PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: bupranolol drug pathway
Accession: PW:0002134
browse the term
Definition: The pharmacokinetics and pharmacodynamics pathway of buoranolol - a non-selective adrenergic beta receptor blocker, used for the treatment of hypertension and other cardiovascular conditions. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
Synonyms: related_synonym: SMP:00670
G
ABCC8
ATP binding cassette subfamily C member 8
ISO
SMPDB
SMP:00670
NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870
G
ABCC9
ATP binding cassette subfamily C member 9
ISO
SMPDB
SMP:00670
NCBI chr12:64,357,176...64,500,358
Ensembl chr12:66,960,888...67,102,496
G
ADRB1
adrenoceptor beta 1
ISO
SMPDB
SMP:00670
NCBI chr10:110,642,491...110,646,595
G
AGTR1
angiotensin II receptor type 1
ISO
SMPDB
SMP:00670
NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380
G
ALG10B
ALG10 alpha-1,2-glucosyltransferase B
ISO
SMPDB
SMP:00670
NCBI chr12:50,384,038...50,391,416
G
ATP1A1
ATPase Na+/K+ transporting subunit alpha 1
ISO
SMPDB
SMP:00670
NCBI chr 1:86,162,401...86,193,883
Ensembl chr 1:121,212,488...121,243,099
G
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
ISO
SMPDB
SMP:00670
NCBI chr 1:135,469,495...135,497,303
Ensembl chr 1:139,390,549...139,418,303
G
ATP1A3
ATPase Na+/K+ transporting subunit alpha 3
ISO
SMPDB
SMP:00670
NCBI chr19:38,854,243...38,882,034
Ensembl chr19:47,358,281...47,384,716
G
ATP1A4
ATPase Na+/K+ transporting subunit alpha 4
ISO
SMPDB
SMP:00670
NCBI chr 1:135,504,929...135,540,651
Ensembl chr 1:139,426,556...139,462,393
G
ATP1B1
ATPase Na+/K+ transporting subunit beta 1
ISO
SMPDB
SMP:00670
NCBI chr 1:144,592,667...144,621,052
Ensembl chr 1:148,314,793...148,342,050
G
ATP1B2
ATPase Na+/K+ transporting subunit beta 2
ISO
SMPDB
SMP:00670
NCBI chr17:7,681,831...7,688,710
Ensembl chr17:7,669,626...7,673,834
G
ATP1B3
ATPase Na+/K+ transporting subunit beta 3
ISO
SMPDB
SMP:00670
NCBI chr 3:138,903,371...138,954,915
Ensembl chr 3:146,500,493...146,550,164
G
ATP1B4
ATPase Na+/K+ transporting family member beta 4
ISO
SMPDB
SMP:00670
NCBI chr X:109,633,770...109,654,662
Ensembl chr X:119,820,695...119,841,598
G
ATP2A2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ISO
SMPDB
SMP:00670
NCBI chr12:107,857,009...107,924,938
Ensembl chr12:111,246,508...111,311,923
G
CACNA1C
calcium voltage-gated channel subunit alpha1 C
ISO
SMPDB
SMP:00670
NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826
G
CACNA1G
calcium voltage-gated channel subunit alpha1 G
ISO
SMPDB
SMP:00670
NCBI chr17:44,654,558...44,786,037
Ensembl chr17:49,529,402...49,595,166
G
CACNA1H
calcium voltage-gated channel subunit alpha1 H
ISO
SMPDB
SMP:00670
Ensembl chr16:1,195,364...1,222,917
G
CACNA2D2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
ISO
SMPDB
SMP:00670
NCBI chr 3:50,288,926...50,430,152
Ensembl chr 3:51,526,075...51,640,406
G
CACNB1
calcium voltage-gated channel auxiliary subunit beta 1
ISO
SMPDB
SMP:00670
NCBI chr17:18,073,818...18,098,400
Ensembl chr17:18,349,146...18,373,338
G
CALM1
calmodulin 1
ISO
SMPDB
SMP:00670
NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135
G
CHRM2
cholinergic receptor muscarinic 2
ISO
SMPDB
SMP:00670
NCBI chr 7:128,827,089...128,978,496
Ensembl chr 7:141,466,396...141,467,796
G
DLG1
discs large MAGUK scaffold protein 1
ISO
SMPDB
