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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor 4 signaling pathway
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Accession:GO:0034142 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to toll-like receptor 4.
Synonyms:exact_synonym: TLR4 signaling pathway;   toll-like receptor 4 signalling pathway

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show annotations for term's descendants           Sort by:
toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624743:33,372,023...33,374,438
Ensembl chrNW_004624743:33,367,898...33,373,922 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex involved_in ISO (PMID:26189595) UniProt PMID:26189595 NCBI chrNW_004624737:12,022,081...12,052,128
Ensembl chrNW_004624737:12,022,419...12,052,131 		JBrowse link
G Ecsit ECSIT signaling integrator involved_in ISO (PMID:25371197) UniProt PMID:25371197 NCBI chrNW_004624828:3,264,054...3,276,270
Ensembl chrNW_004624828:3,264,149...3,269,030 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:14660645) UniProt PMID:14660645 NCBI chrNW_004624776:7,858,400...7,862,716
Ensembl chrNW_004624776:7,793,259...7,863,184 		JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 acts_upstream_of_or_within ISO (PMID:10549626) MGI PMID:10549626 NCBI chrNW_004624946:613,392...618,459
Ensembl chrNW_004624946:613,890...618,445 		JBrowse link
G Irak2 interleukin 1 receptor associated kinase 2 involved_in ISO (PMID:17878161) UniProt PMID:17878161 NCBI chrNW_004624731:5,294,464...5,348,426
Ensembl chrNW_004624731:5,294,431...5,348,481 		JBrowse link
G Irf3 interferon regulatory factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624832:4,611,445...4,616,319
Ensembl chrNW_004624832:4,612,374...4,616,276 		JBrowse link
G Lgals9 galectin 9 NOT|involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chrNW_004624786:478,048...491,086 JBrowse link
G LOC101722352 TIR domain-containing adapter molecule 2 involved_in ISO (PMID:28630139) UniProt PMID:28630139 NCBI chrNW_004624733:6,304,454...6,341,827 JBrowse link
G Ly96 lymphocyte antigen 96 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624744:17,209,285...17,241,347
Ensembl chrNW_004624744:17,208,990...17,241,347 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:5913054|PMID:28098138) UniProt PMID:28098138 MGI:5913054 NCBI chrNW_004624886:4,029,318...4,168,797
Ensembl chrNW_004624886:4,027,178...4,168,902 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO (PMID:25371197) UniProt PMID:25371197 NCBI chrNW_004624799:3,554,644...3,623,317
Ensembl chrNW_004624799:3,554,678...3,622,289 		JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:2,677,259...2,681,408
Ensembl chrNW_004624731:2,677,290...2,681,489 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase acts_upstream_of_or_within ISO (PMID:29624734) MGI PMID:29624734 NCBI chrNW_004624795:1,553,582...1,558,110
Ensembl chrNW_004624795:1,553,037...1,558,197 		JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) TreeGrafter
MGI
Ensembl		 PMID:18261938 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624838:1,384,337...1,387,602
Ensembl chrNW_004624838:1,384,204...1,390,205 		JBrowse link
G Nmi N-myc and STAT interactor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624866:4,230,258...4,263,156
Ensembl chrNW_004624866:4,229,535...4,263,688 		JBrowse link
G Oas1 2'-5'-oligoadenylate synthetase 1 involved_in ISO (PMID:30078389) ARUK-UCL PMID:30078389 NCBI chrNW_004624747:19,428,994...19,434,512
Ensembl chrNW_004624747:19,428,833...19,434,550 		JBrowse link
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:8,021,478...8,154,543
Ensembl chrNW_004624737:8,022,836...8,154,422 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:20,732,813...20,742,016
Ensembl chrNW_004624767:20,732,938...20,741,272 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within ISO (PMID:11894098) MGI PMID:11894098 NCBI chrNW_004624744:2,194,339...2,227,498
