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ONTOLOGY REPORT - ANNOTATIONS

Term:diol metabolic process
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Accession:GO:0034311 term browser browse the term
Definition:The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic.
Synonyms:exact_synonym: diol metabolism
 related_synonym: dihydric alcohol metabolic process


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diol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp2 LDL receptor related protein 2 acts_upstream_of_or_within ISO
IEA 		(PMID:10052453)
GO_REF:0000107 		RGD
Ensembl		 PMID:10052453 GO_REF:0000107 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708 		JBrowse link
diol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx1 epoxide hydrolase 1 IDA RGD PMID:2507189 RGD:11252156 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
sphinganine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 acts_upstream_of_or_within ISO
IEA 		MGI:3815115 (PMID:19416652)
GO_REF:0000107 		RGD
Ensembl		 PMID:19416652 GO_REF:0000107 NCBI chr17:12,029,189...12,068,234
Ensembl chr17:11,877,249...11,916,295 		JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 acts_upstream_of_or_within ISO
IEA 		(PMID:9363775)
GO_REF:0000107 		RGD
Ensembl		 PMID:9363775 GO_REF:0000107 NCBI chr 6:112,679,623...112,762,470
Ensembl chr 6:106,950,949...107,031,542 		JBrowse link
sphinganine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Degs2 delta(4)-desaturase, sphingolipid 2 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
SGD:S000002705 (PMID:11937514) 		GO_Central
Ensembl
RGD		 PMID:11937514 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:127,596,063...127,613,293
Ensembl chr 6:127,596,071...127,613,293 		JBrowse link
sphingosine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of_positive_effect ISO
IEA 		(PMID:26510981)
GO_REF:0000107 		RGD
Ensembl		 PMID:26510981 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Acer1 alkaline ceramidase 1 involved_in ISO
IBA
IEA 		(PMID:17713573), (PMID:20207939), (PMID:20628055)
GO_REF:0000033
(PMID:27126290), (PMID:29056331)
GO_REF:0000117 		RGD
GO_Central
UniProt		 PMID:17713573 PMID:20207939 PMID:20628055 PMID:27126290 PMID:29056331 GO_REF:0000033 GO_REF:0000117 NCBI chr 9:1,794,340...1,824,432
Ensembl chr 9:1,793,139...1,824,434 		JBrowse link
G Acer2 alkaline ceramidase 2 involved_in ISO
IBA
IEA 		(PMID:16940153), (PMID:20089856), (PMID:20207939), (PMID:20628055)
GO_REF:0000033
(PMID:29401619)
GO_REF:0000117 		RGD
GO_Central
UniProt		 PMID:16940153 PMID:20089856 PMID:20207939 PMID:20628055 PMID:29401619 GO_REF:0000033 GO_REF:0000117 NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614 		JBrowse link
G Acer3 alkaline ceramidase 3 involved_in ISO
IEA 		(PMID:20068046), (PMID:20207939), (PMID:26792856)
(PMID:26474409)
GO_REF:0000117
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:20068046 PMID:20207939 PMID:26474409 PMID:26792856 GO_REF:0000107 GO_REF:0000117 NCBI chr 1:152,504,180...152,606,596
Ensembl chr 1:152,504,186...152,606,591 		JBrowse link
G Agk acylglycerol kinase involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:69,114,850...69,193,989
Ensembl chr 4:69,114,269...69,193,934 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:10610716), (PMID:12815059)
(PMID:9653654) 		UniProt
Ensembl
RGD		 PMID:9653654 PMID:10610716 PMID:12815059 GO_REF:0000024 GO_REF:0000107 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in IDA
ISO
IBA 		PMID:10488143
(PMID:30154232)
PMID:15217782
PMID:15123644
GO_REF:0000033
(PMID:10652340), (PMID:16126722), (PMID:16380386) 		RGD
GO_Central		 PMID:10652340 PMID:16126722 PMID:16380386 PMID:30154232 PMID:10488143 More... GO_REF:0000033, RGD:13838800, RGD:13838794, RGD:13838793 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162 		JBrowse link
G ENSRNOG00000069695 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 Ensembl chr14:25,729,638...25,730,194 JBrowse link
G Gba1 glucosylceramidase beta 1 involved_in ISO
IEA 		(PMID:19279011)
GO_REF:0000107 		RGD