SMP:00670
NCBI chr 3:194,386,263...194,648,015
Ensembl chr 3:204,323,724...204,584,987
G
FXYD2
FXYD domain containing ion transport regulator 2
ISO
SMPDB
SMP:00670
NCBI chr11:112,654,774...112,666,630
Ensembl chr11:116,587,226...116,595,197
G
HCN4
hyperpolarization activated cyclic nucleotide gated potassium channel 4
ISO
SMPDB
SMP:00670
NCBI chr15:52,231,906...52,285,220
Ensembl chr15:70,997,020...71,042,285
G
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
ISO
SMPDB
SMP:00670
NCBI chr 3:4,448,574...4,802,545
Ensembl chr 3:4,572,921...4,904,811
G
KCNA5
potassium voltage-gated channel subfamily A member 5
ISO
SMPDB
SMP:00670
NCBI chr12:5,165,057...5,168,307
G
KCND3
potassium voltage-gated channel subfamily D member 3
ISO
SMPDB
SMP:00670
NCBI chr 1:114,433,203...114,651,894
Ensembl chr 1:125,696,907...125,909,814
G
KCNE1
potassium voltage-gated channel subfamily E regulatory subunit 1
ISO
SMPDB
SMP:00670
NCBI chr21:20,818,395...20,884,053
Ensembl chr21:34,190,043...34,190,441
G
KCNE2
potassium voltage-gated channel subfamily E regulatory subunit 2
ISO
SMPDB
SMP:00670
G
KCNH2
potassium voltage-gated channel subfamily H member 2
ISO
SMPDB
SMP:00670
NCBI chr 7:142,528,979...142,562,074
G
KCNIP2
potassium voltage-gated channel interacting protein 2
ISO
SMPDB
SMP:00670
NCBI chr10:98,428,619...98,446,581
Ensembl chr10:101,899,898...101,918,691
G
KCNJ11
potassium inwardly rectifying channel subfamily J member 11
ISO
SMPDB
SMP:00670
NCBI chr11:17,440,522...17,444,075
Ensembl chr11:17,127,557...17,128,729
G
KCNJ2
potassium inwardly rectifying channel subfamily J member 2
ISO
SMPDB
SMP:00670
NCBI chr17:64,097,908...64,112,914
Ensembl chr17:69,487,846...69,489,129
G
KCNJ3
potassium inwardly rectifying channel subfamily J member 3
ISO
SMPDB
SMP:00670
NCBI chr2B:41,965,152...42,124,285
G
KCNJ4
potassium inwardly rectifying channel subfamily J member 4
ISO
SMPDB
SMP:00670
NCBI chr22:19,341,699...19,370,666
Ensembl chr22:37,163,760...37,165,097
G
KCNJ5
potassium inwardly rectifying channel subfamily J member 5
ISO
SMPDB
SMP:00670
NCBI chr11:123,705,361...123,735,370
Ensembl chr11:127,606,208...127,634,213
G
KCNJ8
potassium inwardly rectifying channel subfamily J member 8
ISO
SMPDB
SMP:00670
NCBI chr12:64,522,172...64,532,848
Ensembl chr12:67,127,263...67,137,128
G
KCNK1
potassium two pore domain channel subfamily K member 1
ISO
SMPDB
SMP:00670
NCBI chr 1:209,149,558...209,210,873
Ensembl chr 1:214,178,631...214,238,379
G
KCNQ1
potassium voltage-gated channel subfamily Q member 1
ISO
SMPDB
SMP:00670
NCBI chr11:2,469,750...2,874,467
G
MYLK
myosin light chain kinase
ISO
SMPDB
SMP:00670
NCBI chr 3:120,711,705...120,983,432
Ensembl chr 3:127,614,173...127,793,261
G
PLCB1
phospholipase C beta 1
ISO
SMPDB
SMP:00670
NCBI chr20:8,106,665...8,858,572
Ensembl chr20:7,887,960...8,636,019
G
PLN
phospholamban
ISO
SMPDB
SMP:00670
NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668
G
PRKACA
protein kinase cAMP-activated catalytic subunit alpha
ISO
SMPDB
SMP:00670
NCBI chr19:13,657,344...13,683,864
Ensembl chr19:14,385,191...14,406,205
G
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
ISO
SMPDB
SMP:00670
NCBI chr17:62,448,718...62,488,493
Ensembl chr17:67,838,484...67,877,943
G
RYR2
ryanodine receptor 2
ISO
SMPDB
SMP:00670
NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509
G
SCN5A
