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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid metabolic process
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Accession:GO:0042573 term browser browse the term
Definition:The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid metabolism;   vitamin A1 acid metabolic process;   vitamin A1 acid metabolism


show annotations for term's descendants           Sort by:
retinoic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:99,276,369...99,290,985
Ensembl chr 4:99,276,369...99,291,003 		JBrowse link
G ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:99,304,971...99,321,401
Ensembl chr 4:99,304,971...99,321,401 		JBrowse link
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:15193143)
(PMID:10358022), (PMID:12851412)		 GO_Central
MGI		 PMID:10358022 PMID:12851412 PMID:15193143 GO_REF:0000033 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746 		JBrowse link
G ADH6 alcohol dehydrogenase 6 (class V) involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:99,202,639...99,219,246
Ensembl chr 4:99,202,638...99,219,537 		JBrowse link
G ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:10358022), (PMID:10402668) Ensembl
MGI
GO_Central		 PMID:10358022 PMID:10402668 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:99,412,263...99,435,342
Ensembl chr 4:99,412,261...99,435,510 		JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 acts_upstream_of_or_within ISO (PMID:16207763)
(PMID:10191271)
(PMID:12808103), (PMID:12851412)		 MGI PMID:10191271 PMID:12808103 PMID:12851412 PMID:16207763 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 acts_upstream_of_or_within
involved_in		 ISO
IMP
ISS
IEA		 (PMID:14623241)
(PMID:16368932)
(PMID:8797830)
(PMID:33565183)		 RGD
MGI
UniProt
Ensembl		 PMID:8797830 PMID:12547725 PMID:14623241 PMID:16368932 PMID:33565183 GO_REF:0000024 GO_REF:0000107 RGD:1576367 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866 		JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 involved_in
acts_upstream_of_or_within		 IDA
ISO
IEA		 (PMID:11585737)
(PMID:16207763)
(PMID:17207476)		 UniProt
MGI
Ensembl		 PMID:11585737 PMID:16207763 PMID:17207476 GO_REF:0000107 NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,861,924...100,916,626 		JBrowse link
G ALDH8A1 aldehyde dehydrogenase 8 family member A1 involved_in IDA
IBA		 (PMID:11007799) UniProt
GO_Central		 PMID:11007799 GO_REF:0000033 NCBI chr 6:134,917,393...134,950,101
Ensembl chr 6:134,917,393...134,950,115 		JBrowse link
G BCO2 beta-carotene oxygenase 2 involved_in NAS (PMID:11278918) UniProt PMID:11278918 NCBI chr11:112,175,512...112,218,946
Ensembl chr11:112,175,510...112,224,699 		JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9826179) Ensembl
MGI		 PMID:9826179 GO_REF:0000107 NCBI chr 1:156,699,606...156,705,784
Ensembl chr 1:156,699,606...156,705,816 		JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 involved_in
acts_upstream_of_or_within		 IDA
ISO		 (PMID:22020119), (PMID:9716180)
(PMID:15531370)		 UniProt
MGI		 PMID:9716180 PMID:15531370 PMID:22020119 NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885 		JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 involved_in IDA (PMID:22020119) UniProt PMID:22020119 NCBI chr 2:72,129,238...72,147,862
Ensembl chr 2:72,129,238...72,147,862 		JBrowse link
G CYP27C1 cytochrome P450 family 27 subfamily C member 1 involved_in IDA (PMID:27059013) UniProt PMID:27059013 NCBI chr 2:127,183,832...127,220,299
Ensembl chr 2:127,183,832...127,220,313 		JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 involved_in IDA (PMID:11093772) UniProt PMID:11093772 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 involved_in IDA (PMID:11093772) UniProt PMID:11093772 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2S1 cytochrome P450 family 2 subfamily S member 1 involved_in IDA (PMID:12711469) UniProt PMID:12711469 NCBI chr19:41,193,219...41,207,539
Ensembl chr19:41,193,210...41,207,539 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 involved_in IDA (PMID:11093772) UniProt PMID:11093772 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 involved_in IDA (PMID:11093772) UniProt PMID:11093772 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 involved_in IDA (PMID:11093772) UniProt PMID:11093772 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196 		JBrowse link
G CYP3A7-CYP3A51P CYP3A7-CYP3A51P readthrough involved_in IDA (PMID:11093772) UniProt PMID:11093772 NCBI chr 7:99,684,677...99,735,196
Ensembl chr 7:99,684,957...99,735,102 		JBrowse link
G RBP1 retinol binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15193143) Ensembl
MGI		 PMID:15193143 GO_REF:0000107 NCBI chr 3:139,517,438...139,539,742
Ensembl chr 3:139,517,434...139,539,829 		JBrowse link
G RDH16 retinol dehydrogenase 16 ISO RGD PMID:7499345 RGD:1299624 NCBI chr12:56,951,431...56,957,608
Ensembl chr12:56,951,431...56,959,374 		JBrowse link
G SCPEP1 serine carboxypeptidase 1 involved_in ISO
ISS		 RGD
UniProt		 PMID:11447226 GO_REF:0000024 RGD:70518 NCBI chr17:56,978,131...57,006,768
Ensembl chr17:56,978,129...57,006,768 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 involved_in IC (PMID:20308471) BHF-UCL PMID:20308471 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 involved_in IC (PMID:20308471) BHF-UCL PMID:20308471 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT1A7 UDP glucuronosyltransferase family 1 member A7 involved_in IC (PMID:20308471) BHF-UCL PMID:20308471 NCBI chr 2:233,681,901...233,773,300
