RGD Reference Report - Pancreatic metaplasia in the gastro-achlorhydria in WTC-dfk rat, a potassium channel Kcnq1 mutant. - Rat Genome Database

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Pancreatic metaplasia in the gastro-achlorhydria in WTC-dfk rat, a potassium channel Kcnq1 mutant.

Authors: Kuwamura, M  Okajima, R  Yamate, J  Kotani, T  Kuramoto, T  Serikawa, T 
Citation: Kuwamura M, etal., Vet Pathol. 2008 Jul;45(4):586-91.
RGD ID: 2317967
Pubmed: PMID:18587108   (View Abstract at PubMed)
DOI: DOI:10.1354/vp.45-4-586   (Journal Full-text)

The WTC-deafness Kyoto (dfk) rat is a new mutant characterized by deafness and abnormal, imbalanced behavior. WTC-dfk rats carry an intragenic deletion at the Kcnq1 gene; KCNQ1 plays an important role in K(+) homeostasis, and the mutation of Kcnq1 causes a cardiac long QT syndrome in humans. Here, we studied stomach lesions in these WTC-dfk rats. The most characteristic pathologic feature in the stomach was the appearance of hypertrophic gastric glands in the stomach body. The hypertrophic cells had many eosinophilic granules in their cytoplasm, and these granules were stained red with Azan stain; stained positively for trypsinogen, amylase, and chymotrypsin; and did not stain positively for pepsinogen when using immunohistochemical analysis. These staining results suggested a metaplasia toward a pancreatic acinar cells. Extensive fibrosis was found in the bottom part of the mucosa of 34-week-old WTC-dfk rats, suggesting a progression of stomach lesions with aging. Although cells that were positive for proliferating cell nuclear antigen were restricted in the area of the glandular neck in WTC control rats, positive cells in WTC-dfk rats were scattered throughout the mucosa. The parietal cells in WTC-dfk rats were negative for KCNQ1 immunohistochemical analysis. These findings indicate that a deficiency in rat Kcnq1 provokes an abnormal proliferation and differentiation of gastric glandular cells.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Metaplasia  ISOKcnq1 (Rattus norvegicus)2317967; 2317967associated with Stomach DiseasesRGD 
Metaplasia  IAGP 2317967associated with Stomach DiseasesRGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcnq1  (potassium voltage-gated channel subfamily Q member 1)

Genes (Mus musculus)
Kcnq1  (potassium voltage-gated channel, subfamily Q, member 1)

Genes (Homo sapiens)
KCNQ1  (potassium voltage-gated channel subfamily Q member 1)


Additional Information