sodium voltage-gated channel alpha subunit 5
ISO
SMPDB
SMP:00670
NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202
G
SLC8A1
solute carrier family 8 member A1
ISO
SMPDB
SMP:00670
NCBI chr2A:40,169,339...40,586,546
Ensembl chr2A:40,939,900...41,363,038
G
SNTA1
syntrophin alpha 1
ISO
SMPDB
SMP:00670
NCBI chr20:29,696,137...29,732,258
Ensembl chr20:30,810,787...30,844,476
G
SNTB1
syntrophin beta 1
ISO
SMPDB
SMP:00670
NCBI chr 8:117,225,128...117,501,899
Ensembl chr 8:119,996,149...120,268,188
G
SNTB2
syntrophin beta 2
ISO
SMPDB
SMP:00670
NCBI chr16:49,558,099...49,683,554
G
TNNC1
troponin C1, slow skeletal and cardiac type
ISO
SMPDB
SMP:00670
NCBI chr 3:52,393,106...52,396,076
Ensembl chr 3:53,621,749...53,624,726
G
TNNC2
troponin C2, fast skeletal type
ISO
SMPDB
SMP:00670
NCBI chr20:42,162,502...42,172,829
Ensembl chr20:43,249,725...43,254,134
G
TNNI1
troponin I1, slow skeletal type
ISO
SMPDB
SMP:00670
NCBI chr 1:177,006,262...177,054,525
Ensembl chr 1:181,309,609...181,314,889
G
TNNI2
troponin I2, fast skeletal type
ISO
SMPDB
SMP:00670
NCBI chr11:1,874,633...1,878,343
Ensembl chr11:1,902,554...1,910,084
G
TNNI3
troponin I3, cardiac type
ISO
SMPDB
SMP:00670
NCBI chr19:52,193,061...52,198,782
Ensembl chr19:60,887,630...60,894,219
G
TNNT1
troponin T1, slow skeletal type
ISO
SMPDB
SMP:00670
NCBI chr19:52,173,523...52,190,577
Ensembl chr19:60,868,330...60,882,005
G
TNNT2
troponin T2, cardiac type
ISO
SMPDB
SMP:00670
NCBI chr 1:176,957,298...176,976,033
G
TNNT3
troponin T3, fast skeletal type
ISO
SMPDB
SMP:00670
NCBI chr11:1,936,614...1,955,784
Ensembl chr11:1,968,184...1,987,849
G
TPM1
tropomyosin 1
ISO
SMPDB
SMP:00670
NCBI chr15:41,989,239...42,018,520
Ensembl chr15:60,286,587...60,315,530
G
TPM2
tropomyosin 2
ISO
SMPDB
SMP:00670
NCBI chr 9:35,533,982...35,542,033
Ensembl chr 9:36,336,307...36,345,394
G
ABCC8
ATP binding cassette subfamily C member 8
ISO
SMPDB
SMP:00670
NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870
G
ABCC9
ATP binding cassette subfamily C member 9
ISO
SMPDB
SMP:00670
NCBI chr12:64,357,176...64,500,358
Ensembl chr12:66,960,888...67,102,496
G
ADRB1
adrenoceptor beta 1
ISO
SMPDB
SMP:00670
NCBI chr10:110,642,491...110,646,595
G
AGTR1
angiotensin II receptor type 1
ISO
SMPDB
SMP:00670
NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380
G
ALG10B
ALG10 alpha-1,2-glucosyltransferase B
ISO
SMPDB
SMP:00670
NCBI chr12:50,384,038...50,391,416
G
ATP1A1
ATPase Na+/K+ transporting subunit alpha 1
ISO
SMPDB
SMP:00670
NCBI chr 1:86,162,401...86,193,883
Ensembl chr 1:121,212,488...121,243,099
G
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
ISO
SMPDB
SMP:00670
NCBI chr 1:135,469,495...135,497,303
Ensembl chr 1:139,390,549...139,418,303
G
ATP1A3
ATPase Na+/K+ transporting subunit alpha 3
ISO
SMPDB
SMP:00670
NCBI chr19:38,854,243...38,882,034
Ensembl chr19:47,358,281...47,384,716
G
ATP1A4
ATPase Na+/K+ transporting subunit alpha 4
ISO
SMPDB
SMP:00670
NCBI chr 1:135,504,929...135,540,651
Ensembl chr 1:139,426,556...139,462,393
G
ATP1B1
ATPase Na+/K+ transporting subunit beta 1
ISO
SMPDB
SMP:00670
NCBI chr 1:144,592,667...144,621,052
Ensembl chr 1:148,314,793...148,342,050
G
ATP1B2
ATPase Na+/K+ transporting subunit beta 2
ISO
SMPDB
SMP:00670
NCBI chr17:7,681,831...7,688,710
Ensembl chr17:7,669,626...7,673,834
G
ATP1B3
ATPase Na+/K+ transporting subunit beta 3
