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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:epidermal growth factor/neuregulin signaling pathway
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Accession:PW:0000170 term browser browse the term
Definition:Members of the EGF/neuregulin superfamily are important regulators of tissue development and repair. A characteristic feature is the presence of the EGF module, a 36-40 amino acid sequence with a disulfide-bonded three-loop structure necessary for receptor binding.
Synonyms:related_synonym: EGF/neuregulin signaling pathway;   Signaling by EGFR;   epidermal growth factor receptor signaling pathway
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epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 ISO RGD PMID:15688065 RGD:2317976 NCBI chrNW_004624781:13,195,390...13,321,823
Ensembl chrNW_004624781:13,195,755...13,321,823 		JBrowse link
G Adam12 ADAM metallopeptidase domain 12 ISO RGD PMID:15688065 RGD:2317976 NCBI chrNW_004624737:20,650,365...21,107,171
Ensembl chrNW_004624737:20,650,427...21,065,944 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO RGD PMID:15688065 RGD:2317976 NCBI chrNW_004624969:212,089...254,532
Ensembl chrNW_004624969:212,321...253,328 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 ISO RGD PMID:15688065 RGD:2317976 NCBI chrNW_004624733:31,857,795...31,944,252
Ensembl chrNW_004624733:31,858,450...31,944,893 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 ISO RGD PMID:15688065 RGD:2317976 NCBI chrNW_004624780:4,482,696...4,612,475
Ensembl chrNW_004624780:4,480,647...4,612,477 		JBrowse link
G Areg amphiregulin ISO RGD
PID		 PMID:15509566 PMID:15982853 PID:200159 RGD:1578718 RGD:2317963 NCBI chrNW_004624730:1,290,692...1,299,365
Ensembl chrNW_004624730:1,290,655...1,299,410 		JBrowse link
G Btc betacellulin ISO RGD
PID		 PMID:11564606 PMID:15982853 PID:200159 RGD:2317963 RGD:2324625 NCBI chrNW_004624730:917,514...975,159
Ensembl chrNW_004624730:917,630...976,934 		JBrowse link
G Cbl Cbl proto-oncogene ISO RGD PMID:16829981 RGD:2317988 NCBI chrNW_004624784:14,577,582...14,671,816
Ensembl chrNW_004624784:14,577,515...14,667,575 		JBrowse link
G Egfr epidermal growth factor receptor ISO RGD
PID		 PMID:15486316 PMID:15982853 PMID:16648628 PID:200101 PID:200159 RGD:1581898 RGD:1581908 RGD:2317963 NCBI chrNW_004624740:584,133...713,205
Ensembl chrNW_004624740:589,606...713,271 		JBrowse link
G Epgn epithelial mitogen ISO RGD PMID:15982853 RGD:2317963 NCBI chrNW_004624730:1,403,915...1,412,610 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO PID
RGD		 PMID:15982853 PID:200159 RGD:2317963 NCBI chrNW_004624795:3,373,313...3,391,509
Ensembl chrNW_004624795:3,373,000...3,391,602 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO Neuregulin stimulation of glucose transport in muscle cells PID
RGD		 PMID:14711829 PMID:15007074 PMID:16829981 PMID:18519747 PID:200159 RGD:1642700 RGD:2289958 RGD:2317965 RGD:2317988 NCBI chrNW_004624802:11,906,279...11,925,530
Ensembl chrNW_004624802:11,905,271...11,925,707 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:18519747 RGD:2317965 NCBI chrNW_004624765:3,612,781...4,742,219
Ensembl chrNW_004624765:3,613,379...4,734,585 		JBrowse link
G Ereg epiregulin ISO RGD
PID		 PMID:15982853 PID:200159 RGD:2317963 NCBI chrNW_004624730:1,339,017...1,353,869
Ensembl chrNW_004624730:1,339,518...1,353,429 		JBrowse link
G Gab1 GRB2 associated binding protein 1 ISO PID PID:200101 NCBI chrNW_004624853:2,639,882...2,763,195
Ensembl chrNW_004624853:2,639,891...2,765,144 		JBrowse link
G Gnai1 G protein subunit alpha i1 ISO PID PID:200101 NCBI chrNW_004624739:28,995,173...29,074,354
