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ONTOLOGY REPORT - ANNOTATIONS


Term:retinoic acid biosynthetic process
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Accession:GO:0002138 term browser browse the term
Definition:The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid anabolic process


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retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 involved_in IEP
ISO
ISS
IMP
(PMID:29240402)
GO_REF:0000024
RGD
UniProt
PMID:29240402 PMID:15950969 PMID:21138835 GO_REF:0000024, RGD:6771322, RGD:6771354 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 acts_upstream_of_or_within
involved_in
IEP
ISO
ISS
IEA
IMP
(MGI:1927016|PMID:11044606), (MGI:3055622|PMID:11013254), (MGI:3692370|PMID:16241904)
(MGI:3042765|PMID:14623956)
(PMID:27759097)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:11013254 PMID:11044606 PMID:14623956 PMID:16241904 PMID:27759097 More... GO_REF:0000024 GO_REF:0000107 MGI:1927016 MGI:3042765 MGI:3055622 MGI:3692370, RGD:6771322, RGD:6771354 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 IEP
IDA
RGD PMID:15950969 PMID:21138835 RGD:6771322, RGD:6771354 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241
JBrowse link
G Rbp1 retinol binding protein 1 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743
JBrowse link
G Rdh10 retinol dehydrogenase 10 acts_upstream_of_or_within ISO (MGI:3709664|PMID:17473173) RGD PMID:17473173 MGI:3709664 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572
JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2662611|PMID:11876656)
Ensembl
RGD
PMID:11876656 GO_REF:0000107 MGI:2662611 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 acts_upstream_of_or_within ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 acts_upstream_of_or_within ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 involved_in ISO
ISS
(PMID:11304534)
GO_REF:0000024
RGD
UniProt
PMID:11304534 GO_REF:0000024 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241
JBrowse link
G Rdh16 retinol dehydrogenase 16 acts_upstream_of_or_within ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 7:63,616,724...63,624,120
Ensembl chr 7:63,597,536...63,624,124
JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 involved_in ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Prmt3 protein arginine methyltransferase 3 involved_in ISO
ISS
IEA
(PMID:33495566)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:33495566 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435
JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rdh10 retinol dehydrogenase 10 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572
JBrowse link
G Rdh16 retinol dehydrogenase 16 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 7:63,616,724...63,624,120
Ensembl chr 7:63,597,536...63,624,124
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      cellular metabolic process 10721
        cellular hormone metabolic process 145
          retinoic acid metabolic process 27
            retinoic acid biosynthetic process 12
              9-cis-retinoic acid biosynthetic process 6
              negative regulation of retinoic acid biosynthetic process 2
              positive regulation of retinoic acid biosynthetic process 2
              regulation of retinoic acid biosynthetic process + 4
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      primary metabolic process 10531
        lipid metabolic process 1364
          cellular lipid metabolic process 1019
            isoprenoid metabolic process 119
              terpenoid metabolic process 93
                diterpenoid metabolic process 84
                  retinoid metabolic process 75
                    retinoic acid metabolic process 27
                      retinoic acid biosynthetic process 12
                        9-cis-retinoic acid biosynthetic process 6
                        negative regulation of retinoic acid biosynthetic process 2
                        positive regulation of retinoic acid biosynthetic process 2
                        regulation of retinoic acid biosynthetic process + 4
paths to the root