Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor 8 signaling pathway
go back to main search page
Accession:GO:0034158 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 8.
Synonyms:exact_synonym: TLR8 signaling pathway;   toll-like receptor 8 signalling pathway

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
toll-like receptor 8 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myd88 MYD88 innate immune signal transduction adaptor involved_in ISO (PMID:33718825) UniProt PMID:33718825 NCBI chrNW_004624731:2,677,259...2,681,408
Ensembl chrNW_004624731:2,677,290...2,681,489 		JBrowse link
G Tlr7 toll like receptor 7 involved_in ISO (PMID:12032557) GO_Central PMID:12032557 NCBI chrNW_004624882:1,375,216...1,379,705 JBrowse link
G Tlr8 toll like receptor 8 involved_in ISO (PMID:12032557), (PMID:24942581), (PMID:33718825) UniProt PMID:12032557 PMID:24942581 PMID:33718825 NCBI chrNW_004624882:1,240,519...1,247,311
Ensembl chrNW_004624882:1,240,626...1,312,468 		JBrowse link
positive regulation of toll-like receptor 8 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3 X-linked involved_in ISO (PMID:30341167) UniProt PMID:30341167 NCBI chrNW_004624762:14,290,267...14,305,437
Ensembl chrNW_004624762:14,290,267...14,305,633 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISO (PMID:32433612) UniProt PMID:32433612 NCBI chrNW_004624747:26,252,788...26,275,273
Ensembl chrNW_004624747:26,252,492...26,275,173 		JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624762:25,427,519...25,448,180
Ensembl chrNW_004624762:25,430,926...25,448,114 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15135
    cellular process 14753
      signal transduction 5421
        intracellular signal transduction 2703
          intracellular receptor signaling pathway 345
            cytoplasmic pattern recognition receptor signaling pathway 163
              endolysosomal toll-like receptor signaling pathway 44
                toll-like receptor 8 signaling pathway 6
                  negative regulation of toll-like receptor 8 signaling pathway 0
                  positive regulation of toll-like receptor 8 signaling pathway 3
                  regulation of toll-like receptor 8 signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 15135
    response to stimulus 8179
      response to biotic stimulus 1393
        response to external biotic stimulus 1347
          response to other organism 1344
            defense response to other organism 935
              defense response to symbiont 756
                innate immune response 689
                  regulation of innate immune response 390
                    positive regulation of innate immune response 321
                      activation of innate immune response 263
                        innate immune response-activating signaling pathway 247
                          pattern recognition receptor signaling pathway 246
                            cytoplasmic pattern recognition receptor signaling pathway 163
                              endolysosomal toll-like receptor signaling pathway 44
                                toll-like receptor 8 signaling pathway 6
                                  negative regulation of toll-like receptor 8 signaling pathway 0
                                  positive regulation of toll-like receptor 8 signaling pathway 3
                                  regulation of toll-like receptor 8 signaling pathway + 3
paths to the root