MYB (MYB proto-oncogene, transcription factor) - Rat Genome Database

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Gene: MYB (MYB proto-oncogene, transcription factor) Chlorocebus sabaeus
Analyze
Symbol: MYB
Name: MYB proto-oncogene, transcription factor
RGD ID: 18792106
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); WD40-repeat domain binding (ortholog); INVOLVED IN B cell differentiation (ortholog); calcium ion transport (ortholog); cellular response to hydrogen peroxide (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); adult T-cell leukemia/lymphoma (ortholog); asthma (ortholog); FOUND IN RNA polymerase II transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcriptional activator Myb
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11338,203,923 - 38,242,148 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1338,203,731 - 38,241,864 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604010,407,630 - 10,446,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (ISO)
calcium ion transport  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to retinoic acid  (ISO)
embryonic digestive tract development  (ISO)
erythrocyte differentiation  (IEA)
G1/S transition of mitotic cell cycle  (ISO)
homeostasis of number of cells  (ISO)
in utero embryonic development  (ISO)
mitotic cell cycle  (IEA)
myeloid cell differentiation  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of hematopoietic progenitor cell differentiation  (IEA)
negative regulation of megakaryocyte differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
positive regulation of cellular process  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of glial cell proliferation  (ISO)
positive regulation of hepatic stellate cell activation  (ISO)
positive regulation of hepatic stellate cell proliferation  (ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of testosterone secretion  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transforming growth factor beta production  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
skeletal muscle cell proliferation  (ISO)
spleen development  (ISO)
stem cell division  (ISO)
T-helper 2 cell differentiation  (IEA)
thymus development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MYB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11338,203,923 - 38,242,148 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1338,203,731 - 38,241,864 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604010,407,630 - 10,446,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MYB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386135,181,308 - 135,219,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6135,181,308 - 135,219,173 (+)EnsemblGRCh38hg38GRCh38
GRCh376135,502,446 - 135,540,310 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366135,544,146 - 135,582,003 (+)NCBINCBI36Build 36hg18NCBI36
Build 346135,544,145 - 135,582,002NCBI
Celera6136,242,804 - 136,280,663 (+)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6133,066,684 - 133,104,587 (+)NCBIHuRef
CHM1_16135,764,731 - 135,802,560 (+)NCBICHM1_1
T2T-CHM13v2.06136,369,551 - 136,407,418 (+)NCBIT2T-CHM13v2.0
Myb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391021,000,829 - 21,036,883 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1021,000,834 - 21,036,883 (-)EnsemblGRCm39 Ensembl
GRCm381021,124,930 - 21,160,984 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1021,124,935 - 21,160,984 (-)EnsemblGRCm38mm10GRCm38
MGSCv371020,844,736 - 20,880,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361020,814,352 - 20,850,400 (-)NCBIMGSCv36mm8
Celera1021,025,990 - 21,061,964 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map109.75NCBI
Myb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8117,759,309 - 17,793,306 (-)NCBIGRCr8
mRatBN7.2115,939,771 - 15,973,367 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl115,939,761 - 15,973,057 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0116,658,178 - 16,690,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl116,659,442 - 16,687,817 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0117,817,157 - 17,846,532 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera114,360,650 - 14,392,555 (-)NCBICelera
Cytogenetic Map1p12NCBI
Myb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554391,521,292 - 1,560,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554391,523,516 - 1,560,185 (-)NCBIChiLan1.0ChiLan1.0
MYB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25155,158,995 - 155,196,836 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16153,064,563 - 153,102,392 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06132,952,728 - 132,990,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16136,974,525 - 137,086,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6137,048,812 - 137,086,194 (+)Ensemblpanpan1.1panPan2
MYB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1127,908,309 - 27,991,984 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl127,908,364 - 27,991,969 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha128,788,584 - 28,872,250 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0128,064,278 - 28,148,012 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl128,064,302 - 28,148,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1127,950,250 - 28,034,180 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0127,830,605 - 27,914,242 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0128,141,120 - 28,224,856 (+)NCBIUU_Cfam_GSD_1.0
Myb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946123,017,481 - 123,050,430 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365602,796,697 - 2,829,650 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365602,797,943 - 2,828,813 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl128,819,503 - 28,856,999 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1128,819,500 - 28,856,222 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2132,265,822 - 32,303,302 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Myb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248862,455,704 - 2,489,593 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 5
Low 10 19 39
Below cutoff 24 1 16

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000014910   ⟹   ENSCSAP00000012868
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1338,203,731 - 38,241,864 (-)Ensembl
RefSeq Acc Id: XM_008006958   ⟹   XP_008005149
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11338,203,923 - 38,242,148 (-)NCBI
Vero_WHO_p1.0NW_02366604010,407,630 - 10,446,173 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008006959   ⟹   XP_008005150
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11338,203,923 - 38,242,140 (-)NCBI
Vero_WHO_p1.0NW_02366604010,407,630 - 10,446,173 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038000861   ⟹   XP_037856789
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604010,407,630 - 10,444,032 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008005149 (Get FASTA)   NCBI Sequence Viewer  
  XP_008005150 (Get FASTA)   NCBI Sequence Viewer  
  XP_037856789 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012868.1
Reference Protein Sequences
RefSeq Acc Id: XP_008005149   ⟸   XM_008006958
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RW79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008005150   ⟸   XM_008006959
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RW79 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000012868   ⟸   ENSCSAT00000014910
RefSeq Acc Id: XP_037856789   ⟸   XM_038000861
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RW79 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016815 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014910.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro C-myb_C UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Myb_dom UniProtKB/TrEMBL
  SANT/Myb UniProtKB/TrEMBL
  Tscrpt_reg_Wos2-domain UniProtKB/TrEMBL
NCBI Gene MYB ENTREZGENE
PANTHER MYB PROTEIN UniProtKB/TrEMBL
  MYB PROTEIN-RELATED UniProtKB/TrEMBL
Pfam Cmyb_C UniProtKB/TrEMBL
  LMSTEN UniProtKB/TrEMBL
  Myb_DNA-binding UniProtKB/TrEMBL
PROSITE HTH_MYB UniProtKB/TrEMBL
  MYB_LIKE UniProtKB/TrEMBL
SMART SANT UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A0D9RW79 ENTREZGENE, UniProtKB/TrEMBL