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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:integrin mediated signaling pathway
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Accession:PW:0000286 term browser browse the term
Definition:Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival.
Synonyms:related_synonym: Integrin signaling;   integrin-mediated signaling pathway
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integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein ISO RGD PMID:18363565 RGD:2300340 NCBI chrNW_004624796:2,512,292...2,621,505
Ensembl chrNW_004624796:2,510,878...2,568,532 		JBrowse link
G Fabp3 fatty acid binding protein 3 ISO RGD PMID:23719537 RGD:7364738 NCBI chrNW_004624764:14,698,062...14,705,379
Ensembl chrNW_004624764:14,698,062...14,705,972 		JBrowse link
G Fermt1 FERM domain containing kindlin 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chrNW_004624741:6,881,477...6,914,910
Ensembl chrNW_004624741:6,880,877...6,915,051 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chrNW_004624731:16,168,179...16,247,747
Ensembl chrNW_004624731:16,168,207...16,246,778 		JBrowse link
G Fermt3 FERM domain containing kindlin 3 ISO RGD PMID:23860236 RGD:7349373 NCBI chrNW_004624767:22,082,431...22,101,003
Ensembl chrNW_004624767:22,082,436...22,100,969 		JBrowse link
G Flna filamin A ISO RGD PMID:23719537 RGD:7364738 NCBI chrNW_004624946:812,278...836,307
Ensembl chrNW_004624946:812,287...837,273 		JBrowse link
G Flnb filamin B ISO RGD PMID:23719537 RGD:7364738 NCBI chrNW_004624821:691,291...835,244
Ensembl chrNW_004624821:691,272...836,322 		JBrowse link
G Flnc filamin C ISO RGD PMID:23719537 RGD:7364738 NCBI chrNW_004624783:7,334,421...7,360,795
Ensembl chrNW_004624783:7,334,312...7,361,134 		JBrowse link
G Ilk integrin linked kinase ISO RGD PMID:8538749 PMID:12629168 PMID:16493410 RGD:2300344 RGD:2302091 RGD:40924646 NCBI chrNW_004624817:8,096,539...8,103,096
Ensembl chrNW_004624817:8,096,898...8,106,683 		JBrowse link
G Ilkap ILK associated serine/threonine phosphatase ISO RGD PMID:16493410 RGD:2300344 NCBI chrNW_004624847:3,321,400...3,344,725
Ensembl chrNW_004624847:3,320,788...3,344,705 		JBrowse link
G Itga1 integrin subunit alpha 1 ISO RGD PMID:17543136 RGD:5135538 NCBI chrNW_004624759:6,397,743...6,543,652
Ensembl chrNW_004624759:6,404,758...6,543,211 		JBrowse link
G Itga10 integrin subunit alpha 10 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chrNW_004624772:17,253,972...17,269,796
Ensembl chrNW_004624772:17,255,598...17,269,669 		JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chrNW_004624781:4,709,436...4,807,384
Ensembl chrNW_004624781:4,709,360...4,806,366 		JBrowse link
G Itga2 integrin subunit alpha 2 ISO RGD PMID:12941079 PMID:17543136 RGD:1302878 RGD:5135538 NCBI chrNW_004624759:6,281,698...6,376,702
Ensembl chrNW_004624759:6,281,561...6,376,712 		JBrowse link
G Itga2b integrin subunit alpha 2b ISO RGD PMID:17543136 RGD:5135538 NCBI chrNW_004624795:683,899...695,262
Ensembl chrNW_004624795:683,968...703,710 		JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chrNW_004624795:6,062,438...6,092,556
Ensembl chrNW_004624795:6,062,290...6,092,557 		JBrowse link
G Itga4 integrin subunit alpha 4 ISO RGD PMID:11782963 PMID:17543136 RGD:1302879 RGD:5135538 NCBI chrNW_004624844:3,264,794...3,353,355
Ensembl chrNW_004624844:3,265,110...3,354,087 		JBrowse link
G Itga5 integrin subunit alpha 5 ISO RGD PMID:12821041 PMID:17543136 RGD:1300196 RGD:5135538 NCBI chrNW_004624904:2,418,140...2,439,945