Ensembl		 PMID:19279011 GO_REF:0000107 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO
IEA
IBA 		UniProtKB:Q9NRA0 (PMID:23106337)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:23106337 GO_REF:0000033 GO_REF:0000107 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO
IEA 		UniProtKB:Q9NYA1 (PMID:23106337)
GO_REF:0000107 		RGD
Ensembl		 PMID:23106337 GO_REF:0000107 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391 		JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 involved_in
acts_upstream_of_or_within 		ISO
IBA
IEA 		(PMID:19416851), (PMID:33558761)
GO_REF:0000033
MGI:3815115 (PMID:16216550)
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:16216550 PMID:19416851 PMID:33558761 GO_REF:0000033 GO_REF:0000107 NCBI chr17:12,029,189...12,068,234
Ensembl chr17:11,877,249...11,916,295 		JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:19416851), (PMID:33558761)
GO_REF:0000107
GO_REF:0000033
MGI:3815117 (PMID:16216550) 		RGD
Ensembl
GO_Central		 PMID:16216550 PMID:19416851 PMID:33558761 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:112,679,623...112,762,470
Ensembl chr 6:106,950,949...107,031,542 		JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 involved_in ISO
IBA
IEA 		(PMID:19416851)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:19416851 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:147,301,570...147,431,696
Ensembl chr 3:126,847,878...126,978,010 		JBrowse link
G Sptssa serine palmitoyltransferase, small subunit A involved_in ISO
IEA 		(PMID:19416851), (PMID:33558761)
GO_REF:0000107 		RGD
Ensembl		 PMID:19416851 PMID:33558761 GO_REF:0000107 NCBI chr 6:77,879,931...77,891,344
Ensembl chr 6:72,144,714...72,156,214 		JBrowse link
G Sptssb serine palmitoyltransferase, small subunit B involved_in ISO (PMID:19416851) RGD PMID:19416851 NCBI chr 2:156,432,509...156,461,936
Ensembl chr 2:154,133,733...154,163,120 		JBrowse link
sphingosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in ISO
ISS 		(PMID:10781606), (PMID:15946935), (PMID:16229686), (PMID:17475390), (PMID:26190575)
GO_REF:0000024 		RGD
UniProt		 PMID:10781606 PMID:15946935 PMID:16229686 PMID:17475390 PMID:26190575 GO_REF:0000024 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162 		JBrowse link
G Naaa N-acylethanolamine acid amidase involved_in ISO
IEA
ISS 		(PMID:15655246)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:15655246 GO_REF:0000024 GO_REF:0000107 NCBI chr14:16,061,599...16,080,703
Ensembl chr14:15,777,306...15,796,410 		JBrowse link
G Plpp1 phospholipid phosphatase 1 involved_in IDA
ISO
IEA 		PMID:10359651
(PMID:10359651)
GO_REF:0000107
PMID:8663293
(PMID:9705349) 		RGD
Ensembl		 PMID:9705349 PMID:10359651 PMID:10359651 PMID:8663293 GO_REF:0000107, RGD:15090857, RGD:15090855 NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268 		JBrowse link
G Plpp2 phospholipid phosphatase 2 involved_in ISS
ISO 		GO_REF:0000024
(PMID:9705349) 		UniProt
RGD		 PMID:9705349 GO_REF:0000024 NCBI chr 7:10,175,918...10,184,032
Ensembl chr 7:10,175,948...10,184,071 		JBrowse link
G Plpp3 phospholipid phosphatase 3 involved_in ISO
ISS 		(PMID:9305923), (PMID:9705349)
GO_REF:0000024 		RGD
UniProt		 PMID:9305923 PMID:9705349 GO_REF:0000024 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205 		JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 involved_in
acts_upstream_of_or_within 		IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:11756451) 		GO_Central
Ensembl
RGD		 PMID:11756451 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534 		JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 involved_in ISO
IBA 		(PMID:12411432)
GO_REF:0000033 		RGD
GO_Central		 PMID:12411432 GO_REF:0000033 NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO
IEA
ISS 		(PMID:20577214)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:20577214 GO_REF:0000024 GO_REF:0000107 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Sphk2 sphingosine kinase 2 acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:3580701 (PMID:16093248)
GO_REF:0000107
(PMID:17346996) 		RGD
