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ONTOLOGY REPORT - ANNOTATIONS

Term:sphingosine metabolic process
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Accession:GO:0006670 term browser browse the term
Definition:The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
Synonyms:exact_synonym: (4E)-sphing-4-enine metabolic process;   (4E)-sphing-4-enine metabolism;   sphing-4-enine metabolic process;   sphing-4-enine metabolism;   sphingosine metabolism


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sphingosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASAH2 N-acylsphingosine amidohydrolase 2 involved_in IMP
IDA		 (PMID:10781606), (PMID:15946935)
(PMID:16229686), (PMID:17475390), (PMID:26190575)		 UniProt PMID:10781606 PMID:15946935 PMID:16229686 PMID:17475390 PMID:26190575 NCBI chr10:50,184,861...50,251,516
Ensembl chr10:50,182,778...50,279,720 		JBrowse link
G NAAA N-acylethanolamine acid amidase involved_in IDA (PMID:15655246) UniProt PMID:15655246 NCBI chr 4:75,910,655...75,941,013
Ensembl chr 4:75,913,660...75,941,013 		JBrowse link
G PLPP1 phospholipid phosphatase 1 involved_in IEA
IDA		 (PMID:9705349) Ensembl
UniProt		 PMID:9705349 GO_REF:0000107 NCBI chr 5:55,424,854...55,534,964
Ensembl chr 5:55,424,854...55,534,969 		JBrowse link
G PLPP2 phospholipid phosphatase 2 involved_in IDA (PMID:9705349) UniProt PMID:9705349 NCBI chr19:281,043...291,403
Ensembl chr19:281,040...291,403 		JBrowse link
G PLPP3 phospholipid phosphatase 3 involved_in IDA (PMID:9305923), (PMID:9705349) UniProt PMID:9305923 PMID:9705349 NCBI chr 1:56,494,761...56,579,563
Ensembl chr 1:56,494,761...56,645,301 		JBrowse link
G SGPP1 sphingosine-1-phosphate phosphatase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:11756451) Ensembl
MGI
GO_Central		 PMID:11756451 GO_REF:0000033 GO_REF:0000107 NCBI chr14:63,684,216...63,728,065
Ensembl chr14:63,684,216...63,728,065 		JBrowse link
G SGPP2 sphingosine-1-phosphate phosphatase 2 involved_in IDA
IBA
IEA		 (PMID:12411432) UniProt
GO_Central
TreeGrafter		 PMID:12411432 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:222,423,988...222,562,621
Ensembl chr 2:222,424,543...222,562,621 		JBrowse link
G SPHK1 sphingosine kinase 1 involved_in IDA (PMID:20577214) UniProt PMID:20577214 NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860 		JBrowse link
G SPHK2 sphingosine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 (PMID:16093248) Ensembl
MGI
UniProt		 PMID:16093248 GO_REF:0000024 GO_REF:0000107 NCBI chr19:48,619,506...48,630,405
Ensembl chr19:48,619,291...48,630,717 		JBrowse link
sphingosine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of_positive_effect IDA (PMID:26510981) ARUK-UCL PMID:26510981 NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915 		JBrowse link
G ACER1 alkaline ceramidase 1 involved_in IMP
IBA
IEA
IDA		 (PMID:20207939)
(PMID:17713573), (PMID:20628055)		 UniProt
GO_Central
BHF-UCL
Ensembl		 PMID:17713573 PMID:20207939 PMID:20628055 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr19:6,306,142...6,360,368
Ensembl chr19:6,306,142...6,333,612 		JBrowse link
G ACER2 alkaline ceramidase 2 involved_in IEA
IBA
IDA
IMP		 (PMID:16940153), (PMID:20089856), (PMID:20628055)
(PMID:20207939)		 Ensembl
GO_Central
TreeGrafter
UniProt
BHF-UCL		 PMID:16940153 PMID:20089856 PMID:20207939 PMID:20628055 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr 9:19,409,009...19,452,505
Ensembl chr 9:19,409,009...19,452,505 		JBrowse link
G ACER3 alkaline ceramidase 3 involved_in IMP
IEA
IDA		 (PMID:20207939), (PMID:26792856)
(PMID:20068046)		 UniProt
Ensembl		 PMID:20068046 PMID:20207939 PMID:26792856 GO_REF:0000107 GO_REF:0000117 NCBI chr11:76,860,918...77,026,797