Ensembl chrNW_004624744:2,201,319...2,226,890 		JBrowse link
G S100a14 S100 calcium binding protein A14 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624885:3,529,813...3,531,314
Ensembl chrNW_004624885:3,529,026...3,532,182 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624786:8,975,216...8,982,825
Ensembl chrNW_004624786:8,974,587...9,007,986 		JBrowse link
G Tbk1 TANK binding kinase 1 involved_in ISO (PMID:28747347) UniProt PMID:28747347 NCBI chrNW_004624802:3,861,821...3,914,061
Ensembl chrNW_004624802:3,862,709...3,914,028 		JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 involved_in ISO (PMID:12471095) UniProt PMID:12471095 NCBI chrNW_004624828:4,964,199...4,973,465
Ensembl chrNW_004624828:4,971,093...4,973,198 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624812:433,540...445,517
Ensembl chrNW_004624812:439,319...446,646 		JBrowse link
G Tlr4 toll like receptor 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25549946) MGI
Ensembl
TreeGrafter		 PMID:25549946 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120 		JBrowse link
G Tmem126a transmembrane protein 126A acts_upstream_of_or_within ISO (PMID:25549946) MGI PMID:25549946 NCBI chrNW_004624845:4,264,497...4,272,973 JBrowse link
G Tnip3 TNFAIP3 interacting protein 3 involved_in ISO (PMID:17088249) UniProt PMID:17088249 NCBI chrNW_004624777:1,124,389...1,222,450
Ensembl chrNW_004624777:1,124,204...1,158,324 		JBrowse link
G Traf3 TNF receptor associated factor 3 involved_in ISO (PMID:18222170) UniProt PMID:18222170 NCBI chrNW_004624734:1,728,353...1,820,345
Ensembl chrNW_004624734:1,728,255...1,786,010 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in ISO (PMID:25371197) UniProt PMID:25371197 NCBI chrNW_004624767:10,729,766...10,803,253
Ensembl chrNW_004624767:10,729,413...10,748,455 		JBrowse link
G Tril TLR4 interactor with leucine rich repeats involved_in ISO (PMID:19710467) UniProt PMID:19710467 NCBI chrNW_004624739:1,663,916...1,668,258
Ensembl chrNW_004624739:1,664,432...1,666,867 		JBrowse link
MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrfip2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) MGI PMID:19265123 NCBI chrNW_004624788:15,158,920...15,294,785 JBrowse link
negative regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in ISO (MGI:5490396|PMID:23609450) UniProt PMID:23609450 MGI:5490396 NCBI chrNW_004624751:23,478,263...23,488,834
Ensembl chrNW_004624751:23,478,096...23,483,521 		JBrowse link
G Bpifb1 BPI fold containing family B member 1 involved_in ISO (PMID:21900486) UniProt PMID:21900486 NCBI chrNW_004624842:5,951,202...5,972,212
Ensembl chrNW_004624842:5,951,203...5,972,212 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO (PMID:19948740) UniProt PMID:19948740 NCBI chrNW_004624760:13,472,500...13,658,070
Ensembl chrNW_004624760:13,472,672...13,657,930 		JBrowse link
G LOC101722352 TIR domain-containing adapter molecule 2 involved_in ISO (PMID:19412184) UniProt PMID:19412184 NCBI chrNW_004624733:6,304,454...6,341,827 JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:4456928|PMID:20385881) UniProt PMID:20385881 MGI:4456928 NCBI chrNW_004624886:4,029,318...4,168,797
Ensembl chrNW_004624886:4,027,178...4,168,902 		JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:28609714) UniProt PMID:28609714 NCBI chrNW_004624839:4,908,861...5,000,218
Ensembl chrNW_004624839:4,908,639...5,000,677 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1 group D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624795:3,102,424...3,109,497
Ensembl chrNW_004624795:3,102,439...3,109,497 		JBrowse link
G Rab7b RAB7B, member RAS oncogene family involved_in ISO (MGI:3834524|PMID:17395780) UniProt PMID:17395780 MGI:3834524 NCBI chrNW_004624807:5,307,361...5,334,578
Ensembl chrNW_004624807:5,307,440...5,334,945 		JBrowse link