Ensembl chrNW_004624739:28,995,179...29,073,813 		JBrowse link
G Gnai3 G protein subunit alpha i3 ISO PID PID:200101 NCBI chrNW_004624772:5,272,086...5,309,834 JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO RGD PMID:20445128 RGD:4892084 NCBI chrNW_004624740:26,627,560...26,632,483
Ensembl chrNW_004624740:26,627,473...26,632,027 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO RGD
PID		 PMID:16829981 PID:200101 RGD:2317988 NCBI chrNW_004624801:5,143,239...5,219,136
Ensembl chrNW_004624801:5,143,141...5,219,244 		JBrowse link
G Gsn gelsolin ISO PID PID:200101 NCBI chrNW_004624760:13,943,680...14,004,660
Ensembl chrNW_004624760:13,943,888...13,969,905 		JBrowse link
G Hbegf heparin binding EGF like growth factor ISO PID
RGD		 PMID:15486316 PMID:15982853 PID:200159 RGD:1581908 RGD:2317963 NCBI chrNW_004624743:33,112,105...33,124,145
Ensembl chrNW_004624743:33,112,036...33,124,169 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200101 NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200159 NCBI chrNW_004624734:2,233,932...2,239,687
Ensembl chrNW_004624734:2,233,547...2,241,436 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO PID PID:200101 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO PID PID:200101 NCBI chrNW_004624782:13,150,824...13,158,327
Ensembl chrNW_004624782:13,152,039...13,159,113 		JBrowse link
G Nck1 NCK adaptor protein 1 ISO PID PID:200101 NCBI chrNW_004624730:13,271,575...13,366,930
Ensembl chrNW_004624730:13,226,315...13,366,661 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO PID PID:200101 NCBI chrNW_004624749:9,765,308...9,884,472 JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO PID PID:200101 NCBI chrNW_004624772:10,358,554...10,369,371 JBrowse link
G Nrg1 neuregulin 1 ISO RGD PMID:18519747 RGD:2317965 NCBI chrNW_004624780:11,297,306...11,525,236
Ensembl chrNW_004624780:11,301,182...12,424,066 		JBrowse link
G Nrg2 neuregulin 2 ISO RGD
PID		 PMID:9348101 PMID:18519747 PID:200159 RGD:1304015 RGD:2317965 NCBI chrNW_004624743:32,620,025...32,810,990
Ensembl chrNW_004624743:32,620,295...32,810,391 		JBrowse link
G Nrg3 neuregulin 3 ISO RGD
PID		 PMID:18519747 PID:200159 RGD:2317965 NCBI chrNW_004624841:4,213,089...5,285,255
Ensembl chrNW_004624841:4,219,084...5,285,240 		JBrowse link
G Nrg4 neuregulin 4 ISO RGD
PID		 PMID:18519747 PID:200159 RGD:2317965 NCBI chrNW_004624894:2,057,477...2,167,321
Ensembl chrNW_004624894:2,087,302...2,158,167 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO PID PID:200101 NCBI chrNW_004624863:442,465...609,159
Ensembl chrNW_004624863:439,541...525,918 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 ISO Neuregulin stimulation of glucose transport in muscle cells RGD PMID:15007074 RGD:1642700 NCBI chrNW_004624787:9,917,366...9,956,393
Ensembl chrNW_004624787:9,917,309...9,959,875 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200101 NCBI chrNW_004624730:56,895,065...56,970,563
Ensembl chrNW_004624730:56,938,215...56,966,137 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO PID PID:200101 NCBI chrNW_004624730:15,226,786...15,399,097
Ensembl chrNW_004624730:15,226,379...15,355,857 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ISO PID PID:200101 NCBI chrNW_004624818:2,751,724...2,789,145
Ensembl chrNW_004624818:2,751,724...2,779,999 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID
RGD		 PMID:16829981 PID:200101 RGD:2317988 NCBI chrNW_004624815:1,290,106...1,376,961
Ensembl chrNW_004624815:1,289,997...1,369,610 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO PID PID:200101 NCBI chrNW_004624908:1,513,916...1,523,723
Ensembl chrNW_004624908:1,513,969...1,523,295 		JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma ISO PID PID:200101 NCBI chrNW_004624828:6,324,156...6,369,394 JBrowse link
