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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid biosynthetic process
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Accession:GO:0002138 term browser browse the term
Definition:The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.
Synonyms:exact_synonym: retinoic acid anabolic process;   retinoic acid biosynthesis


show annotations for term's descendants           Sort by:
retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 ISO RGD PMID:21138835 RGD:6771354 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 involved_in ISO
IMP
IEA
IDA		 (PMID:33565183)
(PMID:29240402)		 RGD
UniProt
Ensembl		 PMID:15950969 PMID:21138835 PMID:29240402 PMID:33565183 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866 		JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 acts_upstream_of_or_within
involved_in		 ISO
IDA
IEA		 (PMID:11013254), (PMID:11044606), (PMID:16241904)
(PMID:27759097)		 RGD
MGI
UniProt
Ensembl		 PMID:11013254 PMID:11044606 PMID:15950969 PMID:16241904 PMID:21138835 More... GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,877,714...100,916,626 		JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 ISO RGD PMID:15950969 RGD:6771322 NCBI chr 1:156,699,606...156,705,784
Ensembl chr 1:156,699,606...156,705,816 		JBrowse link
G DHRS9 dehydrogenase/reductase 9 involved_in ISO
IEA		 RGD
Ensembl		 PMID:15950969 PMID:21138835 GO_REF:0000107 RGD:6771322 RGD:6771354 NCBI chr 2:169,067,077...169,096,167
Ensembl chr 2:169,064,789...169,096,167 		JBrowse link
G RBP1 retinol binding protein 1 involved_in ISO
IEA		 RGD
InterPro
Ensembl		 PMID:15950969 GO_REF:0000002 GO_REF:0000107 RGD:6771322 NCBI chr 3:139,517,438...139,539,742
Ensembl chr 3:139,517,434...139,539,829 		JBrowse link
G RDH10 retinol dehydrogenase 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17473173) Ensembl
MGI		 PMID:17473173 GO_REF:0000107 NCBI chr 8:73,294,602...73,325,281
Ensembl chr 8:73,294,602...73,325,281 		JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866 		JBrowse link
G ALDH8A1 aldehyde dehydrogenase 8 family member A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11876656) Ensembl
MGI		 PMID:11876656 GO_REF:0000107 NCBI chr 6:134,917,393...134,950,101
Ensembl chr 6:134,917,393...134,950,115 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 involved_in ISO
IEA		 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD
Ensembl		 PMID:8765131 GO_REF:0000107 RGD:2306683 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G DHRS9 dehydrogenase/reductase 9 involved_in IDA (PMID:11304534) UniProt PMID:11304534 NCBI chr 2:169,067,077...169,096,167
Ensembl chr 2:169,064,789...169,096,167 		JBrowse link
G RDH16 retinol dehydrogenase 16 acts_upstream_of_or_within ISO (PMID:11876656) MGI PMID:11876656 NCBI chr12:56,951,431...56,957,608
Ensembl chr12:56,951,431...56,959,374 		JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1 member C3 involved_in IDA (PMID:21851338) UniProt PMID:21851338 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G PRMT3 protein arginine methyltransferase 3 involved_in IMP (PMID:33495566) UniProt PMID:33495566 NCBI chr11:20,387,716...20,509,338
Ensembl chr11:20,387,558...20,509,338 		JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RDH10 retinol dehydrogenase 10 involved_in ISO
IEA		 RGD
Ensembl		 PMID:21138835 GO_REF:0000107 RGD:6771354 NCBI chr 8:73,294,602...73,325,281
Ensembl chr 8:73,294,602...73,325,281 		JBrowse link
G RDH16 retinol dehydrogenase 16 ISO RGD PMID:21138835 RGD:6771354 NCBI chr12:56,951,431...56,957,608
Ensembl chr12:56,951,431...56,959,374 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    metabolic process 13065
      hormone metabolic process 272
        retinoic acid metabolic process 36
          retinoic acid biosynthetic process 12
            9-cis-retinoic acid biosynthetic process 6
            negative regulation of retinoic acid biosynthetic process 2
            positive regulation of retinoic acid biosynthetic process 2
            regulation of retinoic acid biosynthetic process + 4
Path 2
Term Annotations click to browse term
  biological_process 19770
    metabolic process 13065
      primary metabolic process 11398
        lipid metabolic process 1520
          cellular lipid metabolic process 1099
            isoprenoid metabolic process 130
              terpenoid metabolic process 107
                diterpenoid metabolic process 96
                  retinoid metabolic process 87
                    retinoic acid metabolic process 36
                      retinoic acid biosynthetic process 12
                        9-cis-retinoic acid biosynthetic process 6
                        negative regulation of retinoic acid biosynthetic process 2
                        positive regulation of retinoic acid biosynthetic process 2
                        regulation of retinoic acid biosynthetic process + 4
paths to the root