KCNQ1 (potassium voltage-gated channel subfamily Q member 1) - Rat Genome Database

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Pathways
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Gene: KCNQ1 (potassium voltage-gated channel subfamily Q member 1) Pan paniscus
Analyze
Symbol: KCNQ1
Name: potassium voltage-gated channel subfamily Q member 1
RGD ID: 11917071
Description: ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); identical protein binding (ortholog); outward rectifier potassium channel activity (ortholog); INVOLVED IN atrial cardiac muscle cell action potential (ortholog); cellular response to cAMP (ortholog); cellular response to xenobiotic stimulus (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Achlorhydria (ortholog); adenocarcinoma (ortholog); atrial fibrillation (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral part of cell (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,855,419 - 5,260,218 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1114,067,311 - 4,472,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,469,750 - 2,874,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,498,001 - 2,902,198 (+)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenergic receptor signaling pathway  (IEA)
atrial cardiac muscle cell action potential  (ISO)
auditory receptor cell development  (IEA)
cardiac conduction  (IEA)
cardiac muscle contraction  (IEA)
cellular response to cAMP  (ISO)
cellular response to epinephrine stimulus  (IEA)
cellular response to xenobiotic stimulus  (ISO)
chloride ion homeostasis  (IEA)
cochlea development  (IEA)
corticosterone secretion  (IEA)
detection of mechanical stimulus involved in sensory perception of sound  (IEA)
digestive system process  (IEA,ISO)
erythrocyte differentiation  (IEA)
gastric acid secretion  (IEA)
gastrin-induced gastric acid secretion  (IEA)
glucose metabolic process  (IEA)
heart development  (IEA)
inner ear development  (IEA,ISO)
inner ear morphogenesis  (IEA)
intestinal absorption  (ISO)
intracellular chloride ion homeostasis  (IEA)
iodide transport  (IEA)
male gonad development  (ISO)
membrane repolarization  (IEA)
membrane repolarization during action potential  (IEA)
membrane repolarization during atrial cardiac muscle cell action potential  (ISO)
membrane repolarization during cardiac muscle cell action potential  (ISO)
membrane repolarization during ventricular cardiac muscle cell action potential  (IEA,ISO)
negative regulation of delayed rectifier potassium channel activity  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of voltage-gated potassium channel activity  (ISO)
non-motile cilium assembly  (IEA)
positive regulation of cardiac muscle contraction  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of potassium ion transmembrane transport  (ISO)
potassium ion export across plasma membrane  (ISO)
potassium ion homeostasis  (IEA)
potassium ion import across plasma membrane  (IEA)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (IEA,ISO)
regulation of atrial cardiac muscle cell membrane repolarization  (ISO)
regulation of blood pressure  (IEA)
regulation of gastric acid secretion  (IEA)
regulation of heart rate  (IEA)
regulation of heart rate by cardiac conduction  (ISO)
regulation of membrane potential  (ISO)
regulation of membrane repolarization  (ISO)
regulation of transporter activity  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (IEA)
regulation of voltage-gated sodium channel activity  (ISO)
renal absorption  (IEA)
renal sodium ion absorption  (IEA)
response to anesthetic  (ISO)
response to insulin  (IEA)
rhythmic behavior  (IEA)
sensory perception of sound  (IEA)
social behavior  (IEA)
sodium ion transport  (IEA)
stomach development  (IEA)
transmembrane transport  (IEA)
ventricular cardiac muscle cell action potential  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNQ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,855,419 - 5,260,218 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1114,067,311 - 4,472,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,469,750 - 2,874,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,498,001 - 2,902,198 (+)NCBIpanpan1.1PanPan1.1panPan2
KCNQ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,445,008 - 2,849,105 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,444,654 - 2,849,105 (+)EnsemblGRCh38hg38GRCh38
GRCh37112,466,238 - 2,870,335 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,422,797 - 2,826,916 (+)NCBINCBI36Build 36hg18NCBI36
Build 34112,439,259 - 2,826,915NCBI
Celera112,501,049 - 2,905,069 (+)NCBICelera
Cytogenetic Map11p15.5-p15.4NCBI
HuRef112,256,184 - 2,658,673 (+)NCBIHuRef
CHM1_1112,465,155 - 2,869,215 (+)NCBICHM1_1
T2T-CHM13v2.0112,534,332 - 2,938,419 (+)NCBIT2T-CHM13v2.0