ISO
SMPDB
SMP:00670
NCBI chr 3:138,903,371...138,954,915
Ensembl chr 3:146,500,493...146,550,164
G
ATP1B4
ATPase Na+/K+ transporting family member beta 4
ISO
SMPDB
SMP:00670
NCBI chr X:109,633,770...109,654,662
Ensembl chr X:119,820,695...119,841,598
G
ATP2A2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ISO
SMPDB
SMP:00670
NCBI chr12:107,857,009...107,924,938
Ensembl chr12:111,246,508...111,311,923
G
CACNA1C
calcium voltage-gated channel subunit alpha1 C
ISO
SMPDB
SMP:00670
NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826
G
CACNA1G
calcium voltage-gated channel subunit alpha1 G
ISO
SMPDB
SMP:00670
NCBI chr17:44,654,558...44,786,037
Ensembl chr17:49,529,402...49,595,166
G
CACNA1H
calcium voltage-gated channel subunit alpha1 H
ISO
SMPDB
SMP:00670
Ensembl chr16:1,195,364...1,222,917
G
CACNA2D2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
ISO
SMPDB
SMP:00670
NCBI chr 3:50,288,926...50,430,152
Ensembl chr 3:51,526,075...51,640,406
G
CACNB1
calcium voltage-gated channel auxiliary subunit beta 1
ISO
SMPDB
SMP:00670
NCBI chr17:18,073,818...18,098,400
Ensembl chr17:18,349,146...18,373,338
G
CALM1
calmodulin 1
ISO
SMPDB
SMP:00670
NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135
G
CHRM2
cholinergic receptor muscarinic 2
ISO
SMPDB
SMP:00670
NCBI chr 7:128,827,089...128,978,496
Ensembl chr 7:141,466,396...141,467,796
G
DLG1
discs large MAGUK scaffold protein 1
ISO
SMPDB
SMP:00670
NCBI chr 3:194,386,263...194,648,015
Ensembl chr 3:204,323,724...204,584,987
G
FXYD2
FXYD domain containing ion transport regulator 2
ISO
SMPDB
SMP:00670
NCBI chr11:112,654,774...112,666,630
Ensembl chr11:116,587,226...116,595,197
G
HCN4
hyperpolarization activated cyclic nucleotide gated potassium channel 4
ISO
SMPDB
SMP:00670
NCBI chr15:52,231,906...52,285,220
Ensembl chr15:70,997,020...71,042,285
G
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
ISO
SMPDB
SMP:00670
NCBI chr 3:4,448,574...4,802,545
Ensembl chr 3:4,572,921...4,904,811
G
KCNA5
potassium voltage-gated channel subfamily A member 5
ISO
SMPDB
SMP:00670
NCBI chr12:5,165,057...5,168,307
G
KCND3
potassium voltage-gated channel subfamily D member 3
ISO
SMPDB
SMP:00670
NCBI chr 1:114,433,203...114,651,894
Ensembl chr 1:125,696,907...125,909,814
G
KCNE1
potassium voltage-gated channel subfamily E regulatory subunit 1
ISO
SMPDB
SMP:00670
NCBI chr21:20,818,395...20,884,053
Ensembl chr21:34,190,043...34,190,441
G
KCNE2
potassium voltage-gated channel subfamily E regulatory subunit 2
ISO
SMPDB
SMP:00670
G
KCNH2
potassium voltage-gated channel subfamily H member 2
ISO
SMPDB
SMP:00670
NCBI chr 7:142,528,979...142,562,074
G
KCNIP2
potassium voltage-gated channel interacting protein 2
ISO
SMPDB
SMP:00670
NCBI chr10:98,428,619...98,446,581
Ensembl chr10:101,899,898...101,918,691
G
KCNJ11
potassium inwardly rectifying channel subfamily J member 11
ISO
SMPDB
SMP:00670
NCBI chr11:17,440,522...17,444,075
Ensembl chr11:17,127,557...17,128,729
G
KCNJ2
potassium inwardly rectifying channel subfamily J member 2
ISO
SMPDB
SMP:00670
NCBI chr17:64,097,908...64,112,914
Ensembl chr17:69,487,846...69,489,129
G
KCNJ3
potassium inwardly rectifying channel subfamily J member 3
ISO
SMPDB
SMP:00670
NCBI chr2B:41,965,152...42,124,285
G
KCNJ4
potassium inwardly rectifying channel subfamily J member 4
ISO
SMPDB
SMP:00670