Ensembl chrNW_004624904:2,417,269...2,440,087 		JBrowse link
G Itga6 integrin subunit alpha 6 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chrNW_004624787:9,821,802...9,903,851
Ensembl chrNW_004624787:9,821,769...9,904,679 		JBrowse link
G Itga7 integrin subunit alpha 7 ISO RGD PMID:1315319 PMID:17543136 RGD:5135538 RGD:70774 NCBI chrNW_004624802:12,303,969...12,332,737
Ensembl chrNW_004624802:12,312,679...12,336,587 		JBrowse link
G Itga8 integrin subunit alpha 8 ISO RGD PMID:9054500 PMID:17543136 RGD:40903006 RGD:5135538 NCBI chrNW_004624796:11,908,927...12,103,806
Ensembl chrNW_004624796:11,908,964...12,101,139 		JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chrNW_004624773:20,336,975...20,735,081
Ensembl chrNW_004624773:20,341,335...20,735,189 		JBrowse link
G Itgae integrin subunit alpha E ISO RGD PMID:9394838 PMID:17543136 RGD:5135538 RGD:633077 NCBI chrNW_004624786:6,354,344...6,425,240
Ensembl chrNW_004624786:6,354,616...6,410,710 		JBrowse link
G Itgal integrin subunit alpha L ISO RGD PMID:17543136 RGD:5135538 NCBI chrNW_004624782:13,635,217...13,671,401
Ensembl chrNW_004624782:13,640,996...13,669,541 		JBrowse link
G Itgam integrin subunit alpha M ISO RGD PMID:17543136 PMID:34630381 RGD:329849126 RGD:5135538 NCBI chrNW_004624782:14,316,505...14,367,841
Ensembl chrNW_004624782:14,318,499...14,367,922 		JBrowse link
G Itgav integrin subunit alpha V ISO RGD PMID:12297042 PMID:12639933 PMID:17543136 RGD:1358329 RGD:1625134 RGD:5135538 NCBI chrNW_004624899:3,235,434...3,292,584
Ensembl chrNW_004624899:3,239,112...3,291,586 		JBrowse link
G Itgax integrin subunit alpha X ISO RGD PMID:17543136 RGD:5135538 NCBI chrNW_004624782:14,380,234...14,397,552
Ensembl chrNW_004624782:14,380,399...14,395,916 		JBrowse link
G Itgb1 integrin subunit beta 1 ISO RGD PMID:12639933 PMID:17543136 RGD:1625134 RGD:5135538 NCBI chrNW_004624805:8,748,848...8,800,259
Ensembl chrNW_004624805:8,765,949...8,802,149 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 ISO RGD PMID:23719537 PMID:23860236 RGD:7349373 RGD:7364738 NCBI chrNW_004624969:290,601...307,152
Ensembl chrNW_004624969:290,570...301,189 		JBrowse link
G Itgb2 integrin subunit beta 2 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chrNW_004624745:30,452,576...30,479,036
Ensembl chrNW_004624745:30,452,576...30,470,611 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO RGD PMID:12639933 PMID:17543136 RGD:1625134 RGD:5135538 NCBI chrNW_004624849:1,895,378...1,952,755
Ensembl chrNW_004624849:1,895,914...1,952,665 		JBrowse link
G Itgb4 integrin subunit beta 4 ISO RGD PMID:8026337 PMID:17543136 RGD:5135538 RGD:729025 NCBI chrNW_004624801:5,613,752...5,646,046
Ensembl chrNW_004624801:5,613,861...5,650,214 		JBrowse link
G Itgb5 integrin subunit beta 5 ISO RGD PMID:8799848 PMID:17543136 RGD:41410438 RGD:5135538 NCBI chrNW_004624731:804,272...914,204
Ensembl chrNW_004624731:802,854...914,167 		JBrowse link
G Itgb6 integrin subunit beta 6 ISO RGD PMID:17543136 RGD:5135538 NCBI chrNW_004624732:5,348,589...5,499,826
Ensembl chrNW_004624732:5,403,956...5,499,855 		JBrowse link
G Itgb7 integrin subunit beta 7 ISO RGD PMID:9233649 PMID:17543136 RGD:5135538 RGD:633040 NCBI chrNW_004624904:1,238,524...1,253,575
Ensembl chrNW_004624904:1,238,785...1,247,622 		JBrowse link
G Itgb8 integrin subunit beta 8 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chrNW_004624739:10,164,645...10,261,732