Ensembl chr11:76,860,859...77,026,797 		JBrowse link
G AGK acylglycerol kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:141,551,410...141,655,244
Ensembl chr 7:141,551,278...141,655,244 		JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 involved_in IDA
IEA
IMP		 (PMID:12815059)
(PMID:10610716)		 UniProt
Ensembl		 PMID:10610716 PMID:12815059 GO_REF:0000107 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998 		JBrowse link
G ASAH2 N-acylsphingosine amidohydrolase 2 involved_in IMP
IBA		 (PMID:30154232) UniProt
GO_Central		 PMID:30154232 GO_REF:0000033 NCBI chr10:50,184,861...50,251,516
Ensembl chr10:50,182,778...50,279,720 		JBrowse link
G GBA1 glucosylceramidase beta 1 involved_in IMP (PMID:19279011) BHF-UCL PMID:19279011 NCBI chr 1:155,234,452...155,244,627
Ensembl chr 1:155,234,452...155,244,699 		JBrowse link
G SPHK1 sphingosine kinase 1 involved_in IGI
IEA
IBA
IMP		 (PMID:23106337) UniProt
TreeGrafter
GO_Central		 PMID:23106337 GO_REF:0000033 GO_REF:0000118 NCBI chr17:76,383,204...76,387,855
Ensembl chr17:76,376,584...76,387,860 		JBrowse link
G SPHK2 sphingosine kinase 2 involved_in IGI
IEA
IBA
IMP		 (PMID:23106337) UniProt
TreeGrafter
GO_Central		 PMID:23106337 GO_REF:0000033 GO_REF:0000118 NCBI chr19:48,619,506...48,630,405
Ensembl chr19:48,619,291...48,630,717 		JBrowse link
G SPTLC1 serine palmitoyltransferase long chain base subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
IDA		 (PMID:16216550)
(PMID:19416851), (PMID:33558761)		 Ensembl
MGI
GO_Central
TreeGrafter
ComplexPortal		 PMID:16216550 PMID:19416851 PMID:33558761 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:92,031,147...92,115,413
Ensembl chr 9:92,000,087...92,115,413 		JBrowse link
G SPTLC2 serine palmitoyltransferase long chain base subunit 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
IDA		 (PMID:16216550)
(PMID:19416851), (PMID:33558761)		 Ensembl
MGI
GO_Central
ComplexPortal		 PMID:16216550 PMID:19416851 PMID:33558761 GO_REF:0000033 GO_REF:0000107 NCBI chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,637 		JBrowse link
G SPTLC3 serine palmitoyltransferase long chain base subunit 3 involved_in IDA
IBA		 (PMID:19416851) ComplexPortal
GO_Central		 PMID:19416851 GO_REF:0000033 NCBI chr20:13,008,972...13,169,103
Ensembl chr20:13,008,972...13,169,103 		JBrowse link
G SPTSSA serine palmitoyltransferase small subunit A involved_in IDA (PMID:19416851), (PMID:33558761) ComplexPortal PMID:19416851 PMID:33558761 NCBI chr14:34,432,788...34,462,240
Ensembl chr14:34,432,788...34,462,240 		JBrowse link
G SPTSSB serine palmitoyltransferase small subunit B involved_in IDA (PMID:19416851) ComplexPortal PMID:19416851 NCBI chr 3:161,344,798...161,371,517
Ensembl chr 3:161,344,798...161,372,880 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12467
      small molecule metabolic process 2010
        alcohol metabolic process 419
          polyol metabolic process 125
            diol metabolic process 33
              sphingosine metabolic process 21
                sphingosine biosynthetic process 15
                sphingosine catabolic process 0
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12467
      organic substance metabolic process 11970
        lipid metabolic process 1531
          cellular lipid metabolic process 1121
            membrane lipid metabolic process 227
              sphingolipid metabolic process 177
                sphingoid metabolic process 23
                  sphingosine metabolic process 21
                    sphingosine biosynthetic process 15
                    sphingosine catabolic process 0
paths to the root