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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingosine biosynthetic process
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Accession:GO:0046512 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
Synonyms:exact_synonym: sphingosine anabolism;   sphingosine biosynthesis;   sphingosine formation;   sphingosine synthesis


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sphingosine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO
IEA
(PMID:26510981)
GO_REF:0000107
RGD
Ensembl
PMID:26510981 GO_REF:0000107 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Acer1 alkaline ceramidase 1 ISO (PMID:17713573), (PMID:20207939), (PMID:20628055)
(MGI:MGI:5800647|PMID:27126290), (MGI:MGI:6107252|PMID:29056331)
RGD PMID:17713573, PMID:20207939, PMID:20628055, PMID:27126290, PMID:29056331 MGI:MGI:5800647, MGI:MGI:6107252 NCBI chr 9:10,061,978...10,093,588
Ensembl chr 9:10,061,978...10,093,588
JBrowse link
G Acer2 alkaline ceramidase 2 ISO (PMID:16940153), (PMID:20089856), (PMID:20207939), (PMID:20628055)
(MGI:MGI:6116621|PMID:29401619)
RGD PMID:16940153, PMID:20089856, PMID:20207939, PMID:20628055, PMID:29401619 MGI:MGI:6116621 NCBI chr 5:105,230,540...105,279,732
Ensembl chr 5:105,230,580...105,279,731
JBrowse link
G Acer3 alkaline ceramidase 3 ISO (PMID:20068046), (PMID:20207939), (PMID:26792856)
(MGI:MGI:5749603|PMID:26474409)
RGD PMID:20068046, PMID:20207939, PMID:26474409, PMID:26792856 MGI:MGI:5749603 NCBI chr 1:163,160,987...163,263,621
Ensembl chr 1:163,160,979...163,263,606
JBrowse link
G Agk acylglycerol kinase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:68,483,345...68,561,518
Ensembl chr 4:68,483,320...68,560,801
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 IEA
ISO
ISS
GO_REF:0000107
(PMID:10610716), (PMID:12815059)
GO_REF:0000024
(MGI:MGI:1267186|PMID:9653654)
Ensembl
RGD
UniProt
PMID:9653654, PMID:10610716, PMID:12815059 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1267186 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 IDA
IBA
ISO
PMID:10488143
PMID:21873635
(MGI:MGI:3608219|PMID:16126722), (MGI:MGI:3640407|PMID:16380386), (MGI:MGI:6275120|PMID:10652340)
(PMID:30154232)
PMID:15217782
PMID:15123644
RGD PMID:10652340, PMID:16126722, PMID:16380386, PMID:30154232, PMID:10488143, PMID:21873635, PMID:15217782, PMID:15123644 MGI:MGI:3608219, MGI:MGI:3640407, MGI:MGI:6275120, RGD:13838800, RGD:13792537, RGD:13838794, RGD:13838793 NCBI chr 1:250,557,042...250,665,083
Ensembl chr 1:250,557,044...250,630,677
JBrowse link
G Gba glucosylceramidase beta ISO (PMID:19279011) RGD PMID:19279011 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Sphk1 sphingosine kinase 1 ISO
IBA
IEA
UniProtKB:Q9NRA0 (PMID:23106337)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:23106337, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Sphk2 sphingosine kinase 2 ISO
IBA
UniProtKB:Q9NYA1 (PMID:23106337)
PMID:21873635
RGD PMID:23106337, PMID:21873635 RGD:13792537 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 ISO
IBA
MGI:MGI:3815115 (MGI:MGI:3814228|PMID:16216550)
PMID:21873635
RGD PMID:16216550, PMID:21873635 MGI:MGI:3814228, RGD:13792537 NCBI chr17:11,856,525...11,895,566
Ensembl chr17:11,856,525...11,895,566
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 ISO
IBA
MGI:MGI:3815117 (MGI:MGI:3814228|PMID:16216550)
PMID:21873635
RGD PMID:16216550, PMID:21873635 MGI:MGI:3814228, RGD:13792537 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954
JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:132,560,437...132,689,313
Ensembl chr 3:132,560,506...132,692,737
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      cellular metabolic process 11085
        cellular biosynthetic process 6060
          cellular nitrogen compound biosynthetic process 5067
            sphingosine biosynthetic process 13
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      organic substance metabolic process 11660
        lipid metabolic process 1374
          cellular lipid metabolic process 1023
            membrane lipid metabolic process 191
              sphingolipid metabolic process 142
                sphingoid metabolic process 21
                  sphingosine metabolic process 19
                    sphingosine biosynthetic process 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.