Fermt1 (FERM domain containing kindlin 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Fermt1 (FERM domain containing kindlin 1) Heterocephalus glaber
Analyze
Symbol: Fermt1
Name: FERM domain containing kindlin 1 (Ensembl:fermitin family member 1)
RGD ID: 18922501
Description: ENCODES a protein that exhibits actin filament binding (ortholog); INVOLVED IN basement membrane organization (ortholog); establishment of epithelial cell polarity (ortholog); keratinocyte migration (ortholog); PARTICIPATES IN integrin mediated signaling pathway; ASSOCIATED WITH Atrophy (ortholog); Erythema (ortholog); genetic disease (ortholog); FOUND IN cell junction (ortholog); cell periphery (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fermitin family homolog 1; fermitin family member 1; Fermitin family-like protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247416,880,877 - 6,915,051 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247416,881,477 - 6,914,910 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fermt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247416,880,877 - 6,915,051 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247416,881,477 - 6,914,910 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
FERMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38206,074,845 - 6,123,030 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl206,074,845 - 6,123,214 (-)EnsemblGRCh38hg38GRCh38
GRCh37206,055,492 - 6,103,677 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36206,003,492 - 6,052,191 (-)NCBINCBI36Build 36hg18NCBI36
Build 34206,003,492 - 6,052,191NCBI
Celera206,126,766 - 6,175,354 (-)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef206,012,168 - 6,061,355 (-)NCBIHuRef
CHM1_1206,055,497 - 6,104,189 (-)NCBICHM1_1
T2T-CHM13v2.0206,116,428 - 6,164,613 (-)NCBIT2T-CHM13v2.0
Fermt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392132,746,097 - 132,787,956 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2132,746,309 - 132,787,826 (-)EnsemblGRCm39 Ensembl
GRCm382132,904,177 - 132,946,036 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2132,904,389 - 132,945,906 (-)EnsemblGRCm38mm10GRCm38
MGSCv372132,729,915 - 132,771,772 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362132,595,620 - 132,637,477 (-)NCBIMGSCv36mm8
Celera2134,125,730 - 134,167,433 (-)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.8NCBI
Fermt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83140,624,434 - 140,666,419 (-)NCBIGRCr8
mRatBN7.23120,171,301 - 120,213,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,171,561 - 120,213,555 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3124,066,663 - 124,106,362 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03132,670,283 - 132,712,190 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03130,322,805 - 130,362,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03125,566,744 - 125,607,864 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3125,566,643 - 125,607,735 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03132,049,511 - 132,090,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43120,699,769 - 120,744,016 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13120,607,515 - 120,645,912 (-)NCBI
Celera3118,957,538 - 118,999,128 (-)NCBICelera
Cytogenetic Map3q36NCBI
Fermt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541516,446,934 - 16,483,369 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541516,447,921 - 16,483,221 (-)NCBIChiLan1.0ChiLan1.0
FERMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2216,995,642 - 7,045,908 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1206,997,144 - 7,043,349 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0206,063,480 - 6,120,206 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1205,856,287 - 5,902,251 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl205,856,287 - 5,902,251 (-)Ensemblpanpan1.1panPan2
FERMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12415,748,632 - 15,785,025 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2415,748,629 - 15,782,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2415,570,788 - 15,607,260 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02416,151,297 - 16,187,696 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2416,153,502 - 16,185,964 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12415,757,632 - 15,794,124 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02415,866,168 - 15,902,611 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02416,197,744 - 16,234,285 (+)NCBIUU_Cfam_GSD_1.0
Fermt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640164,550,560 - 164,587,721 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648512,985,552 - 13,016,906 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648512,985,552 - 13,016,997 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FERMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1715,080,587 - 15,137,753 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11715,080,585 - 15,137,947 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21716,443,838 - 16,504,032 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FERMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1232,006,824 - 32,060,838 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl232,009,615 - 32,062,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607112,480,750 - 12,534,757 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000026333   ⟹   ENSHGLP00000026101
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247416,880,877 - 6,915,051 (-)Ensembl
RefSeq Acc Id: XM_013070726   ⟹   XP_012926180
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247416,881,477 - 6,914,910 (-)NCBI
RefSeq Acc Id: XM_013070728   ⟹   XP_012926182
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247416,885,492 - 6,914,910 (-)NCBI
RefSeq Acc Id: XM_021255042   ⟹   XP_021110701
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247416,881,477 - 6,914,801 (-)NCBI
RefSeq Acc Id: XM_021255043   ⟹   XP_021110702
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247416,881,477 - 6,912,609 (-)NCBI
RefSeq Acc Id: XM_021255044   ⟹   XP_021110703
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247416,881,477 - 6,911,038 (-)NCBI
RefSeq Acc Id: XR_002393466
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247416,883,514 - 6,914,910 (-)NCBI
RefSeq Acc Id: XR_002393467
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247416,883,515 - 6,914,910 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_012926180   ⟸   XM_013070726
- Peptide Label: isoform X1
- UniProtKB: G5BY82 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110701   ⟸   XM_021255042
- Peptide Label: isoform X1
- UniProtKB: G5BY82 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110702   ⟸   XM_021255043
- Peptide Label: isoform X1
- UniProtKB: G5BY82 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021110703   ⟸   XM_021255044
- Peptide Label: isoform X2
RefSeq Acc Id: XP_012926182   ⟸   XM_013070728
- Peptide Label: isoform X3
RefSeq Acc Id: ENSHGLP00000026101   ⟸   ENSHGLT00000026333


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018580 Ensembl, ENTREZGENE
  ENSHGLG00100004632 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000026333 ENTREZGENE
  ENSHGLT00100054017 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  Kindlin/fermitin UniProtKB/TrEMBL
  Kindlin_2_N UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_Kindlin/fermitin UniProtKB/TrEMBL
NCBI Gene Fermt1 ENTREZGENE
PANTHER FERMITIN FAMILY HOMOLOG 1 UniProtKB/TrEMBL
  PTHR16160 UniProtKB/TrEMBL
Pfam FERM_M UniProtKB/TrEMBL
  Kindlin_2_N UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
UniProt G5BY82 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-16 Fermt1  FERM domain containing kindlin 1  Fermt1  fermitin family member 1  Symbol and/or name change 5135510 APPROVED