TPM2 (tropomyosin 2) - Rat Genome Database

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Gene: TPM2 (tropomyosin 2) Pan paniscus
Analyze
Symbol: TPM2
Name: tropomyosin 2
RGD ID: 11929292
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein heterodimerization activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN actin filament organization (inferred); muscle contraction (inferred); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); arthrogryposis multiplex congenita (ortholog); FOUND IN actin cytoskeleton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tropomyosin 2 (beta); tropomyosin beta chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,896,692 - 88,905,357 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,903,269 - 88,911,296 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,533,982 - 35,542,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,336,307 - 36,345,394 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,336,307 - 36,345,394 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TPM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,896,692 - 88,905,357 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,903,269 - 88,911,296 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,533,982 - 35,542,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,336,307 - 36,345,394 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,336,307 - 36,345,394 (-)Ensemblpanpan1.1panPan2
TPM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,681,993 - 35,690,056 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,681,992 - 35,690,056 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,681,990 - 35,690,053 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,671,990 - 35,680,053 (-)NCBINCBI36Build 36hg18NCBI36
Celera935,615,536 - 35,623,601 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,637,598 - 35,645,663 (-)NCBIHuRef
CHM1_1935,681,818 - 35,689,882 (-)NCBICHM1_1
T2T-CHM13v2.0935,702,645 - 35,710,710 (-)NCBIT2T-CHM13v2.0
Tpm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,513,726 - 43,523,583 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,514,711 - 43,523,765 (-)EnsemblGRCm39 Ensembl
GRCm38443,513,726 - 43,523,583 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,514,711 - 43,523,765 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,527,584 - 43,536,260 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,535,812 - 43,544,488 (-)NCBIMGSCv36mm8
Celera443,548,571 - 43,557,214 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Tpm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,566,712 - 62,576,066 (-)NCBIGRCr8
mRatBN7.2557,770,919 - 57,780,278 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,770,864 - 57,779,992 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,750,807 - 59,759,817 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,569,623 - 61,578,633 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,540,839 - 61,549,996 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,016,616 - 59,025,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,016,622 - 59,025,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,541,215 - 63,550,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,994,101 - 60,003,261 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera556,351,476 - 56,360,486 (-)NCBICelera
Cytogenetic Map5q22NCBI
Tpm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472611,028 - 617,821 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955472611,079 - 617,823 (+)NCBIChiLan1.0ChiLan1.0
TPM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,212,372 - 52,219,947 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,212,401 - 52,219,923 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,779,956 - 50,787,531 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,277,326 - 53,284,901 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,277,355 - 53,284,866 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,821,901 - 51,829,478 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,805,386 - 51,812,960 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,507,526 - 52,515,101 (-)NCBIUU_Cfam_GSD_1.0
Tpm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,132,139 - 167,140,168 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,679,560 - 3,688,308 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,679,719 - 3,687,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,402,251 - 236,410,905 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,402,249 - 236,410,390 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,127,284 - 264,135,301 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q23-q27NCBI
TPM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,912,250 - 44,920,615 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,912,223 - 44,919,456 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603842,015,821 - 42,025,459 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248685,101,090 - 5,109,820 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248685,101,713 - 5,109,560 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000038087   ⟹   ENSPPAP00000015397
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl936,336,307 - 36,345,394 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000038092   ⟹   ENSPPAP00000015402
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl936,336,307 - 36,345,394 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000038096   ⟹   ENSPPAP00000015406
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl936,337,007 - 36,344,107 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000038098   ⟹   ENSPPAP00000015408
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl936,337,458 - 36,344,107 (-)Ensembl
RefSeq Acc Id: XM_008955232   ⟹   XP_008953480
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,897,275 - 88,905,357 (+)NCBI
NHGRI_mPanPan1988,903,269 - 88,911,296 (+)NCBI
Mhudiblu_PPA_v0935,533,982 - 35,541,947 (-)NCBI
PanPan1.1936,336,307 - 36,345,394 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955233   ⟹   XP_008953481
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,896,692 - 88,905,357 (+)NCBI
NHGRI_mPanPan1988,903,322 - 88,911,296 (+)NCBI
Mhudiblu_PPA_v0935,533,982 - 35,542,033 (-)NCBI
PanPan1.1936,336,307 - 36,345,394 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034967399   ⟹   XP_034823290
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,896,721 - 88,905,357 (+)NCBI
NHGRI_mPanPan1988,903,322 - 88,911,296 (+)NCBI
Mhudiblu_PPA_v0935,534,910 - 35,542,033 (-)NCBI
RefSeq Acc Id: XM_034967400   ⟹   XP_034823291
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,897,305 - 88,905,357 (+)NCBI
NHGRI_mPanPan1988,903,322 - 88,910,349 (+)NCBI
Mhudiblu_PPA_v0935,534,910 - 35,541,947 (-)NCBI
RefSeq Acc Id: XR_004673283
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,896,721 - 88,903,099 (+)NCBI
NHGRI_mPanPan1988,903,297 - 88,909,038 (+)NCBI
Mhudiblu_PPA_v0935,536,226 - 35,541,947 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008953480   ⟸   XM_008955232
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AEL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008953481   ⟸   XM_008955233
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AEL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034823290   ⟸   XM_034967399
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034823291   ⟸   XM_034967400
- Peptide Label: isoform X4
- UniProtKB: A0A2R9AK12 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000015408   ⟸   ENSPPAT00000038098
RefSeq Acc Id: ENSPPAP00000015406   ⟸   ENSPPAT00000038096
RefSeq Acc Id: ENSPPAP00000015402   ⟸   ENSPPAT00000038092
RefSeq Acc Id: ENSPPAP00000015397   ⟸   ENSPPAT00000038087


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030835 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000038087.1 UniProtKB/TrEMBL
  ENSPPAT00000038092.1 UniProtKB/TrEMBL
  ENSPPAT00000038096.1 UniProtKB/TrEMBL
  ENSPPAT00000038098.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  1.20.5.340 UniProtKB/TrEMBL
  1.20.5.370 UniProtKB/TrEMBL
InterPro Tropomyosin UniProtKB/TrEMBL
  XRCC4-like_C UniProtKB/TrEMBL
KEGG Report pps:100988547 UniProtKB/TrEMBL
NCBI Gene TPM2 ENTREZGENE
PANTHER TROPOMYOSIN UniProtKB/TrEMBL
  TROPOMYOSIN BETA CHAIN UniProtKB/TrEMBL
Pfam Tropomyosin UniProtKB/TrEMBL
PRINTS TROPOMYOSIN UniProtKB/TrEMBL
PROSITE TROPOMYOSIN UniProtKB/TrEMBL
Superfamily-SCOP Tropomyosin UniProtKB/TrEMBL
UniProt A0A2R9ADN5_PANPA UniProtKB/TrEMBL
  A0A2R9AEL6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AEL9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AK12 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-30 TPM2  tropomyosin 2    tropomyosin 2 (beta)  Symbol and/or name change 5135510 APPROVED