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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor 8 signaling pathway
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Accession:GO:0034158 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 8.
Synonyms:exact_synonym: TLR8 signaling pathway;   toll-like receptor 8 signalling pathway

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toll-like receptor 8 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myd88 MYD88 innate immune signal transduction adaptor involved_in ISO (PMID:33718825) UniProt PMID:33718825 NCBI chrNW_004624731:2,677,259...2,681,408
Ensembl chrNW_004624731:2,677,290...2,681,489 		JBrowse link
G Tlr8 toll like receptor 8 involved_in ISO (PMID:12032557), (PMID:24942581), (PMID:33718825) UniProt PMID:12032557 PMID:24942581 PMID:33718825 NCBI chrNW_004624882:1,240,519...1,247,311
Ensembl chrNW_004624882:1,240,626...1,312,468 		JBrowse link
positive regulation of toll-like receptor 8 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3 X-linked involved_in ISO (PMID:30341167) UniProt PMID:30341167 NCBI chrNW_004624762:14,290,267...14,305,437
Ensembl chrNW_004624762:14,290,267...14,305,633 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISO (PMID:32433612) UniProt PMID:32433612 NCBI chrNW_004624747:26,252,788...26,275,273
Ensembl chrNW_004624747:26,252,492...26,275,173 		JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624762:25,427,519...25,448,180
Ensembl chrNW_004624762:25,430,926...25,448,114 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    cellular process 14237
      signal transduction 5415
        intracellular receptor signaling pathway 340
          cytoplasmic pattern recognition receptor signaling pathway 151
            endolysosomal toll-like receptor signaling pathway 44
              toll-like receptor 8 signaling pathway 5
                negative regulation of toll-like receptor 8 signaling pathway 0
                positive regulation of toll-like receptor 8 signaling pathway 3
                regulation of toll-like receptor 8 signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 15093
    response to stimulus 8161
      response to biotic stimulus 1361
        response to external biotic stimulus 1317
          response to other organism 1314
            defense response to other organism 906
              defense response to symbiont 802
                innate immune response 664
                  regulation of innate immune response 371
                    positive regulation of innate immune response 309
                      activation of innate immune response 253
                        innate immune response-activating signaling pathway 237
                          pattern recognition receptor signaling pathway 235
                            cytoplasmic pattern recognition receptor signaling pathway 151
                              endolysosomal toll-like receptor signaling pathway 44
                                toll-like receptor 8 signaling pathway 5
                                  negative regulation of toll-like receptor 8 signaling pathway 0
                                  positive regulation of toll-like receptor 8 signaling pathway 3
                                  regulation of toll-like receptor 8 signaling pathway + 3
paths to the root