGAACTCTGGGTTCTTGTCAGATGTGGAGGAAGTAAAGAATCATTTGAATTGGGACTAAGACGTTACCTCAGTCAGTCACG
TGCCTGTTGCATATCTGTGACCTGAGTTCACCCCCAGCAGCCCGTGTAAGGGCTGGACATGGCACCTAACACCGTGTAAAATCCAGTACTGCGGGGTGGCAGTGGGGAGGAGACAGGCAGGCCCCTGG
CGCTTACTGACAGCGCATAGCCAGTCCGTGCGCTTC

hide sequence


Protein RefSeqs	NP_001178807	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM17096	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009746.5
	ENSRNOP00000099075

RefSeq Acc Id:

NP_001178807 ⟸ NM_001191878

- UniProtKB:

D3ZV30 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDVLAEEFGSLTPEELAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIR
NALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIFKAMGVESDQEIVQMIG
TEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGGPKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNKRLELAGQLLSLLFEDLFKKFNSEM
KKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDMEDGPII
KLAGNLGVEDVNLLCGEELSYPNVFLVFLNGNILGVIRDHKKLVSTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEEND
CNIALYEHTINKDTTHLEIEPFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIDFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGR
CLVYKNAKCTLKRYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDK
FSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKMHARA
RGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVCGQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLAKYNE

hide sequence

Ensembl Acc Id:

ENSRNOP00000009746 ⟸ ENSRNOT00000009746

Protein Domains

DNA-directed RNA polymerase subunit 2 hybrid- RNA polymerase beta subunit protrusion RNA polymerase Rpb2

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZV30-F1-model_v2	AlphaFold	D3ZV30	1-1133	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13695099

Promoter ID:

EPDNEW_R5624

Type:

initiation region

Name:

Polr3b_1

Description:

RNA polymerase III subunit B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	24,851,303 - 24,851,363	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-34622	BioCyc
Ensembl Genes	ENSRNOG00000007432	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009746.7	UniProtKB/TrEMBL
	ENSRNOT00000164981	ENTREZGENE
Gene3D-CATH	2.40.270.10	UniProtKB/TrEMBL
	2.40.50.150	UniProtKB/TrEMBL
	3.90.1100.10	UniProtKB/TrEMBL
	RNA polymerase alpha subunit dimerisation domain	UniProtKB/TrEMBL
InterPro	DNA-dir_RNA_pol_su2	UniProtKB/TrEMBL
	DNA-dir_RNA_pol_su2_6	UniProtKB/TrEMBL
	DNA-dir_RNAP_su2_hyb_sf	UniProtKB/TrEMBL
	RNA_pol_bsu_CS	UniProtKB/TrEMBL
	RNA_pol_bsu_protrusion	UniProtKB/TrEMBL
	RNA_pol_Rpb2_2	UniProtKB/TrEMBL
	RNA_pol_Rpb2_3	UniProtKB/TrEMBL
	RNA_pol_Rpb2_4	UniProtKB/TrEMBL
	RNA_pol_Rpb2_5	UniProtKB/TrEMBL
	RNA_pol_Rpb2_7	UniProtKB/TrEMBL
	RNA_pol_RPB2_OB-fold	UniProtKB/TrEMBL
KEGG Report	rno:362858	UniProtKB/TrEMBL
NCBI Gene	362858	ENTREZGENE
PANTHER	RNA_pol_I_sub2	UniProtKB/TrEMBL
Pfam	RNA_pol_Rpb2_1	UniProtKB/TrEMBL
	RNA_pol_Rpb2_2	UniProtKB/TrEMBL
	RNA_pol_Rpb2_3	UniProtKB/TrEMBL
	RNA_pol_Rpb2_4	UniProtKB/TrEMBL
	RNA_pol_Rpb2_5	UniProtKB/TrEMBL
	RNA_pol_Rpb2_6	UniProtKB/TrEMBL
	RNA_pol_Rpb2_7	UniProtKB/TrEMBL
PhenoGen	Polr3b	PhenoGen
PROSITE	RNA_POL_BETA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007432	RatGTEx
Superfamily-SCOP	beta and beta-prime subunits of DNA dependent RNA-polymerase	UniProtKB/TrEMBL
UniProt	D3ZV30	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-21	Polr3b	RNA polymerase III subunit B	Polr3b	polymerase (RNA) III subunit B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-08	Polr3b	polymerase (RNA) III subunit B	Polr3b	polymerase (RNA) III (DNA directed) polypeptide B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Polr3b	polymerase (RNA) III (DNA directed) polypeptide B	RGD1565311_predicted	similar to RNA polymerase III subunit RPC2 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1565311_predicted	similar to RNA polymerase III subunit RPC2 (predicted)	LOC362858	similar to RNA polymerase III subunit RPC2	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC362858	similar to RNA polymerase III subunit RPC2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - CTD

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RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)