Kcnq1 (potassium voltage-gated channel subfamily Q member 1) - Rat Genome Database

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Gene: Kcnq1 (potassium voltage-gated channel subfamily Q member 1) Ictidomys tridecemlineatus
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Symbol: Kcnq1
Name: potassium voltage-gated channel subfamily Q member 1
RGD ID: 12715828
Description: ENCODES a protein that exhibits calmodulin binding (ortholog); delayed rectifier potassium channel activity (ortholog); identical protein binding (ortholog); INVOLVED IN adrenergic receptor signaling pathway (ortholog); atrial cardiac muscle cell action potential (ortholog); auditory receptor cell development (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Achlorhydria (ortholog); adenocarcinoma (ortholog); atrial fibrillation (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral part of cell (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,763,921 - 3,051,025 (+)NCBI
SpeTri2.0NW_004936794707,122 - 994,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenergic receptor signaling pathway  (ISO)
atrial cardiac muscle cell action potential  (ISO)
auditory receptor cell development  (ISO)
cardiac conduction  (ISO)
cardiac muscle contraction  (ISO)
cellular chloride ion homeostasis  (ISO)
cellular response to cAMP  (ISO)
cellular response to epinephrine stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
chloride ion homeostasis  (ISO)
circulatory system development  (ISO)
cochlea development  (ISO)
corticosterone secretion  (ISO)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
erythrocyte differentiation  (ISO)
gastric acid secretion  (ISO)
gastrin-induced gastric acid secretion  (ISO)
gene expression  (ISO)
glucose metabolic process  (ISO)
heart development  (ISO)
inner ear development  (ISO)
inner ear morphogenesis  (ISO)
intestinal absorption  (ISO)
iodide transport  (ISO)
male gonad development  (ISO)
membrane repolarization  (ISO)
membrane repolarization during action potential  (ISO)
membrane repolarization during atrial cardiac muscle cell action potential  (ISO)
membrane repolarization during cardiac muscle cell action potential  (ISO)
membrane repolarization during ventricular cardiac muscle cell action potential  (ISO)
negative regulation of delayed rectifier potassium channel activity  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of voltage-gated potassium channel activity  (ISO)
neuromuscular process  (ISO)
non-motile cilium assembly  (ISO)
positive regulation of cardiac muscle contraction  (ISO)
positive regulation of gastric acid secretion  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of potassium ion transmembrane transport  (ISO)
potassium ion export across plasma membrane  (ISO)
potassium ion homeostasis  (ISO)
potassium ion import across plasma membrane  (ISO)
potassium ion transmembrane transport  (ISO)
potassium ion transport  (ISO)
regulation of atrial cardiac muscle cell membrane repolarization  (ISO)
regulation of blood pressure  (ISO)
regulation of gastric acid secretion  (ISO)
regulation of gene expression by genetic imprinting  (ISO)
regulation of heart rate  (ISO)
regulation of heart rate by cardiac conduction  (ISO)
regulation of membrane potential  (ISO)
regulation of membrane repolarization  (ISO)
regulation of transporter activity  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
regulation of voltage-gated sodium channel activity  (ISO)
renal absorption  (ISO)
renal sodium ion absorption  (ISO)
response to anesthetic  (ISO)
response to epinephrine  (ISO)
response to insulin  (ISO)
response to nicotine  (ISO)
rhythmic behavior  (ISO)
sensory perception of sound  (ISO)
social behavior  (ISO)
sodium ion transport  (ISO)
stomach development  (ISO)
ventricular cardiac muscle cell action potential  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

Genomics

Comparative Map Data
Kcnq1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,763,921 - 3,051,025 (+)NCBI
SpeTri2.0NW_004936794707,122 - 994,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl112,444,684 - 2,849,105 (+)EnsemblGRCh38hg38GRCh38
GRCh38112,445,008 - 2,849,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,466,238 - 2,870,340 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,422,797 - 2,826,916 (+)NCBINCBI36hg18NCBI36
Build 34112,439,259 - 2,826,915NCBI
Celera112,501,049 - 2,905,069 (+)NCBI
Cytogenetic Map11p15.5-p15.4NCBI
HuRef112,256,184 - 2,658,673 (+)NCBIHuRef
CHM1_1112,465,155 - 2,869,215 (+)NCBICHM1_1
Kcnq1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,660,614 - 142,980,787 (+)NCBIGRCm39mm39
GRCm39 Ensembl7142,660,099 - 142,980,779 (+)Ensembl
GRCm387143,106,877 - 143,427,050 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,106,362 - 143,427,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv377150,293,159 - 150,612,947 (+)NCBIGRCm37mm9NCBIm37
MGSCv367142,916,644 - 143,236,432 (+)NCBImm8
Celera7142,862,859 - 143,182,707 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.12NCBI
Kcnq1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21198,291,711 - 198,624,683 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1198,291,766 - 198,624,669 (+)Ensembl
Rnor_6.01216,293,087 - 216,630,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,293,087 - 216,630,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,154,713 - 223,490,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,383,401 - 203,803,687 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11203,536,853 - 203,957,140 (+)NCBI
Celera1195,860,199 - 196,193,008 (+)NCBICelera
Cytogenetic Map1q42NCBI
Kcnq1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542214,212,553 - 14,544,556 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542214,212,563 - 14,544,556 (+)NCBIChiLan1.0ChiLan1.0
KCNQ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1112,498,001 - 2,902,198 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0112,469,750 - 2,874,467 (+)NCBIMhudiblu_PPA_v0panPan3
KCNQ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,554,390 - 46,830,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,518,908 - 46,830,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1845,116,523 - 45,440,309 (+)NCBI
ROS_Cfam_1.01847,186,461 - 47,510,762 (+)NCBI
UMICH_Zoey_3.11846,634,218 - 46,955,821 (+)NCBI
UNSW_CanFamBas_1.01846,214,974 - 46,538,652 (+)NCBI
UU_Cfam_GSD_1.01846,962,029 - 47,285,048 (+)NCBI
KCNQ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,675,360 - 1,989,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,675,323 - 1,989,110 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNQ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112,261,448 - 2,661,840 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl12,261,845 - 2,661,863 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603899,462,284 - 99,862,831 (+)NCBIVero_WHO_p1.0
Kcnq1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_