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PPARbeta/delta activation inhibits angiotensin II-induced collagen type I expression in rat cardiac fibroblasts.

Authors: Zhang, H  Pi, R  Li, R  Wang, P  Tang, F  Zhou, S  Gao, J  Jiang, J  Chen, S  Liu, P 
Citation: Zhang H, etal., Arch Biochem Biophys. 2007 Apr 1;460(1):25-32. Epub 2007 Feb 16.
Pubmed: (View Article at PubMed) PMID:17346664
DOI: Full-text: DOI:10.1016/j.abb.2007.01.028

Peroxisome proliferator-activated receptors (PPARalpha, beta/delta and gamma) are nuclear receptors and PPARgamma activation was previously reported to inhibit collagen expression in the heart, but whether PPARbeta/delta also regulates collagen expression in the heart remains unclear. In this study, we investigated the effect of PPARbeta/delta activation on angiotensin II (Ang II)-induced collagen type I expression in adult rat cardiac fibroblasts. The results showed that PPARbeta/delta was expressed at the moderate level in cardiac fibroblasts. GW501516, a selective PPARbeta/delta agonist, depressed Ang II-stimulated collagen type I expression and collagen synthesis in cardiac fibroblasts in a concentration-dependent manner. Furthermore, these inhibitory effects of GW501516 were completely reversed by the knockdown of PPARbeta/delta via RNA interference. In summary, we find that PPARbeta/delta is present in cardiac fibroblasts and PPARbeta/delta activation inhibits Ang II-induced collagen type I expression at least in part via decreasing collagen synthesis. PPARbeta/delta may be a promising therapeutic target for myocardial fibrosis.

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RGD Object Information
RGD ID: 2324888
Created: 2010-05-14
Species: All species
Last Modified: 2010-05-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.