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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
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Accession:GO:1901030 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
Comment:Caspase 8 may be annotated to this term when it is shown to stimulate MOMP by cleaving the BH3-only protein BID.
Synonyms:exact_synonym: positive regulation of MOMP;   up regulation of MOMP;   up regulation of mitochondrial outer membrane permeabilization;   upregulation of MOMP;   upregulation of mitochondrial outer membrane permeabilization
 narrow_synonym: activation of MOMP;   activation of mitochondrial outer membrane permeabilization
 broad_synonym: positive regulation of mitochondrial outer membrane permeabilization
 xref: Reactome:R-HSA-111452 "Activation and oligomerization of BAK protein";   Reactome:R-HSA-114294 "Activation, translocation and oligomerization of BAX"


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positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 acts_upstream_of_or_within ISO (PMID:19096392) RGD PMID:19096392 NCBI chr 5:150,022,960...150,026,677
Ensembl chr 5:150,022,960...150,026,677 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:26949185)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:26949185 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISS
ISO 		GO_REF:0000024
(PMID:16543145) 		UniProt
RGD		 PMID:16543145 GO_REF:0000024 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:89,943,669...89,953,593 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISS
ISO 		GO_REF:0000024
(PMID:16543145) 		UniProt
RGD		 PMID:16543145 GO_REF:0000024 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO
IEA 		UniProtKB:Q9HD36 (PMID:19255499)
GO_REF:0000107 		RGD
Ensembl		 PMID:19255499 GO_REF:0000107 NCBI chr12:32,590,164...32,618,841
Ensembl chr12:38,251,086...38,279,654 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO
IEA 		(PMID:21370995)
GO_REF:0000107 		RGD
Ensembl		 PMID:21370995 GO_REF:0000107 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor involved_in ISO (PMID:15034012) RGD PMID:15034012 NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:137,526,031...137,530,790 		JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO
IEA 		(PMID:22306510)
GO_REF:0000107 		RGD
Ensembl		 PMID:22306510 GO_REF:0000107 NCBI chr10:13,119,707...13,128,284
Ensembl chr10:13,120,084...13,128,243 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    positive regulation of biological process 6855
      positive regulation of transport 1088
        positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      cellular component organization or biogenesis 7219
        cellular component organization 6928
          organelle organization 3741
            mitochondrion organization 470
              mitochondrial membrane organization 125
                regulation of mitochondrial membrane permeability 65
                  positive regulation of mitochondrial membrane permeability 49
                    mitochondrial outer membrane permeabilization involved in programmed cell death 45
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process 43
                        mitochondrial outer membrane permeabilization 36
                          regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 28
                            positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 8
paths to the root