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ONTOLOGY REPORT - ANNOTATIONS

Term:collagen biosynthetic process
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Accession:GO:0032964 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
Synonyms:exact_synonym: collagen anabolism;   collagen biosynthesis;   collagen formation;   collagen synthesis

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collagen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:20,793,392...21,068,712
Ensembl chr 7:20,793,399...21,048,515 		JBrowse link
G ARG1 arginase 1 ISO RGD PMID:20107769 RGD:4143276 NCBI chr13:41,971,955...41,983,372
Ensembl chr13:41,971,802...41,983,049 		JBrowse link
G COL1A1 collagen type I alpha 1 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:43,134,648...43,152,313
Ensembl chr16:43,134,779...43,150,930 		JBrowse link
G COL5A1 collagen type V alpha 1 chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:3,301,643...3,507,300
Ensembl chr12:3,301,175...3,459,607 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20837772) Ensembl
MGI		 PMID:20837772 GO_REF:0000107 NCBI chr14:79,201,128...79,222,363
Ensembl chr14:79,201,649...79,222,373 		JBrowse link
G LOC103235043 reticulocalbin-3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,706,120...42,718,677
Ensembl chr 6:42,705,585...42,718,594 		JBrowse link
G P3H3 prolyl 3-hydroxylase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:6,861,123...6,872,934
Ensembl chr11:6,860,891...6,872,549 		JBrowse link
G P3H4 prolyl 3-hydroxylase family member 4 (inactive) involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:64,448,360...64,457,865
Ensembl chr16:64,449,057...64,457,868 		JBrowse link
G RCN3 reticulocalbin 3 involved_in ISO (PMID:28939891) UniProt PMID:28939891
G SERPINH1 serpin family H member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10995453) Ensembl
MGI		 PMID:10995453 GO_REF:0000107 NCBI chr 1:66,787,978...66,798,930
Ensembl chr 1:66,788,240...66,799,072 		JBrowse link
G TMEM131 transmembrane protein 131 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:1,454,466...1,699,469
Ensembl chr14:1,454,420...1,699,656 		JBrowse link
G TRAM2 translocation associated membrane protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:19,926,550...20,000,968
Ensembl chr17:19,926,619...20,000,097 		JBrowse link
G TRAPPC8 trafficking protein particle complex subunit 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:48,788,760...48,900,322
Ensembl chr18:48,789,136...48,901,279 		JBrowse link
negative regulation of collagen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor ISO RGD PMID:9535419 RGD:2316149 NCBI chr16:15,682,669...15,712,079
Ensembl chr16:15,683,077...15,711,858 		JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO RGD PMID:21872885 RGD:7245949 NCBI chr17:39,847,343...39,851,288
Ensembl chr17:39,847,759...39,851,127 		JBrowse link
G CYGB cytoglobin ISO RGD PMID:20719976 RGD:9685174 NCBI chr16:45,140,130...45,151,068
Ensembl chr16:45,140,284...45,151,082 		JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 ISO RGD PMID:25840911 PMID:29656108 RGD:12904676 RGD:150520032 NCBI chr20:73,083,312...73,115,174
Ensembl chr20:73,083,389...73,115,077 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 ISO RGD PMID:15521018 RGD:15045602 NCBI chr 8:54,475,801...54,489,329
Ensembl chr 8:54,477,105...54,485,649 		JBrowse link
G EMILIN1 elastin microfibril interfacer 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:80,531,973...80,539,820 JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 ISO RGD PMID:19204184 RGD:9685562 NCBI chr20:123,738,971...123,753,575
Ensembl chr20:123,738,973...123,755,809 		JBrowse link
G FN1 fibronectin 1 ISO RGD PMID:15980055 RGD:1625201 NCBI chr10:101,177,867...101,254,613
Ensembl chr10:101,176,789...101,254,633 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:26880260 RGD:13504840 NCBI chr 9:92,463,017...92,489,227
