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ONTOLOGY REPORT - ANNOTATIONS


Term:diol metabolic process
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Accession:GO:0034311 term browser browse the term
Definition:The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic.
Synonyms:exact_synonym: diol metabolism
 related_synonym: dihydric alcohol metabolic process



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diol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrp2 LDL receptor related protein 2 acts_upstream_of_or_within ISO (MGI:1331347|PMID:10052453) RGD PMID:10052453 MGI:1331347 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
JBrowse link
diol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx1 epoxide hydrolase 1 IDA RGD PMID:2507189 RGD:11252156 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
sphinganine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 acts_upstream_of_or_within ISO MGI:3815115 (MGI:3846467|PMID:19416652) RGD PMID:19416652 MGI:3846467 NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1098386|PMID:9363775)
GO_REF:0000107
RGD
Ensembl
PMID:9363775 GO_REF:0000107 MGI:1098386 NCBI chr 6:106,948,681...107,031,584
Ensembl chr 6:106,950,949...107,031,542
JBrowse link
sphinganine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Degs2 delta(4)-desaturase, sphingolipid 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
SGD:S000002705 (MGI:3505861|PMID:11937514)
(MGI:3694278|PMID:16571104)
RGD PMID:11937514 PMID:16571104 PMID:21873635 MGI:3505861 MGI:3694278, RGD:13792537 NCBI chr 6:127,596,063...127,613,293
Ensembl chr 6:127,596,071...127,613,293
JBrowse link
sphingosine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of_positive_effect
involved_in
ISO
IEA
(PMID:26510981)
GO_REF:0000107
RGD
Ensembl
PMID:26510981 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Acer1 alkaline ceramidase 1 involved_in ISO
IBA
(PMID:17713573), (PMID:20207939), (PMID:20628055)
(MGI:5800647|PMID:27126290), (MGI:6107252|PMID:29056331)
PMID:21873635
RGD PMID:17713573 PMID:20207939 PMID:20628055 PMID:27126290 PMID:29056331 More... MGI:5800647 MGI:6107252, RGD:13792537 NCBI chr 9:1,792,790...1,824,434
Ensembl chr 9:1,793,139...1,824,434
JBrowse link
G Acer2 alkaline ceramidase 2 involved_in ISO
IBA
(PMID:16940153), (PMID:20089856), (PMID:20207939), (PMID:20628055)
(MGI:6116621|PMID:29401619)
PMID:21873635
RGD PMID:16940153 PMID:20089856 PMID:20207939 PMID:20628055 PMID:29401619 More... MGI:6116621, RGD:13792537 NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
JBrowse link
G Acer3 alkaline ceramidase 3 involved_in ISO (PMID:20068046), (PMID:20207939), (PMID:26792856)
(MGI:5749603|PMID:26474409)
RGD PMID:20068046 PMID:20207939 PMID:26474409 PMID:26792856 MGI:5749603 NCBI chr 1:152,504,180...152,606,596
Ensembl chr 1:152,504,186...152,606,591
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:10610716), (PMID:12815059)
(MGI:1267186|PMID:9653654)
UniProt
Ensembl
RGD
PMID:9653654 PMID:10610716 PMID:12815059 GO_REF:0000024 GO_REF:0000107 MGI:1267186 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in IDA
ISO
IBA
PMID:10488143
(PMID:30154232)
PMID:21873635
PMID:15217782
(MGI:3608219|PMID:16126722), (MGI:3640407|PMID:16380386), (MGI:6275120|PMID:10652340)
PMID:15123644
RGD PMID:10652340 PMID:16126722 PMID:16380386 PMID:30154232 PMID:10488143 More... MGI:3608219 MGI:3640407 MGI:6275120, RGD:13838800, RGD:13792537, RGD:13838794, RGD:13838793 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
JBrowse link
G ENSRNOG00000069695 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 Ensembl chr14:25,729,638...25,730,194 JBrowse link
