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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:integrin mediated signaling pathway
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Accession:PW:0000286 term browser browse the term
Definition:Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival.
Synonyms:related_synonym: Integrin signaling;   integrin-mediated signaling pathway
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integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APBB1IP amyloid beta precursor protein binding family B member 1 interacting protein ISO RGD PMID:18363565 RGD:2300340 NCBI chr 9:26,163,881...26,289,713
Ensembl chr 9:26,122,428...26,289,708 		JBrowse link
G FABP3 fatty acid binding protein 3 ISO RGD PMID:23719537 RGD:7364738 NCBI chr20:101,464,899...101,472,223
Ensembl chr20:101,464,960...101,474,350 		JBrowse link
G FBLIM1 filamin binding LIM protein 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr20:116,518,768...116,545,907
Ensembl chr20:116,518,679...116,546,280 		JBrowse link
G FERMT1 FERM domain containing kindlin 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 2:32,006,824...32,060,838
Ensembl chr 2:32,009,615...32,062,211 		JBrowse link
G FERMT2 FERM domain containing kindlin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr24:29,954,706...30,053,012 JBrowse link
G FERMT3 FERM domain containing kindlin 3 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 1:10,012,007...10,031,177
Ensembl chr 1:10,009,626...10,031,209 		JBrowse link
G FLNA filamin A ISO RGD PMID:23719537 RGD:7364738 NCBI chr  X:128,657,580...128,683,812
Ensembl chr  X:128,657,393...128,680,531 		JBrowse link
G FLNB filamin B ISO RGD PMID:23719537 RGD:7364738 NCBI chr22:19,304,822...19,468,037
Ensembl chr22:19,304,781...19,468,036 		JBrowse link
G FLNC filamin C ISO RGD PMID:23719537 RGD:7364738 NCBI chr21:97,431,666...97,460,178
Ensembl chr21:97,431,648...97,461,135 		JBrowse link
G ILK integrin linked kinase ISO RGD PMID:8538749 PMID:12629168 PMID:16493410 RGD:2300344 RGD:2302091 RGD:40924646 NCBI chr 1:58,214,630...58,221,770
Ensembl chr 1:58,213,310...58,221,217 		JBrowse link
G ILKAP ILK associated serine/threonine phosphatase ISO RGD PMID:16493410 RGD:2300344 NCBI chr10:124,191,926...124,225,735
Ensembl chr10:124,190,785...124,225,678 		JBrowse link
G ITGA1 integrin subunit alpha 1 ISO RGD PMID:17543136 RGD:5135538 NCBI chr 4:49,081,687...49,248,321
Ensembl chr 4:49,082,787...49,246,186 		JBrowse link
G ITGA11 integrin subunit alpha 11 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr26:15,045,728...15,178,151
Ensembl chr26:15,046,058...15,176,837 		JBrowse link
G ITGA2 integrin subunit alpha 2 ISO RGD PMID:12941079 PMID:17543136 RGD:1302878 RGD:5135538 NCBI chr 4:49,280,289...49,382,101
Ensembl chr 4:49,317,648...49,380,051 		JBrowse link
G ITGA2B integrin subunit alpha 2b ISO RGD PMID:17543136 RGD:5135538 NCBI chr16:62,001,082...62,019,470
Ensembl chr16:62,001,352...62,019,289 		JBrowse link
G ITGA3 integrin subunit alpha 3 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr16:43,248,341...43,282,045
Ensembl chr16:43,250,435...43,281,670 		JBrowse link
G ITGA4 integrin subunit alpha 4 ISO RGD PMID:11782963 PMID:17543136 RGD:1302879 RGD:5135538 NCBI chr10:66,984,687...67,063,158
Ensembl chr10:66,984,887...67,061,636 		JBrowse link