NCBI chr22:19,341,699...19,370,666
Ensembl chr22:37,163,760...37,165,097
G
KCNJ5
potassium inwardly rectifying channel subfamily J member 5
ISO
SMPDB
SMP:00670
NCBI chr11:123,705,361...123,735,370
Ensembl chr11:127,606,208...127,634,213
G
KCNJ8
potassium inwardly rectifying channel subfamily J member 8
ISO
SMPDB
SMP:00670
NCBI chr12:64,522,172...64,532,848
Ensembl chr12:67,127,263...67,137,128
G
KCNK1
potassium two pore domain channel subfamily K member 1
ISO
SMPDB
SMP:00670
NCBI chr 1:209,149,558...209,210,873
Ensembl chr 1:214,178,631...214,238,379
G
KCNQ1
potassium voltage-gated channel subfamily Q member 1
ISO
SMPDB
SMP:00670
NCBI chr11:2,469,750...2,874,467
G
MYLK
myosin light chain kinase
ISO
SMPDB
SMP:00670
NCBI chr 3:120,711,705...120,983,432
Ensembl chr 3:127,614,173...127,793,261
G
PLCB1
phospholipase C beta 1
ISO
SMPDB
SMP:00670
NCBI chr20:8,106,665...8,858,572
Ensembl chr20:7,887,960...8,636,019
G
PLN
phospholamban
ISO
SMPDB
SMP:00670
NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668
G
PRKACA
protein kinase cAMP-activated catalytic subunit alpha
ISO
SMPDB
SMP:00670
NCBI chr19:13,657,344...13,683,864
Ensembl chr19:14,385,191...14,406,205
G
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
ISO
SMPDB
SMP:00670
NCBI chr17:62,448,718...62,488,493
Ensembl chr17:67,838,484...67,877,943
G
RYR2
ryanodine receptor 2
ISO
SMPDB
SMP:00670
NCBI chr 1:212,600,198...213,387,312
Ensembl chr 1:217,815,676...218,383,509
G
SCN5A
sodium voltage-gated channel alpha subunit 5
ISO
SMPDB
SMP:00670
NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202
G
SLC8A1
solute carrier family 8 member A1
ISO
SMPDB
SMP:00670
NCBI chr2A:40,169,339...40,586,546
Ensembl chr2A:40,939,900...41,363,038
G
SNTA1
syntrophin alpha 1
ISO
SMPDB
SMP:00670
NCBI chr20:29,696,137...29,732,258
Ensembl chr20:30,810,787...30,844,476
G
SNTB1
syntrophin beta 1
ISO
SMPDB
SMP:00670
NCBI chr 8:117,225,128...117,501,899
Ensembl chr 8:119,996,149...120,268,188
G
SNTB2
syntrophin beta 2
ISO
SMPDB
SMP:00670
NCBI chr16:49,558,099...49,683,554
G
TNNC1
troponin C1, slow skeletal and cardiac type
ISO
SMPDB
SMP:00670
NCBI chr 3:52,393,106...52,396,076
Ensembl chr 3:53,621,749...53,624,726
G
TNNC2
troponin C2, fast skeletal type
ISO
SMPDB
SMP:00670
NCBI chr20:42,162,502...42,172,829
Ensembl chr20:43,249,725...43,254,134
G
TNNI1
troponin I1, slow skeletal type
ISO
SMPDB
SMP:00670
NCBI chr 1:177,006,262...177,054,525
Ensembl chr 1:181,309,609...181,314,889
G
TNNI2
troponin I2, fast skeletal type
ISO
SMPDB
SMP:00670
NCBI chr11:1,874,633...1,878,343
Ensembl chr11:1,902,554...1,910,084
G
TNNI3
troponin I3, cardiac type
ISO
SMPDB
SMP:00670
NCBI chr19:52,193,061...52,198,782
Ensembl chr19:60,887,630...60,894,219
G
TNNT1
troponin T1, slow skeletal type
ISO
SMPDB
SMP:00670
NCBI chr19:52,173,523...52,190,577
Ensembl chr19:60,868,330...60,882,005
G
TNNT2
troponin T2, cardiac type
ISO
SMPDB
SMP:00670
NCBI chr 1:176,957,298...176,976,033
G
TNNT3
troponin T3, fast skeletal type
ISO
SMPDB
SMP:00670
NCBI chr11:1,936,614...1,955,784
Ensembl chr11:1,968,184...1,987,849
G
TPM1
tropomyosin 1
ISO
SMPDB
SMP:00670
NCBI chr15:41,989,239...42,018,520
Ensembl chr15:60,286,587...60,315,530
G
TPM2
tropomyosin 2
ISO
SMPDB
SMP:00670
NCBI chr 9:35,533,982...35,542,033
Ensembl chr 9:36,336,307...36,345,394
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all