G Sqstm1 sequestosome 1 involved_in ISO (PMID:31281713) UniProt PMID:31281713 NCBI chrNW_004624733:42,689,454...42,700,916
Ensembl chrNW_004624733:42,691,841...42,700,916 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 involved_in ISO (PMID:28898289) UniProt PMID:28898289 NCBI chrNW_004624739:2,800,453...2,894,355
Ensembl chrNW_004624739:2,801,301...2,885,094 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6152919|PMID:29407460)
(MGI:6695864|PMID:31134514)		 ARUK-UCL PMID:29407460 PMID:31134514 MGI:6152919 MGI:6695864 NCBI chrNW_004624754:17,643,397...17,649,255
Ensembl chrNW_004624754:17,643,363...17,648,231 		JBrowse link
G Trim32 tripartite motif containing 32 involved_in ISO (PMID:28898289) UniProt PMID:28898289 NCBI chrNW_004624760:18,577,764...18,600,869
Ensembl chrNW_004624760:18,585,279...18,599,659 		JBrowse link
positive regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule involved_in ISO (MGI:5645195|PMID:24380872) UniProt PMID:24380872 MGI:5645195 NCBI chrNW_004624743:33,372,023...33,374,438
Ensembl chrNW_004624743:33,367,898...33,373,922 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:18622013) UniProt PMID:18622013 NCBI chrNW_004624869:1,326,605...1,337,195 JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (MGI:5788395|PMID:16267105) UniProt PMID:16267105 MGI:5788395 NCBI chrNW_004624776:7,858,400...7,862,716
Ensembl chrNW_004624776:7,793,259...7,863,184 		JBrowse link
G Ifi35 interferon induced protein 35 involved_in ISO (PMID:29038465) UniProt PMID:29038465 NCBI chrNW_004624795:1,260,476...1,268,015
Ensembl chrNW_004624795:1,260,476...1,262,080 		JBrowse link
G Lbp lipopolysaccharide binding protein involved_in ISO (PMID:11528597) BHF-UCL PMID:11528597 NCBI chrNW_004624842:1,306,299...1,332,269
Ensembl chrNW_004624842:1,301,831...1,332,346 		JBrowse link
G LOC101722352 TIR domain-containing adapter molecule 2 involved_in ISO (PMID:22685567)
(PMID:19412184)		 UniProt PMID:19412184 PMID:22685567 NCBI chrNW_004624733:6,304,454...6,341,827 JBrowse link
G Ltf lactotransferrin involved_in ISO (PMID:20345905) UniProt PMID:20345905 NCBI chrNW_004624730:74,636,554...74,656,817
Ensembl chrNW_004624730:74,636,522...74,656,886 		JBrowse link
G Ninj1 ninjurin 1 involved_in ISO (MGI:6694429|PMID:25860173) UniProt PMID:25860173 MGI:6694429 NCBI chrNW_004624868:3,430,539...3,442,205
Ensembl chrNW_004624868:3,430,209...3,445,542 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1 group H member 3 involved_in ISO (PMID:18511497) BHF-UCL PMID:18511497 NCBI chrNW_004624767:1,459,601...1,473,224
Ensembl chrNW_004624767:1,459,601...1,467,795 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 acts_upstream_of_or_within ISO (PMID:19734906) MGI PMID:19734906 NCBI chrNW_004624762:9,328,275...9,382,996
Ensembl chrNW_004624762:9,328,109...9,386,067 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624772:9,472,869...9,552,751
Ensembl chrNW_004624772:9,472,913...9,550,990 		JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:19509286) BHF-UCL PMID:19509286 NCBI chrNW_004624812:433,540...445,517
Ensembl chrNW_004624812:439,319...446,646 		JBrowse link
G Wdfy1 WD repeat and FYVE domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624823:1,353,601...1,405,762
Ensembl chrNW_004624823:1,353,621...1,401,160 		JBrowse link
G Znrf1 zinc and ring finger 1 involved_in ISO (PMID:28593998) UniProt PMID:28593998 NCBI chrNW_004624746:11,847,627...11,954,637
Ensembl chrNW_004624746:11,848,425...11,954,784 		JBrowse link
regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (MGI:6270783|PMID:27219021) UniProt PMID:27219021 MGI:6270783 NCBI chrNW_004624822:31,175...74,252
Ensembl chrNW_004624822:33,880...74,308 		JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6270783|PMID:27219021) UniProt PMID:27219021 MGI:6270783 NCBI chrNW_004624750:3,789,015...3,827,079
Ensembl chrNW_004624750:3,789,022...3,827,079 		JBrowse link