Ensembl chrNW_004624739:10,168,495...10,259,804 		JBrowse link
G Krit1 KRIT1 ankyrin repeat containing ISO RGD PMID:23719537 PMID:23860236 RGD:7349373 RGD:7364738 NCBI chrNW_004624809:978,391...1,036,313
Ensembl chrNW_004624809:978,789...1,039,091 		JBrowse link
G Lims1 LIM zinc finger domain containing 1 ISO RGD PMID:16493410 RGD:2300344 NCBI chrNW_004624749:11,720,492...11,846,571 JBrowse link
G Lims2 LIM zinc finger domain containing 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chrNW_004624732:14,102,543...14,144,479
Ensembl chrNW_004624732:14,102,543...14,144,722 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chrNW_004624749:9,765,308...9,884,472 JBrowse link
G Parva parvin alpha ISO RGD PMID:16493410 RGD:2300344 NCBI chrNW_004624766:4,390,952...4,544,550
Ensembl chrNW_004624766:4,391,010...4,544,842 		JBrowse link
G Parvb parvin beta ISO RGD PMID:16493410 RGD:2300344 NCBI chrNW_004624752:5,039,180...5,121,056
Ensembl chrNW_004624752:5,039,037...5,121,116 		JBrowse link
G Parvg parvin gamma ISO RGD PMID:16493410 RGD:2300344 NCBI chrNW_004624752:5,005,402...5,024,577
Ensembl chrNW_004624752:5,004,642...5,024,642 		JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO RGD PMID:15108811 RGD:2300402 NCBI chrNW_004624735:15,356,911...15,713,219
Ensembl chrNW_004624735:15,461,178...15,714,071 		JBrowse link
G Pxn paxillin ISO RGD PMID:16493410 RGD:2300344 NCBI chrNW_004624747:13,371,128...13,435,619
Ensembl chrNW_004624747:13,370,243...13,435,714 		JBrowse link
G Sharpin SHANK associated RH domain interactor ISO RGD PMID:23719537 PMID:23860236 RGD:7349373 RGD:7364738 NCBI chrNW_004624735:12,719,196...12,723,578
Ensembl chrNW_004624735:12,719,762...12,723,348 		JBrowse link
G Tln1 talin 1 ISO RGD PMID:18363565 PMID:23860236 RGD:2300340 RGD:7349373 NCBI chrNW_004624868:5,061,108...5,095,433
Ensembl chrNW_004624868:5,061,290...5,095,661 		JBrowse link
G Tln2 talin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chrNW_004624781:9,626,031...10,030,427
Ensembl chrNW_004624781:9,623,413...9,965,960 		JBrowse link
altered integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ilk integrin linked kinase ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004624817:8,096,539...8,103,096
Ensembl chrNW_004624817:8,096,898...8,106,683 		JBrowse link
G Itga1 integrin subunit alpha 1 ISO RGD PMID:10536667 RGD:1302875 NCBI chrNW_004624759:6,397,743...6,543,652
Ensembl chrNW_004624759:6,404,758...6,543,211 		JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004624781:4,709,436...4,807,384
Ensembl chrNW_004624781:4,709,360...4,806,366 		JBrowse link
G Itga4 integrin subunit alpha 4 ISO RGD PMID:11782963 PMID:18772397 RGD:1302879 RGD:5490966 NCBI chrNW_004624844:3,264,794...3,353,355
Ensembl chrNW_004624844:3,265,110...3,354,087 		JBrowse link
G Itga8 integrin subunit alpha 8 ISO RGD PMID:9054500 RGD:40903006 NCBI chrNW_004624796:11,908,927...12,103,806
Ensembl chrNW_004624796:11,908,964...12,101,139 		JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:18772397 RGD:5490966 NCBI chrNW_004624773:20,336,975...20,735,081
Ensembl chrNW_004624773:20,341,335...20,735,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3915
    signaling pathway 1874
      mechanotransduction pathway 68
        integrin mediated signaling pathway 48
          altered integrin mediated signaling pathway 6
          integrin mediated cell-cell signaling pathway 0
          integrin mediated cell-extracellular matrix signaling pathway 0
paths to the root