Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered integrin mediated signaling pathway
go back to main search page
Accession:PW:0000295 term browser browse the term
Definition:An integrin signaling pathway that deviates from what its normal course should be. Aberrant integrin signaling pathway, alone or in combination with other pathways underlies various diseases. An example is hypertrophic cardiomyopathy that involves integrins and the synergy between integrins and growth factors. Aberrant integrin signaling has also been correlated with tumor progression in several cancers.


show annotations for term's descendants           Sort by:
altered integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ilk integrin-linked kinase ISO RGD PMID:18772397 RGD:5490966 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Itga1 integrin subunit alpha 1 IMP RGD PMID:10536667 RGD:1302875 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407 		JBrowse link
G Itga4 integrin subunit alpha 4 IMP
ISO		 RGD PMID:11782963 PMID:18772397 RGD:1302879, RGD:5490966 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Itga5 integrin subunit alpha 5 ISS RGD PMID:10536667 RGD:1302875 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Itga8 integrin subunit alpha 8 ISO RGD PMID:9054500 RGD:40903006 NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510 		JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754 		JBrowse link
G Itgb1 integrin subunit beta 1 ISS RGD PMID:9633916 RGD:1302874 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      cell adhesion signaling pathway 413
        integrin mediated signaling pathway 50
          altered integrin mediated signaling pathway 8
paths to the root