G ITGA5 integrin subunit alpha 5 ISO RGD PMID:12821041 PMID:17543136 RGD:1300196 RGD:5135538 NCBI chr11:50,507,673...50,535,358
Ensembl chr11:50,510,714...50,535,328 		JBrowse link
G ITGA6 integrin subunit alpha 6 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr10:57,933,434...58,013,152
Ensembl chr10:57,933,535...58,014,170 		JBrowse link
G ITGA7 integrin subunit alpha 7 ISO RGD PMID:1315319 PMID:17543136 RGD:5135538 RGD:70774 NCBI chr11:51,634,324...51,656,251 JBrowse link
G ITGA8 integrin subunit alpha 8 ISO RGD PMID:9054500 PMID:17543136 RGD:40903006 RGD:5135538 NCBI chr 9:15,482,746...15,684,161
Ensembl chr 9:15,482,750...15,683,481 		JBrowse link
G ITGA9 integrin subunit alpha 9 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr15:1,585,811...1,961,798
Ensembl chr15:1,581,676...1,961,435 		JBrowse link
G ITGAD integrin subunit alpha D ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr 5:28,095,341...28,128,498 JBrowse link
G ITGAE integrin subunit alpha E ISO RGD PMID:9394838 PMID:17543136 RGD:5135538 RGD:633077 NCBI chr16:3,215,758...3,288,801 JBrowse link
G ITGAL integrin subunit alpha L ISO RGD PMID:17543136 RGD:5135538 NCBI chr 5:27,157,866...27,206,802
Ensembl chr 5:27,157,878...27,206,714 		JBrowse link
G ITGAM integrin subunit alpha M ISO RGD PMID:17543136 PMID:34630381 RGD:329849126 RGD:5135538 NCBI chr 5:27,957,162...28,042,697
Ensembl chr 5:27,957,324...28,042,691 		JBrowse link
G ITGAV integrin subunit alpha V ISO RGD PMID:12297042 PMID:12639933 PMID:17543136 RGD:1358329 RGD:1625134 RGD:5135538 NCBI chr10:72,125,710...72,216,757
Ensembl chr10:72,125,962...72,216,809 		JBrowse link
G ITGAX integrin subunit alpha X ISO RGD PMID:17543136 RGD:5135538 NCBI chr 5:28,058,172...28,087,253
Ensembl chr 5:28,058,456...28,086,838 		JBrowse link
G ITGB1 integrin subunit beta 1 ISO RGD PMID:12639933 PMID:17543136 RGD:1625134 RGD:5135538 NCBI chr 9:32,201,030...32,258,247
Ensembl chr 9:32,202,204...32,258,154 		JBrowse link
G ITGB1BP1 integrin subunit beta 1 binding protein 1 ISO RGD PMID:23719537 PMID:23860236 RGD:7349373 RGD:7364738 NCBI chr14:98,226,666...98,244,094
Ensembl chr14:98,230,100...98,248,862 		JBrowse link
G ITGB2 integrin subunit beta 2 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr 2:88,597,554...88,644,890
Ensembl chr 2:88,597,556...88,624,025 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO RGD PMID:12639933 PMID:17543136 RGD:1625134 RGD:5135538 NCBI chr16:59,372,171...59,431,434
Ensembl chr16:59,374,889...59,410,857 		JBrowse link
G ITGB4 integrin subunit beta 4 ISO RGD PMID:8026337 PMID:17543136 RGD:5135538 RGD:729025 NCBI chr16:45,926,543...45,962,967 JBrowse link
G ITGB5 integrin subunit beta 5 ISO RGD PMID:8799848 PMID:17543136 RGD:41410438 RGD:5135538 NCBI chr22:55,944,810...56,070,605
Ensembl chr22:55,944,865...56,069,930 		JBrowse link
G ITGB6 integrin subunit beta 6 ISO RGD PMID:17543136 RGD:5135538 NCBI chr10:45,506,355...45,650,979
Ensembl chr10:45,504,987...45,595,543 		JBrowse link
G ITGB7 integrin subunit beta 7 ISO RGD PMID:9233649 PMID:17543136 RGD:5135538 RGD:633040 NCBI chr11:49,297,849...49,315,627
Ensembl chr11:49,297,458...49,315,716 		JBrowse link
G ITGB8 integrin subunit beta 8 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr21:37,811,811...37,896,539
Ensembl chr21:37,817,572...37,895,560 		JBrowse link
G KRIT1 KRIT1 ankyrin repeat containing ISO RGD PMID:23719537 PMID:23860236 RGD:7349373 RGD:7364738 NCBI chr21:56,770,694...56,816,409