Ensembl chr 9:92,462,782...92,488,310 		JBrowse link
G IL6 interleukin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237 		JBrowse link
G IL6R interleukin 6 receptor involved_in ISO (PMID:12419823) BHF-UCL PMID:12419823 NCBI chr20:9,345,723...9,418,963
Ensembl chr20:9,361,152...9,396,610 		JBrowse link
G NOTCH1 notch receptor 1 ISO RGD PMID:28100501 RGD:152995503 NCBI chr12:1,656,815...1,707,566
Ensembl chr12:1,656,918...1,709,585 		JBrowse link
G NPPC natriuretic peptide C ISO RGD PMID:12746286 RGD:1580115 NCBI chr10:117,919,889...117,924,306
Ensembl chr10:117,919,760...117,924,273 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 ISO RGD PMID:15980055 RGD:1625201 NCBI chr11:95,792,428...95,877,989
Ensembl chr11:95,792,996...95,878,293 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta ISO RGD PMID:17346664 RGD:2324888 NCBI chr17:36,695,546...36,779,554
Ensembl chr17:36,695,494...36,779,577 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO RGD PMID:16202214 RGD:8553021 NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418 		JBrowse link
G RAP1A RAP1A, member of RAS oncogene family ISO RGD PMID:22012077 RGD:9850086 NCBI chr20:21,895,829...21,989,008
Ensembl chr20:21,899,669...21,917,350 		JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 ISO RGD PMID:22012077 RGD:9850086 NCBI chr11:43,954,517...43,979,068
Ensembl chr11:43,957,425...43,978,047 		JBrowse link
positive regulation of collagen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVR1B activin A receptor type 1B ISO RGD PMID:27477354 RGD:151665478 NCBI chr11:48,120,765...48,166,520
Ensembl chr11:48,145,003...48,166,813 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:28274926 RGD:13506828 NCBI chr16:4,191,040...4,202,382
Ensembl chr16:4,191,172...4,202,385 		JBrowse link
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:31,097,673...31,104,774
Ensembl chr24:31,097,538...31,101,225 		JBrowse link
G CBX8 chromobox 8 ISO RGD PMID:23572236 RGD:9586727 NCBI chr16:71,755,598...71,760,611
Ensembl chr16:71,755,627...71,760,632 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:8663511 RGD:8549527 NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416 		JBrowse link
G CCN2 cellular communication network factor 2 ISO RGD PMID:19570811 RGD:2314490 NCBI chr13:41,613,838...41,617,010
Ensembl chr13:41,613,798...41,617,651 		JBrowse link
G CREB3L1 cAMP responsive element binding protein 3 like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:19,009,169...19,054,841
Ensembl chr 1:19,009,035...19,054,804 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 ISO RGD PMID:24938620 PMID:26674152 RGD:11554781 RGD:150429973 NCBI chr20:1,298,636...1,451,872
Ensembl chr20:1,299,574...1,359,674 		JBrowse link
G DICER1 dicer 1, ribonuclease III ISO RGD PMID:24337369 RGD:150340618 NCBI chr24:72,915,550...72,986,658
Ensembl chr24:72,915,499...72,963,006 		JBrowse link
G ENG endoglin ISO RGD PMID:20156938 RGD:7257540 NCBI chr12:10,274,705...10,315,715
Ensembl chr12:10,275,064...10,315,040 		JBrowse link
G EP300 E1A binding protein p300 ISO RGD PMID:18292803 RGD:2312266 NCBI chr19:23,634,132...23,726,095
Ensembl chr19:23,634,571...23,724,979 		JBrowse link
G F2R coagulation factor II thrombin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:70,992,406...71,010,512
Ensembl chr 4:70,992,477...71,009,456 		JBrowse link
G GLI2 GLI family zinc finger 2 ISO RGD PMID:26823780 RGD:155791684 NCBI chr10:9,302,890...9,561,287
Ensembl chr10:9,304,645...9,369,115 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10208865) Ensembl
MGI		 PMID:10208865 GO_REF:0000107 NCBI chr10:104,960,296...104,966,596
Ensembl chr10:104,960,120...104,966,585 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:20644901 RGD:4889158 NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150 		JBrowse link
G INHBA inhibin subunit beta A ISO RGD PMID:27477354 RGD:151665478 NCBI chr21:16,936,054...16,951,430
Ensembl chr21:16,936,175...16,946,880 		JBrowse link