Ensembl chr 2:233,681,901...233,773,300 		JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 involved_in IC (PMID:20308471) BHF-UCL PMID:20308471 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,633...233,773,300 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 involved_in IC (PMID:20308471) BHF-UCL PMID:20308471 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866 		JBrowse link
G ALDH8A1 aldehyde dehydrogenase 8 family member A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chr 6:134,917,393...134,950,101
Ensembl chr 6:134,917,393...134,950,115 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 involved_in ISO
IEA		 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD
Ensembl		 PMID:8765131 GO_REF:0000107 RGD:2306683 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G DHRS9 dehydrogenase/reductase 9 involved_in IDA (PMID:11304534) UniProt PMID:11304534 NCBI chr 2:169,067,077...169,096,167
Ensembl chr 2:169,064,789...169,096,167 		JBrowse link
G RDH16 retinol dehydrogenase 16 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chr12:56,951,431...56,957,608
Ensembl chr12:56,951,431...56,959,374 		JBrowse link
9-cis-retinoic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO RGD PMID:17167544 RGD:2306320 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1 member C3 involved_in IDA (PMID:21851338) UniProt PMID:21851338 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G PRMT3 protein arginine methyltransferase 3 involved_in IMP (PMID:33495566) UniProt PMID:33495566 NCBI chr11:20,387,716...20,509,338
Ensembl chr11:20,387,558...20,509,338 		JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RDH10 retinol dehydrogenase 10 involved_in ISO
IEA		 RGD
Ensembl		 PMID:21138835 GO_REF:0000107 RGD:6771354 NCBI chr 8:73,294,602...73,325,281
Ensembl chr 8:73,294,602...73,325,281 		JBrowse link
G RDH16 retinol dehydrogenase 16 ISO RGD PMID:21138835 RGD:6771354 NCBI chr12:56,951,431...56,957,608
Ensembl chr12:56,951,431...56,959,374 		JBrowse link
retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO RGD PMID:21138835 RGD:6771354 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 involved_in ISO
IMP
IEA
IDA		 (PMID:33565183)
(PMID:29240402)		 RGD
UniProt
Ensembl		 PMID:15950969 PMID:21138835 PMID:29240402 PMID:33565183 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866 		JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 acts_upstream_of_or_within
involved_in		 ISO
IDA
IEA		 (PMID:11013254), (PMID:11044606), (PMID:16241904)
(PMID:27759097)		 RGD
MGI
UniProt
Ensembl		 PMID:11013254 PMID:11044606 PMID:15950969 PMID:16241904 PMID:21138835 More... GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,861,924...100,916,626 		JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 ISO RGD PMID:15950969 RGD:6771322 NCBI chr 1:156,699,606...156,705,784
Ensembl chr 1:156,699,606...156,705,816 		JBrowse link
G DHRS9 dehydrogenase/reductase 9 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15950969 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr 2:169,067,077...169,096,167
Ensembl chr 2:169,064,789...169,096,167 		JBrowse link
G RBP1 retinol binding protein 1 involved_in ISO
IEA		 RGD
InterPro
Ensembl		 PMID:15950969 GO_REF:0000002 GO_REF:0000107 RGD:6771322 NCBI chr 3:139,517,438...139,539,742
Ensembl chr 3:139,517,434...139,539,829 		JBrowse link
G RDH10 retinol dehydrogenase 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17473173) Ensembl
MGI		 PMID:17473173 GO_REF:0000107 NCBI chr 8:73,294,602...73,325,281
Ensembl chr 8:73,294,602...73,325,281 		JBrowse link
retinoic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 involved_in IDA
IBA		 (PMID:10823918) BHF-UCL
GO_Central		 PMID:10823918 GO_REF:0000033 NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885 		JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 involved_in ISO
IBA
IEA
IDA		 (PMID:10823918) RGD
GO_Central
Ensembl
BHF-UCL		 PMID:10823918 PMID:21138835 GO_REF:0000033 GO_REF:0000107 RGD:6771354 NCBI chr 2:72,129,238...72,147,862
Ensembl chr 2:72,129,238...72,147,862 		JBrowse link
G CYP26C1 cytochrome P450 family 26 subfamily C member 1 involved_in IDA
IBA		 (PMID:14532297) BHF-UCL
GO_Central		 PMID:14532297 GO_REF:0000033 NCBI chr10:93,060,798...93,069,540
Ensembl chr10:93,060,798...93,069,540 		JBrowse link
G CYP2W1 cytochrome P450 family 2 subfamily W member 1 involved_in IDA (PMID:26936974) UniProt PMID:26936974 NCBI chr 7:983,181...989,640
Ensembl chr 7:983,181...989,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19711
    cellular process 18963
      metabolic process 12918
        hormone metabolic process 276
          retinoic acid metabolic process 36
            9-cis-retinoic acid metabolic process + 6
            retinoic acid biosynthetic process + 12
            retinoic acid catabolic process 4
            retinoic acid metabolic process in spinal cord anterior-posterior patterning 0
Path 2
Term Annotations click to browse term
  biological_process 19711
    cellular process 18963
      metabolic process 12918
        primary metabolic process 11235
          lipid metabolic process 1515
            isoprenoid metabolic process 136
              terpenoid metabolic process 111
                diterpenoid metabolic process 100
                  retinoid metabolic process 91
                    retinoic acid metabolic process 36
                      9-cis-retinoic acid metabolic process + 6
                      retinoic acid biosynthetic process + 12
                      retinoic acid catabolic process 4
                      retinoic acid metabolic process in spinal cord anterior-posterior patterning 0
paths to the root