G Gba glucosylceramidase beta involved_in ISO (PMID:19279011) RGD PMID:19279011 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO
IBA
IEA
UniProtKB:Q9NRA0 (PMID:23106337)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:23106337 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO
IBA
UniProtKB:Q9NYA1 (PMID:23106337)
PMID:21873635
RGD PMID:23106337 PMID:21873635 RGD:13792537 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:3815115 (MGI:3814228|PMID:16216550)
(PMID:19416851), (PMID:33558761)
PMID:21873635
RGD PMID:16216550 PMID:19416851 PMID:33558761 PMID:21873635 MGI:3814228, RGD:13792537 NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
MGI:3815117 (MGI:3814228|PMID:16216550)
(PMID:19416851), (PMID:33558761)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:16216550 PMID:19416851 PMID:33558761 PMID:21873635 GO_REF:0000107 MGI:3814228, RGD:13792537 NCBI chr 6:106,948,681...107,031,584
Ensembl chr 6:106,950,949...107,031,542
JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 involved_in ISO
IBA
(PMID:19416851)
PMID:21873635
RGD PMID:19416851 PMID:21873635 RGD:13792537 NCBI chr 3:126,847,878...126,978,010
Ensembl chr 3:126,847,878...126,978,010
JBrowse link
G Sptssa serine palmitoyltransferase, small subunit A involved_in ISO (PMID:19416851), (PMID:33558761) RGD PMID:19416851 PMID:33558761 NCBI chr 6:72,144,714...72,156,130
Ensembl chr 6:72,144,714...72,156,214
JBrowse link
G Sptssb serine palmitoyltransferase, small subunit B involved_in ISO (PMID:19416851) RGD PMID:19416851 NCBI chr 2:154,133,728...154,162,127
Ensembl chr 2:154,133,733...154,163,120
JBrowse link
sphingosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asah2 N-acylsphingosine amidohydrolase 2 involved_in ISO
ISS
(PMID:10781606), (PMID:15946935), (PMID:16229686), (PMID:17475390), (PMID:26190575)
GO_REF:0000024
RGD
UniProt
PMID:10781606 PMID:15946935 PMID:16229686 PMID:17475390 PMID:26190575 GO_REF:0000024 NCBI chr 1:229,865,662...229,973,253
Ensembl chr 1:229,865,662...229,939,162
JBrowse link
G Naaa N-acylethanolamine acid amidase involved_in ISO
ISS
(PMID:15655246)
GO_REF:0000024
RGD
UniProt
PMID:15655246 GO_REF:0000024 NCBI chr14:15,777,306...15,796,411
Ensembl chr14:15,777,306...15,796,410
JBrowse link
G Plpp1 phospholipid phosphatase 1 involved_in IDA
ISO
PMID:10359651
(MGI:6383560|PMID:10359651)
PMID:8663293
(PMID:9705349)
RGD PMID:9705349 PMID:10359651 PMID:10359651 PMID:8663293 MGI:6383560, RGD:15090857, RGD:15090855 NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268
JBrowse link
G Plpp2 phospholipid phosphatase 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:9705349)
UniProt
RGD
PMID:9705349 GO_REF:0000024 NCBI chr 7:10,175,918...10,184,032
Ensembl chr 7:10,175,948...10,184,071
JBrowse link
G Plpp3 phospholipid phosphatase 3 involved_in ISO
IEA
ISS
(PMID:9305923), (PMID:9705349)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:9305923 PMID:9705349 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(MGI:2176350|PMID:11756451)
Ensembl
RGD
PMID:11756451 PMID:21873635 GO_REF:0000107 MGI:2176350, RGD:13792537 NCBI chr 6:94,425,339...94,446,534
Ensembl chr 6:94,425,339...94,446,534
JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 involved_in ISO
IBA
(PMID:12411432)
PMID:21873635
RGD PMID:12411432 PMID:21873635 RGD:13792537 NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO
ISS
(PMID:20577214)
GO_REF:0000024
RGD
UniProt
PMID:20577214 GO_REF:0000024 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in
acts_upstream_of_or_within
ISO (MGI:3703830|PMID:17346996)
MGI:3580701 (MGI:3608224|PMID:16093248)
RGD PMID:16093248 PMID:17346996 MGI:3608224 MGI:3703830 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