Kcnq1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,660,614 - 142,980,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,660,099 - 142,980,779 (+)EnsemblGRCm39 Ensembl
GRCm387143,106,877 - 143,427,050 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,106,362 - 143,427,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv377150,293,159 - 150,612,947 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,916,644 - 143,236,432 (+)NCBIMGSCv36mm8
Celera7142,862,859 - 143,182,707 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.12NCBI
Kcnq1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,721,134 - 208,054,073 (+)NCBIGRCr8
mRatBN7.21198,291,711 - 198,624,683 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,291,766 - 198,624,669 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,670,364 - 207,003,324 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,756,445 - 214,089,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,430,601 - 206,763,990 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,293,087 - 216,630,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,293,087 - 216,630,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,154,713 - 223,490,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,383,401 - 203,803,687 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,536,853 - 203,957,140 (+)NCBI
Celera1195,860,199 - 196,193,008 (+)NCBICelera
Cytogenetic Map1q42NCBI
Kcnq1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542214,212,553 - 14,544,556 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542214,212,563 - 14,544,556 (+)NCBIChiLan1.0ChiLan1.0
KCNQ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,554,390 - 46,830,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,518,908 - 46,830,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1845,116,523 - 45,440,309 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,186,461 - 47,510,762 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,186,461 - 47,517,416 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,634,218 - 46,955,821 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,214,974 - 46,538,652 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,962,029 - 47,285,048 (+)NCBIUU_Cfam_GSD_1.0
Kcnq1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,763,921 - 3,051,025 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936794707,119 - 994,778 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936794707,122 - 994,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,675,360 - 1,989,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,675,323 - 1,989,110 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNQ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112,261,448 - 2,661,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12,261,845 - 2,661,863 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603899,462,284 - 99,862,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnq1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,252,950 - 15,613,562 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476715,252,961 - 15,613,373 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_008969085   ⟹   XP_008967333
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v294,855,419 - 5,260,218 (+)NCBI
NHGRI_mPanPan1114,067,313 - 4,472,166 (+)NCBI
Mhudiblu_PPA_v0112,469,750 - 2,874,467 (+)NCBI
PanPan1.1112,498,001 - 2,902,198 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034931950   ⟹   XP_034787841
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v294,855,419 - 5,260,218 (+)NCBI
NHGRI_mPanPan1114,067,311 - 4,472,166 (+)NCBI
Mhudiblu_PPA_v0112,469,774 - 2,874,467 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008967333 (Get FASTA)   NCBI Sequence Viewer  
  XP_034787841 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000024652.1
  ENSPPAP00000024659
  ENSPPAP00000024659.1
RefSeq Acc Id: XP_008967333   ⟸   XM_008969085
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BBV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034787841   ⟸   XM_034931950
- Peptide Label: isoform X2
Protein Domains
Ion transport   Potassium channel voltage dependent KCNQ C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035461 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047477.1 UniProtKB/TrEMBL
  ENSPPAT00000047484.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  6.10.140.1910 UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ_C UniProtKB/TrEMBL
  K_chnl_volt-dep_KCQN1 UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene KCNQ1 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1 UniProtKB/TrEMBL
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  KCNQ_channel UniProtKB/TrEMBL
PRINTS KCHANNEL UniProtKB/TrEMBL
  KCNQ1CHANNEL UniProtKB/TrEMBL
  KCNQCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A2R9B4Z8_PANPA UniProtKB/TrEMBL
  A0A2R9BBV4 ENTREZGENE, UniProtKB/TrEMBL