Ensembl		 PMID:16093248 PMID:17346996 GO_REF:0000107 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391 		JBrowse link
tetrahydrobiopterin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07068905.1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 8:817,915...819,124 JBrowse link
G Dhfr dihydrofolate reductase involved_in ISO (PMID:23707606)
(PMID:19666465), (PMID:21402147) 		RGD PMID:19666465 PMID:21402147 PMID:23707606 NCBI chr 2:25,320,895...25,346,004
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in ISO
IBA
IEA 		(PMID:17101830), (PMID:19666465), (PMID:7678411), (PMID:9445252)
GO_REF:0000033
GO_REF:0000043 		RGD
GO_Central
UniProt		 PMID:7678411 PMID:9445252 PMID:17101830 PMID:19666465 GO_REF:0000033 GO_REF:0000043 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 involved_in IEA GO_REF:0000043
GO_REF:0000002 		UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr20:29,573,362...29,587,181
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292 		JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 involved_in IEA GO_REF:0000043
GO_REF:0000002 		UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr17:8,845,161...8,896,343
Ensembl chr17:8,845,084...8,910,539 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase acts_upstream_of_or_within
involved_in 		TAS
IEA
ISO 		GO_REF:0000107
GO_REF:0000043
GO_REF:0000002
(PMID:9894812)
GO_REF:0000041 		Ensembl
UniProt
InterPro
RGD		 PMID:9894812 PMID:1939130 GO_REF:0000002 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107, RGD:68294 NCBI chr 8:50,870,838...50,877,869
Ensembl chr 8:50,870,841...50,877,869 		JBrowse link
G Qdpr quinoid dihydropteridine reductase involved_in TAS
IBA
IEA
IMP
IDA 		GO_REF:0000033
GO_REF:0000043
PMID:1898002 		GO_Central
UniProt
RGD		 PMID:3680258 PMID:1898002 PMID:9235988 PMID:660556 GO_REF:0000033 GO_REF:0000043, RGD:729701, RGD:8553309, RGD:5128582, RGD:4139903 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854 		JBrowse link
G Spr sepiapterin reductase involved_in TAS
IEA
ISO
IBA
IMP 		GO_REF:0000002
(PMID:23640889)
GO_REF:0000033 		InterPro
RGD
GO_Central		 PMID:23640889 PMID:2201030 PMID:2179471 GO_REF:0000002 GO_REF:0000033, RGD:70022, RGD:1600056 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
G Spr-ps1 sepiapterin reductase, pseudogene 1 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 4:117,689,458...117,693,286
Ensembl chr 4:117,689,458...117,692,891 		JBrowse link
G Txndc15 thioredoxin domain containing 15 involved_in IEA GO_REF:0000043
GO_REF:0000002 		UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr17:8,898,074...8,910,538
Ensembl chr17:8,845,084...8,910,539
Ensembl chr 7:8,845,084...8,910,539 		JBrowse link
tetrahydrobiopterin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gch1 GTP cyclohydrolase 1 involved_in ISO MGI:1856903 (PMID:19286659), (PMID:7524491) RGD PMID:7524491 PMID:19286659 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase involved_in ISO
IEA 		MGI:2669870 (PMID:11517215)
GO_REF:0000107 		RGD
Ensembl		 PMID:11517215 GO_REF:0000107 NCBI chr 8:50,870,838...50,877,869
Ensembl chr 8:50,870,841...50,877,869 		JBrowse link
G Spr sepiapterin reductase acts_upstream_of_or_within
involved_in 		ISO MGI:3757641 (PMID:16532389)
MGI:3528977 (PMID:23647001) 		RGD PMID:16532389 PMID:23647001 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      metabolic process 12158
        small molecule metabolic process 1944
          alcohol metabolic process 401
            polyol metabolic process 119
              diol metabolic process 35
                (+)-secoisolariciresinol metabolic process + 0
                (-)-secoisolariciresinol metabolic process + 0
                asperfuranone metabolic process + 0
                diol biosynthetic process + 27
                diol catabolic process + 0
                glycol metabolic process + 0
                sphinganine metabolic process + 3
                sphingosine metabolic process + 22
                tetrahydrobiopterin metabolic process + 10
                verruculogen metabolic process + 0
paths to the root