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ONTOLOGY REPORT - ANNOTATIONS

Term:mitochondrial outer membrane permeabilization
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Accession:GO:0097345 term browser browse the term
Definition:The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
Comment:BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively).
Synonyms:exact_synonym: MOMP;   mitochondrion outer membrane permeabilization
 broad_synonym: mitochondrial outer membrane permeabilization during apoptotic cell death

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mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within ISO (PMID:20436477) MGI PMID:20436477 NCBI chrNW_004624735:9,557,732...9,590,862
Ensembl chrNW_004624735:9,579,979...9,589,260 		JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in ISO (PMID:18188704) UniProt PMID:18188704 NCBI chrNW_004624737:12,095,175...12,101,595
Ensembl chrNW_004624737:12,094,309...12,102,030 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624737:14,848,355...14,863,731
Ensembl chrNW_004624737:14,848,350...14,862,965 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624758:21,284,165...21,309,957
Ensembl chrNW_004624758:21,284,167...21,310,398 		JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (PMID:11700312) MGI PMID:11700312 NCBI chrNW_004624790:7,620,935...7,852,072
Ensembl chrNW_004624790:7,620,756...7,775,933 		JBrowse link
G Rhot1 ras homolog family member T1 involved_in ISO (PMID:12482879) UniProt PMID:12482879 NCBI chrNW_004624875:242,550...311,871 JBrowse link
G Rhot2 ras homolog family member T2 involved_in ISO (PMID:12482879) UniProt PMID:12482879 NCBI chrNW_004624913:1,480,569...1,486,502 JBrowse link
G Rtl10 retrotransposon Gag like 10 involved_in ISO (PMID:23055042) UniProt PMID:23055042 NCBI chrNW_004624747:484,995...486,791 JBrowse link
G Vdac2 voltage dependent anion channel 2 involved_in ISO (PMID:31015432) UniProt PMID:31015432 NCBI chrNW_004624754:8,587,698...8,601,757
Ensembl chrNW_004624754:8,587,920...8,602,761 		JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in ISO (PMID:18371312) UniProt PMID:18371312 NCBI chrNW_004624778:13,307,236...13,336,347
Ensembl chrNW_004624778:13,307,094...13,336,120 		JBrowse link
G Bak1 BCL2 antagonist/killer 1 involved_in ISO (PMID:15901672) ComplexPortal PMID:15901672 NCBI chrNW_004624754:23,297,077...23,302,366
Ensembl chrNW_004624754:23,296,800...23,301,223 		JBrowse link
G Bcl2l1 BCL2 like 1 involved_in ISO (PMID:15901672), (PMID:9393856) ComplexPortal PMID:9393856 PMID:15901672 NCBI chrNW_004624741:788,445...838,513
Ensembl chrNW_004624741:789,355...839,507 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) UniProt PMID:27098698 MGI:5796062 NCBI chrNW_004624847:5,564,671...5,573,459
Ensembl chrNW_004624847:5,564,979...5,573,459 		JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15288121) MGI
Ensembl		 PMID:15288121 GO_REF:0000107 NCBI chrNW_004624850:749,046...793,654
Ensembl chrNW_004624850:749,050...793,959 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO (PMID:19096392) MGI PMID:19096392 NCBI chrNW_004624754:24,991,650...24,992,645
Ensembl chrNW_004624754:24,991,690...24,992,643 		JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004624824:8,707,104...8,723,649
Ensembl chrNW_004624824:8,707,145...8,722,613 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624769:15,989,527...15,993,609
Ensembl chrNW_004624769:15,989,547...15,997,680 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624895:3,472,810...3,475,713
Ensembl chrNW_004624895:3,472,791...3,477,568 		JBrowse link
G Slc25a6 solute carrier family 25 member 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624834:654,552...657,580
Ensembl chrNW_004624834:653,599...657,556 		JBrowse link
G Slc35f6 solute carrier family 35 member F6 involved_in IEA UniProt GO_REF:0000104 NCBI chrNW_004624738:8,875,717...8,890,439
Ensembl chrNW_004624738:8,875,438...8,888,571 		JBrowse link
G Tmem14a transmembrane protein 14A involved_in ISO (PMID:21723035) UniProt PMID:21723035 NCBI chrNW_004624855:3,388,292...3,411,943
Ensembl chrNW_004624855:3,388,847...3,394,990 		JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 acts_upstream_of_or_within ISO (PMID:19096392) MGI PMID:19096392 NCBI chrNW_004624764:12,068,518...12,070,542
Ensembl chrNW_004624764:12,068,638...12,072,190 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796067|PMID:26949185) UniProt PMID:26949185 MGI:5796067 NCBI chrNW_004624847:5,564,671...5,573,459
Ensembl chrNW_004624847:5,564,979...5,573,459 		JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624747:10,411,933...10,413,969
Ensembl chrNW_004624747:10,412,012...10,413,969 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (MGI:5514334|PMID:16543145) UniProt PMID:16543145 MGI:5514334 NCBI chrNW_004624907:511,919...522,106
Ensembl chrNW_004624907:511,889...522,168 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO (MGI:5514334|PMID:16543145) UniProt PMID:16543145 MGI:5514334 NCBI chrNW_004624731:28,178,647...28,368,784
Ensembl chrNW_004624731:28,178,628...28,366,420 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (PMID:19255499) ParkinsonsUK-UCL PMID:19255499 NCBI chrNW_004624747:22,876,183...22,897,557
Ensembl chrNW_004624747:22,876,276...22,896,584 		JBrowse link
G Siva1 SIVA1 apoptosis inducing factor involved_in ISO (PMID:15034012) BHF-UCL PMID:15034012 NCBI chrNW_004624734:530,711...535,281 JBrowse link
G Znf205 zinc finger protein 205 involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004624824:837,369...852,439
Ensembl chrNW_004624824:837,373...852,710 		JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:5,560,071...5,566,763
Ensembl chrNW_004624764:5,557,560...5,586,964 		JBrowse link
G Tmem102 transmembrane protein 102 involved_in ISO (PMID:17828305) UniProt PMID:17828305 NCBI chrNW_004624786:10,047,087...10,049,324
Ensembl chrNW_004624786:10,046,666...10,052,108 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    cellular process 14252
      signal transduction 5427
        apoptotic signaling pathway 620
          mitochondrial outer membrane permeabilization 30
            negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 12
            positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 8
            regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 21
Path 2
Term Annotations click to browse term
  biological_process 15093
    cellular process 14252
      cellular component organization or biogenesis 6215
        cellular component organization 6013
          organelle organization 3378
            mitochondrion organization 514
              mitochondrial membrane organization 108
                regulation of mitochondrial membrane permeability 54
                  positive regulation of mitochondrial membrane permeability 39
                    mitochondrial outer membrane permeabilization involved in programmed cell death 36
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process 34
                        mitochondrial outer membrane permeabilization 30
                          negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 12
                          positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 8
                          regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 21
paths to the root