tetrahydrobiopterin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in ISO (PMID:23707606)
(MGI:5645206|PMID:19666465)
RGD PMID:19666465 PMID:23707606 MGI:5645206 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Gch1 GTP cyclohydrolase 1 involved_in TAS
IEA
IBA
ISO
GO_REF:0000043
PMID:21873635
(PMID:17101830), (PMID:19666465), (PMID:7678411), (PMID:9445252)
UniProt
RGD
PMID:7678411 PMID:9445252 PMID:17101830 PMID:19666465 PMID:12051753 More... GO_REF:0000043, RGD:625450, RGD:13792537 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292
JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:8,845,161...8,896,343
Ensembl chr17:8,845,084...8,910,539
JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase acts_upstream_of_or_within
involved_in
TAS
ISO
IEA
(MGI:1328867|PMID:9894812)
GO_REF:0000041
RGD
UniProt
PMID:9894812 PMID:1939130 GO_REF:0000041 MGI:1328867, RGD:68294 NCBI chr 8:50,870,838...50,877,878
Ensembl chr 8:50,870,841...50,877,869
JBrowse link
G Qdpr quinoid dihydropteridine reductase involved_in TAS
IBA
IMP
IDA
PMID:21873635
PMID:1898002
RGD
GO_Central
UniProt
PMID:3680258 PMID:21873635 PMID:1898002 PMID:9235988 PMID:660556 RGD:729701, RGD:13792537, RGD:8553309, RGD:5128582, RGD:4139903 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854
JBrowse link
G Spr sepiapterin reductase involved_in TAS
IBA
IMP
PMID:21873635 RGD
GO_Central
PMID:2201030 PMID:21873635 PMID:2179471 RGD:70022, RGD:13792537, RGD:1600056 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678
JBrowse link
G Spr-ps1 sepiapterin reductase, pseudogene 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:117,689,458...117,693,286
Ensembl chr 4:117,689,458...117,692,891
JBrowse link
G Txndc15 thioredoxin domain containing 15 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:8,898,074...8,910,538
Ensembl chr17:8,845,084...8,910,539
JBrowse link
tetrahydrobiopterin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spr sepiapterin reductase acts_upstream_of_or_within ISO MGI:3757641 (MGI:3722569|PMID:16532389) RGD PMID:16532389 MGI:3722569 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    metabolic process 12353
      small molecule metabolic process 1931
        alcohol metabolic process 381
          polyol metabolic process 127
            diol metabolic process 33
              (+)-secoisolariciresinol metabolic process + 0
              (-)-secoisolariciresinol metabolic process + 0
              asperfuranone metabolic process + 0
              diol biosynthetic process + 25
              diol catabolic process + 0
              glycol metabolic process + 0
              sphinganine metabolic process + 3
              sphingosine metabolic process + 21
              tetrahydrobiopterin metabolic process + 9
              verruculogen metabolic process + 0
Path 2
Term Annotations click to browse term
  biological_process 20099
    metabolic process 12353
      organic substance metabolic process 11873
        organic hydroxy compound metabolic process 577
          alcohol metabolic process 381
            polyol metabolic process 127
              diol metabolic process 33
                (+)-secoisolariciresinol metabolic process + 0
                (-)-secoisolariciresinol metabolic process + 0
                asperfuranone metabolic process + 0
                diol biosynthetic process + 25
                diol catabolic process + 0
                glycol metabolic process + 0
                sphinganine metabolic process + 3
                sphingosine metabolic process + 21
                tetrahydrobiopterin metabolic process + 9
                verruculogen metabolic process + 0
paths to the root