Ensembl chr21:56,774,487...56,816,049 		JBrowse link
G LIMS1 LIM zinc finger domain containing 1 ISO RGD PMID:16493410 RGD:2300344 NCBI chr14:12,059,347...12,210,779
Ensembl chr14:12,059,411...12,213,064 		JBrowse link
G LIMS2 LIM zinc finger domain containing 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr10:2,540,383...2,578,117
Ensembl chr10:2,543,091...2,579,332 		JBrowse link
G LOC103224063 peroxisomal membrane protein 11B ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr20:12,835,551...12,854,342
Ensembl chr20:12,827,633...12,835,517
Ensembl chr20:12,827,633...12,835,517 		JBrowse link
G NCK2 NCK adaptor protein 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr14:9,412,677...9,515,565
Ensembl chr14:9,437,301...9,515,561 		JBrowse link
G PARVA parvin alpha ISO RGD PMID:16493410 RGD:2300344 NCBI chr 1:52,310,145...52,470,617
Ensembl chr 1:52,310,494...52,470,369 		JBrowse link
G PARVB parvin beta ISO RGD PMID:16493410 RGD:2300344 NCBI chr19:26,536,346...26,672,740
Ensembl chr19:26,606,974...26,672,190 		JBrowse link
G PARVG parvin gamma ISO RGD PMID:16493410 RGD:2300344 NCBI chr19:26,684,758...26,710,880
Ensembl chr19:26,687,728...26,711,541 		JBrowse link
G PTK2 protein tyrosine kinase 2 ISO RGD PMID:15108811 RGD:2300402 NCBI chr 8:134,897,511...135,246,300 JBrowse link
G PXN paxillin ISO RGD PMID:16493410 RGD:2300344 NCBI chr11:115,560,859...115,619,093
Ensembl chr11:115,560,662...115,619,029 		JBrowse link
G SHARPIN SHANK associated RH domain interactor ISO RGD PMID:23719537 PMID:23860236 RGD:7349373 RGD:7364738 NCBI chr 8:138,310,036...138,315,120
Ensembl chr 8:138,307,581...138,315,101 		JBrowse link
G TLN1 talin 1 ISO RGD PMID:18363565 PMID:23860236 RGD:2300340 RGD:7349373 NCBI chr12:44,870,004...44,906,686
Ensembl chr12:44,876,643...44,907,072 		JBrowse link
G TLN2 talin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr26:20,688,048...21,140,585
Ensembl chr26:20,691,779...20,940,450 		JBrowse link
altered integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ILK integrin linked kinase ISO RGD PMID:18772397 RGD:5490966 NCBI chr 1:58,214,630...58,221,770
Ensembl chr 1:58,213,310...58,221,217 		JBrowse link
G ITGA1 integrin subunit alpha 1 ISO RGD PMID:10536667 RGD:1302875 NCBI chr 4:49,081,687...49,248,321
Ensembl chr 4:49,082,787...49,246,186 		JBrowse link
G ITGA11 integrin subunit alpha 11 ISO RGD PMID:18772397 RGD:5490966 NCBI chr26:15,045,728...15,178,151
Ensembl chr26:15,046,058...15,176,837 		JBrowse link
G ITGA4 integrin subunit alpha 4 ISO RGD PMID:11782963 PMID:18772397 RGD:1302879 RGD:5490966 NCBI chr10:66,984,687...67,063,158
Ensembl chr10:66,984,887...67,061,636 		JBrowse link
G ITGA8 integrin subunit alpha 8 ISO RGD PMID:9054500 RGD:40903006 NCBI chr 9:15,482,746...15,684,161
Ensembl chr 9:15,482,750...15,683,481 		JBrowse link
G ITGA9 integrin subunit alpha 9 ISO RGD PMID:18772397 RGD:5490966 NCBI chr15:1,585,811...1,961,798
Ensembl chr15:1,581,676...1,961,435 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4027
    signaling pathway 1918
      mechanotransduction pathway 70
        integrin mediated signaling pathway 50
          altered integrin mediated signaling pathway 6
          integrin mediated cell-cell signaling pathway 0
          integrin mediated cell-extracellular matrix signaling pathway 0
paths to the root