G Plcg1 phospholipase C gamma 1 ISO PID PID:200101 NCBI chrNW_004624919:1,766,533...1,800,130
Ensembl chrNW_004624919:1,766,149...1,803,097 		JBrowse link
G Prkcz protein kinase C zeta ISO Neuregulin stimulation of glucose transport in muscle cells RGD PMID:15007074 RGD:1642700 NCBI chrNW_004624818:7,758,192...7,846,950
Ensembl chrNW_004624818:7,759,770...7,847,208 		JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 ISO PID PID:200101 NCBI chrNW_004624790:5,070,537...5,135,243
Ensembl chrNW_004624790:5,073,476...5,135,181 		JBrowse link
G Ptpn11 protein tyrosine phosphatase non-receptor type 11 ISO PID PID:200101 NCBI chrNW_004624747:19,721,581...19,813,639
Ensembl chrNW_004624747:19,721,468...19,813,670 		JBrowse link
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 ISO PID PID:200101 NCBI chrNW_004624860:3,580,225...3,595,403
Ensembl chrNW_004624860:3,580,560...3,595,090 		JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J ISO RGD PMID:16829981 RGD:2317988 NCBI chrNW_004624767:942,786...1,051,112
Ensembl chrNW_004624767:945,553...1,051,138 		JBrowse link
G Rasa1 RAS p21 protein activator 1 ISO PID PID:200101 NCBI chrNW_004624743:6,750,476...6,882,556
Ensembl chrNW_004624743:6,788,108...6,882,223 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO RGD PMID:16829981 RGD:2317988 NCBI chrNW_004624885:2,511,039...2,520,883
Ensembl chrNW_004624885:2,511,240...2,521,155 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID
RGD		 PMID:8577724 PMID:16829981 PID:200101 RGD:1581110 RGD:2317988 NCBI chrNW_004624738:20,466,120...20,591,966
Ensembl chrNW_004624738:20,466,117...20,591,910 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 ISO RGD PMID:16829981 RGD:2317988 NCBI chrNW_004624731:18,601,652...18,694,593
Ensembl chrNW_004624731:18,601,651...18,695,603 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID
RGD		 PMID:15856020 PID:200101 RGD:1581134 NCBI chrNW_004624842:2,212,561...2,260,514
Ensembl chrNW_004624842:2,211,020...2,230,132 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200101 NCBI chrNW_004624854:5,067,578...5,106,052
Ensembl chrNW_004624854:5,067,535...5,102,106 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO PID PID:200101 NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200 		JBrowse link
G Tgfa transforming growth factor alpha ISO RGD
PID		 PMID:15982853 PID:200159 RGD:2317963 NCBI chrNW_004624762:2,832,073...2,941,150
Ensembl chrNW_004624762:2,832,078...2,937,318 		JBrowse link
G Tln1 talin 1 ISO PID PID:200101 NCBI chrNW_004624868:5,061,108...5,095,433
Ensembl chrNW_004624868:5,061,290...5,095,661 		JBrowse link
G Wasl WASP like actin nucleation promoting factor ISO PID PID:200101 NCBI chrNW_004624783:12,239,467...12,322,403
Ensembl chrNW_004624783:12,254,715...12,323,232 		JBrowse link
altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor ISO RGD PMID:19506583 PMID:20519133 PMID:20951313 RGD:5133241 RGD:5133242 RGD:5490965 NCBI chrNW_004624740:584,133...713,205
Ensembl chrNW_004624740:589,606...713,271 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:19078924 PMID:21277552 RGD:4143515 RGD:5133243 NCBI chrNW_004624795:3,373,313...3,391,509
Ensembl chrNW_004624795:3,373,000...3,391,602 		JBrowse link
G Tgfa transforming growth factor alpha ISO RGD PMID:19506583 RGD:5490965 NCBI chrNW_004624762:2,832,073...2,941,150
Ensembl chrNW_004624762:2,832,078...2,937,318 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3915
    signaling pathway 1874
      growth factor signaling pathway 365
        epidermal growth factor/neuregulin signaling pathway 56
          altered epidermal growth factor/neuregulin signaling pathway 3
paths to the root