G ITGA2 integrin subunit alpha 2 ISO RGD PMID:10867645 RGD:2307406 NCBI chr 4:49,280,289...49,382,101
Ensembl chr 4:49,317,648...49,380,051 		JBrowse link
G LARP6 La ribonucleoprotein 6, translational regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:12,605,050...12,626,661
Ensembl chr26:12,605,147...12,628,761 		JBrowse link
G LOC103236354 prothrombin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:18,589,658...18,627,459
Ensembl chr 1:18,620,215...18,627,511
Ensembl chr 1:18,620,215...18,627,511 		JBrowse link
G LTBP1 latent transforming growth factor beta binding protein 1 ISO RGD PMID:9607192 RGD:10412058 NCBI chr14:74,063,258...74,441,042
Ensembl chr14:74,064,087...74,548,825 		JBrowse link
G MKX mohawk homeobox acts_upstream_of_or_within ISO (PMID:20498044) MGI PMID:20498044 NCBI chr 9:27,228,061...27,305,852 JBrowse link
G MRTFA myocardin related transcription factor A ISO RGD PMID:31928221 RGD:529195969 NCBI chr19:22,980,071...23,197,199
Ensembl chr19:22,981,216...23,034,179 		JBrowse link
G MYB MYB proto-oncogene, transcription factor ISO RGD PMID:15534927 RGD:11532676 NCBI chr13:38,203,923...38,242,148
Ensembl chr13:38,203,731...38,241,864 		JBrowse link
G PDGFB platelet derived growth factor subunit B ISO RGD PMID:15358192 RGD:10449487 NCBI chr19:21,865,792...21,888,068
Ensembl chr19:21,863,768...21,886,395 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta ISO RGD PMID:15978205 RGD:2292205 NCBI chr23:52,724,061...52,766,264
Ensembl chr23:52,724,005...52,766,234 		JBrowse link
G PRDX5 peroxiredoxin 5 involved_in ISO (PMID:15276323) UniProt PMID:15276323 NCBI chr 1:9,912,947...9,917,439
Ensembl chr 1:9,912,898...9,917,361 		JBrowse link
G RGCC regulator of cell cycle involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:19,681,700...19,695,655
Ensembl chr 3:19,681,874...19,693,644 		JBrowse link
G SCX scleraxis bHLH transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:138,476,902...138,482,185
Ensembl chr 8:138,478,458...138,480,459 		JBrowse link
G SERPINB7 serpin family B member 7 ISO RGD PMID:21945418 RGD:7207383 NCBI chr18:15,992,154...16,020,001
Ensembl chr18:15,992,186...16,044,650 		JBrowse link
G SERPINE1 serpin family E member 1 ISO RGD PMID:15828931 RGD:13208547 NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202 		JBrowse link
G SERPINF2 serpin family F member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:1,392,562...1,404,574
Ensembl chr16:1,392,571...1,404,636 		JBrowse link
G SUCO SUN domain containing ossification factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:56,541,074...56,623,086
Ensembl chr25:56,541,038...56,623,201 		JBrowse link
G TGFB1 transforming growth factor beta 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:26923362 GO_REF:0000107 RGD:11073665 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
G TGFB3 transforming growth factor beta 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:53,203,593...53,227,483
Ensembl chr24:53,203,301...53,227,325 		JBrowse link
G UCN urocortin ISO RGD PMID:11087261 RGD:1642796 NCBI chr14:80,303,210...80,304,910
Ensembl chr14:80,304,416...80,304,790 		JBrowse link
G UTS2 urotensin 2 ISO RGD PMID:17184580 PMID:18475149 RGD:2306811 RGD:2306814 NCBI chr20:123,903,137...123,910,180 JBrowse link
G VIM vimentin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:17,183,466...17,191,771
Ensembl chr 9:17,183,388...17,191,829 		JBrowse link
G WNT4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:110,517,391...110,543,802
Ensembl chr20:110,517,564...110,541,203 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17042
    cellular process 16559
      metabolic process 10932
        collagen metabolic process 127
          collagen biosynthetic process 69
            negative regulation of collagen biosynthetic process 18
            positive regulation of collagen biosynthetic process 38
            regulation of collagen biosynthetic process + 56
paths to the root