G Flot1 flotillin 1 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chrNW_004624754:24,992,961...25,000,463
Ensembl chrNW_004624754:24,992,929...25,003,759 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624815:1,290,106...1,376,961
Ensembl chrNW_004624815:1,289,997...1,369,610 		JBrowse link
TIRAP-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:11544529) BHF-UCL PMID:11544529 NCBI chrNW_004624812:433,540...445,517
Ensembl chrNW_004624812:439,319...446,646 		JBrowse link
TRAM-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101722352 TIR domain-containing adapter molecule 2 involved_in ISO (PMID:22685567)
(PMID:19412184)		 UniProt PMID:19412184 PMID:22685567 NCBI chrNW_004624733:6,304,454...6,341,827 JBrowse link
G Prkce protein kinase C epsilon involved_in ISO (MGI:3652658|PMID:16757566) UniProt PMID:16757566 MGI:3652658 NCBI chrNW_004624738:27,118,764...27,630,733
Ensembl chrNW_004624738:27,118,145...27,627,606 		JBrowse link
G Rab11fip2 RAB11 family interacting protein 2 involved_in ISO (PMID:30883606) UniProt PMID:30883606 NCBI chrNW_004624737:28,633,815...28,675,773
Ensembl chrNW_004624737:28,634,079...28,686,886 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    immune system process 2103
      activation of immune response 460
        immune response-activating signaling pathway 405
          immune response-activating cell surface receptor signaling pathway 247
            innate immune response activating cell surface receptor signaling pathway 73
              cell surface pattern recognition receptor signaling pathway 70
                cell surface toll-like receptor signaling pathway 66
                  toll-like receptor 4 signaling pathway 58
                    MyD88-dependent toll-like receptor 4 signaling pathway 1
                    TIRAP-dependent toll-like receptor 4 signaling pathway 1
                    TRAM-dependent toll-like receptor 4 signaling pathway 3
                    TRIF-dependent toll-like receptor 4 signaling pathway 0
                    negative regulation of toll-like receptor 4 signaling pathway 12
                    positive regulation of toll-like receptor 4 signaling pathway 14
                    regulation of toll-like receptor 4 signaling pathway + 29
Path 2
Term Annotations click to browse term
  biological_process 15093
    response to stimulus 8161
      response to external stimulus 2128
        response to external biotic stimulus 1317
          response to other organism 1314
            defense response to other organism 906
              defense response to symbiont 802
                innate immune response 664
                  regulation of innate immune response 371
                    positive regulation of innate immune response 309
                      activation of innate immune response 253
                        innate immune response-activating signaling pathway 237
                          innate immune response activating cell surface receptor signaling pathway 73
                            cell surface pattern recognition receptor signaling pathway 70
                              cell surface toll-like receptor signaling pathway 66
                                toll-like receptor 4 signaling pathway 58
                                  MyD88-dependent toll-like receptor 4 signaling pathway 1
                                  TIRAP-dependent toll-like receptor 4 signaling pathway 1
                                  TRAM-dependent toll-like receptor 4 signaling pathway 3
                                  TRIF-dependent toll-like receptor 4 signaling pathway 0
                                  negative regulation of toll-like receptor 4 signaling pathway 12
                                  positive regulation of toll-like receptor 4 signaling pathway 14
                                  regulation of toll-like receptor 4 signaling pathway + 29
paths to the root